PDA Journal of Pharmaceutical Science and Technology最新文献

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Bacterial Endotoxins Testing Using Non-Animal Derived Reagents and Innovative Microfluidic Technology on Real World Samples: Poster Presented at PDA Week 2025. 细菌内毒素测试使用非动物源性试剂和创新的微流体技术在真实世界的样品:海报呈现在PDA周2025。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2025.25421
Hayden Skalski
{"title":"Bacterial Endotoxins Testing Using Non-Animal Derived Reagents and Innovative Microfluidic Technology on Real World Samples: Poster Presented at PDA Week 2025.","authors":"Hayden Skalski","doi":"10.5731/pdajpst.2025.25421","DOIUrl":"https://doi.org/10.5731/pdajpst.2025.25421","url":null,"abstract":"<p><p>Annex 1 encourages pharmaceutical companies to adopt new and innovative technologies in order to streamline their manufacturing processes. As well, companies are continually looking to create more sustainable laboratories. Using microfluidics and centripetal force, a new BET platform allows for assay set up in 85% of the time it takes to set up a traditional 96-well microplate; and is fully automated. It increases efficiency and assures precise and accurate results, allowing manufacturers to meet Annex 1 and sustainability goals while remaining in full compliance with regulations to assure patient safety. Addition to Annex 1, the USP has now accepted a new chapter, USP < 86> which will allow users to implement non-animal derived reagents compared to horseshoe crab blood extract (LAL). In this session, we'll review a case study demonstrating acceptable and comparable results using traditional LAL reagents versus non-animal derived reagents on real world samples using a microfluidic platform. This will demonstrate to the audience who are looking at sustainable testing options with new technology that these reagents are suitable for use on pharmaceutical products.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":"79 4","pages":"464-465"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Microbiologists in Drug Product Development. 微生物学家在药物产品开发中的作用。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2025-000010.1
Donald C Singer, Deborah D Gross, Anthony M Cundell
{"title":"The Role of Microbiologists in Drug Product Development.","authors":"Donald C Singer, Deborah D Gross, Anthony M Cundell","doi":"10.5731/pdajpst.2025-000010.1","DOIUrl":"10.5731/pdajpst.2025-000010.1","url":null,"abstract":"<p><p>The role of the microbiologist during product development of medicines ensures patient safety during clinical trials and also the continuation of microbial control through the commercialization of the new product. Microbiological expertise, insight, and cGMP input for new product development is needed for formulation, manufacturing, packaging, and monitoring, plus testing of in-process materials and the finished dosage form as well as stability. Risk assessment and evaluation of potential microbial contamination origin(s) support a phase-appropriate, broad end-to-end analytical approach to microbiological contamination control strategy. The ultimate beneficiary of this robust oversight and management of quality is the patient. Using knowledge and risk assessment along with experience (of nonsterile and sterile drug product development) provide for a balanced approach to microbiological quality in medicines. This paper will discuss more specific area detail to consider for the role of a microbiologist in nonsterile drug product development.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":" ","pages":"401-407"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Commentary on Understanding the Non-Equivalency of Bio-Fluorescent Particle Counts versus the Colony Forming Unit. 回复关于理解生物荧光粒子计数与菌落形成单位的不等效性的评论。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2025-000024.1
Mike Dingle, Jim Cannon, Chris Knutsen, Kim Perkins, Patrick Hutchins, Margit Franz-Riethdorf, Phil Villari
{"title":"Reply to Commentary on Understanding the Non-Equivalency of Bio-Fluorescent Particle Counts versus the Colony Forming Unit.","authors":"Mike Dingle, Jim Cannon, Chris Knutsen, Kim Perkins, Patrick Hutchins, Margit Franz-Riethdorf, Phil Villari","doi":"10.5731/pdajpst.2025-000024.1","DOIUrl":"10.5731/pdajpst.2025-000024.1","url":null,"abstract":"","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":" ","pages":"422"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of Barrier Systems - Where is the A Team? Poster Presented at PDA Week 2025. 屏障系统的实施- A团队在哪里?2025年PDA周的海报。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2025.25423
Marsha L Steed
{"title":"Implementation of Barrier Systems - Where is the A Team? Poster Presented at PDA Week 2025.","authors":"Marsha L Steed","doi":"10.5731/pdajpst.2025.25423","DOIUrl":"10.5731/pdajpst.2025.25423","url":null,"abstract":"<p><p>Companies are implementing barrier systems, RABS and isolators, to align with Annex 1 requirements. The implementation of a new filling line requires a cross-functional team of highly skilled staff to ensure success. Even more critical is the importance of having skilled aseptic processing operators to run the filling lines. Companies used to put in the \"A team\" staff when they implemented a new, barrier system. In a post-covid world, the reality is that staffing in operations has been impacted and there are sometimes less \"A team\" operators to tackle these critical tasks. The importance of ensuring that the staff in place has adequate and thorough aseptic behaviors training is crucial for contamination control on the lines. This talk will highlight concerns and issues with lack of experienced staff and operators in place to qualify and operate the barrier systems and describe solutions to ensure proper competencies and aseptic behaviors training are in place.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":"79 4","pages":"468-469"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ensuring Data Integrity in Digitalized Manufacturing: Risk-Based Strategies for Achieving GxP Compliance: Poster Presented at PDA Week 2025. 确保数字化制造中的数据完整性:实现GxP合规的基于风险的策略:2025年PDA周上的海报
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2025.25415
Peniel Ortega
{"title":"Ensuring Data Integrity in Digitalized Manufacturing: Risk-Based Strategies for Achieving GxP Compliance: Poster Presented at PDA Week 2025.","authors":"Peniel Ortega","doi":"10.5731/pdajpst.2025.25415","DOIUrl":"https://doi.org/10.5731/pdajpst.2025.25415","url":null,"abstract":"<p><p>The digital transformation of pharmaceutical manufacturing brings about several opportunities and challenges in ensuring data integrity, one of the foundational elements of GxP compliance. As automated systems, advanced analytics, and interoperable digital tools become intrinsic parts of the operation, so too does the risk of vulnerabilities in data. This presentation covers the overall framework for mitigating these risks using a risk-based approach to data governance and integrity management.Key topics will include building resilient data governance frameworks, leveraging automation for proactive monitoring, and ensuring data traceability throughout the product lifecycle. Practical case studies will demonstrate how risk-based strategies enhance compliance, drive operational efficiency, and align with regulatory expectations such as FDA, EMA, and global GxP standards.This session bridges the gap between compliance and digital innovation, equipping attendees with actionable strategies to protect data integrity while optimizing manufacturing processes. Whether you are involved in quality assurance, regulatory affairs, or manufacturing science, this presentation will empower you to confidently navigate the complexities of the digital age.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":"79 4","pages":"452-453"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Image-Based Culture Plate Readers and Microbiological Testing of Mixtures - is It Necessary? Poster Presented at PDA Week 2025. 基于图像的培养板阅读器和混合物的微生物检测-有必要吗?2025年PDA周的海报。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2025.25419
Chris Ramsey, Steven Giglio
{"title":"Image-Based Culture Plate Readers and Microbiological Testing of Mixtures - is It Necessary? Poster Presented at PDA Week 2025.","authors":"Chris Ramsey, Steven Giglio","doi":"10.5731/pdajpst.2025.25419","DOIUrl":"https://doi.org/10.5731/pdajpst.2025.25419","url":null,"abstract":"<p><p>As the use of imaging devices and artificial intelligence (AI) gain traction in culture plate reading, the question of performance on detection of mixtures of organisms often arises. This is typically borne through traditional thoughts of validating alternative quantitative methods for micro-organisms to ensure methods do not demonstrate any interference or bias towards organism recovery or detection. This approach, however, may not be applicable to newer technologies. In the case of the APAS Independence, an AI-based culture plate reading system, testing of bacterial mixtures is not necessary. The system is designed to detect both bacterial and mold colonies, with each colony being classified as a result of pixel level detection in an independent and uninfluenced manner. The pixel result is entirely based on the way the algorithm is developed, which remains agnostic to any species identification within bacterial or mold groups themselves and only requires differentiation between these groups at a high level. This poster will provide insights into imaging and AI-analysis tools to demonstrate how mixtures of organisms are detected, highlighting the independent nature of colony assignment. If the segregation of mold and bacterial colonies is important, additional specificity testing may be considered.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":"79 4","pages":"460-461"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming Risk into Opportunity: Unlocking the Power of a Quality Risk Management Playbook: Poster Presented at PDA Week 2025. 将风险转化为机遇:释放质量风险管理手册的力量:在2025年PDA周上发表的海报。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2025.25425
Jerry Tischler
{"title":"Transforming Risk into Opportunity: Unlocking the Power of a Quality Risk Management Playbook: Poster Presented at PDA Week 2025.","authors":"Jerry Tischler","doi":"10.5731/pdajpst.2025.25425","DOIUrl":"https://doi.org/10.5731/pdajpst.2025.25425","url":null,"abstract":"<p><p>Navigating the complexities of compliance in the biopharmaceutical landscape-particularly for cell and gene therapies-requires innovative and effective solutions. In response to these challenges, Syner-G | Sequoia have developed a Quality Risk Management (QRM) Playbook aimed at standardizing and enhancing the adoption of quality and risk management practices across global operations. This Playbook ensures operational excellence through streamlined processes, advanced technologies, and an engaged workforce. One of the key benefits of implementing this Playbook is a transformative shift in organizational culture towards a proactive QRM approach, fostering a collective sense of quality and ownership among teams, particularly in multi-site environments. This cultural evolution not only reduces the risks associated with drug development but also redefines compliance activities by highlighting their critical role in ensuring patient safety. By embracing a practical and effective methodology to quality risk management, organizations can reshape compliance from a perceived obstacle into a strategic advantage, leading to better outcomes for the business and improved patient care. This poster will discuss how the QRM Playbook empowers teams to refine their compliance strategies and advance their drug development initiatives.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":"79 4","pages":"472-473"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Risk-Based Approach for Pre-Use/Post-Sterilization Integrity Test Simulation During Bacterial Retention Testing as Part of the Process-Specific Filter Validation of Sterilizing Grade Filters. 作为灭菌级过滤器的特定工艺过滤器验证的一部分,细菌保留测试期间使用前/灭菌后完整性测试模拟的基于风险的方法。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2024.012990
Mariam Salamatian, Yvonne Groβ, Magnus Stering, Thao Vinh Le, Ashira Bindels
{"title":"A Risk-Based Approach for Pre-Use/Post-Sterilization Integrity Test Simulation During Bacterial Retention Testing as Part of the Process-Specific Filter Validation of Sterilizing Grade Filters.","authors":"Mariam Salamatian, Yvonne Groβ, Magnus Stering, Thao Vinh Le, Ashira Bindels","doi":"10.5731/pdajpst.2024.012990","DOIUrl":"10.5731/pdajpst.2024.012990","url":null,"abstract":"<p><p>Pre-use post-sterilization integrity testing is implemented in sterile filtration applications by drug manufacturers using a risk-based approach with consideration of the stipulation in Eudralex Volume 4, Annex 1, Manufacture of Sterile Medicinal Products, which states that \"The integrity of the sterilizing filter should be verified before use\". Within the bacterial retention test design, performed as part of the process-specific sterile filter validation, it is important to simulate the filtration process under evaluation as closely as possible. Worst-case conditions experienced by the process filter during routine use that may impact the process filters' ability to produce a sterile effluent should be accounted for in the study. As performing pre-use post-sterilization integrity tests introduces additional mechanical stress on the process filter and a new potential route for the introduction of bioburden into the process fluid flow path related to the filter wetting procedure, a risk-based bacterial retention test design incorporating a pre-use post-sterilization integrity test simulation phase should be considered after a thorough evaluation of the process-specific conditions. The risk assessment should include evaluation of process pre-use post-sterilization integrity test conditions, including but not limited to the integrity test method and specifications, the wetting fluid type, the maximum allowable number of pre-use post-sterilization integrity test repetitions, as well as the permitted bioburden level of the pre-use post-sterilization integrity test wetting fluid. The outcome of the assessment provides a basis for the process-specific bacterial retention test design. In the following, we present our perspective on the topic as well as detailed insight into various aspects of pre-use post-sterilization integrity test simulation test design for consideration. Finally, we present all three PUPSIT-BCT approaches described (non-bactericidal, partially bactericidal, and bactericidal). Executed studies yielded acceptable results. Target parameters agreed upon were met.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":" ","pages":"408-421"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Settle Plates with a Diameter of 150 mm Can be Exposed to Unidirectional Airflow for up to 8 Hours. 直径为150毫米的沉降板可以暴露在单向气流中长达8小时。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2024-003029.1
Martin Falke
{"title":"Settle Plates with a Diameter of 150 mm Can be Exposed to Unidirectional Airflow for up to 8 Hours.","authors":"Martin Falke","doi":"10.5731/pdajpst.2024-003029.1","DOIUrl":"10.5731/pdajpst.2024-003029.1","url":null,"abstract":"<p><p>Active and passive air monitoring is crucial for gaining knowledge about the microbial status of clean room environments for aseptic processing. Most agencies require active air monitoring of defined volumes in short time periods. However, active air monitoring methods may disrupt the unidirectional airflow of filtered air and are therefore difficult to use for continuous air monitoring. Hence, settle plates are additionally placed at areas of high risk during the whole filling process, including setup. Although EU GMP Annex 1 9.30 defines a maximum duration of 4 hours for settle plates with a diameter of 90 mm, and USP <1116> defines a maximum of 4-5 hours, there are no recommendations for settle plates with a diameter of 150 mm. Agencies expect validation studies, including recovery rates, as a basis to determine the exposure time. This study provides data that show that settle plates with a diameter of 150 mm can be placed under unidirectional airflow for up to 8 hours in a clean room with moderate humidity. No negative effect on the suitability of the media was observed. Moreover, it is shown that settle plates with a diameter of 150 mm can be exposed to unidirectional airflow for up to 6 hours in a clean room with very low humidity as used for aseptic filling of lyophilized products. Increased exposure times of settle plates for up to 6 to 8 hours significantly reduce the exchange frequency of settle plates, which ultimately lowers the risk of microbial contamination during filling due to less interventions.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":" ","pages":"370-378"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nitrogen Dioxide Sterilization Follows Log-Linear Microbial Inactivation Kinetics Using Geobacillus stearothermophilus Biological Indicators. 二氧化氮灭菌遵循对数线性微生物失活动力学使用嗜热硬脂地杆菌的生物指标。
PDA Journal of Pharmaceutical Science and Technology Pub Date : 2025-08-01 DOI: 10.5731/pdajpst.2024.012997
Thomas Richards, Delaney Lisco, Tiffany Bianchi, Gabriella Shahine, Huyen Nyugen, Natalie Simmons, Sylvie Dufresne, David Opie
{"title":"Nitrogen Dioxide Sterilization Follows Log-Linear Microbial Inactivation Kinetics Using <i>Geobacillus stearothermophilus</i> Biological Indicators.","authors":"Thomas Richards, Delaney Lisco, Tiffany Bianchi, Gabriella Shahine, Huyen Nyugen, Natalie Simmons, Sylvie Dufresne, David Opie","doi":"10.5731/pdajpst.2024.012997","DOIUrl":"10.5731/pdajpst.2024.012997","url":null,"abstract":"<p><p>The primary purpose of this study was to determine the inactivation kinetics of <i>Geobacillus stearothermophilus</i> biological indicators (BIs) exposed to nitrogen dioxide (NO<sub>2</sub>) gas in the presence of humidity. BIs inoculated with 6 log<sub>10</sub> <i>G. stearothermophilus</i> spores were used as a test substrate. Three BI lots manufactured from each of three different BI spore crops were evaluated. Test cycles were run at room temperature with approximately 80% relative humidity. Direct enumeration methods were used to quantify the resistance of spores with surviving populations greater than approximately 50 colony forming units (CFU). Fraction negative methods were used to estimate the surviving spore populations in the quantal region<sub>.</sub> The methods were combined in order to show spore inactivation from 6 log<sub>10</sub> to approximately -2 log<sub>10</sub> The <i>D</i> value and coefficient of determination (r<sup>2</sup>) were calculated. Over 100 direct enumeration and fraction negative cycles were completed at a fixed NO<sub>2</sub> concentration varying only exposure time. Process parameters were maintained over all cycles. Empirical data confirmed a log-linear relationship over an 8 log<sub>10</sub> population range with r<sup>2</sup> values greater than 0.8, allowing for extrapolation of the curve to achieve a sterility assurance level (SAL) of 10<sup>-6</sup> Study outcomes were comparable for all manufactured BI lots. NO<sub>2</sub> sterilization follows first-order log-linear microbial inactivation kinetics, which is consistent with a mechanism of action based on a single active species. This is the first study to report on the microbial inactivation kinetics of NO<sub>2</sub> sterilization.</p>","PeriodicalId":19986,"journal":{"name":"PDA Journal of Pharmaceutical Science and Technology","volume":" ","pages":"379-390"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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