Parasitology International最新文献

{"title":"The gut microbiome–helminth–immune axis in autoimmune diseases","authors":"Chikako Shimokawa","doi":"10.1016/j.parint.2024.102985","DOIUrl":"10.1016/j.parint.2024.102985","url":null,"abstract":"<div><div>The global prevalence of autoimmune diseases has surged in recent decades. Consequently, environmental triggers have emerged as crucial contributors to autoimmune diseases, equally relevant to classical risk factors, such as genetic polymorphisms, infections, and smoking. Sequencing-based approaches have demonstrated distinct gut microbiota compositions in individuals with autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, type 1 diabetes mellitus (T1D), and systemic lupus erythematosus, compared to healthy controls. Furthermore, fecal microbiota transplantation and microbial inoculation experiments have supported the hypothesis that alterations in the gut microbiota can influence autoimmune responses and disease outcomes. Herein, we propose that intestinal helminths may serve as a critical factor in inducing alterations in the gut microbiota. The concept of helminth-mediated suppression of autoimmune diseases in humans is supported by substantial evidence, aligning with the long-standing “hygiene hypothesis.” This review focused on T1D to explore the interactions between parasites, gut microbiota, and the immune system—a topic that remains a black box within this intricate triangular relationship.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102985"},"PeriodicalIF":1.5,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplemental description of Benedenia seriolae (Yamaguti, 1934) Meserve, 1938 (Monogenoidea: Capsalidae) and first record of the parasite infecting a wild greater amberjack, Seriola dumerili (Risso, 1810) Hureau and Tortonese, 1973 (Carangiformes: Carangidae) from the northern Gulf of Mexico","authors":"Micah B. Warren ,&nbsp;Stephen A. Bullard","doi":"10.1016/j.parint.2024.102986","DOIUrl":"10.1016/j.parint.2024.102986","url":null,"abstract":"<div><div>We herein provide a supplemental description of <em>Benedenia seriolae</em> (Yamaguti, 1934) Meserve, 1938 (Monogenoidea: Capsalidae Baird, 1853) based on specimens we collected from the skin of wild-caught greater amberjack (<em>Seriola dumerili</em>) in the northern Gulf of Mexico (GOM). Our specimens of <em>B</em>. <em>seriolae</em> from the GOM resemble those of <em>Benedenia humboldti</em> Baeza, Sepúlveda, and González, 2019 (from yellowtail amberjack, <em>Seriola lalandi</em> Valenciennes, 1833 [Carangidae] off Chile) by having a large body (&gt;7000 μm in total length), non-overlapping anterior and posterior hamuli, an entirely sinistral and convoluted vas deferens, and a common genital pore as well as by lacking glands of Goto. It differs from <em>B</em>. <em>humboldti</em> by the shape of the penis tip. The <em>28S</em> rRNA gene sequence differed from that of <em>B. seriolae</em> (from Japan) by 8 bp (1.1 %) and <em>B. humboldti</em> by 13 bp (2.8 %–1.7 %). The phylogenetic analysis recovered our sequences of <em>B</em>. <em>seriolae</em> sister to conspecific sequences from Japan, with that clade sister to <em>B</em>. <em>humboldti</em> from Chile. <em>Benedenia</em> was paraphyletic, suggesting some systematic revision to the genus could be warranted. Of 25 <em>Benedenia</em> spp., only <em>Benedenia hendorffii</em> (von Linstow, 1889) Odhner, 1905 had been reported previously from the GOM. <em>Benedenia seriolae</em> had previously not been reported from wild greater amberjack (previous records from greater amberjack were from sea cages only). This is also the first record of <em>B</em>. <em>seriolae</em> from the Northwestern Atlantic Ocean (GOM).</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102986"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of pulmonary cryptosporidiosis associated with pulmonary tuberculosis in a patient with advanced HIV infection","authors":"Adriana Topan ,&nbsp;Angela Monica Ionică ,&nbsp;Astrid Binder ,&nbsp;Violeta Briciu ,&nbsp;Mihaela Lupşe","doi":"10.1016/j.parint.2024.102983","DOIUrl":"10.1016/j.parint.2024.102983","url":null,"abstract":"<div><div><em>Cryptosporidium</em> spp., an important food and waterborne protozoan pathogen, can cause severe diarrhea and extraintestinal manifestations in immunocompromised individuals. The case of a 75 -years old patient diagnosed as a late presenter with advanced HIV infection and multiple opportunistic illnesses associated to HIV: cryptosporidiosis, intestinal and pulmonary, Cytomegalovirus colitis and pulmonary tuberculosis is presented. <em>Cryptosporidium parvum</em> was identified in fecal sample and bronchoalveolar lavage using rapid tests, PCR diagnosis, and sequencing, the two sequences being identical. In spite of adequate treatment for all associated infections, including Nitazoxanide for <em>Cryptosporidium</em> spp. infection, antiretroviral therapy, and management in the intensive care unit, the patient evolution was unfavorable, without immune reconstitution, leading to death on the 30th day of hospitalization. This case describes a rare localization of pulmonary cryptosporidiosis in association with pulmonary tuberculosis in a patient with advanced HIV infection. Clinicians should be aware of the possible pulmonary localization of this opportunistic parasite in immunodeficient patients.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102983"},"PeriodicalIF":1.5,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic analysis of immune-related genes in Pacific white snook (Centropomus viridis) gills infected with the monogenean parasite Rhabdosynochus viridisi","authors":"Marian Mirabent-Casals ,&nbsp;Víctor Hugo Caña-Bozada ,&nbsp;Francisco Neptalí Morales-Serna ,&nbsp;Juan Manuel Martínez-Brown ,&nbsp;Rosa María Medina-Guerrero ,&nbsp;Rubí Hernández-Cornejo ,&nbsp;Alejandra García-Gasca","doi":"10.1016/j.parint.2024.102981","DOIUrl":"10.1016/j.parint.2024.102981","url":null,"abstract":"<div><div>The parasite <em>Rhabdosynochus viridisi</em> (Platyhelminthes: Monogenea) infects the Pacific white snook <em>Centropomus viridis</em> gills and can cause adverse effects in the aquaculture industry. The immune responses of Pacific white snook to monogenean infections are poorly understood. Thus, this study aimed to identify differentially expressed genes (DEGs) in the gills of Pacific white snook juveniles experimentally infected with <em>R. viridisi</em>, emphasizing immune-related genes and pathways activated or suppressed during the infection. RNA sequencing was performed on the gills of uninfected (control) and infected fish. The algorithm Seq2Fun was selected without a reference transcriptome to map the reads to transcripts of fishes available from a database for gene orthologs (EcoOmics) and obtain the counting table. The ExpressAnalyst software was used for differential expression and functional analyses. A total of 20,106 transcripts were found, and 1430 (7 %) were differentially expressed genes (DEGs) between infected and control groups. We identified 860 (60 %) downregulated and 570 (40 %) upregulated genes. Thirteen canonical pathways after the Kyoto Encyclopedia of Genes and Genomes (KEGG) database were overrepresented, and most of the DEGs were downregulated, suggesting the inactivation of these pathways. The functions of most of the DEGs with higher fold change found in this study are poorly understood in fish. Even though the well-known pro-inflammatory cytokines remained unchanged in infected gills of <em>C. viridis</em>, and transforming growth factor β (<em>tgfβ</em>) was downregulated, interleukin-17 ligands <em>il17d</em> and <em>il17a/f1</em>, as well as C-X-C motif chemokine receptor 2 (<em>cxcr2</em>) genes were upregulated, indicating that the infection with <em>R. viridisi</em> promotes Th17-like immunity<em>.</em> Overexpression of plasma B cell activity markers such as immunoglobulin light chain-like genes and the v-set pre-B cell surrogate light chain 3 (<em>vpreb3</em>) was also detected in this study. The possible implications of DEGs related to calcium imbalance, hypoxia adaptation, hemostasis, and immunity are discussed. These results will support future studies to improve the prevention and treatment of monogenean infections in finfish aquaculture.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102981"},"PeriodicalIF":1.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and abundance of fleas and rodents of plague importance in the erstwhile endemic states and international seaports of India","authors":"Appadurai Daniel Reegan ,&nbsp;Anok Melvin Marshall ,&nbsp;K.P. Srilatha ,&nbsp;M. Malini ,&nbsp;Shivakumar S. Titti ,&nbsp;Rajesh L. Kademani ,&nbsp;Shubhangi Kulsange ,&nbsp;Monil Singhai","doi":"10.1016/j.parint.2024.102982","DOIUrl":"10.1016/j.parint.2024.102982","url":null,"abstract":"<div><div>Rodents are the reservoirs of the plague bacterium <em>Yersinia pestis</em>, which is transmitted through the bites of infected fleas. In this paper, we studied the distribution and abundance of fleas and rodents in the erstwhile endemic states and seaports of India from 2009 to 2019. The analysis showed that the <em>Rattus rattus</em> (<em>Rr</em>) was the major rodent species found in both Western (66.52 %) and Eastern (48.95 %) seaports of India and the other rodent species recorded were <em>Bandicota indica</em> (<em>Bi</em>) (16.68 % &amp; 34.24 %), <em>Bandicota bengalensis</em> (<em>Bb</em>) (8.88 % &amp; 16.02 %) <em>Rattus norvegicus</em> (<em>Rn</em>) (6.83 % &amp; 0.70 %), <em>Murines hurriane</em> (<em>Mh</em>) (1.08 % &amp; 0 %), <em>Mus musculus</em> (<em>Mm</em>) (0 % &amp; 0.09 %), respectively. Only two flea species namely, <em>Xenopsylla cheopis</em> (<em>X.c</em>) and <em>Xenopsylla astia</em> (<em>X.a</em>) were recorded during the study period in Eastern and Western seaports. Among them, <em>X. astia</em> was found to be the dominant species (55.56 %) and followed by <em>X. cheopis</em> (44.44 %). Further, the female population of <em>X. cheopis</em> and <em>X. astia</em> was higher in both Western and Eastern seaports than the male population. Similarly, <em>Rattus rattus</em> (<em>Rr</em>) (82.43 %,) was the major rodent species found in erstwhile endemic states of India, followed by <em>Tetera indica</em> (<em>Ti</em>) (11.99 %,). Only northern endemic states (HP and UK) reported <em>Rattus rattus terkiminasis</em> (<em>R.rt</em>) (0.01 %). Four flea species namely, <em>Xenopsylla cheopis</em> (64.89 %)<em>, Xenopsylla astia</em> (34.89 %)<em>, Stivalius ahalae</em> (0.18 %), and <em>Nosopsyllus fasciatus</em> (0.02 %) were recorded from endemic states. The presence of rodents and vector fleas warrants sustained plague surveillance in and around seaports and endemic states.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102982"},"PeriodicalIF":1.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of three important tick-borne pathogens in ticks and humans in Shaanxi Province, Northwest China","authors":"Rui Guan ,&nbsp;Na Wei ,&nbsp;Meng Cao ,&nbsp;Jian-Gong Yang ,&nbsp;Ru Wu ,&nbsp;Hui Li","doi":"10.1016/j.parint.2024.102980","DOIUrl":"10.1016/j.parint.2024.102980","url":null,"abstract":"<div><div>The investigation of important prevalent tick-borne pathogens is central to the control of tick-borne diseases. To understand the prevalence of <em>Borrelia burgdorferi</em> s.l., <em>Borrelia miyamotoi</em>, and the Alongshan virus in ticks and patients in Shaanxi Province, China, a total of 670 adult ticks and 524 patient blood samples were collected in the region between 2022 and 2023. In this study, PCR was used to estimate the prevalence of the three pathogens. The results revealed that the overall positive rates of <em>B. burgdorferi</em> s.l, <em>B. miyamotoi</em>, and ALSV infection in the collected ticks were 13.58 %, 2.46 %, and 4.17 %, respectively. Three genospecies of <em>B. burgdorferi</em> s.l. were detected in this study, namely, <em>B. garinii</em>, <em>B. afzelii</em>, and <em>B. bavariensis</em>, with positive rates of 4.63 %, 3.58 %, and 5.37 %, respectively. The prevalence rates of <em>B. miyamotoi</em>, ALSV  and <em>B. burgdorferi</em> s.l. in the patients were 0.38 %, 0.95 %, and 15 %, respectively. Moreover, <em>B. burgdorferi</em> s.l. and ALSV coinfection was also detected in three patients. Evolutionary analysis revealed that the isolate of <em>B. miyamotoi</em> belongs to the Asian type (Siberian type) and that of ALSV is closely related to that of Finland. To our knowledge, this is the first report on <em>B. miyamotoi</em> and ALSV detection in both ticks and humans in Shaanxi Province; the prevalence indicates that the regions in this province might be endemic areas. The results also suggest that humans in these regions are at risk of infection with these three tick-borne diseases.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102980"},"PeriodicalIF":1.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microscopy and molecular survey of Hepatozoon spp. in domestic cats and their ticks: First report of H. silvestris from Türkiye","authors":"Zuhal Önder ,&nbsp;Didem Pekmezci ,&nbsp;Alparslan Yıldırım ,&nbsp;Gökmen Zafer Pekmezci ,&nbsp;Önder Düzlü ,&nbsp;Zeynep Nurselin Kot ,&nbsp;Gamze Nur Konacoğlu ,&nbsp;Gamze Yetişmiş ,&nbsp;Abdullah İnci","doi":"10.1016/j.parint.2024.102979","DOIUrl":"10.1016/j.parint.2024.102979","url":null,"abstract":"<div><div>Hepatozoonosis is a tick-borne infection caused by protozoan species of the <em>Hepatozoon</em> genus in the family Hepatozoidae. This study aimed to determine the presence and prevalence of <em>Hepatozoon</em> spp. in domestic cats and their ticks, to characterize the genotypes, to reveal phylogenetic relationships, and to assess the risk factors associated with infection. Blood samples were collected in EDTA tubes from 311 cats that were brought to the Veterinary Faculty, Animal Hospital for treatment or routine control purposes. Smears were prepared from the buffy coat and <em>examined</em> microscopically for the presence of <em>Hepatozoon</em> spp. <em>gamonts.</em> Ticks were collected during the clinical examination of the cats and the species were identified. Genomic DNA obtained from buffy coats and ticks were analyzed using PCR analyses targeting the 18S rRNA gene region of <em>Hepatozoon</em> spp. The results showed that <em>Hepatozoon</em> spp. gamonts in neutrophils were determined in five samples as 1.6 % (5/311). A total of 58 (18.64 %, 58/311) were positive for the PCR analyses. Twelve ticks were collected from the cats, and all were identified as <em>Rhipicephalus turanicus. Hepatozoon</em> spp. were found in seven (58.3 %) ticks by molecular analyses. Sequence analysis of the 18S rRNA gene region of 58 positive isolates revealed the presence of <em>H. felis</em> (<em>n</em> = 25, 43.1 %) and <em>H. silvestris</em> (<em>n</em> = 33, 56.9 %) species in cats and <em>H. felis</em> in <em>Rh. turanicus</em> (<em>n</em> = 7). This study also presents the first report of <em>H. silvestris</em> in domestic cats from Türkiye. Phylogenetic analyses showed that our <em>H. felis</em> isolates clustered in <em>H. felis</em> genotype I and our <em>H. silvestris</em> were stated in the same cluster with Italian isolates.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102979"},"PeriodicalIF":1.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal detection of pathogens in honeybees kept in natural and laboratory conditions","authors":"Magdalena Kunat-Budzyńska ,&nbsp;Emilia Łabuć ,&nbsp;Aneta A. Ptaszyńska","doi":"10.1016/j.parint.2024.102978","DOIUrl":"10.1016/j.parint.2024.102978","url":null,"abstract":"<div><div>The honeybee is one of the most important pollinators in the world. The frequently observed poor health of honeybee colonies can be caused by various factors, e.g. environmental pollution, nutritional stress, and climate changes. Moreover, honeybees are constantly exposed to a wide spectrum of pathogens, such as parasites, bacteria, and viruses. We examined the occurrence of various diseases in different-aged worker honeybees from two colonies kept in natural and laboratory conditions during spring, summer, and autumn in Poland. The honeybees were examined by PCR to detect infection with selected pathogens: <em>Nosema ceranae, N. apis, N. bombi, Acarapis woodi,</em> trypanosomatids, and neogregarines (<em>Mattesia</em> or <em>Apicystis</em> species) and by RT-PCR to identify deformed wing virus (DWV), black queen cell virus (BQCV), and acute bee paralysis virus (ABPV). DWV and <em>N. ceranae</em> turned out to be the dominant pathogens. Trypanosomatids and BQCV were also found in several samples. We did not detect the presence of the other pathogens: <em>N. apis, N. bombi, A. woodi,</em> neogregarines, or ABPV. As shown in the present study, the dynamics and occurrence of pathogens are influenced by keeping conditions, honeybee age, and seasonality.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102978"},"PeriodicalIF":1.5,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniature pigs as the intermediate host for Taenia asiatica","authors":"Hiroshi Yamasaki ,&nbsp;Hiromu Sugiyama ,&nbsp;Yasuyuki Morishima ,&nbsp;Munehiro Okamoto","doi":"10.1016/j.parint.2024.102977","DOIUrl":"10.1016/j.parint.2024.102977","url":null,"abstract":"<div><div><em>Taenia asiatica</em>, utilizing pigs as an intermediate host, degenerates and/or calcifies within a few months after infection in pigs, whereas <em>Taenia solium</em>, also using pigs as an intermediate host, can develop into a mature metacestode within a couple of months and can survive for prolong periods in pigs. This raises the question of whether pigs are suitable intermediate hosts for <em>T. asiatica.</em> The host-parasite relationships between <em>T. asiatica</em> and pig strains, such as infection rates and development of metacestodes, have been reported in previous studies: however, little is known about the pathological changes that occur in <em>T. asiatica</em> metacestodes in pigs. Therefore, in the present study, the pathological changes in <em>T. asiatica</em> within 30 days of infection were observed using CLAWN miniature pigs as model animals. Metacestodes were observed on the diaphragmatic surface and throughout the parenchyma of the pig liver 9 days after infection; however, these metacestodes were surrounded by eosinophilic abscesses, and some had already begun to degenerate. By day 20 and 30 post-infection, metacestodes were surrounded by eosinophilic abscesses and had completely degenerated without forming a scolex. These results indicate that although <em>T. asiatica</em> infected miniature pigs, the metacestodes degenerated owing to strong immune responses from the pigs. Therefore, the CLAWN miniature pig are not a suitable intermediate host for <em>T. asiatica.</em> The possible reasons why <em>T. asiatica</em> metacestodes were degenerated and the potential roles of pigs in transmitting the parasite to humans in <em>T. asiatica</em>-endemic regions are discussed in this study. Additionally, data debating whether pigs are suitable intermediate hosts for <em>T. asiatica</em> are provided.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102977"},"PeriodicalIF":1.5,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elimination of schistosomiasis mekongi in reach for Lao PDR: The last patient with severe disease?","authors":"Phonesavanh Southisavath ,&nbsp;Kerstin Kling ,&nbsp;Anousin Homsana ,&nbsp;Nicole Probst-Hensch ,&nbsp;Daniel Henry Paris ,&nbsp;Somphou Sayasone ,&nbsp;Peter Odermatt","doi":"10.1016/j.parint.2024.102976","DOIUrl":"10.1016/j.parint.2024.102976","url":null,"abstract":"<div><div>Schistosomiasis mekongi is endemic in a restricted area in Northern Cambodia and the Southern Lao People's Democratic Republic. Severe hepatobiliary morbidity is associated with chronic untreated <em>S. mekongi</em> infection. Since the 1980s extensive control efforts have been employed in endemic areas, resulting in substantial reduction of infection rates and disease burden. We report on a patient with a fatal course of clinically-assessed chronic schistosomiasis. This report underscores that patients with severe chronic Mekong schistosomiasis may still exist and may need treatment support.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102976"},"PeriodicalIF":1.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}