PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.4309

Qudsia Nawaz, Humaira Tabbasum, S. Baqai

{"title":"DISSERTATION WRITING: AN ANALYSIS OF VARIOUS BARRIERS TO ITS SUCCESS IN PROMOTING RESEARCH CULTURE IN PAKISTAN","authors":"Qudsia Nawaz, Humaira Tabbasum, S. Baqai","doi":"10.51253/pafmj.v6i6.4309","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.4309","url":null,"abstract":"Objective: To identify evidence of success or otherwise of measures like dissertation to promote high quality medical research in the students undergoing postgraduate specialty training despite of many efforts, the quality of medical research in the country remains in turmoil and unrest prevails in the medical community as well. \u0000Study Design: Cross-sectional survey. \u0000Place and Duration of Study: Combined Military Hospital Lahore Pakistan, from Jan 2017 to Dec 2018. \u0000Methodology: This study was conducted by using Google forms, interviewing the college’s affiliates, which include supervisors, fresh graduates and current trainees using a structured questionnaire, to get an idea of the participants’ view regarding magnitude of the problem, its causes and possible solution. \u0000Results: A total of 94 participants responded to the online questionnaire. Among these, 34 (36%) fell in the age group 29-34 years, followed by 19 (20.2%) in the age group 35-40 years. Among the participants, 56 (59.6%) were females. Sixty-six (74%) participants agreed that dissertation writing was not an effective tool in promoting research culture in the country. \u0000Conclusion: The current system of Dissertation-writing is not efficient in promoting research skills of the postgraduate trainees and systemic improvements are urgently needed, which would also brighten the image of medical education in the country.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83471931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF ULTRASOUND GUIDED MODIFIED PECTORAL NERVE BLOCK WITH LOCAL ANAESTHESTIC INFILTRATION FOR ANALGESIA IN BREAST CANCER SURGERY 超声引导改良胸神经阻滞与局麻浸润在乳腺癌手术镇痛中的比较

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.4110

Usman Saqib, Rashid Iqbal, S. Usman, R. Hanif

{"title":"COMPARISON OF ULTRASOUND GUIDED MODIFIED PECTORAL NERVE BLOCK WITH LOCAL ANAESTHESTIC INFILTRATION FOR ANALGESIA IN BREAST CANCER SURGERY","authors":"Usman Saqib, Rashid Iqbal, S. Usman, R. Hanif","doi":"10.51253/pafmj.v6i6.4110","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.4110","url":null,"abstract":"Objective: To compare the frequency of pain and mean analgesia requirement after breast surgery under general anaesthesia when comparing pectoral nerve block with local anaesthesia infiltration. \u0000Study Design: Comparative prospective study. \u0000Place and Duration of Study: Combined Military Hospital, Rawalpindi from Mar 2018 to Sep 2019. \u0000Methodology: A total of 60 patients undergoing modified radical mastectomy were included in the study. Group A (n=30) received pectoral nerve blocks while Group B (n=30) received local anaesthetic infiltration. Outcome was assessed at 12 hours after injection of local anaesthetic. \u0000Results: Pain in 7 (23.33%) patients in Group A (Pectoral nerve blocks) and in 20 (66.67%) patients in Group B (Local anaesthetic infiltration), p-value of 0.001 which was considered statistically significant. Mean analgesic requirement was found to be 80 ± 33.73 mg in the Group A (pectoral nerve blocks) compared with 141.67 ± 47.50 mg in Group B (Local anaesthesia infiltration) patients with a p-value of <0.001 which was statistically significant. \u0000Conclusion: Pectoral nerve block significantly reduces early postoperative pain and analgesia requirement when compared with Local anaesthesia infiltration after breast surgery.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80756083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DEPRESSION AND ITS ASSOCIATED FACTORS: A STUDY ON CAREGIVERS OF PSYCHIATRIC PATIENTS 抑郁症及其相关因素:精神病人照护者的研究

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.2971

Nomita Sohail, Shiraz Hussain, S. Kakar, Sana Khan, M. Alimudin, M. Kamran, Sohail Ali

{"title":"DEPRESSION AND ITS ASSOCIATED FACTORS: A STUDY ON CAREGIVERS OF PSYCHIATRIC PATIENTS","authors":"Nomita Sohail, Shiraz Hussain, S. Kakar, Sana Khan, M. Alimudin, M. Kamran, Sohail Ali","doi":"10.51253/pafmj.v6i6.2971","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.2971","url":null,"abstract":"Objective: To determine the frequency and association of depression among caregivers of psychiatric patients. \u0000Study Design: Cross-sectional study. \u0000Study place and duration: Outpatient Department of a Tertiary Care Hospital, Rawalpindi, from Sep 2016 to Apr 2017. \u0000Methodology: A total of 200 caregivers of psychiatric patients were included in this study. Each caregiver was interviewed by a consultant psychiatrist to measure the frequency of depression according to International Classification of Disease-10 (ICD10) criteria and Hospital Anxiety and Depression Scale (HADS) score of >8. Socio-demographic factors were associated with presence of depression by using chi-square test. \u0000Results: The mean age observed was 35.36 ± 8.39 years. There were 84 (42%) males and 116 (58%) females. Depression was found in 95 (47.5%) caregivers of psychiatric patients in our analysis. Female gender, low socio-economic status and type of psychiatric illness had significant relationship with presence of depression among our target population. \u0000Conclusion: Depression was a highly common undiagnosed entity among the caregivers of psychiatric patients. Female caregivers or caregivers with low socio-economic status should be screened especially for depression in addition to caregivers of patients suffering from psychotic illness.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87905783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE SPEECH SOUND ERRORS AND LITERACY SKILLS IN CHILDREN WITH OROFACIAL CLEFTS 唇腭裂儿童的语音错误和读写能力

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.4044

Arooj Khan, Aasma Yousaf, Sharmeen Aslam Tarer, R. Kausar

{"title":"THE SPEECH SOUND ERRORS AND LITERACY SKILLS IN CHILDREN WITH OROFACIAL CLEFTS","authors":"Arooj Khan, Aasma Yousaf, Sharmeen Aslam Tarer, R. Kausar","doi":"10.51253/pafmj.v6i6.4044","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.4044","url":null,"abstract":"Objective: To investigate the speech sound errors and literacy skills in children with orofacial clefts (cleft palate& cleft lip and palate). \u0000Study Design: Comparative cross-sectional study. \u0000Place and Duration of Study: Centre for Clinical Psychology, University of the Punjab, Lahore, from Mar 2016 to Feb 2017. \u0000Methodology: A sample of 42 participants (cleft lip & palate: n=18 and cleft palate: n=24) was collected. Two stage sampling strategy was used. Each child was individually screened through Slosson intelligence test revised checklist of orofacial cleft and diagnostic statistical Manual-V checklist. Then children were provided with assessment measures which included demographic informational questionnaire, community developed VPI Screener, word list for articulation and phonological processes, annual status of education report (ASER) and curriculum-based measurement (Written Expression). Manual SODA (substitution, omission, distortion and addition) analysis was done to know about the type of speech sound errors. \u0000Results: Independent sample t-test was used to compare the differences of speech sound errors (52.11 ± 25.08), (47.29 ± 25.38), reading skills (3.67 ± 1.14), (3.75 ± 1.26) and writing skills (14.61 ± 13.49), (25.14 ± 29.16) in cleft lip & palate and cleft palate respectively, indicated that there were no differences; with p-value: p=0.54, 0.83, 0.13. \u0000Conclusion: Results indicated no significant differences in speech sound errors, reading, writing skills and resonance between children with cleft lip & palate and cleft palate.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88219743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECTIVENESS OF STEROIDS VERSUS IMMUNOMODULATORS INTREATMENT OF VERNAL KERATO-CONJUNCTIVITIS. A STUDY AT ARMED FORCES INSTITUTE OF OPHTHALMOLOGY 类固醇与免疫调节剂治疗春性角膜结膜炎的疗效比较。军队眼科研究所的一项研究

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.5144

Z. Arsalan, Omer Zafar, Syed Abid hassan Naqvi, Q. Ain

{"title":"EFFECTIVENESS OF STEROIDS VERSUS IMMUNOMODULATORS INTREATMENT OF VERNAL KERATO-CONJUNCTIVITIS. A STUDY AT ARMED FORCES INSTITUTE OF OPHTHALMOLOGY","authors":"Z. Arsalan, Omer Zafar, Syed Abid hassan Naqvi, Q. Ain","doi":"10.51253/pafmj.v6i6.5144","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.5144","url":null,"abstract":"Objective: To evaluate whether steroids or immunomodulator is a better mode of treatment in long term management of vernal keratoconjunctivitis.Study Design: A quasi experimental study. \u0000Place and Duration of Study: Armed Forces institute of Ophthalmology, Rawalpindi, from Feb 2019 to Oct 2019. \u0000Methodology: Ninety-two patients in between ages of 5-20 years were divided into two equal groups of 46 patients each. After instillation of 0.1% Fluoromethalone (steroid) into both eyes of patients of vernal keratoconjunctivitis, in group A and outcomes were compared with those of 0.05% Cyclosporine (immunomodulator) administered in the same manner in group B. All the patients were followed up regularly after 1, 3, and 6 weeks, 3 months, and 6 months and data recorded for inference. \u0000Results: Both the drugs were found to effectively reduce the foreign body sensation but had no or minimal effect on visual acuity and intraocular pressure (p-vale<0.001). Few patients in steroid group showed noticeable rise of intraocular pressure. (p=0.02). Cyclosporine was found to markedly reduce the mucoid discharge and photophobia without any adverse side effects (p-value=0.02). \u0000Conclusion: Cyclosporine appears to be more effective in control of mucous discharge and inflammation than steroids in vernal keratoconjunctivitis with minimal or no side effects and hence was found to be a safe alternative to steroid usage in long-term treatment groups.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87460188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

COMPARISON OF PROGRESSIVE MUSCULAR RELAXATION (PMR) AND MUSIC THERAPY (MT) IN REDUCING THE ANXIETY, DEPRESSION AND STRESS SYMPTOMS AMONG NURSES 渐进式肌肉放松(pmr)与音乐疗法(mt)减轻护士焦虑、抑郁和应激症状的比较

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.6338

N. Mustafa, Midhat Farzeen, Shoaib Kiani, Sana Khan, N. Ain, Jaweria Mumtaz

{"title":"COMPARISON OF PROGRESSIVE MUSCULAR RELAXATION (PMR) AND MUSIC THERAPY (MT) IN REDUCING THE ANXIETY, DEPRESSION AND STRESS SYMPTOMS AMONG NURSES","authors":"N. Mustafa, Midhat Farzeen, Shoaib Kiani, Sana Khan, N. Ain, Jaweria Mumtaz","doi":"10.51253/pafmj.v6i6.6338","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.6338","url":null,"abstract":"Objective: To compare the progressive muscular relaxation and music therapy in reducing the anxiety, depression and stress symptoms among nurses. \u0000Study Design: Quasi-experimental Study. \u0000Place and Duration of Study: Various hospitals in Rawalpindi, from Mar 2018 to Mar 2019. \u0000Methodology: Sample of study was 20 female nurses. They were assessed by using depression, anxiety and stress scale (DASS21), Urdu version. Study participants were randomized into two groups, group 1= who received the music therapy (n=10); group 2=who receive progressive muscular relaxation (n=10). Both the groups were provided with 4 sessions of both interventions for one month. After completion of intervention, post assessment was carried immediately and analysis was carried out. \u0000Results: Mean age of nurses was 31 ± 7.42 years (range from 19-45 years). Significant difference was found which showed that progressive muscular relaxation was more effective in reducing the symptoms of depression and stress as compared to music therapy. Whereas, no significant difference (p>0.05) was found on anxiety (both the treatments equally reduced the anxiety). \u0000Conclusion: Progressive muscular relaxation was found to be more effective in reducing stress and depression in nurses than music therapy. The use of such techniques can serve as an additional therapy in the treatment of stress, anxiety and depression and can be used to reduce the need for pharmacological therapy.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85609719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

OVERVIEW OF PATIENT PREFERENCES IN THE SURGICAL MANAGEMENT PLAN OF EARLY BREAST CANCERS 早期乳腺癌手术治疗方案的患者偏好综述

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.7267

Ayesha Khan, Afroz Mushtaq, Syeda Rifaat Qamar Naqvi, R. Bano, Fahad Ali Khan, Ruqia Begum, Said Zaman, Sana Mushtaq

{"title":"OVERVIEW OF PATIENT PREFERENCES IN THE SURGICAL MANAGEMENT PLAN OF EARLY BREAST CANCERS","authors":"Ayesha Khan, Afroz Mushtaq, Syeda Rifaat Qamar Naqvi, R. Bano, Fahad Ali Khan, Ruqia Begum, Said Zaman, Sana Mushtaq","doi":"10.51253/pafmj.v6i6.7267","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.7267","url":null,"abstract":"Objective: To determine patient preferences in the surgical options of early breast cancers and surgeon’s role in the decisionmaking. \u0000Study Design: cross-sectional study. \u0000Place and Duration of Study: Breast Surgery Department, Combined Military Hospital Rawalpindi Pakistan, from Nov 2020 to May 2021. \u0000Methodology: Patients having early carcinoma breast were studied, i.e., clinical stage 1 or 2, and their surgical preference was recorded. The cases were discussed in multidisciplinary meetings, and a discussion session with patient conducted and then final decision taken from the patient was recorded again, and the results compared. \u0000Results: A total of 28 patients were included in this study and their surgical preferences recorded. Of these patients 22 (78.5%) agreed to breast conservation initially, whereas one of the patients wanted mastectomy. Five (17.8%) patients were undecided between the two. After multidisciplinary team recommendation and discussion with surgeon, only one patient opted for mastectomy (3.6%). \u0000Conclusion: Patients with early breast cancer when offered a surgical decision between breast conservation and mastectomy mostly opt for breast conservation; those who select mastectomy do so because of the fear of recurrence.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"135 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90886203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CENTRAL MACULAR THICKNESS AFTER CATARACT SURGERY IN NON-DIABETICS AND DIABETICS WITHOUT RETINOPATHY 非糖尿病患者和无视网膜病变的糖尿病患者白内障术后中央黄斑厚度

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.6840

Marrium Shafi, Muhammad Akmal Khan, Yaseen Lodhi, A. Aftab, M. Sarfraz

{"title":"CENTRAL MACULAR THICKNESS AFTER CATARACT SURGERY IN NON-DIABETICS AND DIABETICS WITHOUT RETINOPATHY","authors":"Marrium Shafi, Muhammad Akmal Khan, Yaseen Lodhi, A. Aftab, M. Sarfraz","doi":"10.51253/pafmj.v6i6.6840","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.6840","url":null,"abstract":"Objective: \u0000To determine the mean change in central macular thickness after cataract surgery and to compare the mean change in central macular thickness after cataract surgery in non-diabetics and diabetics without diabetic retinopathy \u0000Study design: \u0000Case control \u0000 \u0000Study settings and duration: \u0000A case control study was carried out at Ophthalmology department, POF hospital, Wah Cantt. Study duration was 6 months (April 2019-September 2019) \u0000 \u0000Material and methods: \u0000A sample size of 60 patients was calculated by using Open Epi Software. We used non probability consecutive sampling. Patients were divided into two groups; Cases (Diabetic) and controls (non-Diabetic). All patients underwent phacoemulsification and observed after 4 weeks for macular thickness measurement using optical coherence tomography before and after surgery. Data analysis was done with SPSS version 20. Post stratification t test was applied. P value ≤0.05 was considered significant. \u0000 \u0000Results: \u0000Total 60 patients were included. Mean age of patients was 65.31 ±7. 63SD.There were 35 (58.3%) males and 25 (41.7%) female patients in the study. We found a significant increase in central macular thickness in cases and controls [(223.100±15.86SD vs 227.2667±17.9SD, p=0.000) and (221.200±12.16SD vs 226.289±16.7861SD, p =0.001)] before and after phacoemulsification in cases and controls respectively. However, no significant difference was found between the groups (p=0.486). \u0000 \u0000Conclusion: \u0000Central macular thickness was increased after uncomplicated phacoemulsification in both diabetics and non-diabetics without retinopathy for up to a follow-up period of 4 weeks but the thickness did not differ between the two groups.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83661670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IMMUNOGENICITY AND SAFETY OF INACTIVATED SARS-COV-2 VACCINE (VERO CELL), BBIBP-CORV (SINOPHARM); AN OBSERVATIONAL STUDY FROM PAKISTAN sars-cov-2灭活疫苗(vero细胞)bbibp-corv(国药)的免疫原性和安全性一项来自巴基斯坦的观察性研究

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.7034

Muhammad Farooq, Muhammad Fayyaz Malik, Ashfaq Hussain, M. Latif, Muhammad Usman Rathore, Rehan Ahmad Khan Lodhi

{"title":"IMMUNOGENICITY AND SAFETY OF INACTIVATED SARS-COV-2 VACCINE (VERO CELL), BBIBP-CORV (SINOPHARM); AN OBSERVATIONAL STUDY FROM PAKISTAN","authors":"Muhammad Farooq, Muhammad Fayyaz Malik, Ashfaq Hussain, M. Latif, Muhammad Usman Rathore, Rehan Ahmad Khan Lodhi","doi":"10.51253/pafmj.v6i6.7034","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.7034","url":null,"abstract":"Objective: To ascertain the immunogenicity and short-term safety of inactivated SARS-CoV-2 Vaccine (Vero Cell), BBIBPCorV (Sinopharm) in our setup. \u0000Study Design: Cross-sectional study. \u0000Place and Duration of Study: Combined Military Hospital Sialkot Pakistan, from Feb to Apr 2021. \u0000Methodology: A total of 227 health care workers (HCWs) between 18 to 59 years of age were included in the study. Two doses of Inactivated SARS-CoV-2 Vaccine (Vero Cell), BBIBP-CorV were administered to all individuals 21 days apart and they were monitored for any vaccine-related adverse reactions for 7 days after each dose. Neutralizing antibodies (NAbs) in study subjects were detected in three samples i.e. before 1st dose of vaccine, 21 days after 1st dose and 14 days after 2nd dose by Elecsys Anti- SARS-CoV-2 S (Roche Diagnostics). \u0000Results: Mean age of individuals in the study was 36.70 ± 18.08 years and most individuals were in the 31-45 years age group. Fatigue and drowsiness were the most common adverse effects experienced by study subjects after 1st and 2nd dose of the vaccine followed by malaise and headache. Only 42 (39%) individuals developed positive neutralizing antibody titers in a sample taken 21 days after 1st dose while all individuals except one (99%) developed positive neutralizing antibody titers in a sample taken 2 weeks after 2nd vaccine dose. \u0000Conclusion: Inactivated SARS-CoV-2 Vaccine (Vero Cell), BBIBP-CorV is safe and well-tolerated with very few adverse reactions. Immunogenicity was well achieved as the seroconversion rate was 99% two weeks after 2nd dose of the vaccine.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74827639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DIAGNOSTIC ACCURACY OF SERUM FERRITIN AND SOLUBLE SERUM TRANSFERRIN RECEPTOR, TAKING BONE MARROW IRON STAIN AS A GOLD STANDARD FOR IRON DEFICIENCY ANEMIA IN HETEROGENOUS GROUP OF PATIENTS 以骨髓铁染色作为异质组缺铁性贫血金标准的血清铁蛋白和可溶性血清转铁蛋白受体的诊断准确性

PAFMJ Pub Date : 2021-12-30 DOI: 10.51253/pafmj.v6i6.6855

Tayyaba Ashiq, Ammar Hafeez, A. Sattar, Nasiruddin ., N. Saeed, Faiza Mushtaq

{"title":"DIAGNOSTIC ACCURACY OF SERUM FERRITIN AND SOLUBLE SERUM TRANSFERRIN RECEPTOR, TAKING BONE MARROW IRON STAIN AS A GOLD STANDARD FOR IRON DEFICIENCY ANEMIA IN HETEROGENOUS GROUP OF PATIENTS","authors":"Tayyaba Ashiq, Ammar Hafeez, A. Sattar, Nasiruddin ., N. Saeed, Faiza Mushtaq","doi":"10.51253/pafmj.v6i6.6855","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.6855","url":null,"abstract":"Objective: To determine the diagnostic accuracy of serum ferritin and soluble serum transferrin receptor (sTfR), taking bone marrow iron stain as a gold standard for iron deficiency anaemia in heterogeneous group of patients. \u0000Study Design: Cross-sectional diagnostic accuracy study. \u0000Place and Duration of Study: Department of Diagnostic, Combined Military Hospital Lahore, from Mar to Aug 2020. \u0000Methodology: A total of 55 adult patients, of both genders, undergoing bone marrow examination for any reason were enrolled. Patients with known hemolytic condition (sickle cell anemia, megaloblastic anemia), taking erythropoietin/iron supplements, transfused red cell concentrate (RCC) recently or undergoing chemotherapy were excluded. Age, gender, clinical history and results of bone marrow examination, complete blood count (CBC), serum Ferritin and C-reactive protein (CRP) were recorded. \u0000Results: Serum ferritin was found to be less sensitive (28%) but more specific (100%) for reflecting reduced bone marrow iron stores as compared to sTfR (sensitivity: 60%, specificity: 96.6%). sTfR had highest likelihood ratio (15) and diagnostic accuracy (80%). On Receiver Operator Characteristic (ROC) graph Transferrin index (AUC=0.908) showed maximum accuracy, followed by Ferritin (AUC=0.884) and sTfR (AUC=0.879). \u0000Conclusion: Serum soluble transferring receptor (sTfR) and transferrin index has advantage over serum ferritin alone in predicting the bone marrow iron stores and differentiating iron deficiency anemia from anemia of chronic disease.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81670076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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