Pediatric Dental Journal最新文献

{"title":"Salivary 1H NMR analysis of obese pediatric patients with severe dental caries","authors":"Ali Azhar Dawasaz ,&nbsp;Dinesh Kumar ,&nbsp;Anuj Shukla ,&nbsp;Lakshya Raj Khatri ,&nbsp;Rafi A. Togoo ,&nbsp;Zuliani Mahmood ,&nbsp;Ahmad Azlina ,&nbsp;Kannan Thirumulu Ponnuraj","doi":"10.1016/j.pdj.2025.100343","DOIUrl":"10.1016/j.pdj.2025.100343","url":null,"abstract":"<div><h3>Objectives</h3><div>Salivary proton Nuclear Magnetic Resonance Spectroscopy (¹H NMR) has been widely used in metabonomic studies. A research gap still exists in analysing the metabolic profile in obese children suffering from severe dental caries. The aim of this study was to analyse the most identified metabolites in 10–12 years old obese children with severe dental caries and compare them with normal healthy age-matched children.</div></div><div><h3>Materials and methods</h3><div>Obese children with Body Mass Index Z-score &gt; +2 (<em>n</em> = 20) and normal weight children (control) (<em>n</em> = 20) with severe caries underwent 1.5 mL saliva collection followed by ¹H NMR imaging. Spectra were analysed using TopSpin 3.5 and metabolite assignments were made using Chenomx NMR suite and human metabolite database.</div></div><div><h3>Results</h3><div>A total of 38 common metabolites were identified out of which eight were significantly increased in obese children (p &lt; 0.05). Succinylacetone and glutamine among eight other metabolites significantly increased in the saliva of obese children suffering from severe dental caries. They were also the top contributors in the VIP score plot.</div></div><div><h3>Conclusions</h3><div>Thirteen (3 amino acids, 4 carboxylic acids, 2 ketoacids, 1 alcohol and 3 miscellaneous metabolites) out of the 38 metabolites identified in normal and obese children with severe dental caries, had high VIP score. Glutamine and succinylacetone showed the highest VIP score with eight metabolites significantly increased in the saliva of obese children.</div></div><div><h3>Clinical relevance</h3><div>This study could pave way in advancing our understanding of the relationship between caries and obesity and the potential role the metabolites can play in comparison with the normal individuals.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100343"},"PeriodicalIF":0.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of molar-incisor hypomineralization in Mexican population: A systematic review and meta-analysis","authors":"Mario Alberto Alarcón-Sánchez ,&nbsp;Julieta Sarai Becerra-Ruiz ,&nbsp;Carmen Celina Alonso-Sánchez ,&nbsp;Sonia Isela Vázquez-Jiménez ,&nbsp;Lilibeth-Stephania Escoto-Vasquez ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.pdj.2025.100340","DOIUrl":"10.1016/j.pdj.2025.100340","url":null,"abstract":"<div><h3>Background</h3><div>Molar-incisor hypomineralization (MIH) is a qualitative defect in enamel formation with a multifactorial etiology. Studies indicate a high prevalence of MIH across the Americas, yet the prevalence in Mexico remains uncertain.</div></div><div><h3>Aim</h3><div>This study aimed to review the literature on the prevalence of MIH in the Mexican population and its associated factors.</div></div><div><h3>Methods</h3><div>Six electronic databases were searched for relevant studies: PubMed, Scopus, Dentistry &amp; Oral Science, Science Direct, Web of Science, and Google Scholar, covering the period from March 10th, 2024. Cross-sectional studies were assessed for risk of bias using the Joanna Briggs Institute (JBI) tool.</div></div><div><h3>Results</h3><div>Nine studies met the inclusion criteria, encompassing 5039 children aged 6–12 years, with a mean age of 9.02 ± 1.19 years; 50.1% were boys, and 49.9% were girls. The overall prevalence of MIH was 23%, with a higher prevalence in boys (34.1%) than in girls (30.4%). MIH was more common in molars (30.7%) than in incisors (10.8%), with no cases reported in permanent second molars. Five studies (55.5%) noted dental caries in MIH-affected individuals, with 78.7% showing caries and 21.3% caries-free. The JBI analysis found 33.3% of studies with moderate risk and 66.7% with low risk of bias.</div></div><div><h3>Conclusion</h3><div>The prevalence of MIH in Mexico aligns with rates reported in Brazil and Venezuela. The evidence indicates no significant gender differences in MIH distribution, with molars being more frequently affected than incisors. A substantial proportion of Mexican children with MIH also present with dental caries.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100340"},"PeriodicalIF":0.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciduous teeth eruption, gross motor skills, and feeding in children with down syndrome: A cross-sectional study","authors":"Nami Hisamoto ,&nbsp;Masahiro Watanabe ,&nbsp;Sachiyo Hayashi ,&nbsp;Akiko Chigira ,&nbsp;Satoko Otsuka ,&nbsp;Masae Ono ,&nbsp;Akemi Utsumi ,&nbsp;Akiko Ishizaki ,&nbsp;Luna Osakabe ,&nbsp;Mami Ota ,&nbsp;Satoko Yamaguchi ,&nbsp;Kentaro Ishikawa ,&nbsp;Kazutaka Noda ,&nbsp;Shouji Hironaka","doi":"10.1016/j.pdj.2024.100339","DOIUrl":"10.1016/j.pdj.2024.100339","url":null,"abstract":"<div><h3>Introduction</h3><div>Down syndrome (DS) is often associated with delayed teeth eruption, gross motor skill acquisition, and feeding difficulties. In typically developing (TD) children, changes in weaning food texture with deciduous teeth eruption and motor skill acquisition, which improves feeding skills. However, in DS, these processes are delayed, and age alone is not a reliable predictor for such changes. Therefore, we investigated the association between these parameters in children with DS.</div></div><div><h3>Methods</h3><div>We administered questionnaires to parents of 56 children with DS aged 0–3 years. The survey items included timing of deciduous tooth eruption, physical development, acquired gross motor skills, and texture of weaning foods being consumed. The included children were allocated to two groups according to the confirmed eruption of mandibular deciduous central incisor by or after 12 months.</div></div><div><h3>Results</h3><div>The groups significantly differed in height, Kaup index, and acquisition age of pulling to stand, as determined by Mann–Whitney <em>U</em> test. Furthermore, multiple regression analysis revealed a significant association between the age of mandibular central incisor eruption and height along with that of acquisition age of pulling to stand. However, no significant difference was observed in the texture of weaning foods.</div></div><div><h3>Conclusion</h3><div>The observed associations between the eruption of mandibular central incisor, height, and acquisition age of pulling to stand suggest an association between teeth eruption, physical development, and motor development. Despite no differences in weaning food texture, most patients developed dysphagia habilitation, indicating the need to adjust food texture based on delays in physical and motor development.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100339"},"PeriodicalIF":0.6,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral manifestations of Burkitts Lymphoma - Literature review and case report of Burkitt's lymphoma in a 5 years old female","authors":"Anum Khan,&nbsp;Ghaida Al-Jaddir,&nbsp;Jo Maynard,&nbsp;Hani Dajani,&nbsp;Kathleen Villanueva,&nbsp;Kate Barnard,&nbsp;Jacqui Gillet","doi":"10.1016/j.pdj.2024.100338","DOIUrl":"10.1016/j.pdj.2024.100338","url":null,"abstract":"<div><div>Burkitt’s lymphoma (BL) is a non-Hodgkin Lymphoma (NHL) type fast growing neoplasm of the B-cells and is one of the most common subtypes of paediatric lymphomas. A case of 5 years old female presenting with pain and abnormal teeth mobility in the mandible and swelling of right eye. The initial presentation coincided with multiple organ involvement and urgent referral to Oncology was made. Chemotherapy was initiated and patient was in remission within two months, remains in remission 22 months later. This case reports stresses on dentists and GP recognising signs of abnormal presentations and referring to relevant specialities to ensure early detection and management.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100338"},"PeriodicalIF":0.6,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of single cell analysis of dental mesenchyme and human disease database identifies the responsible gene of dentin disorders","authors":"Hidenori Kokubo ,&nbsp;Yuta Chiba ,&nbsp;Triana Marchelina ,&nbsp;Kifu Miyata ,&nbsp;Hidenori Oikawa ,&nbsp;Rion Sho ,&nbsp;Kan Saito ,&nbsp;Aya Yamada ,&nbsp;Satoshi Fukumoto","doi":"10.1016/j.pdj.2024.100337","DOIUrl":"10.1016/j.pdj.2024.100337","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental anomalies are often associated with inherited diseases and are frequently seen in the field of pediatric dentistry. Dentin disorders are caused by genetic mutations of genes expressed in dental mesenchyme and these genetic mutations also cause skeletal dysplasia. However, only little genes are identified as the responsible gene of dentin disorders and therefore the genetic mechanism is poorly understood. Here, we identified the dental mesenchymal cell-specific genes using single-cell RNA-sequence (scRNA-seq) to clarify the pathogenesis of dentin disorders. Furthermore, we examined the association of inherited disease with dentin or skeletal abnormality using human disease database.</div></div><div><h3>Materials and methods</h3><div>scRNA-seq were performed using post-natal day (P) seven mice incisor. Total 6260 cells of scRNA-seq dataset was obtained. Top 20 differentially expressed genes (DEGs) in odontoblast cluster and dental pulp cluster were identified. Inherited diseases of DEGs and their Clinical Synopsis were examined using Online Mendelian Inheritance in Man (OMIM).</div></div><div><h3>Results</h3><div>The prevalence of inherited disease was 17/40 genes (42.5 %) and dental anomalies-associated inherited diseases were 12/35 diseases (34.3 %); 2.8 % in enamel abnormality, 14.3 % in dentin abnormality, and 17.1 % in other abnormality. The prevalence of dentin abnormality was 33.3 % in odontoblast and 7.7 % in dental pulp-associated diseases. The prevalence of skeletal abnormality in identified inherited diseases was 85.7 %.</div></div><div><h3>Conclusion</h3><div>The DEGs in dental mesenchymal cells were highly associated with dentin abnormality and skeletal abnormality. Identification of dental mesenchymal cell specific genes using scRNA-seq may uncover the novel genetic mechanism of dentin disorders.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100337"},"PeriodicalIF":0.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia enhances osteoclastogenesis in periodontal ligament cells via expression of VEGF and RANKL","authors":"Kenchi Hase ,&nbsp;Misa Ishiyama ,&nbsp;Shoko Ozawa ,&nbsp;Yoshitaka Yoshimura ,&nbsp;Takashi Kikuiri","doi":"10.1016/j.pdj.2024.100336","DOIUrl":"10.1016/j.pdj.2024.100336","url":null,"abstract":"<div><h3>Introduction</h3><div>Periodontal ligament (PDL) damage caused by dental trauma can lead to local circulatory disorders. The mechanisms through which PDL cells, once exposed to a transient hypoxic environment, contribute to tissue regeneration or resorption of pathological tooth roots after reoxygenation remain unclear. Therefore, we aimed to examine how changes in oxygen (O₂) concentration affect PDL healing.</div></div><div><h3>Materials and methods</h3><div>Human PDL stem cells (hPDL cells) were cultured under normoxic or hypoxic (20% or 1% O₂ concentration) conditions. Vascular endothelial growth factor (VEGF) and receptor activator of nuclear factor kappa-Β ligand (RANKL) expressions were measured using real-time quantitative polymerase chain reaction or Western blotting. Furthermore, a co-culture of hPDL and osteoclast precursor cells was used to demonstrate the effect of changes in O₂ concentration on osteoclast formation.</div></div><div><h3>Results</h3><div>VEGF expression considerably increased over time under hypoxia compared with normoxia. However, during reoxygenation (24 h hypoxia–24 h normoxia), expression markedly decreased under hypoxia. No significant difference in RANKL expression was observed in both conditions after 24 h; however, it remarkably increased under hypoxia compared with normoxia after 48 h. In the osteoclast formation assay, the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells considerably increased over time under hypoxia compared with normoxia. Notably, when VEGF expression was reduced using small interfering RNA, the number of TRAP-positive multinucleated cells decreased extensively.</div></div><div><h3>Conclusion</h3><div>Under hypoxic conditions, periodontal ligament cells produce VEGF to promote angiogenesis. However, excessive VEGF production, along with RANKL production, induces osteoclast formation. Osteoclast formation can be suppressed using rapid reoxygenation.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100336"},"PeriodicalIF":0.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental approach to a pediatric patient with congenital insensitivity to pain and anhidrosis (CIPA) syndrome: A case report","authors":"Uğur Akdağ ,&nbsp;Kamile Nur Tozar","doi":"10.1016/j.pdj.2024.11.006","DOIUrl":"10.1016/j.pdj.2024.11.006","url":null,"abstract":"<div><div>Congenital pain insensitivity syndrome with anhidrosis (CIPA, MIM <span><span>256800</span><svg><path></path></svg></span>) or hereditary sensory and autonomic neuropathy (HSAN) type IV is a rare autosomal recessive disease. CIPA has characteristic symptoms such as failure to respond to painful stimuli, lack of thermal sensitivity, decreased or absent sweating (anhidrosis), varying degrees of reduced intellectual disability, musculoskeletal fractures, and joint deformities. A 4-year-old female patient diagnosed with CIPA syndrome presented to our clinic with the complaint of self-harm with her anterior teeth. In the clinical examination, sores were detected on the child's hands, fingers, mouth, and tongue. The front teeth of the patient, which caused the trauma, were extracted. In the 6-month follow-up, the patient's wounds healed. In this case report, the treatment of a patient with CIPA syndrome who was severely self-harming is described.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100335"},"PeriodicalIF":0.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Number of children with developmental insufficiency of oral function: A study using Japan's national database","authors":"Hiroyuki Yamada ,&nbsp;Fumiyo Tamura ,&nbsp;Takeshi Kikutani","doi":"10.1016/j.pdj.2024.11.005","DOIUrl":"10.1016/j.pdj.2024.11.005","url":null,"abstract":"<div><h3>Introduction</h3><div>In 2018, disease of developmental insufficiency of oral function (DIOF) was added to the Japanese national dental health insurance for typically developing children. We aimed to confirm the actual number of typically developing children with DIOF using the national database (NDB) and estimate the incidence rate of DIOF among such children.</div></div><div><h3>Methods</h3><div>The number of children with DIOF was calculated using the NDB in 2020, 2021, and 2022 and activities in the June 2023 of Public Health Insurance. We based the population data on the annual report of single year current population estimates in 2022.</div></div><div><h3>Results</h3><div>Using the 2022 population data of children aged 0–17 y (17,738,000 children) and the 2022 DIOF patient data, we calculated that the incidence rate was 2431.3/100,000 children (2.4%) in 2022. The number of these children increased each year between June 2020, June 2021, and June 2022; in June 2022, there were almost 1.3 times the number of visits as that in June 2021. There were 130,259 visits based on the estimated DIOF outpatient data in June 2023, 1.1 times that of June 2022.</div></div><div><h3>Conclusion</h3><div>This study is the first to report the incidence rate of DIOF in typically developing children in Japan. However, we only assessed outpatients; there may be more affected children in Japan. Therefor DIOF examination is a necessary public health approach to support oral function development and to reduce the incidence of DIOF.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100334"},"PeriodicalIF":0.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental abnormality localized to mandibular left primary incisor","authors":"Tamami Kadota,&nbsp;Marin Ochiai,&nbsp;Misato Takagi,&nbsp;Maika Fujisaki,&nbsp;Rena Okawa,&nbsp;Kazuhiko Nakano","doi":"10.1016/j.pdj.2024.11.003","DOIUrl":"10.1016/j.pdj.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Tooth anomalies may occur during the various developmental stages.</div></div><div><h3>Case presentation</h3><div>A 2Y3M-old Japanese girl came to our clinic. At 1Y8M, the mandibular left primary central incisor had erupted with little or no crown formation, and also showed dysplasia and pulp exposure. Root canal treatment was performed at the first visit, with crown restoration performed with composite resin. The permanent tooth germ showed the same development as the contralateral one.</div></div><div><h3>Conclusion</h3><div>Symptoms observed in the affected tooth were somewhat similar to those in regional odontodysplasia cases. Careful follow-up examinations until permanent tooth replacement will be necessary.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100332"},"PeriodicalIF":0.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longevity of retained deciduous teeth: A retrospective cohort study","authors":"Risako Kinoshita,&nbsp;Naomi Tanoue","doi":"10.1016/j.pdj.2024.10.004","DOIUrl":"10.1016/j.pdj.2024.10.004","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the factors related to the survival of retained deciduous teeth (RDTs).</div></div><div><h3>Materials and methods</h3><div>RDTs were identified in panoramic X-ray images in 13,516 patients at Nagasaki University Hospital from 2014 to 2018. The survival status of the RDTs was tracked using medical records; survival rates were calculated. The RDTs were divided into two groups: before and after the completion of stable permanent dentition. A shared frailty analysis was performed in each group, estimating hazard ratios and 95% confidence intervals for variables related to survival.</div></div><div><h3>Results</h3><div>A total of 138 patients (50 male and 88 female participants, 1.02%) had RDTs. The total number of RDTs was 274, with survival rates of 62.48% at 10 years and 53.30% at 20 years. Before the completion of permanent dentition, the longevity of RDTs was associated with two variables: tooth type (anterior/molar) and presence or absence of successive permanent teeth. No variables were associated with RDT survival after permanent dentition was stabilized.</div></div><div><h3>Conclusion</h3><div>Multiple congenital factors affect the longevity of RDTs before the stabilization of permanent dentition. However, no significant influence was observed based on factors identified retrospectively after the permanent dentition was stabilized.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 152-157"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}