Pediatric Dental Journal最新文献

{"title":"Oral manifestations of Burkitts Lymphoma - Literature review and case report of Burkitt's lymphoma in a 5 years old female","authors":"Anum Khan,&nbsp;Ghaida Al-Jaddir,&nbsp;Jo Maynard,&nbsp;Hani Dajani,&nbsp;Kathleen Villanueva,&nbsp;Kate Barnard,&nbsp;Jacqui Gillet","doi":"10.1016/j.pdj.2024.100338","DOIUrl":"10.1016/j.pdj.2024.100338","url":null,"abstract":"<div><div>Burkitt’s lymphoma (BL) is a non-Hodgkin Lymphoma (NHL) type fast growing neoplasm of the B-cells and is one of the most common subtypes of paediatric lymphomas. A case of 5 years old female presenting with pain and abnormal teeth mobility in the mandible and swelling of right eye. The initial presentation coincided with multiple organ involvement and urgent referral to Oncology was made. Chemotherapy was initiated and patient was in remission within two months, remains in remission 22 months later. This case reports stresses on dentists and GP recognising signs of abnormal presentations and referring to relevant specialities to ensure early detection and management.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100338"},"PeriodicalIF":0.6,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of single cell analysis of dental mesenchyme and human disease database identifies the responsible gene of dentin disorders","authors":"Hidenori Kokubo ,&nbsp;Yuta Chiba ,&nbsp;Triana Marchelina ,&nbsp;Kifu Miyata ,&nbsp;Hidenori Oikawa ,&nbsp;Rion Sho ,&nbsp;Kan Saito ,&nbsp;Aya Yamada ,&nbsp;Satoshi Fukumoto","doi":"10.1016/j.pdj.2024.100337","DOIUrl":"10.1016/j.pdj.2024.100337","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental anomalies are often associated with inherited diseases and are frequently seen in the field of pediatric dentistry. Dentin disorders are caused by genetic mutations of genes expressed in dental mesenchyme and these genetic mutations also cause skeletal dysplasia. However, only little genes are identified as the responsible gene of dentin disorders and therefore the genetic mechanism is poorly understood. Here, we identified the dental mesenchymal cell-specific genes using single-cell RNA-sequence (scRNA-seq) to clarify the pathogenesis of dentin disorders. Furthermore, we examined the association of inherited disease with dentin or skeletal abnormality using human disease database.</div></div><div><h3>Materials and methods</h3><div>scRNA-seq were performed using post-natal day (P) seven mice incisor. Total 6260 cells of scRNA-seq dataset was obtained. Top 20 differentially expressed genes (DEGs) in odontoblast cluster and dental pulp cluster were identified. Inherited diseases of DEGs and their Clinical Synopsis were examined using Online Mendelian Inheritance in Man (OMIM).</div></div><div><h3>Results</h3><div>The prevalence of inherited disease was 17/40 genes (42.5 %) and dental anomalies-associated inherited diseases were 12/35 diseases (34.3 %); 2.8 % in enamel abnormality, 14.3 % in dentin abnormality, and 17.1 % in other abnormality. The prevalence of dentin abnormality was 33.3 % in odontoblast and 7.7 % in dental pulp-associated diseases. The prevalence of skeletal abnormality in identified inherited diseases was 85.7 %.</div></div><div><h3>Conclusion</h3><div>The DEGs in dental mesenchymal cells were highly associated with dentin abnormality and skeletal abnormality. Identification of dental mesenchymal cell specific genes using scRNA-seq may uncover the novel genetic mechanism of dentin disorders.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100337"},"PeriodicalIF":0.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia enhances osteoclastogenesis in periodontal ligament cells via expression of VEGF and RANKL","authors":"Kenchi Hase ,&nbsp;Misa Ishiyama ,&nbsp;Shoko Ozawa ,&nbsp;Yoshitaka Yoshimura ,&nbsp;Takashi Kikuiri","doi":"10.1016/j.pdj.2024.100336","DOIUrl":"10.1016/j.pdj.2024.100336","url":null,"abstract":"<div><h3>Introduction</h3><div>Periodontal ligament (PDL) damage caused by dental trauma can lead to local circulatory disorders. The mechanisms through which PDL cells, once exposed to a transient hypoxic environment, contribute to tissue regeneration or resorption of pathological tooth roots after reoxygenation remain unclear. Therefore, we aimed to examine how changes in oxygen (O₂) concentration affect PDL healing.</div></div><div><h3>Materials and methods</h3><div>Human PDL stem cells (hPDL cells) were cultured under normoxic or hypoxic (20% or 1% O₂ concentration) conditions. Vascular endothelial growth factor (VEGF) and receptor activator of nuclear factor kappa-Β ligand (RANKL) expressions were measured using real-time quantitative polymerase chain reaction or Western blotting. Furthermore, a co-culture of hPDL and osteoclast precursor cells was used to demonstrate the effect of changes in O₂ concentration on osteoclast formation.</div></div><div><h3>Results</h3><div>VEGF expression considerably increased over time under hypoxia compared with normoxia. However, during reoxygenation (24 h hypoxia–24 h normoxia), expression markedly decreased under hypoxia. No significant difference in RANKL expression was observed in both conditions after 24 h; however, it remarkably increased under hypoxia compared with normoxia after 48 h. In the osteoclast formation assay, the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells considerably increased over time under hypoxia compared with normoxia. Notably, when VEGF expression was reduced using small interfering RNA, the number of TRAP-positive multinucleated cells decreased extensively.</div></div><div><h3>Conclusion</h3><div>Under hypoxic conditions, periodontal ligament cells produce VEGF to promote angiogenesis. However, excessive VEGF production, along with RANKL production, induces osteoclast formation. Osteoclast formation can be suppressed using rapid reoxygenation.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100336"},"PeriodicalIF":0.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental approach to a pediatric patient with congenital insensitivity to pain and anhidrosis (CIPA) syndrome: A case report","authors":"Uğur Akdağ ,&nbsp;Kamile Nur Tozar","doi":"10.1016/j.pdj.2024.11.006","DOIUrl":"10.1016/j.pdj.2024.11.006","url":null,"abstract":"<div><div>Congenital pain insensitivity syndrome with anhidrosis (CIPA, MIM <span><span>256800</span><svg><path></path></svg></span>) or hereditary sensory and autonomic neuropathy (HSAN) type IV is a rare autosomal recessive disease. CIPA has characteristic symptoms such as failure to respond to painful stimuli, lack of thermal sensitivity, decreased or absent sweating (anhidrosis), varying degrees of reduced intellectual disability, musculoskeletal fractures, and joint deformities. A 4-year-old female patient diagnosed with CIPA syndrome presented to our clinic with the complaint of self-harm with her anterior teeth. In the clinical examination, sores were detected on the child's hands, fingers, mouth, and tongue. The front teeth of the patient, which caused the trauma, were extracted. In the 6-month follow-up, the patient's wounds healed. In this case report, the treatment of a patient with CIPA syndrome who was severely self-harming is described.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100335"},"PeriodicalIF":0.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Number of children with developmental insufficiency of oral function: A study using Japan's national database","authors":"Hiroyuki Yamada ,&nbsp;Fumiyo Tamura ,&nbsp;Takeshi Kikutani","doi":"10.1016/j.pdj.2024.11.005","DOIUrl":"10.1016/j.pdj.2024.11.005","url":null,"abstract":"<div><h3>Introduction</h3><div>In 2018, disease of developmental insufficiency of oral function (DIOF) was added to the Japanese national dental health insurance for typically developing children. We aimed to confirm the actual number of typically developing children with DIOF using the national database (NDB) and estimate the incidence rate of DIOF among such children.</div></div><div><h3>Methods</h3><div>The number of children with DIOF was calculated using the NDB in 2020, 2021, and 2022 and activities in the June 2023 of Public Health Insurance. We based the population data on the annual report of single year current population estimates in 2022.</div></div><div><h3>Results</h3><div>Using the 2022 population data of children aged 0–17 y (17,738,000 children) and the 2022 DIOF patient data, we calculated that the incidence rate was 2431.3/100,000 children (2.4%) in 2022. The number of these children increased each year between June 2020, June 2021, and June 2022; in June 2022, there were almost 1.3 times the number of visits as that in June 2021. There were 130,259 visits based on the estimated DIOF outpatient data in June 2023, 1.1 times that of June 2022.</div></div><div><h3>Conclusion</h3><div>This study is the first to report the incidence rate of DIOF in typically developing children in Japan. However, we only assessed outpatients; there may be more affected children in Japan. Therefor DIOF examination is a necessary public health approach to support oral function development and to reduce the incidence of DIOF.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100334"},"PeriodicalIF":0.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental abnormality localized to mandibular left primary incisor","authors":"Tamami Kadota,&nbsp;Marin Ochiai,&nbsp;Misato Takagi,&nbsp;Maika Fujisaki,&nbsp;Rena Okawa,&nbsp;Kazuhiko Nakano","doi":"10.1016/j.pdj.2024.11.003","DOIUrl":"10.1016/j.pdj.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Tooth anomalies may occur during the various developmental stages.</div></div><div><h3>Case presentation</h3><div>A 2Y3M-old Japanese girl came to our clinic. At 1Y8M, the mandibular left primary central incisor had erupted with little or no crown formation, and also showed dysplasia and pulp exposure. Root canal treatment was performed at the first visit, with crown restoration performed with composite resin. The permanent tooth germ showed the same development as the contralateral one.</div></div><div><h3>Conclusion</h3><div>Symptoms observed in the affected tooth were somewhat similar to those in regional odontodysplasia cases. Careful follow-up examinations until permanent tooth replacement will be necessary.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100332"},"PeriodicalIF":0.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longevity of retained deciduous teeth: A retrospective cohort study","authors":"Risako Kinoshita,&nbsp;Naomi Tanoue","doi":"10.1016/j.pdj.2024.10.004","DOIUrl":"10.1016/j.pdj.2024.10.004","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the factors related to the survival of retained deciduous teeth (RDTs).</div></div><div><h3>Materials and methods</h3><div>RDTs were identified in panoramic X-ray images in 13,516 patients at Nagasaki University Hospital from 2014 to 2018. The survival status of the RDTs was tracked using medical records; survival rates were calculated. The RDTs were divided into two groups: before and after the completion of stable permanent dentition. A shared frailty analysis was performed in each group, estimating hazard ratios and 95% confidence intervals for variables related to survival.</div></div><div><h3>Results</h3><div>A total of 138 patients (50 male and 88 female participants, 1.02%) had RDTs. The total number of RDTs was 274, with survival rates of 62.48% at 10 years and 53.30% at 20 years. Before the completion of permanent dentition, the longevity of RDTs was associated with two variables: tooth type (anterior/molar) and presence or absence of successive permanent teeth. No variables were associated with RDT survival after permanent dentition was stabilized.</div></div><div><h3>Conclusion</h3><div>Multiple congenital factors affect the longevity of RDTs before the stabilization of permanent dentition. However, no significant influence was observed based on factors identified retrospectively after the permanent dentition was stabilized.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 152-157"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Space maintenance for early loss of a second deciduous molar using the novel W-type loop","authors":"Issei Saitoh ,&nbsp;Yuria Hori ,&nbsp;Mie Anayama-Kurosawa ,&nbsp;Saeko Tsukuno ,&nbsp;Yuki Kiyokawa ,&nbsp;Masahiko Terajima","doi":"10.1016/j.pdj.2024.09.002","DOIUrl":"10.1016/j.pdj.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>To ensure healthy dental and occlusal development, various space maintainers are used to maintain gap spaces due to the early loss of deciduous teeth.</div></div><div><h3>Case presentation</h3><div>A W-shaped loop was used to maintain the gap between the extracted mandibular second deciduous molars bilaterally. Space maintenance using the W-shaped loop prevented mesial shift and inclination of the first permanent molars during eruption, and prevented the opposing teeth from overeruption by positioning the wire section parallel to the occlusal plane.</div></div><div><h3>Conclusion</h3><div>The newly developed W-shaped loop for space maintenance overcomes the disadvantages of distal shoe space maintainers.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 186-190"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulp preservation for dens invaginatus case: Report of direct pulp capping on invagination and partial pulpotomy to the main structure","authors":"Olcay Özdemir","doi":"10.1016/j.pdj.2024.10.002","DOIUrl":"10.1016/j.pdj.2024.10.002","url":null,"abstract":"<div><div>Root canal treatment can be considered a conservative approach for complex root canal configurations due to the aberrant and unpredictable internal anatomy. Although advanced imaging, current irrigation systems, and biomaterials have improved the management of anomalies like dens invaginatus, early identification and pulp preserver approaches are crucial in preventing pulpal pathology, avoiding complex-specialized endodontic treatment, and unintentional complications. This report presents a management utilizing pulp preservation of a 14-year-old patient and successful prognosis with a 2-year follow-up, including partial pulpotomy to the main canal and direct capping to the pulp of invaginated structure in Type II dens invaginatus.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 191-195"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal hyperthyroidism in rats causes histomorphometric changes in the cranio-dental development of rat offspring at weaning","authors":"Douglas Marinho Abreu ,&nbsp;Felipe Martins Pastor ,&nbsp;Fabiana Rocha Araújo ,&nbsp;Rogéria Serakides ,&nbsp;Juneo de Freitas Silva ,&nbsp;Natália de Melo Ocarino","doi":"10.1016/j.pdj.2024.10.001","DOIUrl":"10.1016/j.pdj.2024.10.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Gestational hyperthyroidism is an important cause of bone modifications in offspring, resulting from changes in endochondral growth. However, its effect on the craniodental development in offspring is unknown.</div></div><div><h3>Objective</h3><div>The objective of this study was to demonstrate the effect of maternal hyperthyroidism on the craniodental development of offspring.</div></div><div><h3>Methods</h3><div>Five pregnant Wistar rats with hyperthyroidism and five euthyroid rats were used in this study. At weaning, three pups per mother were selected from both groups. Blood was collected from the mothers on the day of birth of their offspring and from pups at weaning to measure plasma-free thyroxine levels.</div></div><div><h3>Results</h3><div>The influence of maternal hormones on offspring was confirmed by thyroid histomorphometry. The size of the rostro-caudal and latero-lateral axes of the skull, frontal bone width, and the thicknesses of the sutures and the bones were measured. In the molar teeth, the thicknesses of the dentin, pre-dentin, and odontoblast layers, as well as the thickness of the periodontal ligament, were evaluated. The concentration of free T4 was higher in hyperthyroid rats. The height of the thyroid follicular epithelium was lower in offspring of hyperthyroid mothers. Additionally, these offsprings showed a reduction in the width of the frontal bones and an increase in suture thickness. The molars in the hyperthyroid mothers showed a reduction in the thickness of the odontoblast and pre-dentin layers and an increase in the thickness of the periodontal ligament.</div></div><div><h3>Conclusion</h3><div>We conclude that maternal hyperthyroidism in rats causes significant changes in the cranialdental development of offspring.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 143-151"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}