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A case report on long-term management of trisomy 9p syndrome with severe delayed eruption 9p三体综合征伴严重迟发性皮疹的长期治疗1例报告
IF 0.6
Pediatric Dental Journal Pub Date : 2025-08-01 Epub Date: 2025-03-18 DOI: 10.1016/j.pdj.2025.100344
Kimiko Ueda , Yuki Akazawa , Hiroshi Nakagawa , Yoshihito Yamakawa , Yukari Suzuki , Tomonori Iwasaki
{"title":"A case report on long-term management of trisomy 9p syndrome with severe delayed eruption","authors":"Kimiko Ueda ,&nbsp;Yuki Akazawa ,&nbsp;Hiroshi Nakagawa ,&nbsp;Yoshihito Yamakawa ,&nbsp;Yukari Suzuki ,&nbsp;Tomonori Iwasaki","doi":"10.1016/j.pdj.2025.100344","DOIUrl":"10.1016/j.pdj.2025.100344","url":null,"abstract":"<div><h3>Background</h3><div>No long-term dental studies have been conducted on tooth eruption in patients with Trisomy 9p syndrome.</div></div><div><h3>Case presentation</h3><div>We report a case of a child with a duplication restricted to p24.3 of chromosome 9 and a severe delayed eruption of permanent teeth. Timely extraction of the deciduous teeth prevented the need for orthodontic treatment to address the impacted permanent teeth.</div></div><div><h3>Conclusion</h3><div>Achieving healthy dentition and occlusion can contribute to overall health, significantly enhancing the quality of life. Therefore, treatment strategies to allow the eruption of permanent teeth from an early age are crucial in this syndrome.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100344"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demographic and socioeconomic determinants of maternal knowledge and confidence in promoting infant and toddler oral health: An exploratory study 人口统计学和社会经济因素对促进婴幼儿口腔健康的母亲知识和信心的影响:一项探索性研究
IF 0.6
Pediatric Dental Journal Pub Date : 2025-08-01 Epub Date: 2025-05-20 DOI: 10.1016/j.pdj.2025.100351
Hayat Alghutaimel , Adeeb Alnajashi , Meshaal Alahmari , Sultan Alshamrani , Zaid Alonazi , Hasan Jamal
{"title":"Demographic and socioeconomic determinants of maternal knowledge and confidence in promoting infant and toddler oral health: An exploratory study","authors":"Hayat Alghutaimel ,&nbsp;Adeeb Alnajashi ,&nbsp;Meshaal Alahmari ,&nbsp;Sultan Alshamrani ,&nbsp;Zaid Alonazi ,&nbsp;Hasan Jamal","doi":"10.1016/j.pdj.2025.100351","DOIUrl":"10.1016/j.pdj.2025.100351","url":null,"abstract":"<div><h3>Introduction</h3><div>Infancy and toddlerhood are unique periods that lay the foundations for a child's oral health. Proper nutrition, feeding practices, and oral care habits during these periods influence oral and general health. The present study explores the effect of demographics, socioeconomic variables, health-related factors, and information sources on expectant mothers' knowledge and confidence in promoting infants' and toddlers' oral health (ITOH).</div></div><div><h3>Methods</h3><div>A questionnaire was used to identify participants’ ages, nationalities, education, employment, incomes, and previous motherhood experience. Availability of health insurance, access to healthcare, attitude toward visiting the dentist, attitude toward fluoride, and sources of ITOH information were also recorded. Ten questions on factors influencing ITOH were used to assess knowledge. Self-reported confidence was captured using a five-point scale.</div></div><div><h3>Results</h3><div>The results demonstrated limited awareness of ITOH evidence-based practices, particularly concerning breast- and bottle-feeding and fluoride exposure. Low knowledge levels were evident for young participants, first-time mothers, participants with low incomes, and those who reported negative opinions toward fluoride. Low confidence levels were evident for young participants, first-time mothers, and those who had no formal education. Dentists emerged as the most reliable source of information, correlating with higher maternal knowledge than web searches and social media.</div></div><div><h3>Conclusion</h3><div>Socioeconomic factors, particularly household income and previous motherhood experience, are significant determinants of maternal ITOH knowledge and confidence levels, in addition to demographic variables, such as age and education level. The findings underscore the need for targeted educational interventions and call for efforts to establish public access to reliable information sources on child oral health.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100351"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a device for measuring bite force on individual teeth using a capacitive surface pressure distribution sensor 一种利用电容式表面压力分布传感器测量单个牙齿咬合力的装置的研制
IF 0.6
Pediatric Dental Journal Pub Date : 2025-08-01 Epub Date: 2025-04-17 DOI: 10.1016/j.pdj.2025.100348
Takashi Ogihara , Yota Kokubo , Kosuke Heki , Kentaro Igarashi , Hirohiko Hirano , Kaori Ishii , Shinichi Negishi , Takehiko Shimizu , Kazumasa Morikawa , Tomonori Hoshino
{"title":"Development of a device for measuring bite force on individual teeth using a capacitive surface pressure distribution sensor","authors":"Takashi Ogihara ,&nbsp;Yota Kokubo ,&nbsp;Kosuke Heki ,&nbsp;Kentaro Igarashi ,&nbsp;Hirohiko Hirano ,&nbsp;Kaori Ishii ,&nbsp;Shinichi Negishi ,&nbsp;Takehiko Shimizu ,&nbsp;Kazumasa Morikawa ,&nbsp;Tomonori Hoshino","doi":"10.1016/j.pdj.2025.100348","DOIUrl":"10.1016/j.pdj.2025.100348","url":null,"abstract":"<div><h3>Introduction</h3><div>Measuring the bite force of the full jaw in pediatric patients is challenging due to the changing occlusal relationships during the transition from deciduous to permanent teeth, and younger children often struggle to occlude their dental arch as instructed by the measurement sensor. Therefore, a practical approach is to use the measured occlusal pressure at the second primary or first permanent molar as the pediatric bite force.</div></div><div><h3>Materials and methods</h3><div>We applied a capacitive surface pressure distribution sensor, approximately 12 mm thick, and developed a device capable of measuring the bite force on individual teeth by detecting changes in capacitance. The accuracy of the results was examined by comparing them with the push-in load of the universal testing machine.</div></div><div><h3>Results</h3><div>The bite force values calculated from the output of the developed capacitive surface pressure distribution sensor showed a high correlation with the load values of the universal testing machine (R<sup>2</sup> = 0.99). The results of repeated measurements at a load of 500 N indicated that each measurement error remained within ±15 %, even after conducting 50 measurements.</div></div><div><h3>Conclusion</h3><div>The newly developed capacitive surface pressure distribution sensor can measure occlusal pressure in the second primary or first permanent molar, making it a useful tool for measuring bite forces at specific sites in clinical and epidemiological settings.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100348"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Relationship between childhood caries and social background: Regarding the novel emerged correlation between induced abortion and dental caries” [Pediatric Dental J 35 (1) (2025) 100341] “儿童龋齿与社会背景的关系:关于人工流产与龋齿之间新出现的相关性”的更正[儿科牙科J 35 (1) (2025) 100341]
IF 0.6
Pediatric Dental Journal Pub Date : 2025-08-01 Epub Date: 2025-05-21 DOI: 10.1016/j.pdj.2025.100350
Takafumi Nagao , Naoki Nakao , Masataka Nagao , Hiroko Oka , Ayumu Nakashima , Mitsuhiro Uchida , Ayumu Ito , Ryota Nomura , Kazuhiro Shimamura , Akira Namera , Takahiro Harada , Kazuhiro Murata , Kouki Hatori
{"title":"Corrigendum to “Relationship between childhood caries and social background: Regarding the novel emerged correlation between induced abortion and dental caries” [Pediatric Dental J 35 (1) (2025) 100341]","authors":"Takafumi Nagao ,&nbsp;Naoki Nakao ,&nbsp;Masataka Nagao ,&nbsp;Hiroko Oka ,&nbsp;Ayumu Nakashima ,&nbsp;Mitsuhiro Uchida ,&nbsp;Ayumu Ito ,&nbsp;Ryota Nomura ,&nbsp;Kazuhiro Shimamura ,&nbsp;Akira Namera ,&nbsp;Takahiro Harada ,&nbsp;Kazuhiro Murata ,&nbsp;Kouki Hatori","doi":"10.1016/j.pdj.2025.100350","DOIUrl":"10.1016/j.pdj.2025.100350","url":null,"abstract":"","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100350"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful eruption of maxillary bilateral central incisors following extraction of four supernumerary teeth in maxillary anterior region – Case report 上颌前区拔除四颗多生牙后,双侧中切牙成功出牙- 1例报告
IF 0.6
Pediatric Dental Journal Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI: 10.1016/j.pdj.2025.100346
Masatoshi Otsugu , Makoto Okuda , Fumikazu Tojo , Tamami Kadota , Masakazu Hamada , Rena Okawa , Kazuhiko Nakano
{"title":"Successful eruption of maxillary bilateral central incisors following extraction of four supernumerary teeth in maxillary anterior region – Case report","authors":"Masatoshi Otsugu ,&nbsp;Makoto Okuda ,&nbsp;Fumikazu Tojo ,&nbsp;Tamami Kadota ,&nbsp;Masakazu Hamada ,&nbsp;Rena Okawa ,&nbsp;Kazuhiko Nakano","doi":"10.1016/j.pdj.2025.100346","DOIUrl":"10.1016/j.pdj.2025.100346","url":null,"abstract":"<div><h3>Background</h3><div>Three or more supernumerary teeth in a patient without a systemic disease is rarely encountered.</div></div><div><h3>Case presentation</h3><div>A Japanese boy aged 9 years 1 month was referred for a malformed tooth in the maxillary central region. Panoramic radiography and cone-beam computed tomography revealed four supernumerary teeth inhibiting eruption of the maxillary bilateral central incisors. Extraction of the supernumerary teeth and use of a fenestration technique led to successful eruption of both incisors.</div></div><div><h3>Conclusion</h3><div>A supernumerary tooth can strongly affect permanent dentition, thus early detection and appropriate management are important.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100346"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interference in permanent tooth eruption: A case of lobular capillary hemangioma with retained primary molar 恒牙萌出干扰:小叶毛细血管瘤伴第一磨牙保留1例
IF 0.6
Pediatric Dental Journal Pub Date : 2025-08-01 Epub Date: 2025-03-19 DOI: 10.1016/j.pdj.2025.100347
Bareera Iram, Akash Bhatnagar, Saman Seraj, Anchal Goel, Palak Mishra
{"title":"Interference in permanent tooth eruption: A case of lobular capillary hemangioma with retained primary molar","authors":"Bareera Iram,&nbsp;Akash Bhatnagar,&nbsp;Saman Seraj,&nbsp;Anchal Goel,&nbsp;Palak Mishra","doi":"10.1016/j.pdj.2025.100347","DOIUrl":"10.1016/j.pdj.2025.100347","url":null,"abstract":"<div><div>Pyogenic granuloma (PG) is a benign vascular lesion typically caused by trauma or chronic irritation. Although uncommon in pediatric patients, it can have significant implications for dental development. This report discusses the case of a 12-year-old girl presenting with a PG in the lower left back tooth region, obstructing the eruption of a permanent premolar. Surgical removal of the lesion successfully restored the normal eruption process without complications. This case highlights the critical importance of timely diagnosis and intervention to prevent developmental disruptions in pediatric dentistry.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 2","pages":"Article 100347"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of molar-incisor hypomineralization in Mexican population: A systematic review and meta-analysis 墨西哥人群中磨牙-门牙低矿化的患病率:一项系统回顾和荟萃分析
IF 0.6
Pediatric Dental Journal Pub Date : 2025-04-01 Epub Date: 2025-01-30 DOI: 10.1016/j.pdj.2025.100340
Mario Alberto Alarcón-Sánchez , Julieta Sarai Becerra-Ruiz , Carmen Celina Alonso-Sánchez , Sonia Isela Vázquez-Jiménez , Lilibeth-Stephania Escoto-Vasquez , Seyed Ali Mosaddad , Artak Heboyan
{"title":"Prevalence of molar-incisor hypomineralization in Mexican population: A systematic review and meta-analysis","authors":"Mario Alberto Alarcón-Sánchez ,&nbsp;Julieta Sarai Becerra-Ruiz ,&nbsp;Carmen Celina Alonso-Sánchez ,&nbsp;Sonia Isela Vázquez-Jiménez ,&nbsp;Lilibeth-Stephania Escoto-Vasquez ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.pdj.2025.100340","DOIUrl":"10.1016/j.pdj.2025.100340","url":null,"abstract":"<div><h3>Background</h3><div>Molar-incisor hypomineralization (MIH) is a qualitative defect in enamel formation with a multifactorial etiology. Studies indicate a high prevalence of MIH across the Americas, yet the prevalence in Mexico remains uncertain.</div></div><div><h3>Aim</h3><div>This study aimed to review the literature on the prevalence of MIH in the Mexican population and its associated factors.</div></div><div><h3>Methods</h3><div>Six electronic databases were searched for relevant studies: PubMed, Scopus, Dentistry &amp; Oral Science, Science Direct, Web of Science, and Google Scholar, covering the period from March 10th, 2024. Cross-sectional studies were assessed for risk of bias using the Joanna Briggs Institute (JBI) tool.</div></div><div><h3>Results</h3><div>Nine studies met the inclusion criteria, encompassing 5039 children aged 6–12 years, with a mean age of 9.02 ± 1.19 years; 50.1% were boys, and 49.9% were girls. The overall prevalence of MIH was 23%, with a higher prevalence in boys (34.1%) than in girls (30.4%). MIH was more common in molars (30.7%) than in incisors (10.8%), with no cases reported in permanent second molars. Five studies (55.5%) noted dental caries in MIH-affected individuals, with 78.7% showing caries and 21.3% caries-free. The JBI analysis found 33.3% of studies with moderate risk and 66.7% with low risk of bias.</div></div><div><h3>Conclusion</h3><div>The prevalence of MIH in Mexico aligns with rates reported in Brazil and Venezuela. The evidence indicates no significant gender differences in MIH distribution, with molars being more frequently affected than incisors. A substantial proportion of Mexican children with MIH also present with dental caries.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100340"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of salivary zinc level and its impact on periodontal health among children and adolescence with sickle cell anemia 评估儿童和青少年镰状细胞性贫血患者唾液锌水平及其对牙周健康的影响
IF 0.6
Pediatric Dental Journal Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1016/j.pdj.2025.100342
Rogyia Hassan , Lamis Kaddam
{"title":"Assessment of salivary zinc level and its impact on periodontal health among children and adolescence with sickle cell anemia","authors":"Rogyia Hassan ,&nbsp;Lamis Kaddam","doi":"10.1016/j.pdj.2025.100342","DOIUrl":"10.1016/j.pdj.2025.100342","url":null,"abstract":"<div><h3>Objectives</h3><div>Sickle cell anemia (SCA) is the most common inherited disorder around the world. Several studies revealed a low level of serum zinc among sickle patients. However, none of them investigated the impact of SCA on salivary zinc levels. This is the first conducted to measure zinc level in saliva and its influence on the periodontal health of children and adolescents with SCA.</div></div><div><h3>Results</h3><div>The mean ages in the sickle cell anemic group were 10.37 ± 4.13 years old, while the mean ages of subjects in the control group were 9.37 ± 3.6 years (P.Value: 0.169). Salivary zinc level was significantly lower among SCA patients (P.Value &lt; 0.001) than control group. None of the participants were diagnosed with periodontitis. The salivary zinc level was significantly higher in SCA with standard pocket depth and no clinical attachment loss than patients diagnosed with gingivitis (P. value:0.025). Sickle patients have a low level of zinc in saliva, which may contribute to some manifestations of sickle cell disease and may make them more susceptible to periodontal disease in the future. We recommend conducting more research on oral and periodontal health among children affected with SCA to improve their quality of life.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100342"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciduous teeth eruption, gross motor skills, and feeding in children with down syndrome: A cross-sectional study 唐氏综合症儿童乳牙萌出、粗大运动技能和喂养:一项横断面研究
IF 0.6
Pediatric Dental Journal Pub Date : 2025-04-01 Epub Date: 2025-01-18 DOI: 10.1016/j.pdj.2024.100339
Nami Hisamoto , Masahiro Watanabe , Sachiyo Hayashi , Akiko Chigira , Satoko Otsuka , Masae Ono , Akemi Utsumi , Akiko Ishizaki , Luna Osakabe , Mami Ota , Satoko Yamaguchi , Kentaro Ishikawa , Kazutaka Noda , Shouji Hironaka
{"title":"Deciduous teeth eruption, gross motor skills, and feeding in children with down syndrome: A cross-sectional study","authors":"Nami Hisamoto ,&nbsp;Masahiro Watanabe ,&nbsp;Sachiyo Hayashi ,&nbsp;Akiko Chigira ,&nbsp;Satoko Otsuka ,&nbsp;Masae Ono ,&nbsp;Akemi Utsumi ,&nbsp;Akiko Ishizaki ,&nbsp;Luna Osakabe ,&nbsp;Mami Ota ,&nbsp;Satoko Yamaguchi ,&nbsp;Kentaro Ishikawa ,&nbsp;Kazutaka Noda ,&nbsp;Shouji Hironaka","doi":"10.1016/j.pdj.2024.100339","DOIUrl":"10.1016/j.pdj.2024.100339","url":null,"abstract":"<div><h3>Introduction</h3><div>Down syndrome (DS) is often associated with delayed teeth eruption, gross motor skill acquisition, and feeding difficulties. In typically developing (TD) children, changes in weaning food texture with deciduous teeth eruption and motor skill acquisition, which improves feeding skills. However, in DS, these processes are delayed, and age alone is not a reliable predictor for such changes. Therefore, we investigated the association between these parameters in children with DS.</div></div><div><h3>Methods</h3><div>We administered questionnaires to parents of 56 children with DS aged 0–3 years. The survey items included timing of deciduous tooth eruption, physical development, acquired gross motor skills, and texture of weaning foods being consumed. The included children were allocated to two groups according to the confirmed eruption of mandibular deciduous central incisor by or after 12 months.</div></div><div><h3>Results</h3><div>The groups significantly differed in height, Kaup index, and acquisition age of pulling to stand, as determined by Mann–Whitney <em>U</em> test. Furthermore, multiple regression analysis revealed a significant association between the age of mandibular central incisor eruption and height along with that of acquisition age of pulling to stand. However, no significant difference was observed in the texture of weaning foods.</div></div><div><h3>Conclusion</h3><div>The observed associations between the eruption of mandibular central incisor, height, and acquisition age of pulling to stand suggest an association between teeth eruption, physical development, and motor development. Despite no differences in weaning food texture, most patients developed dysphagia habilitation, indicating the need to adjust food texture based on delays in physical and motor development.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100339"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of single cell analysis of dental mesenchyme and human disease database identifies the responsible gene of dentin disorders 整合单细胞分析牙本质间充质和人类疾病数据库确定牙本质疾病的负责基因
IF 0.6
Pediatric Dental Journal Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1016/j.pdj.2024.100337
Hidenori Kokubo , Yuta Chiba , Triana Marchelina , Kifu Miyata , Hidenori Oikawa , Rion Sho , Kan Saito , Aya Yamada , Satoshi Fukumoto
{"title":"Integration of single cell analysis of dental mesenchyme and human disease database identifies the responsible gene of dentin disorders","authors":"Hidenori Kokubo ,&nbsp;Yuta Chiba ,&nbsp;Triana Marchelina ,&nbsp;Kifu Miyata ,&nbsp;Hidenori Oikawa ,&nbsp;Rion Sho ,&nbsp;Kan Saito ,&nbsp;Aya Yamada ,&nbsp;Satoshi Fukumoto","doi":"10.1016/j.pdj.2024.100337","DOIUrl":"10.1016/j.pdj.2024.100337","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental anomalies are often associated with inherited diseases and are frequently seen in the field of pediatric dentistry. Dentin disorders are caused by genetic mutations of genes expressed in dental mesenchyme and these genetic mutations also cause skeletal dysplasia. However, only little genes are identified as the responsible gene of dentin disorders and therefore the genetic mechanism is poorly understood. Here, we identified the dental mesenchymal cell-specific genes using single-cell RNA-sequence (scRNA-seq) to clarify the pathogenesis of dentin disorders. Furthermore, we examined the association of inherited disease with dentin or skeletal abnormality using human disease database.</div></div><div><h3>Materials and methods</h3><div>scRNA-seq were performed using post-natal day (P) seven mice incisor. Total 6260 cells of scRNA-seq dataset was obtained. Top 20 differentially expressed genes (DEGs) in odontoblast cluster and dental pulp cluster were identified. Inherited diseases of DEGs and their Clinical Synopsis were examined using Online Mendelian Inheritance in Man (OMIM).</div></div><div><h3>Results</h3><div>The prevalence of inherited disease was 17/40 genes (42.5 %) and dental anomalies-associated inherited diseases were 12/35 diseases (34.3 %); 2.8 % in enamel abnormality, 14.3 % in dentin abnormality, and 17.1 % in other abnormality. The prevalence of dentin abnormality was 33.3 % in odontoblast and 7.7 % in dental pulp-associated diseases. The prevalence of skeletal abnormality in identified inherited diseases was 85.7 %.</div></div><div><h3>Conclusion</h3><div>The DEGs in dental mesenchymal cells were highly associated with dentin abnormality and skeletal abnormality. Identification of dental mesenchymal cell specific genes using scRNA-seq may uncover the novel genetic mechanism of dentin disorders.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100337"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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