Pediatric Dental Journal最新文献

{"title":"Prevalence of molar-incisor hypomineralization in Mexican population: A systematic review and meta-analysis","authors":"Mario Alberto Alarcón-Sánchez ,&nbsp;Julieta Sarai Becerra-Ruiz ,&nbsp;Carmen Celina Alonso-Sánchez ,&nbsp;Sonia Isela Vázquez-Jiménez ,&nbsp;Lilibeth-Stephania Escoto-Vasquez ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.pdj.2025.100340","DOIUrl":"10.1016/j.pdj.2025.100340","url":null,"abstract":"<div><h3>Background</h3><div>Molar-incisor hypomineralization (MIH) is a qualitative defect in enamel formation with a multifactorial etiology. Studies indicate a high prevalence of MIH across the Americas, yet the prevalence in Mexico remains uncertain.</div></div><div><h3>Aim</h3><div>This study aimed to review the literature on the prevalence of MIH in the Mexican population and its associated factors.</div></div><div><h3>Methods</h3><div>Six electronic databases were searched for relevant studies: PubMed, Scopus, Dentistry &amp; Oral Science, Science Direct, Web of Science, and Google Scholar, covering the period from March 10th, 2024. Cross-sectional studies were assessed for risk of bias using the Joanna Briggs Institute (JBI) tool.</div></div><div><h3>Results</h3><div>Nine studies met the inclusion criteria, encompassing 5039 children aged 6–12 years, with a mean age of 9.02 ± 1.19 years; 50.1% were boys, and 49.9% were girls. The overall prevalence of MIH was 23%, with a higher prevalence in boys (34.1%) than in girls (30.4%). MIH was more common in molars (30.7%) than in incisors (10.8%), with no cases reported in permanent second molars. Five studies (55.5%) noted dental caries in MIH-affected individuals, with 78.7% showing caries and 21.3% caries-free. The JBI analysis found 33.3% of studies with moderate risk and 66.7% with low risk of bias.</div></div><div><h3>Conclusion</h3><div>The prevalence of MIH in Mexico aligns with rates reported in Brazil and Venezuela. The evidence indicates no significant gender differences in MIH distribution, with molars being more frequently affected than incisors. A substantial proportion of Mexican children with MIH also present with dental caries.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100340"},"PeriodicalIF":0.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciduous teeth eruption, gross motor skills, and feeding in children with down syndrome: A cross-sectional study","authors":"Nami Hisamoto ,&nbsp;Masahiro Watanabe ,&nbsp;Sachiyo Hayashi ,&nbsp;Akiko Chigira ,&nbsp;Satoko Otsuka ,&nbsp;Masae Ono ,&nbsp;Akemi Utsumi ,&nbsp;Akiko Ishizaki ,&nbsp;Luna Osakabe ,&nbsp;Mami Ota ,&nbsp;Satoko Yamaguchi ,&nbsp;Kentaro Ishikawa ,&nbsp;Kazutaka Noda ,&nbsp;Shouji Hironaka","doi":"10.1016/j.pdj.2024.100339","DOIUrl":"10.1016/j.pdj.2024.100339","url":null,"abstract":"<div><h3>Introduction</h3><div>Down syndrome (DS) is often associated with delayed teeth eruption, gross motor skill acquisition, and feeding difficulties. In typically developing (TD) children, changes in weaning food texture with deciduous teeth eruption and motor skill acquisition, which improves feeding skills. However, in DS, these processes are delayed, and age alone is not a reliable predictor for such changes. Therefore, we investigated the association between these parameters in children with DS.</div></div><div><h3>Methods</h3><div>We administered questionnaires to parents of 56 children with DS aged 0–3 years. The survey items included timing of deciduous tooth eruption, physical development, acquired gross motor skills, and texture of weaning foods being consumed. The included children were allocated to two groups according to the confirmed eruption of mandibular deciduous central incisor by or after 12 months.</div></div><div><h3>Results</h3><div>The groups significantly differed in height, Kaup index, and acquisition age of pulling to stand, as determined by Mann–Whitney <em>U</em> test. Furthermore, multiple regression analysis revealed a significant association between the age of mandibular central incisor eruption and height along with that of acquisition age of pulling to stand. However, no significant difference was observed in the texture of weaning foods.</div></div><div><h3>Conclusion</h3><div>The observed associations between the eruption of mandibular central incisor, height, and acquisition age of pulling to stand suggest an association between teeth eruption, physical development, and motor development. Despite no differences in weaning food texture, most patients developed dysphagia habilitation, indicating the need to adjust food texture based on delays in physical and motor development.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100339"},"PeriodicalIF":0.6,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral manifestations of Burkitts Lymphoma - Literature review and case report of Burkitt's lymphoma in a 5 years old female","authors":"Anum Khan,&nbsp;Ghaida Al-Jaddir,&nbsp;Jo Maynard,&nbsp;Hani Dajani,&nbsp;Kathleen Villanueva,&nbsp;Kate Barnard,&nbsp;Jacqui Gillet","doi":"10.1016/j.pdj.2024.100338","DOIUrl":"10.1016/j.pdj.2024.100338","url":null,"abstract":"<div><div>Burkitt’s lymphoma (BL) is a non-Hodgkin Lymphoma (NHL) type fast growing neoplasm of the B-cells and is one of the most common subtypes of paediatric lymphomas. A case of 5 years old female presenting with pain and abnormal teeth mobility in the mandible and swelling of right eye. The initial presentation coincided with multiple organ involvement and urgent referral to Oncology was made. Chemotherapy was initiated and patient was in remission within two months, remains in remission 22 months later. This case reports stresses on dentists and GP recognising signs of abnormal presentations and referring to relevant specialities to ensure early detection and management.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100338"},"PeriodicalIF":0.6,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of single cell analysis of dental mesenchyme and human disease database identifies the responsible gene of dentin disorders","authors":"Hidenori Kokubo ,&nbsp;Yuta Chiba ,&nbsp;Triana Marchelina ,&nbsp;Kifu Miyata ,&nbsp;Hidenori Oikawa ,&nbsp;Rion Sho ,&nbsp;Kan Saito ,&nbsp;Aya Yamada ,&nbsp;Satoshi Fukumoto","doi":"10.1016/j.pdj.2024.100337","DOIUrl":"10.1016/j.pdj.2024.100337","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental anomalies are often associated with inherited diseases and are frequently seen in the field of pediatric dentistry. Dentin disorders are caused by genetic mutations of genes expressed in dental mesenchyme and these genetic mutations also cause skeletal dysplasia. However, only little genes are identified as the responsible gene of dentin disorders and therefore the genetic mechanism is poorly understood. Here, we identified the dental mesenchymal cell-specific genes using single-cell RNA-sequence (scRNA-seq) to clarify the pathogenesis of dentin disorders. Furthermore, we examined the association of inherited disease with dentin or skeletal abnormality using human disease database.</div></div><div><h3>Materials and methods</h3><div>scRNA-seq were performed using post-natal day (P) seven mice incisor. Total 6260 cells of scRNA-seq dataset was obtained. Top 20 differentially expressed genes (DEGs) in odontoblast cluster and dental pulp cluster were identified. Inherited diseases of DEGs and their Clinical Synopsis were examined using Online Mendelian Inheritance in Man (OMIM).</div></div><div><h3>Results</h3><div>The prevalence of inherited disease was 17/40 genes (42.5 %) and dental anomalies-associated inherited diseases were 12/35 diseases (34.3 %); 2.8 % in enamel abnormality, 14.3 % in dentin abnormality, and 17.1 % in other abnormality. The prevalence of dentin abnormality was 33.3 % in odontoblast and 7.7 % in dental pulp-associated diseases. The prevalence of skeletal abnormality in identified inherited diseases was 85.7 %.</div></div><div><h3>Conclusion</h3><div>The DEGs in dental mesenchymal cells were highly associated with dentin abnormality and skeletal abnormality. Identification of dental mesenchymal cell specific genes using scRNA-seq may uncover the novel genetic mechanism of dentin disorders.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100337"},"PeriodicalIF":0.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia enhances osteoclastogenesis in periodontal ligament cells via expression of VEGF and RANKL","authors":"Kenchi Hase ,&nbsp;Misa Ishiyama ,&nbsp;Shoko Ozawa ,&nbsp;Yoshitaka Yoshimura ,&nbsp;Takashi Kikuiri","doi":"10.1016/j.pdj.2024.100336","DOIUrl":"10.1016/j.pdj.2024.100336","url":null,"abstract":"<div><h3>Introduction</h3><div>Periodontal ligament (PDL) damage caused by dental trauma can lead to local circulatory disorders. The mechanisms through which PDL cells, once exposed to a transient hypoxic environment, contribute to tissue regeneration or resorption of pathological tooth roots after reoxygenation remain unclear. Therefore, we aimed to examine how changes in oxygen (O₂) concentration affect PDL healing.</div></div><div><h3>Materials and methods</h3><div>Human PDL stem cells (hPDL cells) were cultured under normoxic or hypoxic (20% or 1% O₂ concentration) conditions. Vascular endothelial growth factor (VEGF) and receptor activator of nuclear factor kappa-Β ligand (RANKL) expressions were measured using real-time quantitative polymerase chain reaction or Western blotting. Furthermore, a co-culture of hPDL and osteoclast precursor cells was used to demonstrate the effect of changes in O₂ concentration on osteoclast formation.</div></div><div><h3>Results</h3><div>VEGF expression considerably increased over time under hypoxia compared with normoxia. However, during reoxygenation (24 h hypoxia–24 h normoxia), expression markedly decreased under hypoxia. No significant difference in RANKL expression was observed in both conditions after 24 h; however, it remarkably increased under hypoxia compared with normoxia after 48 h. In the osteoclast formation assay, the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells considerably increased over time under hypoxia compared with normoxia. Notably, when VEGF expression was reduced using small interfering RNA, the number of TRAP-positive multinucleated cells decreased extensively.</div></div><div><h3>Conclusion</h3><div>Under hypoxic conditions, periodontal ligament cells produce VEGF to promote angiogenesis. However, excessive VEGF production, along with RANKL production, induces osteoclast formation. Osteoclast formation can be suppressed using rapid reoxygenation.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"35 1","pages":"Article 100336"},"PeriodicalIF":0.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longevity of retained deciduous teeth: A retrospective cohort study","authors":"Risako Kinoshita,&nbsp;Naomi Tanoue","doi":"10.1016/j.pdj.2024.10.004","DOIUrl":"10.1016/j.pdj.2024.10.004","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the factors related to the survival of retained deciduous teeth (RDTs).</div></div><div><h3>Materials and methods</h3><div>RDTs were identified in panoramic X-ray images in 13,516 patients at Nagasaki University Hospital from 2014 to 2018. The survival status of the RDTs was tracked using medical records; survival rates were calculated. The RDTs were divided into two groups: before and after the completion of stable permanent dentition. A shared frailty analysis was performed in each group, estimating hazard ratios and 95% confidence intervals for variables related to survival.</div></div><div><h3>Results</h3><div>A total of 138 patients (50 male and 88 female participants, 1.02%) had RDTs. The total number of RDTs was 274, with survival rates of 62.48% at 10 years and 53.30% at 20 years. Before the completion of permanent dentition, the longevity of RDTs was associated with two variables: tooth type (anterior/molar) and presence or absence of successive permanent teeth. No variables were associated with RDT survival after permanent dentition was stabilized.</div></div><div><h3>Conclusion</h3><div>Multiple congenital factors affect the longevity of RDTs before the stabilization of permanent dentition. However, no significant influence was observed based on factors identified retrospectively after the permanent dentition was stabilized.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 152-157"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Space maintenance for early loss of a second deciduous molar using the novel W-type loop","authors":"Issei Saitoh ,&nbsp;Yuria Hori ,&nbsp;Mie Anayama-Kurosawa ,&nbsp;Saeko Tsukuno ,&nbsp;Yuki Kiyokawa ,&nbsp;Masahiko Terajima","doi":"10.1016/j.pdj.2024.09.002","DOIUrl":"10.1016/j.pdj.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>To ensure healthy dental and occlusal development, various space maintainers are used to maintain gap spaces due to the early loss of deciduous teeth.</div></div><div><h3>Case presentation</h3><div>A W-shaped loop was used to maintain the gap between the extracted mandibular second deciduous molars bilaterally. Space maintenance using the W-shaped loop prevented mesial shift and inclination of the first permanent molars during eruption, and prevented the opposing teeth from overeruption by positioning the wire section parallel to the occlusal plane.</div></div><div><h3>Conclusion</h3><div>The newly developed W-shaped loop for space maintenance overcomes the disadvantages of distal shoe space maintainers.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 186-190"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulp preservation for dens invaginatus case: Report of direct pulp capping on invagination and partial pulpotomy to the main structure","authors":"Olcay Özdemir","doi":"10.1016/j.pdj.2024.10.002","DOIUrl":"10.1016/j.pdj.2024.10.002","url":null,"abstract":"<div><div>Root canal treatment can be considered a conservative approach for complex root canal configurations due to the aberrant and unpredictable internal anatomy. Although advanced imaging, current irrigation systems, and biomaterials have improved the management of anomalies like dens invaginatus, early identification and pulp preserver approaches are crucial in preventing pulpal pathology, avoiding complex-specialized endodontic treatment, and unintentional complications. This report presents a management utilizing pulp preservation of a 14-year-old patient and successful prognosis with a 2-year follow-up, including partial pulpotomy to the main canal and direct capping to the pulp of invaginated structure in Type II dens invaginatus.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 191-195"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal hyperthyroidism in rats causes histomorphometric changes in the cranio-dental development of rat offspring at weaning","authors":"Douglas Marinho Abreu ,&nbsp;Felipe Martins Pastor ,&nbsp;Fabiana Rocha Araújo ,&nbsp;Rogéria Serakides ,&nbsp;Juneo de Freitas Silva ,&nbsp;Natália de Melo Ocarino","doi":"10.1016/j.pdj.2024.10.001","DOIUrl":"10.1016/j.pdj.2024.10.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Gestational hyperthyroidism is an important cause of bone modifications in offspring, resulting from changes in endochondral growth. However, its effect on the craniodental development in offspring is unknown.</div></div><div><h3>Objective</h3><div>The objective of this study was to demonstrate the effect of maternal hyperthyroidism on the craniodental development of offspring.</div></div><div><h3>Methods</h3><div>Five pregnant Wistar rats with hyperthyroidism and five euthyroid rats were used in this study. At weaning, three pups per mother were selected from both groups. Blood was collected from the mothers on the day of birth of their offspring and from pups at weaning to measure plasma-free thyroxine levels.</div></div><div><h3>Results</h3><div>The influence of maternal hormones on offspring was confirmed by thyroid histomorphometry. The size of the rostro-caudal and latero-lateral axes of the skull, frontal bone width, and the thicknesses of the sutures and the bones were measured. In the molar teeth, the thicknesses of the dentin, pre-dentin, and odontoblast layers, as well as the thickness of the periodontal ligament, were evaluated. The concentration of free T4 was higher in hyperthyroid rats. The height of the thyroid follicular epithelium was lower in offspring of hyperthyroid mothers. Additionally, these offsprings showed a reduction in the width of the frontal bones and an increase in suture thickness. The molars in the hyperthyroid mothers showed a reduction in the thickness of the odontoblast and pre-dentin layers and an increase in the thickness of the periodontal ligament.</div></div><div><h3>Conclusion</h3><div>We conclude that maternal hyperthyroidism in rats causes significant changes in the cranialdental development of offspring.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 143-151"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potassium nitrate in polycarboxylate cement in direct pulp capping of carious, immature permanent molars: An 18-month randomised controlled trail","authors":"Ahmad Abdel Hamid Elheeny ,&nbsp;Moustafa Mohammed Sayed ,&nbsp;Khaled Radad","doi":"10.1016/j.pdj.2024.08.002","DOIUrl":"10.1016/j.pdj.2024.08.002","url":null,"abstract":"<div><h3>Aim</h3><div>The current study aimed to compare the clinical and radiographic success of potassium nitrate in polycarboxylate cement (KNO₃/PCA) compared to mineral trioxide aggregate (MTA) in direct pulp capping (DPC) of carious, immature permanent molars over an 18-month follow-up.</div></div><div><h3>Materials and methods</h3><div>A two-armed parallel randomised trial included one hundred children with 104 M have been included and assigned equally. The success rate was evaluated clinically and radiographically. Chi-square and Fisher's exact tests were used to compare the clinical and radiographic success rates. The percentage change in radiographic parameters was tested using an independent sample <em>t-test</em>. The effect of time on the mean values of radiographic parameters was tested using the general linear model (GLM). A significant level was set at 5%.</div></div><div><h3>Results</h3><div>The overall success rates after 18 months of follow-up for KNO₃/PCA and MTA were 90.4% and 92.3%, respectively (<em>p</em> &gt; 0.05). Similarly, root maturation indicators showed no significant difference between the two groups over the follow-up (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>With comparable clinical and radiographic results to MTA, KNO₃/PCA is an effective treatment option in the DPC of carious, immature permanent teeth.</div></div>","PeriodicalId":19977,"journal":{"name":"Pediatric Dental Journal","volume":"34 3","pages":"Pages 113-121"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}