Parasitology最新文献_第9页

Novel insight into the genetic diversity of strongylid nematodes infecting South-East and East Asian primates 对东南亚和东亚灵长类动物感染的强线虫遗传多样性的新认识

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-17 DOI: 10.1017/s0031182024000386

Bethan Mason, Barbora Cervena, Liesbeth Frias, Benoit Goossens, Hideo Hasegawa, Kenneth Keuk, Abdullah Langgeng, Kasia Majewski, Takashi Matsumoto, Keiko Matsuura, Renata Mendonça, Munehiro Okamoto, Steve Peter, Klara J. Petrzelkova, Symphorosa Sipangkui, Zhihong Xu, Barbora Pafco, Andrew J.J. MacIntosh

{"title":"Novel insight into the genetic diversity of strongylid nematodes infecting South-East and East Asian primates","authors":"Bethan Mason, Barbora Cervena, Liesbeth Frias, Benoit Goossens, Hideo Hasegawa, Kenneth Keuk, Abdullah Langgeng, Kasia Majewski, Takashi Matsumoto, Keiko Matsuura, Renata Mendonça, Munehiro Okamoto, Steve Peter, Klara J. Petrzelkova, Symphorosa Sipangkui, Zhihong Xu, Barbora Pafco, Andrew J.J. MacIntosh","doi":"10.1017/s0031182024000386","DOIUrl":"https://doi.org/10.1017/s0031182024000386","url":null,"abstract":"With many non-human primates (NHPs) showing continued population decline, there is an ongoing need to better understand their ecology and conservation threats. One such threat is the risk of disease, with various bacterial, viral and parasitic infections previously reported to have damaging consequences for NHP hosts. Strongylid nematodes are one of the most commonly reported parasitic infections in NHPs. Current knowledge of NHP strongylid infections is restricted by their typical occurrence as mixed infections of multiple genera, which are indistinguishable through traditional microscopic approaches. Here, modern metagenomics approaches were applied for insight into the genetic diversity of strongylid infections in South-East and East Asian NHPs. We hypothesized that strongylid nematodes occur in mixed communities of multiple taxa, dominated by Oesophagostomum, matching previous findings using single-specimen genetics. Utilizing the Illumina MiSeq platform, ITS-2 strongylid metabarcoding was applied to 90 samples from various wild NHPs occurring in Malaysian Borneo and Japan. A clear dominance of Oesophagostomum aculeatum was found, with almost all sequences assigned to this species. This study suggests that strongylid communities of Asian NHPs may be less species-rich than those in African NHPs, where multi-genera communities are reported. Such knowledge contributes baseline data, assisting with ongoing monitoring of health threats to NHPs.","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":"62 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140609206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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List of reviewers in 2023 2023 年审查员名单

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-08 DOI: 10.1017/s0031182024000301

引用次数: 0

Mitochondrial genome and nuclear ribosomal RNA analysis place Alveonasus lahorensis within the Argasinae and suggest that the genus Alveonasus is paraphyletic 线粒体基因组和核核糖体 RNA 分析将 Alveonasus lahorensis 放在 Argasinae 内，并表明 Alveonasus 属是旁系物种

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-08 DOI: 10.1017/s0031182024000441

Ben J. Mans, Lidia Chitimia-Dobler, Ronel Pienaar, Minique de Castro, Mehran Khan, Mashal M. Almutairi, Abdulaziz Alouffi, Abid Ali

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N⁶-methyltubercidin gives sterile cure in a cutaneous Leishmania amazonensis mouse model. N6-Methyltubercidin 能使皮肤利什曼病小鼠模型无菌治愈。

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-01 Epub Date: 2024-03-27 DOI: 10.1017/S0031182024000362

Cassandra Present, Roberson Donola Girão, Cai Lin, Guy Caljon, Serge Van Calenbergh, Otacilio Moreira, Leonardo Alexandre de Souza Ruivo, Marcos Meuser Batista, Raquel Azevedo, Denise da Gama Jaen Batista, Maria de Nazaré Correia Soeiro

{"title":"N6-methyltubercidin gives sterile cure in a cutaneous Leishmania amazonensis mouse model.","authors":"Cassandra Present, Roberson Donola Girão, Cai Lin, Guy Caljon, Serge Van Calenbergh, Otacilio Moreira, Leonardo Alexandre de Souza Ruivo, Marcos Meuser Batista, Raquel Azevedo, Denise da Gama Jaen Batista, Maria de Nazaré Correia Soeiro","doi":"10.1017/S0031182024000362","DOIUrl":"10.1017/S0031182024000362","url":null,"abstract":"Leishmania is a trypanosomatid parasite that causes skin lesions in its cutaneous form. Current therapies rely on old and expensive drugs, against which the parasites have acquired considerable resistance. Trypanosomatids are unable to synthesize purines relying on salvaging from the host, and nucleoside analogues have emerged as attractive antiparasitic drug candidates. 4-Methyl-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine (CL5564), an analogue of tubercidin in which the amine has been replaced by a methyl group, demonstrates activity against Trypanosoma cruzi and Leishmania infantum. Herein, we investigated its in vitro and in vivo activity against L. amazonensis. CL5564 was 6.5-fold (P = 0.0002) more potent than milteforan™ (ML) against intracellular forms in peritoneal mouse macrophages, and highly selective, while combination with ML gave an additive effect. These results stimulated us to study the activity of CL5564 in mouse model of cutaneous Leishmania infection. BALB/c female and male mice infected by L. amazonensis treated with CL5564 (10 mg kg−1, intralesional route for five days) presented a >93% reduction of paw lesion size likely ML given orally at 40 mg kg−1, while the combination (10 + 40 mg kg−1 of CL5564 and ML, respectively) caused >96% reduction. The qPCR confirmed the suppression of parasite load, but only the combination approach reached 66% of parasitological cure. These results support additional studies with nucleoside derivatives.","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"506-513"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale spatial drivers of avian schistosomes in Northern Michigan inland lakes. 北密歇根内陆湖禽血吸虫的大尺度空间驱动因素。

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-01 Epub Date: 2024-03-11 DOI: 10.1017/S0031182024000337

Jason P Sckrabulis, Madelyn L Messner, Jenna Stanny, Ryan B McWhinnie, Hamzah D Ansari, Aleena M Hajek, Alexander Bageris, Thomas R Raffel

{"title":"Large-scale spatial drivers of avian schistosomes in Northern Michigan inland lakes.","authors":"Jason P Sckrabulis, Madelyn L Messner, Jenna Stanny, Ryan B McWhinnie, Hamzah D Ansari, Aleena M Hajek, Alexander Bageris, Thomas R Raffel","doi":"10.1017/S0031182024000337","DOIUrl":"10.1017/S0031182024000337","url":null,"abstract":"Avian schistosomes are snail-borne trematode parasites (Trichobilharzia spp.) that can cause a nasty skin rash in humans when their cercariae mistake us for their normal bird hosts. We sought to investigate drivers of the spatial distribution of Trichobilharzia cercaria abundance throughout Northern Michigan lakes. For 38 sites on 16 lakes, we assessed several dozen potential environmental predictors that we hypothesized might have direct or indirect effects on overall cercaria abundance, based on known relationships between abiotic and biotic factors in wetland ecosystems. We included variables quantifying local densities of intermediate hosts, temperature, periphyton growth rates, human land use and hydrology. We also measured daily abundance of schistosome cercariae in the water over a 5-week period, supported by community scientists who collected and preserved filtered water samples for qPCR. The strongest predictor of cercaria abundance was Lymnaea host snail density. Lymnaea density was higher in deeper lakes and at sites with more deciduous tree cover, consistent with their association with cool temperature habitats. Contrary to past studies of human schistosomes, we also found a significant negative relationship between cercaria abundance and submerged aquatic vegetation, possibly due to vegetation blocking cercaria movement from offshore snail beds. If future work shows that these effects are indeed causal, then these results suggest possible new approaches to managing swimmer's itch risk in northern MI lakes, such as modifying tree cover and shallow-water vegetation at local sites.","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"495-505"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology, genetic characterization and phylogeny of Moniliformis tupaia n. sp. (Acanthocephala: Moniliformidae) from the northern tree shrew Tupaia belangeri chinensis Anderson (Mammalia: Scandentia). 来自北方树鼩Tupaia belangeri chinensis Anderson（哺乳纲：Scandentia）的Moniliformis tupaia n. sp.（Acanthocephala：Moniliformidae）的形态学、遗传特征和系统发育。

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-01 Epub Date: 2024-03-04 DOI: 10.1017/S0031182024000271

Hui-Xia Chen, Zhi-Jun Yu, Jun Ma, Cui-Hong Zhao, Fu-Qiong Cao, Liang Li

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Lost companions: a new quill mite species and its possible coextinction with the Carolina parakeet. 失落的同伴：一种新的翮螨物种及其与卡罗莱纳小鹦鹉共同灭绝的可能性。

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-01 Epub Date: 2023-12-27 DOI: 10.1017/S0031182023001373

Maciej Skoracki, Markus Unsöld, Milena Patan, Bozena Sikora

引用次数: 0

The neurotropic schistosome vs experimental autoimmune encephalomyelitis: are there any winners? 神经性血吸虫与实验性自身免疫性脑脊髓炎：有赢家吗？

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI: 10.1017/S0031182024000210

Barbora Šmídová, Martin Majer, Jan Novák, Alena Revalová, Petr Horák, Tomáš Macháček

{"title":"The neurotropic schistosome vs experimental autoimmune encephalomyelitis: are there any winners?","authors":"Barbora Šmídová, Martin Majer, Jan Novák, Alena Revalová, Petr Horák, Tomáš Macháček","doi":"10.1017/S0031182024000210","DOIUrl":"10.1017/S0031182024000210","url":null,"abstract":"The incidences of multiple sclerosis have risen worldwide, yet neither the trigger nor efficient treatment is known. Some research is dedicated to looking for treatment by parasites, mainly by helminths. However, little is known about the effect of helminths that infect the nervous system. Therefore, we chose the neurotropic avian schistosome Trichobilharzia regenti, which strongly promotes M2 polarization and tissue repair in the central nervous system, and we tested its effect on the course of experimental autoimmune encephalomyelitis (EAE) in mice. Surprisingly, the symptoms of EAE tended to worsen after the infection with T. regenti. The infection did not stimulate tissue repair, as indicated by the similar level of demyelination. Eosinophils heavily infiltrated the infected tissue, and the microglia number increased as well. Furthermore, splenocytes from T. regenti-infected EAE mice produced more interferon (IFN)-γ than splenocytes from EAE mice after stimulation with myelin oligodendrocyte glycoprotein. Our research indicates that the combination of increased eosinophil numbers and production of IFN-γ tends to worsen the EAE symptoms. Moreover, the data highlight the importance of considering the direct effect of the parasite on the tissue, as the migrating parasite may further tissue damage and make tissue repair even more difficult.","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"412-420"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11044066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary morphology of haptoral anchors in monogenoids (Dactylogyridae) of marine catfish (Siluriformes: Ariidae) from the Atlantic coast of South America. 南美洲大西洋沿岸海洋鲶鱼（Siluriformes: Ariidae）单源鱼（Dactylogyridae）触角锚的进化形态。

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-01 Epub Date: 2024-02-23 DOI: 10.1017/S0031182024000192

Geusivam Barbosa Soares, Edson Aparecido Adriano, Marcus Vinicius Domingues, Abril Rodríguez-González, Juan Antonio Balbuena

{"title":"Evolutionary morphology of haptoral anchors in monogenoids (Dactylogyridae) of marine catfish (Siluriformes: Ariidae) from the Atlantic coast of South America.","authors":"Geusivam Barbosa Soares, Edson Aparecido Adriano, Marcus Vinicius Domingues, Abril Rodríguez-González, Juan Antonio Balbuena","doi":"10.1017/S0031182024000192","DOIUrl":"10.1017/S0031182024000192","url":null,"abstract":"Exploring the phylogenetic signal of morphological traits using geometric morphometry represents a powerful approach to assess the relative weights of convergence and shared evolutionary history in shaping species' forms. We evaluated the phylogenetic signal in shape and size of ventral and dorsal haptoral anchors of 10 species of monogenoids (Hamatopeduncularia, Chauhanellus and Susanlimocotyle) occurring in marine catfish (Siluriformes: Ariidae) from the Atlantic coast of South America. The phylogenetic relationships among these species were mapped onto the morphospaces of shape and size of dorsal and ventral anchors. Two different tests (squared change-parsimony and Kmult) were applied to establish whether the spatial positions in the phylomorphospace were influenced by phylogenetic relationships. A significant phylogenetic signal was found between anchor form and parasite phylogeny. Allometric effects on anchor shape were non-significant. Phylogenetically distant species on the same host differed markedly in anchor morphology, suggesting little influence of host species on anchor form. A significantly higher level of shape variation among ventral anchors was also found, suggesting that the evolutionary forces shaping ventral anchor morphology may operate with differing intensities or exhibit distinct mechanisms compared to their dorsal counterparts. Our results suggest that phylogenetic relationships were a key driver of changes in shape (but not size) of anchors of monogenoids of South American ariids. However, it seems that the emergence of the digitiform haptor in Hamatopenducularia and in some species of Chauhanellus played an important role in the reduction in anchor size and may cause secondary losses of anchors in other groups of monogenoids.","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"390-399"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11044069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New molecular evidence on the members of the genus Ortholinea (Cnidaria, Myxozoa) and the description of Ortholinea hamsiensis n. sp. infecting the urinary bladder of European anchovy Engraulis engrasicolus in the Black Sea. Ortholinea hamsiensis n. sp.感染黑海欧洲鳀鱼 Engraulis engrasicolus 膀胱的新分子证据。

IF 2.4 3区医学

Parasitology Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI: 10.1017/S0031182024000325

Sevilay Okkay, Cem Tolga Gürkanlı, Yılmaz Çiftçi, Ahmet Özer

{"title":"New molecular evidence on the members of the genus Ortholinea (Cnidaria, Myxozoa) and the description of Ortholinea hamsiensis n. sp. infecting the urinary bladder of European anchovy Engraulis engrasicolus in the Black Sea.","authors":"Sevilay Okkay, Cem Tolga Gürkanlı, Yılmaz Çiftçi, Ahmet Özer","doi":"10.1017/S0031182024000325","DOIUrl":"10.1017/S0031182024000325","url":null,"abstract":"Members of the genus Ortholinea are among the worldwide distributed myxozoan parasites that mainly infect marine fish. In this study, a new myxosporean species, Ortholinea hamsiensis n. sp., was isolated from the urinary bladder of European anchovy Engraulis engrasicolus collected from the Sinop coasts of the Black Sea. The prevalence and density values of infection were 1.4% and 1–5 individuals in the field of view (1 + ), respectively. Mature myxospores are subspherical with slight tapering down to the less pronounced tip in the frontal view and subspherical in the sutural view. Myxospores measured 9.1 ± 0.25 (8.8–9.9) μm in length, 9.2 ± 0.11 (8.9–9.4) μm in thickness, and 8.4 ± 0.33 (8.2-9.1) μm in width. Two polar capsules equal in size measured 3.1 ± 0.11 (3.0–3.3) μm in length and 2.7 ± 0.11 (2.6–2.9) μm in width. The polar tubule had 3–4 coils. Along with morphological peculiarities, the results of the 18S rDNA also revealed it to be a new species for science compared to the other species of the genus. In this study, another myxosporean species O. gobiusi was also detected in round goby Neogobius melanostomus with a prevalence of infection value of 4.8% and a density of 1–5 individuals in the field of view (1 + ). The present study also provided the first data of 18S rDNA of O. gobiusi from N. melanostomus and type species of the genus O. divergens from Gobius niger and the phylogenetic relationships of these species with other Ortholinea species have been revealed.","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"485-494"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0