Parasitology最新文献

{"title":"How patient, infection, and cysticercus characteristics impact the evolution of <i>Taenia solium</i> larva in the human brain: a unique cyst-level analysis.","authors":"Hongbin Zhang, Meghana G Shamsunder, Pryanka Bawa, Arturo Carpio, W Allen Hauser, Karina Quinde-Herrera, Alex Jaramillo, Elizabeth A Kelvin","doi":"10.1017/S003118202400163X","DOIUrl":"https://doi.org/10.1017/S003118202400163X","url":null,"abstract":"","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-47"},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and immune response to coinfection by avian haemosporidians in wild Eurasian blackbirds <i>Turdus merula</i>.","authors":"Ellie Lebeau, Jenny C Dunn","doi":"10.1017/S0031182024000829","DOIUrl":"https://doi.org/10.1017/S0031182024000829","url":null,"abstract":"<p><p>Coinfection of a host by more than 1 parasite is more common than single infection in wild environments and can have differing impacts, although coinfections have relatively rarely been quantified. Host immune responses to coinfection can contribute to infection costs but are often harder to predict than those associated with single infection, due to the influence of within-host parasite–parasite interactions on infection virulence. To first quantify coinfection in a common bird species, and then to test for immune-related impacts of coinfection, we investigated the prevalence and immune response to avian haemosporidian (genera: <i>Plasmodium</i>, <i>Haemoproteus</i> and <i>Leucocytozoon</i>) coinfection in wild blackbirds. Coinfection status was diagnosed using a 1-step multiplex polymerase chain reaction, immune response was quantified through white blood cell counts and heterophil: lymphocyte ratios, and parasitaemia was quantified for each infected sample. We detected high rates of haemosporidian infection and coinfection, although neither impacted immune activity, despite a significantly higher parasitaemia in individuals experiencing double <i>vs</i> single infection. This suggests that immune-related costs of haemosporidian single and coinfection are low in this system. This could be due to long-term host–parasite coevolution, which has decreased infection virulence, or a consequence of reduced costs associated with chronic infections compared to acute infections. Alternatively, our results may obscure immune-related costs associated with specific combinations of coinfecting haemosporidian genera, species or lineages. Future research should investigate interactions that occur between haemosporidian parasites within hosts, as well as the ways in which these interactions and resulting impacts may vary depending on parasite identity.</p>","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and diversity of <i>Aphanomyces astaci</i> in cambarid crayfish of Pennsylvania: Where native and introduced hosts meet.","authors":"Adam Petrusek, Michaela Mojžišová, Adéla Mikešová, Radka Piálková, David A Lieb","doi":"10.1017/S0031182025000022","DOIUrl":"https://doi.org/10.1017/S0031182025000022","url":null,"abstract":"","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-43"},"PeriodicalIF":2.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention.","authors":"Thiery Masserey, Lydia Braunack-Mayer, R Scott Miller, Jörg J Möhrle, Melissa A Penny","doi":"10.1017/S0031182025000071","DOIUrl":"https://doi.org/10.1017/S0031182025000071","url":null,"abstract":"","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-36"},"PeriodicalIF":2.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passage of <i>Angiostrongylus cantonensis</i> through the trophic web: an experimental study on reptiles.","authors":"Lucia Anettová, Anna Šipková, Vivienne Velič, Jana Kačmaříková, Kristýna Javorská, Ladislav Novotný, Petr Cibulka, Martin Květoň, David Modrý","doi":"10.1017/S0031182025000034","DOIUrl":"https://doi.org/10.1017/S0031182025000034","url":null,"abstract":"","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-29"},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Hydatigera parva</i> population genetics in Iberian rodents provides insights into its introduction from Africa.","authors":"Milan Miljević, Marija Rajičić, Javier Marco, Jelena Blagojević, Ruth Rodríguez-Pastor, Branka Bajić, Javier Millán","doi":"10.1017/S0031182025000058","DOIUrl":"https://doi.org/10.1017/S0031182025000058","url":null,"abstract":"","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-24"},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the recombinant protein <i>Sh</i>-TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests.","authors":"María Pilar Luzón-García, Laura Navarro, Esther Rodríguez, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, María Isabel Cabeza-Barrera, Alex Loukas, Nerea Castillo-Fernández, María Jesús Perteguer, Javier Sotillo, Joaquín Salas-Coronas","doi":"10.1017/S0031182024001574","DOIUrl":"https://doi.org/10.1017/S0031182024001574","url":null,"abstract":"<p><p>Different agencies have emphasized the need to evaluate current serological methods for screening patients with suspected urogenital schistosomiasis. However, there is still a lack of evidence regarding the most appropriate methods for this purpose. Here we assessed the diagnostic efficacy of a newly developed serological technique that utilizes the recombinant protein <i>Sh</i>-TSP-2, applied to the urine and serum of migrants suspected of having urogenital schistosomiasis. The sensitivity, specificity, positive and negative predictive values of an in-house enzyme-linked immunosorbent assay (ELISA) using the recombinant protein <i>Sh</i>-TSP-2 were analysed and compared with other commercial serological methods. Due to the limitations of microscopy as a perfect reference method, a latent class analysis (LCA) and composite reference standard (CRS) approach was used to determine the sensitivity and specificity of each test. According to the LCA model, the commercial tests NovaLisa^® and immunochromatography test (ICT) immunoglobulin G–immunoglobulin M (IgG–IgM) presented the highest sensitivity (100%), whereas the <i>Sh</i>-TSP-2 serum ELISA test had 79.2%. The <i>Sh</i>-TSP-2 urine and serum ELISA tests had the highest specificities among the serological methods (87.5 and 75%, respectively). CRS modelling showed that the ICT IgG–IgM, NovaLisa^® and <i>Sh</i>-TSP-2 serum tests led in sensitivity at 97.1, 88.6 and 71.4%, respectively, with all tests except that the ICT IgG–IgM test having a specificity >90%. <i>Sh</i>-TSP-2 has been validated as a screening tool for patients suspected of having urogenital schistosomiasis. Although commercial serological tests have shown higher sensitivities, <i>Sh</i>-TSP-2 could be valuable for confirming results from tests with lower specificity. Nevertheless, further studies with larger patient cohorts are necessary to fully verify its potential.</p>","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A generalist vector-transmitted parasite exhibits population genetic structure among host genera.","authors":"Vincenzo A Ellis, Mélanie Duc, Arif Ciloglu, Olof Hellgren, Staffan Bensch","doi":"10.1017/S0031182024001641","DOIUrl":"https://doi.org/10.1017/S0031182024001641","url":null,"abstract":"","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-33"},"PeriodicalIF":2.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Sinistroporomonorchis bolini</i> n. sp. (Trematoda: Monorchiidae) from the Ocellated killifish, <i>Floridichthys polyommus</i> (Cyprinodontidae) in the Yucatán Peninsula, Mexico based on an integrative taxonomy analysis.","authors":"Leopoldo Andrade-Gómez, Juan F Espínola-Novelo, Brenda Solórzano-García, Gerardo Pérez-Ponce de León","doi":"10.1017/S0031182025000010","DOIUrl":"https://doi.org/10.1017/S0031182025000010","url":null,"abstract":"","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-27"},"PeriodicalIF":2.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ivermectin <i>vs</i> moxidectin for treating <i>Strongyloides stercoralis</i> infection: a systematic review.","authors":"Cesar Henriquez-Camacho, Jose A Pérez-Molina, Dora Buonfrate, Paola Rodari, Eduardo Gotuzzo, Benilde Luengo, María Nieves Plana","doi":"10.1017/S0031182024001215","DOIUrl":"https://doi.org/10.1017/S0031182024001215","url":null,"abstract":"<p><p>The aim was to assess the efficacy of ivermectin <i>vs</i> moxidectin for treating <i>Strongyloides stercoralis</i> infection. Ovid MEDLINE, Embase and Web of Science databases were searched for studies comparing ivermectin and moxidectin from inception to February 2024. The outcomes: elimination of infection or parasitological cure, mortality and serious adverse events. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) for dichotomous data. Heterogeneity was assessed using Chi2 test for statistical heterogeneity and results of the <i>I</i>² statistic. Two trials met the inclusion criteria that included 821 adult participants. Both studies were conducted in southeast Asia (Cambodia and Laos). Neither trial included immunocompromised patients. The mean age of the participants ranged from 40 to 45 years old, with a similar distribution of males and females. For all participants, <i>S. stercoralis</i> infection was confirmed by Baermann method. The evidence was moderate for parasitological cure rate. Certainty was downgraded by 1 level because of imprecision. Moxidectin was not inferior to ivermectin: OR 0.67, 95% CI 0.36–1.25 (<i>P</i> = 0.21), <i>I</i>² = 0%, 821 participants. No deaths were reported in either trial. One trial reported mild adverse events. In total, 153/726 (21%) participants had an adverse event. The most reported symptoms were abdominal pain and headache. There is evidence for moderate quality that moxidectin is non-inferior to, and as safe as ivermectin; however, more high-quality and well-designed trials are needed. For patients with some underlying immunosuppressive disorder, or in patients who are very young or very old, current data are insufficient to be recommended.</p>","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}