Pakistan Journal of Pharmaceutical Research最新文献_第2页

Simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in a pharmaceutical (syrup) formulations by RP-HPLC using PDA detector PDA检测器反相高效液相色谱法同时测定制剂(糖浆)中盐酸苯肾上腺素、马来酸氯苯那敏和右美沙芬的含量

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.2016289-97

S. A. Kumar, M. Debnath, D. Vimala

{"title":"Simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in a pharmaceutical (syrup) formulations by RP-HPLC using PDA detector","authors":"S. A. Kumar, M. Debnath, D. Vimala","doi":"10.22200/PJPR.2016289-97","DOIUrl":"https://doi.org/10.22200/PJPR.2016289-97","url":null,"abstract":"The present study aimed to develop and validate the simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in tablet dosage forms. A gradient reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 220 nm has been developed for the simulataneous determination of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in pharmaceutical dosage forms (Syrup). Good chromatographic separation was achieved by using a stainless steel analytical column, the Hypersil BDS C8 column (4.6 X 250 mm; 5 μm). The system was operated at 25 ± 2°C using a mobile phase consisted of HPLC grade water (composed of TEA and 1-octane sulfonic acid sodium salt) (pH adjusted to 3.2 using orthophosphoric acid) and acetonitrile, mixed at gradient mode, manitained flow rate at 1.0 mL/minute. The slope, intercept, and correlation coefficient were found to be y = 34306x - 11042 (r2= 0.999) for phenylephrine HCl, y = 35874x - 13101 (r2= 0.999) for chlorpheniramine maleate and dextromethorphan HBr y = 25516x - 26579 (r2 = 0.999), respectively. The proposed method was validated for its specificity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr simultaneously in a bulk drug samples as well as in a formulations.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"46 1","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89985285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Antimicrobial and antioxidant activity of Embelia robusta: a common adulterant in black pepper 黑胡椒中常见的掺假物——红叶红的抗菌和抗氧化活性

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162136-141

U. Dar, Farooq Saleem, Saad Touqeer

引用次数: 1

CNS depressant activity of Chamomile flower methanol extract in mice 洋甘菊甲醇提取物对小鼠中枢神经系统的抑制作用

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.2016298-102

Y. Taher, A. Samud, J. Mezogi, A. Hamza

引用次数: 2

Pancreatic cancer: From Molecular Biology to Management 胰腺癌:从分子生物学到管理

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162148-152

M. Qadir, Farihah Malik

{"title":"Pancreatic cancer: From Molecular Biology to Management","authors":"M. Qadir, Farihah Malik","doi":"10.22200/PJPR.20162148-152","DOIUrl":"https://doi.org/10.22200/PJPR.20162148-152","url":null,"abstract":"Pancreatic growth is a deadly infection because of which its initial guess is essential. Pancreatic disease causes the passing of numerous patients. We need to take some preventive measures for our security. As to stop smoking, which is the primary driver of PaC. The medications which are accessible as surgery, chemotherapy, radiotherapy are not that effective. Because of which we need to think about the genomics of PaC. Which qualities are included in tumor. Qualities which changed amid PaC are DPC4, p53, and p16 and CDKN2 (Cyclin-Dependent Kinase Inhibitor 2A). despite the fact that the comprehension about those qualities we can follow out the genuine issue and that issue can be cured. We can treat this infection on the off chance that we know about biomarkers which go about as a medication focus to treat the ailment. The accessible biomarkers now days are miRNAs, CA 19-9 and carcinoembryonic antigen (CEA) which give the early forecast of growth conceivable. A few medication targets are found that will assist in ailment treatment. On the off chance that we repress these inhibitor farnesyltransferase, EGFR tyrosine kinases (epidermal development component receptor) ,ERK1/2 (Extracellular Signal-Regulated Kinase) the development of tumor can be diminished.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"22 1","pages":"148-152"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81150403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NANOPARTICLES AS A NOVEL DRUG DELIVERY SYSTEM A REVIEW 纳米颗粒作为一种新型给药系统的研究进展

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162160-167

M. Anees, M. I. Masood, M. Ilyas, Muhammad Ammad

引用次数: 5

PHYTOCHEMICAL EVALUATION AND IN VITRO ANTIOXIDANT STATUS OF CLERODENDRUM VOLUBILE (AN INDIGENOUS MEDICINAL PLANT) 土生药用植物毛竹的植物化学评价及体外抗氧化作用

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-06-15 DOI: 10.22200/PJPR.2016277-88

T. H. Ogunwa, T. Adeyelu, R. Fasimoye, M. B. Oyewale, T. Ademoye, Oluwasogo Ilesanmi, Oluwafemi Busayo Awe, S. A. Ajiboye, Bunmi Oluwayemisi Oloye, Damilola Sholanke

{"title":"PHYTOCHEMICAL EVALUATION AND IN VITRO ANTIOXIDANT STATUS OF CLERODENDRUM VOLUBILE (AN INDIGENOUS MEDICINAL PLANT)","authors":"T. H. Ogunwa, T. Adeyelu, R. Fasimoye, M. B. Oyewale, T. Ademoye, Oluwasogo Ilesanmi, Oluwafemi Busayo Awe, S. A. Ajiboye, Bunmi Oluwayemisi Oloye, Damilola Sholanke","doi":"10.22200/PJPR.2016277-88","DOIUrl":"https://doi.org/10.22200/PJPR.2016277-88","url":null,"abstract":"ABSTRACT Clerodenrum volubile is an important locally used medicinal plant. It is one of the essential herbs nature has provided for mankind to be consumed as spices, vegetable and also used in the treatment of diseases. Qualitative phytoconstituent screening of the plant revealed the presence of steroids, flavonoids, tannins, saponins, and phenolic compound while chalcones, alkaloid and anthraquinone were absent. Quantitative phytochemical evaluation showed values of 8.29±1.26mg/g rutin equivalent for flavonoids, 3.53±0.05mg/g gallic acid equivalent for phenol, 3.97±0.03mg/g tannic acid equivalent for tannins and 13.67±1.27% for saponin per dry weight. As it is imperative to extend research work on therapeutic effects of the arsenal of plants nature has given to us in Africa so as to obtain a cure for various diseases attacking human’s health, antioxidant properties of the plant was evaluated. Antioxidant models used include iron chelating, DPPH radical, superoxide ion, hydrogen peroxide, ABTS radical, hydroxyl radical scavenging activities and ferric ion reducing properties. The obtained IC 50 values against DPPH radical were 141.342 and 120.349µg/mL for Clerodendrum volubile and trolox respectively. The chelating effect of the plant extract at 50% inhibition was close to that of ascorbic acid (standard) with 134.34 and 131.19µg/mL concentration respectively. Overall, the aqueous extract of the plant showed antioxidant potential which was close to the effects exerted by known standard antioxidants (ascorbic acid, trolox and EDTA). The plant could hence provide natural antioxidants which are needed to combat numerous free radical-mediated diseases and complications such as aging, cancer, atherosclerosis, which are linked with oxidative stress.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"2 1","pages":"77-88"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82310351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Development and application of spectrophotometric method for quantitative determination of Metronidazole in pure and tablet formulations 分光光度法测定甲硝唑纯制剂和片剂中甲硝唑的含量及其应用

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-01-27 DOI: 10.22200/PJPR.2016128-32

Zeeshan Masood, M. T. Ansari, Sharjeel Adnan, M. Asad, Muhammad Farooq, M. Ahmad

{"title":"Development and application of spectrophotometric method for quantitative determination of Metronidazole in pure and tablet formulations","authors":"Zeeshan Masood, M. T. Ansari, Sharjeel Adnan, M. Asad, Muhammad Farooq, M. Ahmad","doi":"10.22200/PJPR.2016128-32","DOIUrl":"https://doi.org/10.22200/PJPR.2016128-32","url":null,"abstract":"A rapid, simple and sensitive spectrophotometric method has been developed for the determination of metronidazole in pharmaceutical pure and dosage forms. The method depends on alkaline hydrolysis of metronidazole releases the nitro group as nitrite ion and yielded nitrite ions can be used to give a colored complex that absorbs maximally at 505 nm. Beer’s law is obeyed in the concentration ranges 9-100 mg/ml with molar absorptivity of 1.14 ×10 3 L mole -1 cm -1 . The proposed method is precise, accurate and specific for the quantitative determination of drug in bulk and dosage forms. The results of analysis of commercial formulations and the recovery study of metronidazole suggested that there is no interference from any excipients, which are present in pharmaceutical formulations of metronidazole. Statistical comparison of the results was performed with regard to accuracy and precision using student’s t-test and F-ratio at 95% confidence level. There is no significant difference between the reported and proposed methods with regard to accuracy and precision.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"64 1","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2016-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89558672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Prevalence of Asthma in Southern Punjab, Pakistan. 巴基斯坦旁遮普南部哮喘患病率。

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-01-27 DOI: 10.22200/PJPR.2016133-36

Maryum Khan, Muhammad Ajmal

引用次数: 3

Prevalence of end stage renal disease in diabetic obese and hypertensive patients and cardiovascular risk in dialysis patients 糖尿病、肥胖和高血压患者终末期肾病患病率与透析患者心血管风险

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-01-27 DOI: 10.22200/PJPR.2016142-48

Muhammad Hanif, H. Javed, Umair Jallani, N. M. Ranjha

引用次数: 3

PHYLA NODIFLORA (VERBENACEAE): A REVIEW 马鞭草科马鞭草门研究进展

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-01-27 DOI: 10.22200/PJPR.2016149-54

Bashir Ahmad Chaudhary, Mehreen Jabeen, Umair Jillani, Muhammad Uzair

引用次数: 4