Pakistan Journal of Pharmaceutical Research最新文献_第2页

Correlation of blood groups, clotting time and bleeding time in male and female students; an observational study. 男女学生血型、凝血时间、出血时间的相关性分析一项观察性研究。

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162121-126

A. Aleem, Muqeet Wahid

{"title":"Correlation of blood groups, clotting time and bleeding time in male and female students; an observational study.","authors":"A. Aleem, Muqeet Wahid","doi":"10.22200/PJPR.20162121-126","DOIUrl":"https://doi.org/10.22200/PJPR.20162121-126","url":null,"abstract":"ABSTRACT: Stoppage of bleeding from damaged blood vessels is hemostasis, an essential factor to be checked before any surgical process. Hence blood test is a routine test for hospital prior to surgeries. The aim of this study is to assess the blood groups distribution and to check gender based relationship among blood groups, bleeding and clotting time. The study was conducted in the department of pharmacy, BZU. The available detail reports of 122 students of 1st year of Pharm.D were analyzed in aspects of age, sex, blood groups, bleeding time and clotting time. The blood group were determined with the standard antisera, Duke Method and Capillary tube method were used to find out bleeding time and clotting time respectively. Finally all the parameters were compared and analyzed statistically. In the present study it is found that B blood group is more prevalent in both the sexes than O, A and AB. Clotting time is found to be significantly higher in O and B blood groups in females and males respectively, whereas Bleeding time was found to be prolonged in maximum number of group AB in females and blood group O in males but the difference was statistically insignificant. In females, bleeding and clotting time are slightly on higher side than in males, may be because of hormonal differences. Various cardiovascular and gastrointestinal diseases are associated with the blood groups, so people can take preventive measures according to their blood groups.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"14 1","pages":"121-126"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89986862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Opinion about health issues regarding Transgenic Farm animals 关于转基因农场动物健康问题的意见

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162146-147

M. Qadir, M. Yasmeen

引用次数: 0

Childhood Obesity: Etiology and Management 儿童肥胖:病因和管理

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162153-159

Amna Jafar, M. Qadir

引用次数: 0

Simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in a pharmaceutical (syrup) formulations by RP-HPLC using PDA detector PDA检测器反相高效液相色谱法同时测定制剂(糖浆)中盐酸苯肾上腺素、马来酸氯苯那敏和右美沙芬的含量

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.2016289-97

S. A. Kumar, M. Debnath, D. Vimala

{"title":"Simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in a pharmaceutical (syrup) formulations by RP-HPLC using PDA detector","authors":"S. A. Kumar, M. Debnath, D. Vimala","doi":"10.22200/PJPR.2016289-97","DOIUrl":"https://doi.org/10.22200/PJPR.2016289-97","url":null,"abstract":"The present study aimed to develop and validate the simultaneous estimation of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in tablet dosage forms. A gradient reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 220 nm has been developed for the simulataneous determination of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr in pharmaceutical dosage forms (Syrup). Good chromatographic separation was achieved by using a stainless steel analytical column, the Hypersil BDS C8 column (4.6 X 250 mm; 5 μm). The system was operated at 25 ± 2°C using a mobile phase consisted of HPLC grade water (composed of TEA and 1-octane sulfonic acid sodium salt) (pH adjusted to 3.2 using orthophosphoric acid) and acetonitrile, mixed at gradient mode, manitained flow rate at 1.0 mL/minute. The slope, intercept, and correlation coefficient were found to be y = 34306x - 11042 (r2= 0.999) for phenylephrine HCl, y = 35874x - 13101 (r2= 0.999) for chlorpheniramine maleate and dextromethorphan HBr y = 25516x - 26579 (r2 = 0.999), respectively. The proposed method was validated for its specificity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of phenylephrine HCl, chlorpheniramine maleate and dextromethorphan HBr simultaneously in a bulk drug samples as well as in a formulations.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"46 1","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89985285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Comparative evaluation of moxifloxacin MDR-TB drug; as microspheres with respect to pure drug in lung tissue 莫西沙星耐多药结核药物的比较评价作为微球相对于纯药物在肺组织中

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162103-120

Sanaul Mustafa, V. Devi

{"title":"Comparative evaluation of moxifloxacin MDR-TB drug; as microspheres with respect to pure drug in lung tissue","authors":"Sanaul Mustafa, V. Devi","doi":"10.22200/PJPR.20162103-120","DOIUrl":"https://doi.org/10.22200/PJPR.20162103-120","url":null,"abstract":"A novel moxifloxacin (MOX)-loaded poly (DL-lactide-co-glycolide) (PLGA) microspheres (MPs) suitable for oral administration was prepared by double emulsification solvent evaporation (w/o/w) method. To investigate the pharmacokinetic of MOX-MPs, a simple and rapid high performance liquid chromatographic method was developed for the quantification of MOX in plasma and lung tissue of rats treated with MOX-MPs. Gatifloxacin (0.2µg/ml) was used as an internal standard (IS). The chromatographic separation was achieved on a reversed phase C18 column using isocratic elution with (0.01% Triethanolamine in distilled water): Acetonitrile in the ratio 70:30 v/v pH 2 adjusted with ortho-phosphoric acid, at flow rate of 1 ml/min with a total run time of 6 min. The column effluent was monitored by UV detector at 290 nm. The assay was found to be linear and validated over the concentration range 0.025 to 3.2 µg/ml for MOX in plasma and 0.1 to 2.5 µg/g of lung tissue with correlation coefficient of r2 0.9998 and r2 0.9997 respectively. The system was found to construct sharp peaks for MOX and IS with retention times of 4.08 (±0.012) and 5.84 (±0.026) min for plasma, and 4.17 (±0.016) and 5.84 (±0.022) for lung tissue, respectively. The method exhibited accuracy, precision (inter-day relative standard deviation (RSD) and intra-day RSD values < 15.0 %. The method was applied for determining MOX concentration in plasma and lung after oral administration of 10mg/kg of free MOX and MOX MPs to rats. Results established selectivity and suitability of the method for pharmacokinetic studies of MOX from MOX-MPs","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"32 1","pages":"103-120"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84230158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial and antioxidant activity of Embelia robusta: a common adulterant in black pepper 黑胡椒中常见的掺假物——红叶红的抗菌和抗氧化活性

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162136-141

U. Dar, Farooq Saleem, Saad Touqeer

引用次数: 1

CNS depressant activity of Chamomile flower methanol extract in mice 洋甘菊甲醇提取物对小鼠中枢神经系统的抑制作用

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.2016298-102

Y. Taher, A. Samud, J. Mezogi, A. Hamza

引用次数: 2

Pancreatic cancer: From Molecular Biology to Management 胰腺癌:从分子生物学到管理

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162148-152

M. Qadir, Farihah Malik

{"title":"Pancreatic cancer: From Molecular Biology to Management","authors":"M. Qadir, Farihah Malik","doi":"10.22200/PJPR.20162148-152","DOIUrl":"https://doi.org/10.22200/PJPR.20162148-152","url":null,"abstract":"Pancreatic growth is a deadly infection because of which its initial guess is essential. Pancreatic disease causes the passing of numerous patients. We need to take some preventive measures for our security. As to stop smoking, which is the primary driver of PaC. The medications which are accessible as surgery, chemotherapy, radiotherapy are not that effective. Because of which we need to think about the genomics of PaC. Which qualities are included in tumor. Qualities which changed amid PaC are DPC4, p53, and p16 and CDKN2 (Cyclin-Dependent Kinase Inhibitor 2A). despite the fact that the comprehension about those qualities we can follow out the genuine issue and that issue can be cured. We can treat this infection on the off chance that we know about biomarkers which go about as a medication focus to treat the ailment. The accessible biomarkers now days are miRNAs, CA 19-9 and carcinoembryonic antigen (CEA) which give the early forecast of growth conceivable. A few medication targets are found that will assist in ailment treatment. On the off chance that we repress these inhibitor farnesyltransferase, EGFR tyrosine kinases (epidermal development component receptor) ,ERK1/2 (Extracellular Signal-Regulated Kinase) the development of tumor can be diminished.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"22 1","pages":"148-152"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81150403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NANOPARTICLES AS A NOVEL DRUG DELIVERY SYSTEM A REVIEW 纳米颗粒作为一种新型给药系统的研究进展

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-07-15 DOI: 10.22200/PJPR.20162160-167

M. Anees, M. I. Masood, M. Ilyas, Muhammad Ammad

引用次数: 5

PHYTOCHEMICAL EVALUATION AND IN VITRO ANTIOXIDANT STATUS OF CLERODENDRUM VOLUBILE (AN INDIGENOUS MEDICINAL PLANT) 土生药用植物毛竹的植物化学评价及体外抗氧化作用

Pakistan Journal of Pharmaceutical Research Pub Date : 2016-06-15 DOI: 10.22200/PJPR.2016277-88

T. H. Ogunwa, T. Adeyelu, R. Fasimoye, M. B. Oyewale, T. Ademoye, Oluwasogo Ilesanmi, Oluwafemi Busayo Awe, S. A. Ajiboye, Bunmi Oluwayemisi Oloye, Damilola Sholanke

{"title":"PHYTOCHEMICAL EVALUATION AND IN VITRO ANTIOXIDANT STATUS OF CLERODENDRUM VOLUBILE (AN INDIGENOUS MEDICINAL PLANT)","authors":"T. H. Ogunwa, T. Adeyelu, R. Fasimoye, M. B. Oyewale, T. Ademoye, Oluwasogo Ilesanmi, Oluwafemi Busayo Awe, S. A. Ajiboye, Bunmi Oluwayemisi Oloye, Damilola Sholanke","doi":"10.22200/PJPR.2016277-88","DOIUrl":"https://doi.org/10.22200/PJPR.2016277-88","url":null,"abstract":"ABSTRACT Clerodenrum volubile is an important locally used medicinal plant. It is one of the essential herbs nature has provided for mankind to be consumed as spices, vegetable and also used in the treatment of diseases. Qualitative phytoconstituent screening of the plant revealed the presence of steroids, flavonoids, tannins, saponins, and phenolic compound while chalcones, alkaloid and anthraquinone were absent. Quantitative phytochemical evaluation showed values of 8.29±1.26mg/g rutin equivalent for flavonoids, 3.53±0.05mg/g gallic acid equivalent for phenol, 3.97±0.03mg/g tannic acid equivalent for tannins and 13.67±1.27% for saponin per dry weight. As it is imperative to extend research work on therapeutic effects of the arsenal of plants nature has given to us in Africa so as to obtain a cure for various diseases attacking human’s health, antioxidant properties of the plant was evaluated. Antioxidant models used include iron chelating, DPPH radical, superoxide ion, hydrogen peroxide, ABTS radical, hydroxyl radical scavenging activities and ferric ion reducing properties. The obtained IC 50 values against DPPH radical were 141.342 and 120.349µg/mL for Clerodendrum volubile and trolox respectively. The chelating effect of the plant extract at 50% inhibition was close to that of ascorbic acid (standard) with 134.34 and 131.19µg/mL concentration respectively. Overall, the aqueous extract of the plant showed antioxidant potential which was close to the effects exerted by known standard antioxidants (ascorbic acid, trolox and EDTA). The plant could hence provide natural antioxidants which are needed to combat numerous free radical-mediated diseases and complications such as aging, cancer, atherosclerosis, which are linked with oxidative stress.","PeriodicalId":19952,"journal":{"name":"Pakistan Journal of Pharmaceutical Research","volume":"2 1","pages":"77-88"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82310351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16