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2‐{4‐[ω‐[4‐(2‐Methoxyphenyl)‐1‐piperazinyl]alkoxy]phenyl}‐ 2H‐benzotriazoles and their N‐Oxides as Ligands for some 5‐Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes 2‐{4‐[ω‐[4‐(2‐甲氧基苯基)‐1‐哌嗪基]烷氧基]苯基}‐2H‐苯并三唑及其N -氧化物作为某些5‐羟色胺、多巴胺和肾上腺素受体亚型的配体
Pharmacy and Pharmacology Communications Pub Date : 2000-09-01 DOI: 10.1211/146080800128736303
A. Sparatore, F. Sparatore
{"title":"2‐{4‐[ω‐[4‐(2‐Methoxyphenyl)‐1‐piperazinyl]alkoxy]phenyl}‐ 2H‐benzotriazoles and their N‐Oxides as Ligands for some 5‐Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes","authors":"A. Sparatore, F. Sparatore","doi":"10.1211/146080800128736303","DOIUrl":"https://doi.org/10.1211/146080800128736303","url":null,"abstract":"We have prepared and studied some new 2-methoxyphenylpiperazine derivatives as combined ligands for 5-hydroxytryptamine 5-HT1A and dopamine D3 receptor subtypes. \u0000 \u0000 \u0000 \u0000The compounds displayed affinity for 5-HT1A and D3 receptors, which improved with the lengthening of the intermediate aliphatic chain. Conversely, binding to 5-HT2A, D2 and α1-receptor subtypes was affected in an irregular, and mainly negative, manner by the chain length. Benzotriazole derivatives with 4–5 methylenes exhibited good or excellent selectivity for 5-HT1A and D3 vs 5-HT2A, D2 and α1-receptors.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"42 1","pages":"421-425"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88580647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Anti‐ulcer Effect of Bromocriptine on Indomethacin‐induced Gastric Damage in Rats 溴隐亭对吲哚美辛所致大鼠胃损伤的抗溃疡作用
Pharmacy and Pharmacology Communications Pub Date : 2000-09-01 DOI: 10.1211/146080800128736286
M. Samini, M. Mohagheghi, F. Hasanzadeh, A. Dehpour
{"title":"Anti‐ulcer Effect of Bromocriptine on Indomethacin‐induced Gastric Damage in Rats","authors":"M. Samini, M. Mohagheghi, F. Hasanzadeh, A. Dehpour","doi":"10.1211/146080800128736286","DOIUrl":"https://doi.org/10.1211/146080800128736286","url":null,"abstract":"The anti-ulcer and gastroprotective effects of bromocriptine were studied in rats. Intraperitoneal administration of bromocriptine (2, 4 and 8 mg kg−1), a dopamine receptor agonist, which also acts on α-adrenoceptors, prevented indomethacin-induced gastric ulcer in rats dose-dependently. This protective effect was significantly blocked by the D1-receptor antagonist, SCH 23390 (1 mg kg−1, i.p.), the D2-receptor antagonist, sulpride (0.5 mg kg−1, i.p.) and the α2-receptor antagonist, yohimbine (5 mg kg−1, i.p.), suggesting that the effect of bromocriptine is mediated through dopamine receptors and α-adrenoceptors. \u0000 \u0000 \u0000 \u0000We propose that the anti-ulcer effect of bromocriptine may be due to a decrease in acid secretion and gastric motility through activation of α2-adrenoceptors and dopamine D1 receptors.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"9 1","pages":"411-413"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85017835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Synthesis of New Pyridazinones Substituted by 4-Arylpiperazin-1-yl-carbonylalkyl Moieties and their Analgesic Properties in Mice 4-芳基哌嗪-1-酰基羰基烷基取代的新型吡嗪类化合物的合成及其小鼠镇痛性能
Pharmacy and Pharmacology Communications Pub Date : 2000-09-01 DOI: 10.1211/146080800128736259
P. Coudert, C. Rubat, F. Rohet, F. Léal, J. Fialip, J. Couquelet
{"title":"Synthesis of New Pyridazinones Substituted by 4-Arylpiperazin-1-yl-carbonylalkyl Moieties and their Analgesic Properties in Mice","authors":"P. Coudert, C. Rubat, F. Rohet, F. Léal, J. Fialip, J. Couquelet","doi":"10.1211/146080800128736259","DOIUrl":"https://doi.org/10.1211/146080800128736259","url":null,"abstract":"A new series of 4,6-diaryl pyridazin-3-ones substituted on the nitrogen atom in the 2-position have been prepared and evaluated for their analgesic activity in the phenylbenzo-quinone-induced abdominal constriction test. \u0000 \u0000 \u0000 \u0000Most of the eighteen compounds displayed significant antinociceptive effects with ED50 ranging from 22-2 to 76-7 mg kg−1, intraperitoneally. Pyridazinones 4f and 5f were among the most interesting derivatives with marked analgesic properties associated to weak neurosedative activities (ED50 = 83-3 and 247-2 mg kg−1, i.p., respectively). \u0000 \u0000 \u0000 \u0000Further investigations provided support for the hypothesis that the antinociceptive action of 4f and 5f probably resulted from interactions with opioidergic, 5-hydroxytryptaminergic and noradrenergic pathways.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"27 1","pages":"387-396"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80253175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Mechanisms of Galanin-induced Contraction of Isolated Rat Gastric Fundus Strips { 甘丙肽诱导离体大鼠胃底条收缩的机制
Pharmacy and Pharmacology Communications Pub Date : 2000-09-01 DOI: 10.1211/146080800128736295
R. Korolkiewicz, Z. Konstański, P. Rekowski, J. Ruczyński, A. Szyk, R. Szczepańska, Korolkiewicz Kz, J. Petrusewicz
{"title":"Mechanisms of Galanin-induced Contraction of Isolated Rat Gastric Fundus Strips {","authors":"R. Korolkiewicz, Z. Konstański, P. Rekowski, J. Ruczyński, A. Szyk, R. Szczepańska, Korolkiewicz Kz, J. Petrusewicz","doi":"10.1211/146080800128736295","DOIUrl":"https://doi.org/10.1211/146080800128736295","url":null,"abstract":"Galanin (Gal) constricts rat gastric fundus by acting on receptors located in the cell membrane. We compared the role of intracellular Ca2+ release with extracellular Ca2+ influx in Gal-stimulated contraction of isolated gastric smooth muscle strips. We also tested if phospholipase C (PLC) or protein kinase C (PKC) participate in the signal transduction cascade. \u0000 \u0000 \u0000 \u0000Concentration-contraction curves were constructed non-cumulatively in the presence of atropine, hexamethonium, guanethidine and tetrodotoxin. The half-maximum effective concentration (EC50) of Gal was 21.62nM and Hill's coefficient was 1.02. The effects of Gal were decreased by diltiazem, Ca2+-deficiency in the buffer, Ca2+ removal from the extracellular medium or quercetin. Depletion of intracellular Ca2+-stores, ryanodine and 3,4,5-trimethoxybenzoic acid 8-(diethylamino)-octyl ester diminished the contractile effect of Gal concentration-dependently. Trifluoroperazine and phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitors, neomycin and U-73122, attenuated the gastric fundus response to Gal, whereas phosphatidylcholine-specific phospholipase C (PC-PLC) and phospholipase D (PLD) blockers, D609 and propranolol, were ineffective. The inhibitors of PKC or myosin light chain kinase, calphostin C, chelerythrine, ML-7 and ML-9, lowered the myogenic activity of Gal. \u0000 \u0000 \u0000 \u0000Our data confirmed that the stimulation of Gal receptors in gastric fundus is coupled to Ca2+ influx through voltage-dependent channels and intracellular Ca2+ release from ryanodine- and inositol 1,4,5-triphosphate-sensitive stores. Enzymes such as PI-PLC and PKC, but not PC-PLC or PLD, play a role in the signal transduction cascade. Calmodulin and myosin light chain kinase lie downstream of the increases in intracellular Ca2+ concentration evoked by Gal.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"4 1","pages":"415-420"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86911730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ophiobolin A, a Novel Apoptosis‐inducing Agent from Fungus Strain f‐7438 f - 7438真菌诱导细胞凋亡的一种新药物——蛇血蛋白A
Pharmacy and Pharmacology Communications Pub Date : 2000-09-01 DOI: 10.1211/146080800128736312
H. Fujiwara, K. Matsunaga, H. Kumagai, M. Ishizuka, Y. Ohizumi
{"title":"Ophiobolin A, a Novel Apoptosis‐inducing Agent from Fungus Strain f‐7438","authors":"H. Fujiwara, K. Matsunaga, H. Kumagai, M. Ishizuka, Y. Ohizumi","doi":"10.1211/146080800128736312","DOIUrl":"https://doi.org/10.1211/146080800128736312","url":null,"abstract":"We isolated ophiobolin A from the f-7438 fungus strain. \u0000 \u0000 \u0000 \u0000In the L1210 cell line, ophiobolin A (0-01-1 μM) showed cytotoxicity in a concentration-dependent manner. Morphological observations revealed that ophiobolin A (1 μM) induced shrinkage in cell soma and chromatin condensation, suggesting apoptotic cell death. Moreover, in DNA gel electrophoretic experiments, a typical apoptotic DNA ladder pattern was observed after treatment with this compound. The flow cytometric experiment indicated that ophiobolin A (0.01-1 μM) caused a concentration-dependent apoptosis in close agreement with concentrations that induced cytotoxicity in L1210 cells. \u0000 \u0000 \u0000 \u0000The results suggested that ophiobolin A caused the death of L1210 cells through the apoptotic process. Ophiobolin A may become a powerful pharmacological tool for studying the apoptotic mechanism.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"4 1","pages":"427-431"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78076127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Activity of Liposome‐entrapped Immunomodulator Oligopeptides on Human Epithelial Thymic Cells 脂质体包裹免疫调节剂寡肽对人胸腺上皮细胞的活性
Pharmacy and Pharmacology Communications Pub Date : 2000-09-01 DOI: 10.1211/146080800128736240
V. Cardile, M. Renis, B. Gentile, A. Panico
{"title":"Activity of Liposome‐entrapped Immunomodulator Oligopeptides on Human Epithelial Thymic Cells","authors":"V. Cardile, M. Renis, B. Gentile, A. Panico","doi":"10.1211/146080800128736240","DOIUrl":"https://doi.org/10.1211/146080800128736240","url":null,"abstract":"We have studied the in-vitro effects of liposomal formulations loaded with three oligopeptides (Tp3, Tp4, Tp5), synthetic analogues corresponding to the active site of thymopoietin, on human thymic epithelial cells. \u0000 \u0000 \u0000 \u0000The activity of the peptides entrapped in multilamellar vesicles and in stable plurilamellar liposomal vesicles, with or without cholesterol and containing stearylamine or dipalmitoylphosphatidyl serine, as positive or negative charge-inducer, was tested. The tetrazolium salt assay was performed as a marker of cell growth. To study the response of thymic epithelial cell cultures to liposome addition-dependent stress, we investigated the changes in the level of heat shock proteins (HSPs70). \u0000 \u0000 \u0000 \u0000The results indicated that in-vitro among the peptides tested only Tp4 increased thymic epithelial cell growth. These stimulating effects were improved further when the peptide was entrapped in neutral 1,2-dipalmitoyl-L-α-phosphatidylcholine/cholesterol liposomes. Tp4 was also effective in modulating HSP70 protective effects.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"285 1","pages":"381-386"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86403883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of calcium on ATP-and bradykinin-induced mucin secretion from human pulmonary mucoepidermoid carcinoma cell lines 钙对atp和缓激肽诱导的人肺黏液表皮样癌细胞分泌黏素的影响机制
Pharmacy and Pharmacology Communications Pub Date : 2000-08-01 DOI: 10.1211/146080800128736222
K. Kusano, H. Naito, T. Aiuchi, S. Nakajo, K. Nakaya
{"title":"Mechanism of calcium on ATP-and bradykinin-induced mucin secretion from human pulmonary mucoepidermoid carcinoma cell lines","authors":"K. Kusano, H. Naito, T. Aiuchi, S. Nakajo, K. Nakaya","doi":"10.1211/146080800128736222","DOIUrl":"https://doi.org/10.1211/146080800128736222","url":null,"abstract":"We have shown previously that extracellular ATP and bradykinin can stimulate the release of mucin from cultured human pulmonary mucoepidermoid carcinoma cells (NCI-H292) (Kusano et al 1997). Using this same cell culture system, we studied the mechanism by which this ATP- and bradykinin-induced mucin release occurs. \u0000 \u0000 \u0000 \u0000We found that the mucin secretory response to ATP was not significantly affected by extracellular Ca2+ depletion, but the response to bradykinin was significantly inhibited by Ca2+-free medium. ATP and bradykinin increased the concentration of free intracellular Ca2+ ([Ca2+]i); the ATP-stimulated response was not affected by extracellular Ca2+ depletion, the bradykinin-stimulated response was prevented in the absence of extracellular Ca2+. ATP and bradykinin enhanced the accumulation of inositol 1,4,5-triphosphate in NCI-H292 cells and pretreatment with pertussis toxin blocked the increase in mucin secretion induced by extracellular ATP or bradykinin. \u0000 \u0000 \u0000 \u0000These results suggest that extracellular ATP and bradykinin stimulate mucin release from NCI-H292 cells by a signal transduction that seems to involve ATP- or bradykinin-activated receptors associated with phospholipase C via pertussis toxin-sensitive GTP-binding proteins. These findings may suggest a new direction of research into the regulation of airway mucin secretion.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"249 1","pages":"369-374"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76781602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Benefit of Administering Ranitidine with Food 雷尼替丁与食物一起服用的益处
Pharmacy and Pharmacology Communications Pub Date : 2000-08-01 DOI: 10.1211/146080800128736213
H. Tajerzadeh, M. Rouini, M. Afshar
{"title":"The Benefit of Administering Ranitidine with Food","authors":"H. Tajerzadeh, M. Rouini, M. Afshar","doi":"10.1211/146080800128736213","DOIUrl":"https://doi.org/10.1211/146080800128736213","url":null,"abstract":"This study was performed to determine the effect of food on the pharmacokinetic parameters of ranitidine. In a randomized crossover study, four healthy volunteers received a 150-mg tablet of ranitidine in the fasted state and, two weeks later, after eating a standard breakfast. Blood samples were taken frequently and analysed by reversed-phase HPLC. \u0000 \u0000 \u0000 \u0000With all volunteers secondary peaks were present in the drug concentration-time profiles after administration in the fasted state; these were not present after administration of the drug in the fed state. Differences between AUC(0-∞) (the area under the plot of concentration against time) and between tmax (the time of maximum concentration) in the fasted and fed states were not significant, but Cmax (maximum concentration, fed state) and C1max (the first peak of concentration in the concentration-time profile, fasted state) were significantly different. This difference resulted in short tmax and relatively high Cmax in the presence of food.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"28 1","pages":"365-368"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82912324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
HPLC Quantification of Diltiazem in Plasma from Man 高效液相色谱法测定人血浆中地尔硫卓含量
Pharmacy and Pharmacology Communications Pub Date : 2000-08-01 DOI: 10.1211/146080800128736178
A. Zarghi, S. Dadashzadeh, A. Ebrahimian
{"title":"HPLC Quantification of Diltiazem in Plasma from Man","authors":"A. Zarghi, S. Dadashzadeh, A. Ebrahimian","doi":"10.1211/146080800128736178","DOIUrl":"https://doi.org/10.1211/146080800128736178","url":null,"abstract":"A rapid, simple and sensitive reversed-phase HPLC method has been developed for quantification of diltiazem in plasma. The assay enables the measurement of diltiazem for therapeutic drug monitoring with a minimum detectable limit of 2 ng mL−1. The method involves simple, one-step solvent extraction of the drug with 50:50 (v/v) n-hexane-ether then HPLC on an analytical C18 column with 35:35:30:0.05 ammonium chloride (0.04M)-methanol-acetonitrile-triethylamine, adjusted to pH6.3, as isocratic mobile phase. Diltiazem was monitored by ultra-violet detection at 237 nm. The calibration curve was linear over the concentration range 8–200 ng mL−1 and average recovery was 90±5.3% over the concentration range 50–300 ng mL−1. The coefficients of variation for inter-day and intra-day assay were within the range of clinical usefulness.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"08 1","pages":"341-343"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85858858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effect of Semecarpus anacardium Linn. Nut Extract on Experimental Mammary Carcinoma in Sprague‐Dawley Rats with Reference to Tumour Marker Enzymes 半菖蒲对心绞痛的影响。参考肿瘤标记酶，坚果提取物对Sprague - Dawley大鼠实验性乳腺癌的作用
Pharmacy and Pharmacology Communications Pub Date : 2000-08-01 DOI: 10.1211/146080800128736231
V. Sujatha, P. Sachdanandam
{"title":"Effect of Semecarpus anacardium Linn. Nut Extract on Experimental Mammary Carcinoma in Sprague‐Dawley Rats with Reference to Tumour Marker Enzymes","authors":"V. Sujatha, P. Sachdanandam","doi":"10.1211/146080800128736231","DOIUrl":"https://doi.org/10.1211/146080800128736231","url":null,"abstract":"Plants are rich sources of natural products used in the treatment of diseases. Semecarpus anacardium Linn. of the family Anacardiaceae has many applications in the Ayurvedic and Siddha systems of medicine. Because of its wide therapeutic utility, Semecarpus anacardium nut milk extract (Serankottai nei) has been tested against experimental mammary carcinoma in rats. \u0000 \u0000 \u0000 \u0000Because the activity of tumour marker enzymes is proportional to the extent of malignancy, changes in the activity of these enzymes from the livers and kidneys of experimental rats were used as indices to assess the antineoplastic potency of the drug. A significant reduction in the activity of aspartate and alanine aminotransferases and a sharp increase in that of lactate dehydrogenase, γ-glutamyl transpeptidase, alkaline phosphatase and 5′-nucleotidase were observed in animals with mammary carcinoma. \u0000 \u0000 \u0000 \u0000On administration of Semecarpus anacardium nut extract the activity of these enzymes returned almost to normal control levels. No adverse symptoms or significant changes were observed in drug control rats when compared with normal control rats.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"1 6","pages":"375-379"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91549783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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