{"title":"2‐{4‐[ω‐[4‐(2‐甲氧基苯基)‐1‐哌嗪基]烷氧基]苯基}‐2H‐苯并三唑及其N -氧化物作为某些5‐羟色胺、多巴胺和肾上腺素受体亚型的配体","authors":"A. Sparatore, F. Sparatore","doi":"10.1211/146080800128736303","DOIUrl":null,"url":null,"abstract":"We have prepared and studied some new 2-methoxyphenylpiperazine derivatives as combined ligands for 5-hydroxytryptamine 5-HT1A and dopamine D3 receptor subtypes. \n \n \n \nThe compounds displayed affinity for 5-HT1A and D3 receptors, which improved with the lengthening of the intermediate aliphatic chain. Conversely, binding to 5-HT2A, D2 and α1-receptor subtypes was affected in an irregular, and mainly negative, manner by the chain length. Benzotriazole derivatives with 4–5 methylenes exhibited good or excellent selectivity for 5-HT1A and D3 vs 5-HT2A, D2 and α1-receptors.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"42 1","pages":"421-425"},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"2‐{4‐[ω‐[4‐(2‐Methoxyphenyl)‐1‐piperazinyl]alkoxy]phenyl}‐ 2H‐benzotriazoles and their N‐Oxides as Ligands for some 5‐Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes\",\"authors\":\"A. Sparatore, F. Sparatore\",\"doi\":\"10.1211/146080800128736303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We have prepared and studied some new 2-methoxyphenylpiperazine derivatives as combined ligands for 5-hydroxytryptamine 5-HT1A and dopamine D3 receptor subtypes. \\n \\n \\n \\nThe compounds displayed affinity for 5-HT1A and D3 receptors, which improved with the lengthening of the intermediate aliphatic chain. Conversely, binding to 5-HT2A, D2 and α1-receptor subtypes was affected in an irregular, and mainly negative, manner by the chain length. Benzotriazole derivatives with 4–5 methylenes exhibited good or excellent selectivity for 5-HT1A and D3 vs 5-HT2A, D2 and α1-receptors.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":\"42 1\",\"pages\":\"421-425\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080800128736303\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128736303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
2‐{4‐[ω‐[4‐(2‐Methoxyphenyl)‐1‐piperazinyl]alkoxy]phenyl}‐ 2H‐benzotriazoles and their N‐Oxides as Ligands for some 5‐Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes
We have prepared and studied some new 2-methoxyphenylpiperazine derivatives as combined ligands for 5-hydroxytryptamine 5-HT1A and dopamine D3 receptor subtypes.
The compounds displayed affinity for 5-HT1A and D3 receptors, which improved with the lengthening of the intermediate aliphatic chain. Conversely, binding to 5-HT2A, D2 and α1-receptor subtypes was affected in an irregular, and mainly negative, manner by the chain length. Benzotriazole derivatives with 4–5 methylenes exhibited good or excellent selectivity for 5-HT1A and D3 vs 5-HT2A, D2 and α1-receptors.
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