2‐{4‐[ω‐[4‐(2‐Methoxyphenyl)‐1‐piperazinyl]alkoxy]phenyl}‐ 2H‐benzotriazoles and their N‐Oxides as Ligands for some 5‐Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes

Abstract

We have prepared and studied some new 2-methoxyphenylpiperazine derivatives as combined ligands for 5-hydroxytryptamine 5-HT1A and dopamine D3 receptor subtypes. The compounds displayed affinity for 5-HT1A and D3 receptors, which improved with the lengthening of the intermediate aliphatic chain. Conversely, binding to 5-HT2A, D2 and α1-receptor subtypes was affected in an irregular, and mainly negative, manner by the chain length. Benzotriazole derivatives with 4–5 methylenes exhibited good or excellent selectivity for 5-HT1A and D3 vs 5-HT2A, D2 and α1-receptors.