Pediatric Allergy and Immunology最新文献

{"title":"Systemic reactions to subcutaneous immunotherapy in children and adolescents.","authors":"Siril Yoffe, Avraham Beigelman, Nufar Marcus, Nirit Segal, Yehonatan Pasternak, Basel Badarneh, Eris Greenbaum, Yoram Faitelson","doi":"10.1111/pai.70046","DOIUrl":"https://doi.org/10.1111/pai.70046","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70046"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of Parental Self-Efficacy Scale for Dietary Management of Children with Food Allergies.","authors":"Soo Jin Lee, Seoyoung Yoo, Jayun Kim, Yeji Kim, Yunna Lee, Chiehyeon Lim, Hyemee Kim, Minyoung Jung","doi":"10.1111/pai.70031","DOIUrl":"https://doi.org/10.1111/pai.70031","url":null,"abstract":"<p><strong>Background: </strong>It is necessary to evaluate the parental ability to achieve nutritional adequacy while avoiding allergens for children with food allergies (FA), yet this area is currently understudies. Our study aimed to develop and validate the Parental Self-Efficacy Scale for Dietary Management of Children with Food Allergies (PSED-FA).</p><p><strong>Methods: </strong>PSED-FA was developed through a literature review and semi-structured interviews refined by a panel of five allergists and five dietitians, and validated using responses from caregivers of children with FA. The construction of the tool involved exploratory factor analysis (EFA), confirmatory factor analysis for model fit, and evaluation of internal consistency using Cronbach's alpha. Convergent and divergent validity were assessed using the average variance extracted (AVE), maximum shared variance (MSV), and average shared variance (ASV).</p><p><strong>Results: </strong>Participants included nine focus interview groups, with 114 individuals in the validation group. Egg whites (55.2%), tree nuts (35.2%), and peanuts (22.8%) were the most common allergens. The EFA identified three factors: preparing allergen-free meals, knowledge of nutrition management, and management of food restrictions. The goodness of fit of our model met all the criteria. The tool showed high internal consistency (overall Cronbach's alpha: 0.902) and met the criteria for both convergent (AVE >0.5) and divergent validity (AVE > MSV and ASV).</p><p><strong>Conclusion: </strong>This study validated a reliable and effective tool for assessing parental self-efficacy in managing the dietary needs of children with FA. This tool can aid health professionals in evaluating parental confidence and identifying areas for improving dietary management in children with FA.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70031"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet social needs and greater symptom burden among children with eosinophilic asthma.","authors":"Rosemarie de la Rosa, Adali Martinez, Morgan Ye, Danielle Hessler, Kadiatou Koita, Monica Bucci, Dayna Long, Neeta Thakur","doi":"10.1111/pai.70034","DOIUrl":"https://doi.org/10.1111/pai.70034","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70034"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term comparison of high- and low-dose oral immunotherapy in children with anaphylactic cow's milk allergy.","authors":"Yu Ito, Ken-Ichi Nagakura, Sakura Sato, Motohiro Ebisawa, Noriyuki Yanagida","doi":"10.1111/pai.70033","DOIUrl":"https://doi.org/10.1111/pai.70033","url":null,"abstract":"<p><strong>Background: </strong>Long-term evidence on maintenance doses of oral immunotherapy (OIT) for anaphylactic cow's milk allergy is insufficient.</p><p><strong>Methods: </strong>We retrospectively compared the three-year safety, efficacy, and adherence between OIT with a maintenance dose of 200 mL of cow's milk (HOIT, 2009-2013) and 3 mL of cow's milk (LOIT, 2013-2019). Patients aged 6-18 years with a history of anaphylaxis reacting to ≤3 mL of cow's milk during oral food challenge (OFC) were included. Adverse symptoms, OFC negative rate after 2 weeks of avoidance, dropout rate, and immunological changes were compared.</p><p><strong>Results: </strong>The median ages in the HOIT (n = 78) and LOIT (n = 99) groups were 8.1 and 7.8 years, with milk-specific IgE levels of 56.5 and 49.2 kUA/L, respectively. The percentages of doses triggering symptoms were 20.88%, 13.73%, and 7.31% in the HOIT group and 11.81%, 8.15%, and 6.30% in the LOIT group during years 1, 2, and 3, respectively. After 3 years, 29% of patients in the HOIT group passed the OFC with 200 mL, and 47%, 18%, and 5% of patients in the LOIT group passed the OFC with ≥25 mL, ≥50 mL, and 100 mL of cow's milk, respectively. After 3 years, the dropout rates were 24% and 11% in the HOIT and LOIT groups and milk-specific IgE levels decreased by 88% and 78% in the HOIT and LOIT groups, respectively.</p><p><strong>Conclusion: </strong>HOIT enables higher dose consumptions. LOIT might be safer and have higher adherence in patients with anaphylactic cow's milk allergy.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70033"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of biologics and small molecule drugs in treating pediatric atopic dermatitis in patients aged 2-18 years: A 12-16 week network meta-analysis of randomized controlled trials.","authors":"Su-Boon Yong, Berne Ting, Ikbal Andrian Malau, Suet-Kei Wu, Xin-Zhi Huang, Jiu-Yao Wang, Li Jingling, Chang-Ching Wei","doi":"10.1111/pai.70045","DOIUrl":"https://doi.org/10.1111/pai.70045","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) predominantly manifests before age five, with significant phenotype variations across age groups. Despite increasing systemic treatments for pediatric AD, head-to-head comparisons in network meta-analyses focused on children are scarce.</p><p><strong>Methods: </strong>Through systematic searches of PubMed, Embase, Web of Science, and Cochrane Library up to March 2024, we identified randomized controlled trials (RCTs) evaluating systemic treatments for moderate-to-severe AD in children aged 2-18 years. From 900 screened articles, 8 RCTs (n = 2636) met inclusion criteria, comparing dupilumab, baricitinib, upadacitinib, and abrocitinib versus placebo with standard care. Primary outcome was Eczema Area and Severity Index (EASI) scores at 12-16 weeks.</p><p><strong>Results: </strong>Upadacitinib demonstrated highest efficacy at both 30 mg (risk difference [RD] 0.62 [0.53, 0.71]) and 15 mg (RD 0.52 [0.42, 0.62]). Dupilumab (weight-based dosing with corticosteroids; RD 0.43 [0.29, 0.57]), abrocitinib (200 mg; RD 0.40 [0.29, 0.50]; 100 mg; RD 0.30 [0.20, 0.41]), and baricitinib (4 mg; RD 0.21 [0.06, 0.35]) also showed significant efficacy over placebo.</p><p><strong>Conclusion: </strong>This analysis establishes a hierarchy of effectiveness among systemic therapies for pediatric AD, with upadacitinib showing highest efficacy. However, the predominance of adolescent data emphasizes the need for age-stratified studies in younger children and long-term safety assessments.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70045"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Janus face of Bifidobacterium in the development of atopic eczema: A role for compositional maturation.","authors":"Martin Depner, Diana Hazard Taft, Stefanie Peschel, Caroline Roduit, Anne M Karvonen, Cindy Barnig, Amandine Divaret-Chauveau, Josef Riedler, Juha Pekkanen, Elisabeth Schmausser-Hechfellner, Giulia Pagani, Roger Lauener, Marjut Roponen, Harald Renz, Petra Ina Pfefferle, Bianca Schaub, Erika von Mutius, Pirkka V Kirjavainen, Markus J Ege","doi":"10.1111/pai.70041","DOIUrl":"10.1111/pai.70041","url":null,"abstract":"<p><strong>Background: </strong>Atopic eczema often develops in the first year of life, when the composition of the gut microbiota is most plastic as illustrated by the decrease in bifidobacteria after weaning. This may provide the opportunity for microbial stimuli and their environmental determinants to alter the disease course.</p><p><strong>Objectives: </strong>To determine the role of the genus Bifidobacterium for atopic eczema in early childhood.</p><p><strong>Methods: </strong>We analysed the bacterial composition in fecal samples of 618 children of the PASTURE (\"Protection against Allergy-Study in Rural Environments\") birth cohort using 16S rRNA amplicon sequencing of fecal samples collected at 2 and 12 months of age. Atopic eczema was defined as a parent-reported doctor's diagnosis until 2 years, and patterns of rash symptoms were classified by latent class analysis. We applied mediation models to assess direct and microbiota-mediated effects of environmental determinants on atopic eczema.</p><p><strong>Results: </strong>The Bifidobacterium composition observed at 2 months was inversely related to atopic eczema (OR = 0.68 [0.53-0.87], p = .002) and persistent rash. This association was not seen at 12 months, when the composition of Bifidobacterium amplicon sequence variants (ASVs) was altered. The effect of beneficial ASVs at 2 months (OR = 0.72 [0.57-0.91]) was lost at 12 months (OR = 0.97 [0.76-1.24]), when distinct bifidobacteria tended to be positively related to late-onset rash.</p><p><strong>Conclusions: </strong>The subgenus composition of Bifidobacterium undergoes substantial changes in the first year of life. The protective effect of Bifidobacterium depends on the ASV composition at the respective age of the infant, highlighting the importance of timing in prevention strategies targeting infant-microbe interactions.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70041"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"When I became older, I started having to manage that more myself\"-Experiences of adolescents with food allergies: A qualitative study.","authors":"Meg O'Sullivan, Margaret Curtin, Rachel Flynn, Juan Trujillo, James O'Mahony","doi":"10.1111/pai.70048","DOIUrl":"10.1111/pai.70048","url":null,"abstract":"<p><strong>Background: </strong>It's often caregivers or healthcare professionals' experiences that are studied in the field of allergy, but the adolescents' perspective is crucial to develop interventions that support them in areas they find most challenging. This study aims to explore adolescents' experience of managing food allergies, particularly how they navigate the transition from parental management to self-management.</p><p><strong>Methods: </strong>This is an interpretive descriptive qualitative study. Semi-structured interviews were conducted with ten adolescents with food allergies aged 12-16 years. Reflexive thematic analysis was conducted. The Reflexive Thematic Analysis Reporting Guidelines were used.</p><p><strong>Results: </strong>Four themes were generated, (1) belonging-seeing me, (2) not knowing (3) taking responsibility-\"So I guess when I became older, I started having to manage that more myself\" and (4) variation in coping strategies. These describe adolescents need for belonging, that their peers acknowledge their food allergies without making them feel like a burden. Adolescents understanding of essential food allergy information was lacking, with some unaware of this lack of knowledge. Adolescents were conscious of the need to take over responsibility from their parents, although this could be difficult. Finally, how adolescents coped with all these aspects of their food allergy could be seen as avoidant due to high anxiety, minimizing of risk, or adaptive, where adolescents are aware of and mitigate risks appropriately, without avoiding life experiences.</p><p><strong>Conclusion: </strong>Adolescents find the transition of responsibility from their parents difficult. A trusted source of allergy information is required, aimed at adolescents, covering both physical allergy management and psychosocial content.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70048"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-label use of dupilumab in the management of pediatric urticaria vasculitis: A promising therapeutic choice.","authors":"Shan Wang, Ying Liu, Qiong Wu, Huan Xing, Lin Ma, Bin Zhang","doi":"10.1111/pai.70049","DOIUrl":"https://doi.org/10.1111/pai.70049","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70049"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Just scratching the surface: A review of pediatric skin allergies.","authors":"Mary Grace Baker, Lara S Ford, Dianne E Campbell, Hugh A Sampson","doi":"10.1111/pai.70038","DOIUrl":"https://doi.org/10.1111/pai.70038","url":null,"abstract":"<p><p>The skin is a large and sophisticated organ populated by innate and adaptive immune effector cells. These immune cells provide a critical first line of defense against pathogens, but genetic and environmental factors can lead to inappropriate signaling that may manifest as hypersensitivity. The most common cutaneous allergic disorders in children include atopic dermatitis, urticaria/angioedema, and contact dermatitis. In this review, we will briefly review these conditions, with a focus on recent developments in our understanding of the diagnosis and management of these disorders.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70038"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial comment on \"Diversity of complementary diet and early food allergy risk\".","authors":"Gonçalo Silva, Philippe Eigenmann, Rachel Peters","doi":"10.1111/pai.70042","DOIUrl":"https://doi.org/10.1111/pai.70042","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 2","pages":"e70042"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}