Gergő Dániel Tóth, Gábor Koplányi, Balázs Kenéz, Diána Balogh-Weiser
{"title":"Nanoformulation of Therapeutic Enzymes: A Short Review","authors":"Gergő Dániel Tóth, Gábor Koplányi, Balázs Kenéz, Diána Balogh-Weiser","doi":"10.3311/ppch.22826","DOIUrl":"https://doi.org/10.3311/ppch.22826","url":null,"abstract":"Enzyme replacement therapy (ERT) is a therapeutic approach that involves the administration of specific enzymes to the patient in order to correct metabolic defects caused by enzyme deficiency. The formulation of ERTs involves the production, purification, and formulation of the enzyme into a stable and biologically active drug product, often using recombinant DNA technology. Non-systemic ERTs often involve the immobilization of the enzyme on a carrier, such as hydrogels, liposomes, or nanoparticles. ERT holds great promise for the treatment of a wide range of genetic disorders, and its success regarding lysosomal storage diseases, such as Fabry disease, Gaucher disease, and Pompe disease has paved the way for the development of similar therapies for other genetic disorders too.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135815566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Increasing Flame Ionization Detector Response by Silylation: The Effective Carbon Number of Carboxylic Acids","authors":"Judit Mátyási, Gyula Nyerges, József Balla","doi":"10.3311/ppch.22827","DOIUrl":"https://doi.org/10.3311/ppch.22827","url":null,"abstract":"Detector response of carboxylic acids (C2–C12, straight and branched chain) were investigated using a flame ionization detector (FID) in a capillary gas chromatographic system. The response of the FID for hydrocarbons is almost directly proportional to the carbon quantity introduced into the flame. Heteroatoms in the molecule reduce signal magnitude, depending on their quality and on the bond they are involved in. We expressed this reduced response with the effective carbon number (ECN). We determined the ECN contribution (ΔECN) of the carboxyl group on the alkyl skeleton. We examined how the responses of carboxylic acids change if trimethylsilyl derivatives are evaluated and we compared the ECN of the neat and derivatized form.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135816189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edina Eszterbauer, Bernadett Kiss, Jesse Sakiyo, Pál Tóth, Áron Németh
{"title":"Investigations on Applied Microbiology Regarding Carbon Capture, and Fermentative Production of the Ingredients in Sweeteners, Agricultural Biosurfactants and Cosmetics","authors":"Edina Eszterbauer, Bernadett Kiss, Jesse Sakiyo, Pál Tóth, Áron Németh","doi":"10.3311/ppch.22821","DOIUrl":"https://doi.org/10.3311/ppch.22821","url":null,"abstract":"Regarding the celebration of the Faculty of Chemical Technology and Biotechnology 150 years, we want to highlight our recent results in the Fermentation Pilot Plant Laboratory (F-labor) which have a focus on applied microbiology. In all of our research activities, we first select an appropriate microorganism for the desired tasks, then optimize its cultivation and product formation, finally investigate process scale up and economics. Here we want to shortly summarize and introduce 4 pillars of our recent research topics: 1. carbon capture by microalga cultures, 2. complex utilization of Yarrowia yeasts with main focus on erythtritol production, 3. bacterial formation of biosurfactants and their use against plant pathogenic fungi on the field of agrobiotechnology and 4. development of different fermented cosmetic ingredients with major focus on Lactobacilli. Regarding microalga cultivation among many methodical developments we could build successfully a 850 L scale tank reactor for Spirulina cultivation. In term of Yarrowia non-conventional yeast complex biotechnology utilization was demonstrated from erythritol to cosmetic applications. Agricultural biosurfactants were successfully applied against Alternaria alternata plant pathogenic fungi. Finally Lactobacilli based cosmetic ingredients were proved to be potential skin-moistening agents.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135816594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applying Heterogeneous Catalytic Reactions for Organic Chemical Syntheses","authors":"László Hegedűs, Zoltán Hell","doi":"10.3311/ppch.22745","DOIUrl":"https://doi.org/10.3311/ppch.22745","url":null,"abstract":"In this review the most important results achieved in the recent 12–15 years are summarized focusing on the heterogenous catalytic hydrogenations over transition metals (Pd, Pt, Ru, Rh, La), as well as the application of palladium, copper and other metals on a molecular sieve (4A) support in several organic chemical syntheses in liquid phase.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Byproduct Formation of Chlorination and Chlorine Dioxide Oxidation in Drinking Water Treatment","authors":"Souha Neguez, D. Laky","doi":"10.3311/ppch.22041","DOIUrl":"https://doi.org/10.3311/ppch.22041","url":null,"abstract":"Increasing water scarcity caused by population growth, climate change, pollution from natural and anthropogenic sources, etc. is likely to impact the occurrence of water-associated infectious diseases. Nowadays, access to clean and safe water is a growing concern worldwide. Therefore, disinfection of drinking water is a vital step in public treatment systems as it ensures the removal of various contaminants, including pathogenic microorganisms (protozoa, viruses, bacteria, and intestinal parasites) that give rise to waterborne diseases. Nevertheless, undesirable disinfection byproducts (DBPs) are formed during disinfection as a result of reactions between chemical disinfectants and natural organic matter (NOM), and/or anthropogenic contaminants, and/or bromide/iodide that are present in the raw water. The chemical complexity and heterogeneity of matters in the raw water makes the characterization and the mechanism of DBPs formation quite difficult and ambiguous regardless of the previous hundreds of studies on DBPs generation. As chlorination is still the most economic and most often used disinfection method, and beside chlorination, the application of chlorine dioxide is becoming more widespread, this paper investigates the possible DBPs generated using chlorine and chlorine dioxide with highlighting their adverse health effects. It overviews the reactions of those disinfectants with inorganic and organic compounds. It is important to note that in order to better understand the performance of disinfectants in water treatment, further investigations on the mechanisms of them with inorganic and organic compounds found in water are critically needed.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83432346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effective Carbon Number of Chlorobenzenes","authors":"Judit Mátyási, G. Nyerges, J. Balla","doi":"10.3311/ppch.22100","DOIUrl":"https://doi.org/10.3311/ppch.22100","url":null,"abstract":"Detector response of 12 chlorobenzenes was investigated (mono-, di-, tri-, tetra-, penta-, and hexachlorobenzene, CBs) using flame ionization detector in a capillary gas chromatographic system. We determined the signal-reducing effect of the chlorine atom on the aromatic ring relative to the number of the chlorine substituents and expressed with the effective carbon number (ECN). Benzene was applied as a reference substance. Using the signal-modifying pattern of the chlorine atoms on the benzene's response, we developed an alternative calibration measurement method (CBs-ECN method) for the 12 CBs and compared it with classic calibration. The differences in the concentrations calculated by the two quantitative methods were under 4.5% for 11 CBs and 7% for one compound.Taking advantage of the opportunities provided by the CBs-ECN pattern it is not necessary to apply all of the 12 CBs but only one single component, the hexachlorobenzene for the calibration. With this simplification, the preparation of the calibration standards is faster, does not require purchasing all 12 CBs for each subsequent calibration, and the exposure to harm and expenses are reduced.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89936529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hafsa Bekraoui, D. Nehari, T. Baki, Mouad Bousmaha
{"title":"The Effect of Operating Parameters on Total Cross-membrane Flux in a PVDF Flat Sheet Membrane","authors":"Hafsa Bekraoui, D. Nehari, T. Baki, Mouad Bousmaha","doi":"10.3311/ppch.21815","DOIUrl":"https://doi.org/10.3311/ppch.21815","url":null,"abstract":"Membrane distillation (MD) is an emerging thermal membrane technology that involves water vapor driven by a vapor pressure gradient over a hydrophobic membrane. MD faces several challenges, one of which is the flux of water vapor. The total cross-membrane flux in membrane distillation was investigated in this paper using the co-current PVDF flat sheet for direct contact. membrane distillation applications. The goal of this research is to improve total cross-membrane flux. The effect of various operational parameters is studied, including feed inlet temperature (333.15–358.15 K), feed flow rate (1–2.5 kg/s), permeate inlet temperature (288.15–313.15 K), and feed inlet NaCl concentration (0.035 to 0.485 kg/kg). To acquire a good value of total cross-membrane flux, their interactions with the total cross-membrane flux are studied in this work. The obtained results were computed during MATLAB-Simulations under several scenarios adopting the Trial-&-Error approach. This last inputs various parameters' values and thus draws the required curves to be discussed and analyzed. The results indicated that the PVDF flat sheet membranes provide a significantly higher total cross-membrane flux at higher feed input temperatures, producing a 73.2075 kg/(m2 h) at a feed inlet temperature of 358.15 K, a permeate inlet temperature of 293.15 K, and a flow rate of 2.5 kg/s, with a feed inlet NaCl concentration of 0.035 kg/kg. Feed inlet temperature significantly affected the total flux through the membrane; however, flow rate, permeate inlet temperature, and feed inlet NaCl concentration had a less significant effect.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84590511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kinetics, Equilibrium and Thermodynamic Studies on Removal of Oleic Acid from Sunflower Oil onto Amberlyst A21","authors":"O. Ilgen, Elif Tümkor","doi":"10.3311/ppch.21743","DOIUrl":"https://doi.org/10.3311/ppch.21743","url":null,"abstract":"Amberlyst A21 was used for the oleic acid adsorption from sunflower oil (SFO). The impacts of parameters such as contact time, temperature, and mass ratio of adsorbent on oleic acid adsorption were studied. The characterization of Amberlyst A21 before and after adsorption was performed by using Fourier transform infrared spectrometer (FTIR) and scanning electron microscope (SEM). The adsorption reached equilibrium 480 minutes later. The increase in temperature and the amount of adsorbent caused an increase in the amount of adsorbed oleic acid. The adsorption kinetics, isotherms, and thermodynamics were studied. The pseudo-first order kinetics well described the adsorption for all studied temperatures. The Langmuir, Freundlich, and Dubinin−Radushkevich isotherms and thermodynamic analysis were investigated at equilibrium. The suitability of the Langmuir and Freundlich isotherms indicated that the adsorption takes place under monolayer and heterogeneous surfaces. Thermodynamical results showed that adsorption occurs spontaneously and endothermic.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90712100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Selvam, Amit Kumar Sharma, Manivannan Ramachandran
{"title":"Study on Corrosion Characteristics of Aluminum Alloy Al3102 in Sulfate-reducing Bacteria Environment and Investigating the Use of Azadirachta indica Leaves Extract in its Control","authors":"N. Selvam, Amit Kumar Sharma, Manivannan Ramachandran","doi":"10.3311/ppch.22213","DOIUrl":"https://doi.org/10.3311/ppch.22213","url":null,"abstract":"An effort to understand the corrosion characteristics of aluminium Al3102 alloy in a neutral medium in the presence of Desulfovibrio desulfuricans was made. The corrosion rate increased up to tenfold in the bacterial medium in comparison to the control (abiotic) medium. Scanning electron microscopy (SEM) studies showed substantial sulfate-reducing bacteria (SRB) adhesion on the alloy surface and pit formation. Supplementation of 1000 ppm Azadirachta indica leaves extract decreased corrosion by 82%. Sulfide analysis, SEM, and X-ray photoelectron spectroscopy (XPS) studies showed a significant effect of neem leaf extract (NLE) on bacterial metabolic activity and confirmed the adsorption of the inhibitor molecules on Al3102 surface. Electrochemical impedance spectroscopy studies showed that the NLE formed a highly resistive external layer which protected the alloy surface from the corrosive effects. The gas chromatography-mass spectroscopy studies (GC-MS) showed appreciable amount of esters, terpenoids, heterocyclic nitrogen, sulfur compounds, and organic bromine compounds in NLE.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76310666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. W. Trisnawati, I. Cahyani, Diah Safriyani, E. Pramono, V. Suryanti
{"title":"Cellulose, Cellulose Benzoate and Cellulose Citrate from Screw Pine (Pandanus tectorius) Leaves as PVDF Filler for Improved Permeability and Anti-fouling Properties","authors":"E. W. Trisnawati, I. Cahyani, Diah Safriyani, E. Pramono, V. Suryanti","doi":"10.3311/ppch.22043","DOIUrl":"https://doi.org/10.3311/ppch.22043","url":null,"abstract":"Cellulose was isolated from screw pine (Pandanus tectorius) leaves through an alkalization and bleaching process and synthesized into cellulose benzoate and cellulose citrate. Cellulose, cellulose benzoate, and cellulose citrate were introduced to polyvinylidene fluoride (PVDF) matrix as fillers via blending-phase inversion method to improve PVDF membrane permeability and anti-fouling properties. The effect of cellulose, cellulose benzoate, and cellulose citrate fillers on PVDF membrane hydrophilicity, permeability, selectivity, anti-fouling properties, and morphology was investigated. The result demonstrates that the PVDF membrane's hydrophilicity, permeability, and anti-fouling properties were improved by the addition of filler. With the addition of 0.3% of cellulose, cellulose citrate, and cellulose benzoate, water permeability in PVDF was doubled. PVDF membrane rejection of methylene blue increased up to 86, 85 and 82%, respectively, with the addition of 0.3% cellulose, cellulose citrate, and cellulose benzoate. Anti-fouling properties value increased up to 89% in 0.3% cellulose citrate addition. These results indicated that cellulose, cellulose benzoate, and cellulose citrate from screw pine leaves are excellent for PVDF membrane fillers which are comparable with other reported membranes.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88690973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}