Balázs Lévai, Gábor Varró, A. Simon, L. Hegedűs, I. Kádas
{"title":"Stereoselective Synthesis of Novel (±)-trans-Dihydronarciclasine Analogues: Preparation of a Pivotal Intermediate Containing Two Methoxy Substituents","authors":"Balázs Lévai, Gábor Varró, A. Simon, L. Hegedűs, I. Kádas","doi":"10.3311/ppch.20438","DOIUrl":null,"url":null,"abstract":"An efficient stereoselective synthesis of a pivotal intermediate, a cyclic allyl alcohol derivative containing two methoxy groups [(±)-22], using for the preparation of (±)-trans-dihydronarciclasine analogues was elaborated starting from easily available and inexpensive methyl gallate. This new synthetic route consists of 17 reaction steps, and provides an opportunity to obtain the wanted alkaloid derivative containing an additional methoxy group at position 11, in the ring A of the phenanthridone scaffold.","PeriodicalId":19922,"journal":{"name":"Periodica Polytechnica Chemical Engineering","volume":"28 1","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Periodica Polytechnica Chemical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3311/ppch.20438","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 1
Abstract
An efficient stereoselective synthesis of a pivotal intermediate, a cyclic allyl alcohol derivative containing two methoxy groups [(±)-22], using for the preparation of (±)-trans-dihydronarciclasine analogues was elaborated starting from easily available and inexpensive methyl gallate. This new synthetic route consists of 17 reaction steps, and provides an opportunity to obtain the wanted alkaloid derivative containing an additional methoxy group at position 11, in the ring A of the phenanthridone scaffold.
期刊介绍:
The main scope of the journal is to publish original research articles in the wide field of chemical engineering including environmental and bioengineering.