PAIN®最新文献

{"title":"ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain.","authors":"Yann Quidé, Neda Jahanshad, Jamila Andoh, Georgia Antoniou, Apkar Vania Apkarian, Yoni K Ashar, Bashar W Badran, C Lexi Baird, Luke Baxter, Tyler R Bell, Laura Blanco-Hinojo, Jeffrey Borckardt, Chloe L Cheung, Daniel Ciampi de Andrade, Bruno A Couto, Simon R Cox, Yenisel Cruz-Almeida, Udo Dannlowski, Enrico De Martino, Marina de Tommaso, Joan Deus, Martin Domin, Natalia Egorova-Brumley, James Elliott, Silvia Fanton, Camille Fauchon, Herta Flor, Carol E Franz, Justine M Gatt, Paul Gerdhem, Jodi M Gilman, Randy L Gollub, Varan Govind, Thomas Graven-Nielsen, Gustaf Håkansson, Tim Hales, Courtney Haswell, Nils Jannik Heukamp, Li Hu, Lejian Huang, Ahmed Hussain, Karin Jensen, Tilo Kircher, William S Kremen, Elisabeth J Leehr, Martin Lindquist, Marco L Loggia, Martin Lotze, Katherine T Martucci, Timothy J Meeker, Susanne Meinert, Samantha K Millard, Rajendra A Morey, Carlos Murillo, Frauke Nees, Igor Nenadic, Haeme R P Park, Xiaolong Peng, Markus Ploner, Jesus Pujol, Linda E Robayo, Teddy Salan, David A Seminowicz, Angela Serian, Rebeccah Slater, Frederike Stein, Jennifer Stevens, Sebastian Strauss, Delin Sun, Etienne Vachon-Presseau, Pedro A Valdes-Hernandez, Sven Vanneste, Mark Vernon, Madeleine Verriotis, Tor D Wager, Eva Widerstrom-Noga, Anna Woodbury, Fadel Zeidan, Ravi R Bhatt, Christopher R K Ching, Elizabeth Haddad, Sophia I Thomopoulos, Paul M Thompson, Sylvia M Gustin","doi":"10.1097/j.pain.0000000000003317","DOIUrl":"10.1097/j.pain.0000000000003317","url":null,"abstract":"","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2662-2666"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"I hear you\". Validation in the context of children's pain as an untapped opportunity to prevent chronic pain.","authors":"Sarah B Wallwork, Chad Shenk, C Meghan McMurtry, Anna M Hood, Maria Pavlova, Anneke E Olson, G Lorimer Moseley, Melanie Noel","doi":"10.1097/j.pain.0000000000003350","DOIUrl":"10.1097/j.pain.0000000000003350","url":null,"abstract":"","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2667-2672"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographically selective motor inhibition under threat of pain.","authors":"Sonia Betti, Marco Badioli, Daniela Dalbagno, Sara Garofalo, Giuseppe di Pellegrino, Francesca Starita","doi":"10.1097/j.pain.0000000000003301","DOIUrl":"10.1097/j.pain.0000000000003301","url":null,"abstract":"<p><strong>Abstract: </strong>Pain-related motor adaptations may be enacted predictively at the mere threat of pain, before pain occurrence. Yet, in humans, the neurophysiological mechanisms underlying motor adaptations in anticipation of pain remain poorly understood. We tracked the evolution of changes in corticospinal excitability (CSE) as healthy adults learned to anticipate the occurrence of lateralized, muscle-specific pain to the upper limb. Using a Pavlovian threat conditioning task, different visual stimuli predicted pain to the right or left forearm (experiment 1) or hand (experiment 2). During stimuli presentation before pain occurrence, single-pulse transcranial magnetic stimulation was applied over the left primary motor cortex to probe CSE and elicit motor evoked potentials from target right forearm and hand muscles. The correlation between participants' trait anxiety and CSE was also assessed. Results showed that threat of pain triggered corticospinal inhibition specifically in the limb where pain was expected. In addition, corticospinal inhibition was modulated relative to the threatened muscle, with threat of pain to the forearm inhibiting the forearm and hand muscles, whereas threat of pain to the hand inhibited the hand muscle only. Finally, stronger corticospinal inhibition correlated with greater trait anxiety. These results advance the mechanistic understanding of pain processes showing that pain-related motor adaptations are enacted at the mere threat of pain, as sets of anticipatory, topographically organized motor changes that are associated with the expected pain and are shaped by individual anxiety levels. Including such anticipatory motor changes into models of pain may lead to new treatments for pain-related disorders.</p>","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2851-2862"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators for physical activity in people living with chronic pain: a systematic review and combined analysis.","authors":"Callum Leese, Devashri Gupte, Aikaterini Christogianni, Cassie Higgins, Pauline Adair, Philippa Dall, Paul Cameron, Blair H Smith, Lesley Colvin","doi":"10.1097/j.pain.0000000000003314","DOIUrl":"10.1097/j.pain.0000000000003314","url":null,"abstract":"<p><strong>Abstract: </strong>Chronic pain is a prevalent and complex health issue associated with physical, emotional, and social consequences. Management of pain is multifactorial and challenging; however, physical activity (PA) has consistently been shown to be beneficial. Despite this, PA levels among people with chronic pain are low. This study aimed to identify facilitators and barriers to PA among adults with chronic pain and analyse these using the structure of a validated behaviour change model: the capability, opportunity, and motivation behaviour change model (COM-B). We performed a systematic review of 6 databases and subsequent combined analysis including peer-reviewed primary research published in English up to November 15, 2023. Search terms consisted of 3 components: pain, PA, and facilitators/barriers. Quality appraisal of studies was conducted using appropriate tools. The systematic search yielded 40 eligible studies with a total of 2164 participants. The studies represented various chronic pain conditions, locations, and study designs. The key barriers to engagement in PA were the impact of pain severity, comorbidities, lack of knowledge about PA benefits, and time constraints. Key facilitators were a personalised approach, social support, and awareness of the benefits. The findings were categorised according to the COM-B model, allowing for the identification of modifiable factors. Person-centred approaches, education, and accessible environments were identified as important aspects to consider for successful PA promotion among people with chronic pain. Utilising the factors identified in the COM-B model is crucial for successful future interventions to increasing PA uptake and adherence in this population.</p>","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2721-2732"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroanatomical evidence and a mouse calcitonin gene-related peptide model in line with human functional magnetic resonance imaging data support the involvement of peptidergic Edinger-Westphal nucleus in migraine.","authors":"Ammar Al-Omari, Balázs Gaszner, Dóra Zelena, Kinga Gecse, Gergely Berta, Tünde Biró-Sütő, Péter Szocsics, Zsófia Maglóczky, Péter Gombás, Erika Pintér, Gabriella Juhász, Viktória Kormos","doi":"10.1097/j.pain.0000000000003294","DOIUrl":"10.1097/j.pain.0000000000003294","url":null,"abstract":"<p><strong>Abstract: </strong>The urocortin 1 (UCN1)-expressing centrally projecting Edinger-Westphal (EWcp) nucleus is influenced by circadian rhythms, hormones, stress, and pain, all known migraine triggers. Our study investigated EWcp's potential involvement in migraine. Using RNAscope in situ hybridization and immunostaining, we examined the expression of calcitonin gene-related peptide (CGRP) receptor components in both mouse and human EWcp and dorsal raphe nucleus (DRN). Tracing study examined connection between EWcp and the spinal trigeminal nucleus (STN). The intraperitoneal CGRP injection model of migraine was applied and validated by light-dark box, and von Frey assays in mice, in situ hybridization combined with immunostaining, were used to assess the functional-morphological changes. The functional connectivity matrix of EW was examined using functional magnetic resonance imaging in control humans and interictal migraineurs. We proved the expression of CGRP receptor components in both murine and human DRN and EWcp. We identified a direct urocortinergic projection from EWcp to the STN. Photophobic behavior, periorbital hyperalgesia, increased c-fos gene-encoded protein immunoreactivity in the lateral periaqueductal gray matter and trigeminal ganglia, and phosphorylated c-AMP-responsive element binding protein in the STN supported the efficacy of CGRP-induced migraine-like state. Calcitonin gene-related peptide administration also increased c-fos gene-encoded protein expression, Ucn1 mRNA, and peptide content in EWcp/UCN1 neurons while reducing serotonin and tryptophan hydroxylase-2 levels in the DRN. Targeted ablation of EWcp/UCN1 neurons induced hyperalgesia. A positive functional connectivity between EW and STN as well as DRN has been identified by functional magnetic resonance imaging. The presented data strongly suggest the regulatory role of EWcp/UCN1 neurons in migraine through the STN and DRN with high translational value.</p>","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2774-2793"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury-induced physiological and behavioral maladaptations.","authors":"Randal A Serafini, Zahra Farzinpour, Vishwendra Patel, Abigail M Kelley, Molly Estill, Kerri D Pryce, Farhana Sakloth, Collin D Teague, Angelica Torres-Berrio, Eric J Nestler, Li Shen, Schahram Akbarian, Anushree N Karkhanis, Robert D Blitzer, Venetia Zachariou","doi":"10.1097/j.pain.0000000000003316","DOIUrl":"10.1097/j.pain.0000000000003316","url":null,"abstract":"<p><strong>Abstract: </strong>Preclinical and clinical work has demonstrated altered plasticity and activity in the nucleus accumbens (NAc) under chronic pain states, highlighting critical therapeutic avenues for the management of chronic pain conditions. In this study, we demonstrate that myocyte enhancer factor 2C (MEF2C), a master regulator of neuronal activity and plasticity, is repressed in NAc neurons after prolonged spared nerve injury (SNI). Viral-mediated overexpression of Mef2c in NAc neurons partially ameliorated sensory hypersensitivity and emotional behaviors in mice with SNI, while also altering transcriptional pathways associated with synaptic signaling. Mef2c overexpression also reversed SNI-induced potentiation of phasic dopamine release and neuronal hyperexcitability in the NAc. Transcriptional changes induced by Mef2c overexpression were different than those observed after desipramine treatment, suggesting a mechanism of action different from antidepressants. Overall, we show that interventions in MEF2C-regulated mechanisms in the NAc are sufficient to disrupt the maintenance of chronic pain states, providing potential new treatment avenues for neuropathic pain.</p>","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2733-2748"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting the stage for pain relief: how treatment setting impacts interdisciplinary multimodal pain treatment for patients with chronic back pain.","authors":"Dustin Maser, Diana Müßgens, Julian Kleine-Borgmann, Balint Kincses, Katharina Schmidt, Sigrid Elsenbruch, Daniel Müller, Ulrike Bingel","doi":"10.1097/j.pain.0000000000003318","DOIUrl":"10.1097/j.pain.0000000000003318","url":null,"abstract":"<p><strong>Abstract: </strong>While interdisciplinary multimodal pain treatment (IMPT) is an effective treatment option for chronic low back pain, it is usually accomplished as an inpatient treatment incurring substantial healthcare costs. Day hospital IMPT could be a resource-saving alternative approach, but whether treatment setting is associated with differences in treatment outcomes has not yet been studied. In a retrospective matched cohort study including data from N = 595 patients diagnosed with chronic back pain and undergoing IMPT at the back pain center in Essen, Germany, we investigated the association between treatment setting (ie, inpatient or day patient of an otherwise identical IMPT) and pain intensity, disability, and self-efficacy after treatment. Outcomes were assessed by questionnaires used in clinical routine, collected at pre-IMPT, post-IMPT, and at 3-, 6-, and 12-month follow-up. The results indicate that day patients showed greater improvements in pain-related disability at 3-month post-IMPT (d = 0.74) and in pain intensity at 6-month post-IMPT (d = 0.79), compared to a matched sample of inpatients. Moreover, day patients achieved higher scores in pain-related self-efficacy at discharge, 3- and 6-month post-IMPT (d = 0.62, 0.99, and 1.21, respectively) and reported fewer incapacity-for-work days than inpatients at 6-month post-IMPT (d = 0.45). These data suggest that day hospital IMPT can be as effective as inpatient treatment and might even be more effective for the less afflicted patients. Further research regarding treatment setting and indication could guide optimized and cost-efficient treatments that are more closely tailored to the individual patient's needs.</p>","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2909-2919"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidation of neuronal activity in mouse models of temporomandibular joint injury and inflammation by in vivo GCaMP Ca 2+ imaging of intact trigeminal ganglion neurons.","authors":"Hyeonwi Son, John Shannonhouse, Yan Zhang, Ruben Gomez, Felix Amarista, Daniel Perez, Edward Ellis, Man-Kyo Chung, Yu Shin Kim","doi":"10.1097/j.pain.0000000000003421","DOIUrl":"10.1097/j.pain.0000000000003421","url":null,"abstract":"<p><strong>Abstract: </strong>Patients with temporomandibular disorders (TMDs) typically experience facial pain and discomfort or tenderness in the temporomandibular joint (TMJ), causing disability in daily life. Unfortunately, existing treatments for TMD are not always effective, creating a need for more advanced, mechanism-based therapies. In this study, we used in vivo GCaMP3 Ca 2+ imaging of intact trigeminal ganglia (TG) to characterize functional activity of the TG neurons in vivo, specifically in mouse models of TMJ injury and inflammation. This system allows us to observe neuronal activity in intact anatomical, physiological, and clinical conditions and to assess neuronal function and response to various stimuli. We observed a significant increase in spontaneously and transiently activated neurons responding to mechanical, thermal, and chemical stimuli in the TG of mice with TMJ injection of complete Freund adjuvant or with forced mouth opening (FMO). An inhibitor of the calcitonin gene-related peptide receptor significantly attenuated FMO-induced facial hypersensitivity. In addition, we confirmed the attenuating effect of calcitonin gene-related peptide antagonist on FMO-induced sensitization by in vivo GCaMP3 Ca 2+ imaging of intact TG. Our results contribute to unraveling the role and activity of TG neurons in the TMJ pain, bringing us closer to understanding the pathophysiological processes underlying TMJ pain after TMJ injury. Our study also illustrates the utility of in vivo GCaMP3 Ca 2+ imaging of intact TG for studies aimed at developing more targeted and effective treatments for TMJ pain.</p>","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2794-2803"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimming chronic pain with ultrasound: hope for the future?","authors":"Roland Peyron, Estelle Raffin","doi":"10.1097/j.pain.0000000000003323","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003323","url":null,"abstract":"","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"165 12","pages":"2660-2661"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational needs and preferences of adult patients with acute pain: a mixed-methods systematic review.","authors":"Mélanie Bérubé, Michael Verret, Laurence Bourque, Caroline Côté, Line Guénette, Andréane Richard-Denis, Simon Ouellet, Lesley Norris Singer, Lynn Gauthier, Marie-Pierre Gagnon, Marc-Aurèle Gagnon, Géraldine Martorella","doi":"10.1097/j.pain.0000000000003288","DOIUrl":"10.1097/j.pain.0000000000003288","url":null,"abstract":"<p><strong>Abstract: </strong>Many patients experience acute pain, which has been associated with numerous negative consequences. Pain education has been proposed as a strategy to improve acute pain management. However, studies report limited effects with educational interventions for acute pain in adults, which can be explained by the underuse of the person-centered approach. Thus, we aimed to systematically review and synthetize current evidence from quantitative, qualitative and mixed-methods studies describing patients' needs and preferences for acute pain education in adults. We searched original studies and gray literature in 7 databases, from January 1990 to October 2023. Methodological quality was assessed with the Mixed Methods Appraisal Tool. A total of 32 studies were included (n = 1847 patients), two-thirds of which were qualitative studies of high methodological quality. Most of the studies were conducted over the last 15 years in patients with postsurgical and posttraumatic pain, identified as White, with a low level of education. Patients expressed the greatest need for education when it came to what to expect in pain intensity and duration, as well how to take the medication and its associated adverse effects. The most frequently reported educational preferences were for in-person education while involving caregivers and to obtain information first from physicians, then by other professionals. This review has highlighted the needs and preferences to be considered in pain education interventions, which should be embedded in an approach cultivating communication and partnership with patients and their caregivers. The results still need to be confirmed with different patient populations.</p>","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"e162-e183"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}