IF 7.4 1区医学

PAIN® Pub Date : 2025-08-26 DOI: 10.1097/j.pain.0000000000003796

Neil E O'Connell,Christina Abdel-Shaheed,Riaz Qureshi,Georgia C Richards,Nadia Soliman,Emma Fisher,Aidan G Cashin,Michael C Ferraro

引用次数: 0

Sensory neuron PIEZO1 deletion inhibits dynamic light touch sensitivity in uninjured mice, prevents neuropathic light touch hypersensitivity, and drives compensatory changes in dorsal root ganglia. 感觉神经元PIEZO1缺失抑制未损伤小鼠动态光触敏感性，防止神经性光触超敏反应，驱动背根神经节代偿性改变。

IF 7.4 1区医学

PAIN® Pub Date : 2025-08-26 DOI: 10.1097/j.pain.0000000000003781

Vanessa L Ehlers,Anvitha Sriram,Bradey A R Stuart,Christina M Mecca,Cheryl L Stucky

{"title":"Sensory neuron PIEZO1 deletion inhibits dynamic light touch sensitivity in uninjured mice, prevents neuropathic light touch hypersensitivity, and drives compensatory changes in dorsal root ganglia.","authors":"Vanessa L Ehlers,Anvitha Sriram,Bradey A R Stuart,Christina M Mecca,Cheryl L Stucky","doi":"10.1097/j.pain.0000000000003781","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003781","url":null,"abstract":"Mechanotransduction is vital for sensing various mechanical stimuli, including blunt force and dynamic light touch. The sensation of a punctate mechanical force is very different from that of a brush swept across the skin, yet both involve mechanical stimulation of the skin and embedded sensory afferent endings. However, the sensory neuron mechanisms contributing to punctate vs light touch somatosensation, and how they might become dysregulated in nerve injury to cause pain, remain unclear. Here, we use mice with sensory neuron-specific PIEZO1 deletion to demonstrate sensory neuron PIEZO1 is required for dynamic light mechanical touch, and possibly punctate mechanical force, in healthy animals. These mice are also protected from acute and chronic tibial spared nerve injury-induced dynamic light touch hypersensitivity. However, dorsal root ganglia neurons from uninjured mice with sensory neuron PIEZO1 deletion displayed evidence of developmental compensation, including sensitized mechanically evoked inward currents. Dorsal root ganglia from these mice also exhibit transcriptional and functional compensation of other ion channels, including PIEZO2, TRPV1, and TRPV4. Thus, the behavioral phenotype of mice with sensory neuron-specific PIEZO1 knockout likely reflects these and possibly other forms of genetic compensation resulting from PIEZO1 absence throughout development, in addition to functional sensory neuron PIEZO1 deletion. Research using this transgenic mouse model must account for these caveats to facilitate accurate data interpretation. Furthermore, this article serves as a call for researchers to critically investigate possible genetic compensation in their mice. Such scrutiny is crucial to prevent replication crises and for advancement of scientific knowledge more broadly.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"32 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with opioid craving, opioid intake, and opioid misuse in patients with chronic pain: insights from an ecological momentary assessment study. 慢性疼痛患者中与阿片类药物渴望、阿片类药物摄入和阿片类药物滥用相关的因素：来自生态瞬时评估研究的见解

IF 7.4 1区医学

PAIN® Pub Date : 2025-08-22 DOI: 10.1097/j.pain.0000000000003753

Alice Bruneau,Amanda Sirois,Gabriella Spiegler,Jiaqi Bi,Sarah Petkau,Yami-Louise Djoudi,Juliet Ware,Reem Alghamdi,Nuzhat Nipa,Michel Perreault,M Gabrielle Pagé,Mark A Ware,Jordi Perez,Marc O Martel

{"title":"Factors associated with opioid craving, opioid intake, and opioid misuse in patients with chronic pain: insights from an ecological momentary assessment study.","authors":"Alice Bruneau,Amanda Sirois,Gabriella Spiegler,Jiaqi Bi,Sarah Petkau,Yami-Louise Djoudi,Juliet Ware,Reem Alghamdi,Nuzhat Nipa,Michel Perreault,M Gabrielle Pagé,Mark A Ware,Jordi Perez,Marc O Martel","doi":"10.1097/j.pain.0000000000003753","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003753","url":null,"abstract":"Many patients with chronic noncancer pain (CNCP) are prescribed opioid medication. However, concerns have been raised about the use of high opioid doses and the misuse of opioids in these patients. Research is needed to better understand the factors that influence day-to-day opioid intake patterns and opioid misuse behaviors in patients with CNCP. The first objective of this study was to examine the contribution of pain intensity, psychological factors, and physical dependence symptoms to daily opioid craving and opioid intake in patients with CNCP. The contribution of these factors to opioid misuse was also examined. In this ecological momentary assessment study, patients with CNCP prescribed short-acting opioids completed diaries, in between opioid doses, for 10 consecutive days. Diaries assessed a host of pain, psychological, and opioid-related variables. Diaries also assessed total daily morphine equivalent doses (MED) used by patients. Multilevel analyses indicated that intra-day increases in pain intensity, negative affect, catastrophizing, and withdrawal symptoms were associated with higher opioid craving (all P's < 0.05). Day-to-day increases in pain intensity, catastrophizing, and craving were associated with greater opioid intake (ie, MED) (all P's < 0.05). Patients' daily opioid craving contributed to daily opioid misuse even after accounting for other daily variables (P < 0.05). Our findings provide new insights into the factors contributing to daily opioid craving, opioid intake, and opioid misuse among patients with CNCP. Interventions targeting these factors could potentially prevent opioid dose escalations and opioid-related harms among those maintained on opioid therapy.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"17 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The endometriosis pain course: a randomized controlled trial of an internet-delivered psychological pain management program for endometriosis. 子宫内膜异位症疼痛过程：子宫内膜异位症心理疼痛管理程序的随机对照试验。

IF 7.4 1区医学

PAIN® Pub Date : 2025-08-21 DOI: 10.1097/j.pain.0000000000003784

Shianika S Chandra,Madelyne A Bisby,Amelia J Scott,Nickolai Titov,Blake F Dear

{"title":"The endometriosis pain course: a randomized controlled trial of an internet-delivered psychological pain management program for endometriosis.","authors":"Shianika S Chandra,Madelyne A Bisby,Amelia J Scott,Nickolai Titov,Blake F Dear","doi":"10.1097/j.pain.0000000000003784","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003784","url":null,"abstract":"Limited research has examined psychological treatments for endometriosis-related chronic pain, despite its association with elevated disability, depression, and anxiety. Remotely delivered treatments have the potential to overcome barriers to access face-to-face psychological care, however, no studies have examined this format in endometriosis patients. The current study examined the efficacy and acceptability of an internet-delivered, psychological, pain management program for women with endometriosis-related pain. In this two-arm trial, 193 participants experiencing endometriosis-related pelvic pain were randomly assigned to the 8-week treatment or a waitlist control. The treatment was an adapted version of an established internet-delivered pain management program based on cognitive-behavior therapy principles. Relative to control, the treatment group reported significantly greater improvements (between groups Cohen's d; average percentage change) in the primary outcomes of pain-related disability (d = 0.35; 24%), depression (d = 0.40; 17%), and anxiety (d = 0.26; 17%) from pre- to post-treatment. Improvements were sustained at 3-month follow-up. No between-group difference was observed on the secondary outcome of average pain intensity (d = 0.28; 17%, P = 0.054). High lesson completion and treatment satisfaction rates were observed. Mean clinician time per participant was 70 minutes (SD = 68). The current findings indicate the potential of a pain-focused psychological approach in supporting endometriosis-related pain, and the potential of the internet-delivered format in increasing access to care. Future research is needed to examine long-term outcomes and investigate factors associated with optimal treatment response.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"44 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Descending projections from the insular cortex to the lateral parabrachial nucleus facilitate nocifensive behaviors in rats. 从岛叶皮层到外侧臂旁核的下降投射促进了大鼠的恶意行为。

IF 7.4 1区医学

PAIN® Pub Date : 2025-08-21 DOI: 10.1097/j.pain.0000000000003726

Yuka Nakaya,Kensuke Hirose,Kouhei Kitano,Gege Zhao,Asuka Kobayashi,Hironobu Osaki,Masayuki Kobayashi

{"title":"Descending projections from the insular cortex to the lateral parabrachial nucleus facilitate nocifensive behaviors in rats.","authors":"Yuka Nakaya,Kensuke Hirose,Kouhei Kitano,Gege Zhao,Asuka Kobayashi,Hironobu Osaki,Masayuki Kobayashi","doi":"10.1097/j.pain.0000000000003726","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003726","url":null,"abstract":"The lateral parabrachial nucleus (LPBN) receives orofacial nociceptive inputs from the trigeminal spinal subnucleus caudalis and transmits them to higher brain regions, including the central amygdala (CeA), intralaminar thalamic nucleus, and insular cortex (IC). The IC processes orofacial nociception and sends descending axons to the LPBN. This study aimed to investigate the physiological functions of IC→LPBN projections using optogenetics. We classified LPBN neurons into glutamatergic and noncholinergic (Glu-nonAch), GABAergic and noncholinergic (GABA-nonAch), glutamatergic and cholinergic (Glu-Ach), and GABAergic and cholinergic (GABA-Ach) neurons. Only Glu-nonAch and Glu-Ach neurons projected to the CeA. Fos proto-oncogene (c-Fos) immunoreactivity in response to capsaicin injection into the whisker pad was observed in all types of neurons. Photostimulation-induced evoked excitatory postsynaptic currents (pEPSCs) by depolarization of axons arising from the spinal subnucleus caudalis were primarily observed in Glu-nonAch neurons, whereas activation of IC axons evoked pEPSCs in all neuronal subtypes. Interestingly, in the IC→LPBN projections, Glu-Ach neurons exhibited greater charge transfer with slower temporal kinetics of pEPSCs than Glu-nonAch neurons. Conversely, GABA-nonAch neurons presented less charge transfer and shorter temporal kinetics of pEPSCs than Glu-Ach and GABA-Ach neurons. Selective activation of IC→LPBN inputs under depolarized membrane potential often induced phase-locked action potentials in Glu-nonAch neurons projecting to the CeA. Behavioral tests demonstrated that the activation of IC→LPBN projections increased face-wiping behavior responding to capsaicin injection into the whisker pad and decreased the threshold of the head-withdrawal reflex. These results suggest that IC projections evoke larger EPSCs in LPBN excitatory projection neurons than in GABAergic neurons, contributing to the facilitation of facial pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"111 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the pain field learn from the functional somatic disorder field? 疼痛领域能从功能性躯体障碍领域学习吗？

IF 7.4 1区医学

PAIN® Pub Date : 2025-08-21 DOI: 10.1097/j.pain.0000000000003733

Lise Gormsen,Per Fink,Stephen H Butler,Peter Henningsen,John D Loeser,Winfried Rief,Nanna B Finnerup

引用次数: 0

National income inequality and adolescent chronic pain: a time series analysis of 29 countries. 国民收入不平等与青少年慢性疼痛：29个国家的时间序列分析。

IF 7.4 1区医学

PAIN® Pub Date : 2025-08-18 DOI: 10.1097/j.pain.0000000000003756

Josep Roman-Juan,Richelle Mychasiuk,Gary J Macfarlane,Anna M Hood,Melanie Noel

{"title":"National income inequality and adolescent chronic pain: a time series analysis of 29 countries.","authors":"Josep Roman-Juan,Richelle Mychasiuk,Gary J Macfarlane,Anna M Hood,Melanie Noel","doi":"10.1097/j.pain.0000000000003756","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003756","url":null,"abstract":"Chronic pain is a major public health concern in adolescence. It is not evenly distributed across the population, with higher prevalence among adolescents from lower socioeconomic status (SES) backgrounds. Evidence suggests that countries with greater income inequality report worse adolescent health and wider socioeconomic health disparities. However, international research on the role of national income inequality in shaping adolescent chronic pain remains limited. In this study, we examined whether national income inequality was associated with adolescent chronic pain prevalence and chronic pain-related socioeconomic disparities, and whether changes in income inequality over time corresponded to changes in these outcomes. Data were drawn from adolescents across 29 Western countries/regions that participated in 5 waves (2002, 2006, 2010, 2014, and 2018) of the Health Behaviour in School-aged Children surveys (pooled n = 826,563). Chronic pain and SES data were aggregated to create a country-level slope index of inequality and then combined with country-level national income inequality data. Prais-Winsten time-series regression models with panel-corrected standard errors were conducted. Results showed that higher national income inequality was associated with a higher prevalence of chronic pain (B = 0.303; P < 0.001) and greater chronic pain-related socioeconomic disparities (B = 0.003; P < 0.001). In addition, changes in national income inequality over successive survey years were associated with changes in chronic pain-related socioeconomic disparities (B = 0.004; P = 0.014). The study findings highlight the need for policies addressing structural income inequality and for integrating socioeconomic factors, social support, and community resources into interventions and treatments to reduce chronic pain prevalence and eliminate related disparities, especially among adolescents from lower SES backgrounds.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"35 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of the International Classification for Orofacial Pain Algorithm. 国际口腔面部疼痛分类算法的开发与验证。

IF 5.5 1区医学

PAIN® Pub Date : 2025-08-13 DOI: 10.1097/j.pain.0000000000003783

Hamid Shakeri, Charlotte Vueghs, Rafael Benoliel, Arne May, Paulo Conti, Tara Renton, Lene Baad-Hansen, Frederic Van der Cruyssen

{"title":"Development and validation of the International Classification for Orofacial Pain Algorithm.","authors":"Hamid Shakeri, Charlotte Vueghs, Rafael Benoliel, Arne May, Paulo Conti, Tara Renton, Lene Baad-Hansen, Frederic Van der Cruyssen","doi":"10.1097/j.pain.0000000000003783","DOIUrl":"10.1097/j.pain.0000000000003783","url":null,"abstract":"Abstract: Orofacial pain (OFP) encompasses a complex spectrum of conditions that present significant diagnostic challenges. The International Classification of Orofacial Pain (ICOP), introduced in 2020, offers a comprehensive diagnostic framework encompassing nearly 200 distinct OFP conditions. However, its detailed structure can impede practical use in clinical settings. To address this, we developed the International Classification of Orofacial Pain Algorithm (ICOP-AL), a flowchart-based tool designed to simplify the diagnostic process by methodically guiding users through ICOP's hierarchical criteria. International Classification of Orofacial Pain Algorithm integrates well-established diagnostic standards, including those from the International Classification of Headache Disorders, 3rd edition and Diagnostic Criteria for Temporomandibular Disorders, to enhance clinical applicability and diagnostic precision. The algorithm's validity was assessed in a study with 100 anonymized patient cases and further evaluated by clinicians across varied experience levels. The results demonstrated substantial agreement between ICOP-AL-derived diagnoses and expert clinician diagnoses (Cohen's Kappa κ = 0.688, P < 0.001), with ICOP-AL outperforming nonexpert evaluators, thereby underscoring its reliability and potential to standardize diagnostic outcomes across clinical environments. International Classification of Orofacial Pain Algorithm represents a promising step toward improving OFP diagnosis, providing a structured and accessible approach for integrating ICOP into routine clinical practice. Although early results are encouraging, further refinement and real-world validation, particularly for more detailed diagnoses, are necessary to determine its full potential as a diagnostic and educational tool.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain and suicidality during adolescence: a Danish National Cohort Study. 青春期疼痛与自杀：丹麦国家队列研究。

IF 5.5 1区医学

PAIN® Pub Date : 2025-08-13 DOI: 10.1097/j.pain.0000000000003769

Liv Mathilde Pampiri, Carsten Hjorthøj, Olivia Kirtley, Verena Hinze, Merete Nordentoft, Annette Erlangsen, Trine Madsen

{"title":"Pain and suicidality during adolescence: a Danish National Cohort Study.","authors":"Liv Mathilde Pampiri, Carsten Hjorthøj, Olivia Kirtley, Verena Hinze, Merete Nordentoft, Annette Erlangsen, Trine Madsen","doi":"10.1097/j.pain.0000000000003769","DOIUrl":"10.1097/j.pain.0000000000003769","url":null,"abstract":"Abstract: Pain has been suggested as an important risk factor for suicidality in adolescents. We examined the association between pain at age 11 years and suicidality until age 18 years. Second, we assessed whether psychiatric diagnoses might mediate this association. We used data from the Danish National Birth Cohort's 11-year follow-up (DNBC-11) and 18-year follow-up (DNBC-18). Self-reported head, stomach, neck, and back pain at age 11 years were examined as exposures. Outcomes were formed from data on self-reported suicidal ideation and suicide attempts from the DNBC-18 and hospital-recorded suicide attempts by age 18 years. We used multinomial logistic regressions and mediation analyses, adjusting for covariates and incorporating sampling weights. Among 28,465 eleven-year-olds, 13.5% reported any frequent pain, which was associated with increased risks of suicidal ideation (adjusted relative risk ratio [aRRR] = 1.6, 95% confidence interval [CI]: 1.5-1.7) and suicide attempts (aRRR = 2.4, 95% CI: 2.0-2.8). Individuals who had reported 3 or more pain sites at age 11 years had a higher risk of suicide attempt (aRRR = 6.4, 95% CI: 3.9-10.4) compared with those with no frequent pain. Pain-related functional interference and recurrent pain were associated with significantly elevated risks of suicidal ideation and suicide attempts. Affective and anxiety/stress-related disorders diagnosed between age 11 and 18 years significantly mediated the association between frequent pain and suicidal ideation (14%-16%), as well as between frequent pain and suicide attempts (37%-48%). Frequent pain is a common concern in 11-year-olds in Denmark and prospectively associated with an increased risk of suicidality by age 18 years. Suicide preventive strategies may consider targeting youth with frequent pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect. 在一氧化二氮诱导的镇痛过程中，前扣带皮层活动的矛盾增加揭示了疼痛影响的特征。

IF 5.5 1区医学

PAIN® Pub Date : 2025-08-11 DOI: 10.1097/j.pain.0000000000003771

Jarret A P Weinrich, Cindy D Liu, Madison E Jewell, Christopher R Andolina, Mollie X Bernstein, Jorge Benitez, Sian Rodriguez-Rosado, Joao M Braz, Mervyn Maze, Mikhail I Nemenov, Allan I Basbaum

{"title":"Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect.","authors":"Jarret A P Weinrich, Cindy D Liu, Madison E Jewell, Christopher R Andolina, Mollie X Bernstein, Jorge Benitez, Sian Rodriguez-Rosado, Joao M Braz, Mervyn Maze, Mikhail I Nemenov, Allan I Basbaum","doi":"10.1097/j.pain.0000000000003771","DOIUrl":"10.1097/j.pain.0000000000003771","url":null,"abstract":"Abstract: The general consensus is that increases in neuronal activity in the anterior cingulate cortex (ACC) contribute to pain's negative affect. In this study, using in vivo imaging of calcium dynamics of ACC neurons in mice, we report that nitrous oxide, an inhaled analgesic anesthetic that reduces pain affect in patients, paradoxically, significantly increases ACC activity. This nitrous oxide-induced increase in ACC activity was confirmed by increased expression of the immediate early gene, c-fos . In parallel studies comparing reflexive vs affective-motivational behavioral responses with noxious stimuli delivered by an infrared laser, we established that nitrous oxide also reduces pain affect in mice. To investigate how increases in ACC activity could reduce pain affect, we next assessed the effect of nitrous oxide on nociceptive processing by neurons of the ACC. Unexpectedly, nitrous oxide did not alter the absolute level of laser-evoked ACC activity. However, because nitrous oxide increases prestimulus baseline activity, the relative magnitude of noxious laser-evoked ACC activation, as compared with the control condition, was significantly reduced in mice inhaling nitrous oxide. Importantly, this reduction correlated with nitrous oxide-induced reductions in affective-motivational, but not reflexive behaviors. We suggest that this relative change in activity represents a neural signature of the affective pain experience in mice.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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