IF 5.9 1区医学

PAIN® Pub Date : 2024-12-06 DOI: 10.1097/j.pain.0000000000003499

Christoph Erbacher, Shani Vaknine-Treidel, Nimrod Madrer, Sofia Weinbender, Dimitar Evdokimov, Stefan Unterecker, Gilli Moshitzky, Claudia Sommer, David S Greenberg, Hermona Soreq, Nurcan Üçeyler

{"title":"Altered blood and keratinocyte microRNA/transfer RNA fragment profiles related to fibromyalgia syndrome and its severity.","authors":"Christoph Erbacher, Shani Vaknine-Treidel, Nimrod Madrer, Sofia Weinbender, Dimitar Evdokimov, Stefan Unterecker, Gilli Moshitzky, Claudia Sommer, David S Greenberg, Hermona Soreq, Nurcan Üçeyler","doi":"10.1097/j.pain.0000000000003499","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003499","url":null,"abstract":"Abstract: Fibromyalgia syndrome (FMS) is a debilitating widespread chronic pain condition of unclear pathophysiology. We studied small noncoding RNAs as potential classifiers and mediators of FMS. Blood and keratinocyte microRNAs (miRs) and transfer RNA fragments (tRFs) were profiled by small RNA-sequencing within a comprehensively phenotyped female cohort of 53 patients with FMS vs 34 healthy controls (hCOs) and 15 patients with major depression and chronic physical pain (disease controls). Small RNAs were quantified via RNA-sequencing and candidates validated via qRT-PCR. MicroRNAs and tRFs were tested for association with FMS symptoms and their potential regulatory roles. miR and tRF profiles were altered in FMS compared to hCO in whole blood (n = 69; n = 22) and keratinocytes (n = 41; n = 55). Receiver operating characteristic analysis of blood miR candidates hsa-miR-148a-3p and hsa-miR-182-5p, and tRF candidate tRF-21-WB8647O5D levels separated FMS from hCO. In blood, hsa-miR-182-5p and hsa-miR-576-5p upregulation was validated via qRT-PCR, showing even higher expression in disease control, while TRF-20-40KK5Y93 was selectively increased in FMS. MicroRNAs in blood and keratinocytes were associated with how widespread pain manifested in patients. Keratinocyte tRFs correlated with loss of skin innervation. In blood, altered small RNAs were linked to immune and RNA processes, whereas in keratinocytes, adhesion and epithelial functions were targeted. Modulated tRFs shared sequence motifs in patients with FMS, which may promote concerted pathway regulation. Our findings show miRs/tRFs as key small RNAs dysregulation in FMS pathophysiology and open new perspectives for FMS diagnostics, symptom monitoring, and clinical management.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats.

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-03 DOI: 10.1097/j.pain.0000000000003476

Katherine Zepeda-Morales, David Bravo, Jonathan Aránguiz-Barrera, Estibaliz Ampuero, Georgina M Renard, Teresa Pelissier, Alejandro Hernández, Jeffri S Retamal, Luis Constandil

{"title":"N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats.","authors":"Katherine Zepeda-Morales, David Bravo, Jonathan Aránguiz-Barrera, Estibaliz Ampuero, Georgina M Renard, Teresa Pelissier, Alejandro Hernández, Jeffri S Retamal, Luis Constandil","doi":"10.1097/j.pain.0000000000003476","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003476","url":null,"abstract":"Abstract: A well-recognized molecular entity involved in pain-related neuroplasticity is the N-methyl-D-aspartate receptor (NMDAR), which is crucial for developing chronic pain. Likewise, the pannexin 1 (Panx1) channel has been described as necessary for initiating and maintaining neuropathic pain, driving nociceptive signals dependent on spinal NMDAR through several possible mechanisms. Through behavioral, pharmacological, and molecular approaches, our study in male rats has revealed several key findings: (1) neurons located in spinal cord laminae I and II express functional Panx1 channels in both neuropathic and sham rats. These channels can open (indicated by YOPRO-1 uptake) through the stimulation of NMDARs with intrathecal NMDA; (2) intrathecal NMDA leads to increased expression of pSrc and pPanx1 in dorsal horn neurons. This elevation exacerbates existing mechanical hyperalgesia in nerve-injured rats; (3) inhibition of Src with intrathecal PP2 or blockade of Panx1 with intrathecal 10Panx effectively mitigates NMDA-induced effects and reduces the spontaneous mechanical hyperalgesia of nerve-injured rats. Notably, while 10Panx successfully alleviates hyperalgesia, it does not alter pSrc expression; and (4) NMDA-stimulated YOPRO-1 uptake in neurons of laminae I-II of spinal cord slices were prevented by the NMDAR antagonist D-AP5, the Src inhibitor PP2 (but not PP3), as well as with the 10Panx and carbenoxolone. Therefore, NMDAR activation in dorsal horn neurons triggers an NMDAR-Src-Panx1 signaling pathway, where Panx1 acts as an enhancing effector in neuropathic pain. This implies that disrupting the NMDAR-Panx1 communication (eg, through Src inhibitors and/or Panx1 blockers) may offer a valuable strategy for managing some forms of chronic pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic widespread musculoskeletal pain shares a highly heritable latent pathway with atherosclerosis and arterial stiffness.

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-03 DOI: 10.1097/j.pain.0000000000003486

Maryam Kazemi Naeini, Marina Cecelja, Maxim B Freidin, Isabelle Granville Smith, Pirro Hysi, Christopher Sivert Nielsen, Frances M K Williams

{"title":"Chronic widespread musculoskeletal pain shares a highly heritable latent pathway with atherosclerosis and arterial stiffness.","authors":"Maryam Kazemi Naeini, Marina Cecelja, Maxim B Freidin, Isabelle Granville Smith, Pirro Hysi, Christopher Sivert Nielsen, Frances M K Williams","doi":"10.1097/j.pain.0000000000003486","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003486","url":null,"abstract":"Abstract: Chronic widespread pain (CWP) is prevalent and associated with reduced life expectancy. Cardiovascular disease is one possible mechanism for this. The purpose of this study was to examine the association of CWP with arterial stiffness and carotid plaque measured using ultrasound to determine if shared environmental or genetic factors might account for any observed association. Around 3000 participants from the TwinsUK with CWP information and measures of carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (cIMT), and plaque were considered. The relationship between CWP and cfPWV, cIMT, and plaque was determined. UK Biobank data were used to replicate the association. Cholesky decomposition and multivariate pathway twin models were examined. Using a 2-sample Mendelian randomisation approach, the causal association between CWP and coronary artery disease was assessed. TwinsUK participants demonstrated a significant association between CWP and increased cfPWV consistent with arterial stiffening (OR = 1.35, P-value = 0.012), as well as the presence of carotid plaque (OR = 1.45, P-value = 0.8e-5). The twin modelling showed a common latent component and pathway underlying CWP, cfPWV, and carotid plaque, with genetic factors accounting for 68% and 90% of the latent factor variation, respectively. The 2-sample MR revealed a potential causal association between CWP and coronary artery disease. This study found that those with CWP have increased the risk of arterial stiffness and atherosclerosis and suggests that CWP leads to an increased risk of cardiovascular disease through genetic factors.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 5-day course of repetitive transcranial magnetic stimulation before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency.

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-03 DOI: 10.1097/j.pain.0000000000003484

Nahian S Chowdhury, Khandoker J Taseen, Alan Ki Chiang, Wei-Ju Chang, Samantha K Millard, David A Seminowicz, Siobhan M Schabrun

{"title":"A 5-day course of repetitive transcranial magnetic stimulation before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency.","authors":"Nahian S Chowdhury, Khandoker J Taseen, Alan Ki Chiang, Wei-Ju Chang, Samantha K Millard, David A Seminowicz, Siobhan M Schabrun","doi":"10.1097/j.pain.0000000000003484","DOIUrl":"10.1097/j.pain.0000000000003484","url":null,"abstract":"Abstract: Repetitive transcranial magnetic stimulation (rTMS) has shown promise as an intervention for pain. An unexplored research question is whether the delivery of rTMS prior to pain onset might protect against a future episode of prolonged pain. The present study aimed to determine whether (1) 5 consecutive days of rTMS delivered prior to experimentally induced prolonged jaw pain has a prophylactic effect on future pain intensity and (2) whether these effects were accompanied by increases in corticomotor excitability (CME) and/or sensorimotor peak alpha frequency (PAF). On each day from day 0 to 4, 40 healthy individuals received a single session of active (n = 21) or sham (n = 19) rTMS over the left primary motor cortex. Peak alpha frequency and CME were assessed on day 0 (before rTMS) and day 4 (after rTMS). Prolonged pain was induced via intramuscular injection of nerve growth factor in the right masseter muscle after the final rTMS session. From days 5 to 25, participants completed twice-daily electronic diaries including pain on chewing and yawning (primary outcomes), as well as pain during other activities (eg, talking), functional limitation in jaw function and muscle soreness (secondary outcomes). Compared to sham, individuals who received active rTMS subsequently experienced lower pain on chewing and yawning. Furthermore, active rTMS led to an increase in PAF. This is the first study to show that rTMS delivered prior to prolonged pain onset can protect against future pain. Our findings suggest that rTMS may hold promise as a prophylactic intervention for pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation of pain: psychophysical evidence for a population coding mechanism in humans.

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-02 DOI: 10.1097/j.pain.0000000000003474

Wacław M Adamczyk, Vishwanath Ramu, Catherine Jackson, Geraldine Schulze, Kenneth R Goldschneider, Susmita Kashikar-Zuck, Christopher D King, Robert C Coghill

{"title":"Radiation of pain: psychophysical evidence for a population coding mechanism in humans.","authors":"Wacław M Adamczyk, Vishwanath Ramu, Catherine Jackson, Geraldine Schulze, Kenneth R Goldschneider, Susmita Kashikar-Zuck, Christopher D King, Robert C Coghill","doi":"10.1097/j.pain.0000000000003474","DOIUrl":"10.1097/j.pain.0000000000003474","url":null,"abstract":"Abstract: The spread of pain across body locations remains poorly understood but may provide important insights into the encoding of sensory features of noxious stimuli by populations of neurons. In this psychophysical experiment, we hypothesized that more intense noxious stimuli would lead to spread of pain, but more intense light stimuli would not produce perceptual radiation. Fifty healthy volunteers (27 females, 23 males, ages 14-44 years) participated in this study wherein noxious stimuli (43, 45, 47, and 49°C) were applied to glabrous (hand) and hairy skin (forearm) skin with 5-second and 10-second durations. Also, visual stimuli displayed on the target bodily area were used as a control. Participants provided pain (and light) spatial extent ratings as well as pain (and light) intensity ratings. In the extent rating procedure, participants adjusted the extent of the square displayed on the screen with the extent of pain (or light) that they experienced. Pain extent ratings showed statistically significant radiation of pain indicated by 12.42× greater spatial spread of pain (pain extent) than the area of the stimulation with 49°C (P < 0.001), in contrast to visual ratings, which closely approximated the size of the stimulus (1.22×). Pain radiation was more pronounced in hairy than glabrous skin (P < 0.05) and was more pronounced with longer stimulus duration (P < 0.001). Pain intensity explained only 14% of the pain radiation variability. The relative independence of the pain radiation from pain intensity indicates that distinct components of population coding mechanisms may be involved in the spatial representation of pain vs intensity coding.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stratified health care for low back pain using the STarT Back approach: holy grail or doomed to fail? 使用 STarT Back 方法对腰背痛进行分层保健：圣杯还是注定失败？

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-01 Epub Date: 2024-07-18 DOI: 10.1097/j.pain.0000000000003319

Peter Croft, Jonathan C Hill, Nadine E Foster, Kate M Dunn, Danielle A van der Windt

{"title":"Stratified health care for low back pain using the STarT Back approach: holy grail or doomed to fail?","authors":"Peter Croft, Jonathan C Hill, Nadine E Foster, Kate M Dunn, Danielle A van der Windt","doi":"10.1097/j.pain.0000000000003319","DOIUrl":"10.1097/j.pain.0000000000003319","url":null,"abstract":"Abstract: There have been at least 7 separate randomised controlled trials published between 2011 and 2023 that have examined primary care for nonspecific low back pain informed by the STarT Back approach to stratified care based on risk prediction, compared with care not informed by this approach. The results, across 4 countries, have been contrasting-some demonstrating effectiveness and/or efficiency of this approach, others finding no benefits over comparison interventions. This review considers possible explanations for the differences, particularly whether this is related to poor predictive performance of the STarT Back risk-prediction tool or to variable degrees of success in implementing the whole STarT Back approach (subgrouping and matching treatments to predicted risk of poor outcomes) in different healthcare systems. The review concludes that although there is room for improving and expanding the predictive value of the STarT Back tool, its performance in allocating individuals to their appropriate risk categories cannot alone explain the variation in results of the trials to date. Rather, the learning thus far suggests that challenges in implementing stratified care in clinical practice and in changing professional practice largely explain the contrasting trial results. The review makes recommendations for future research, including greater focus on studying facilitators of implementation of stratified care and developing better treatments for patients with nonspecific low back pain at high risk of poor outcomes.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2679-2692"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral nerve injury results in a biased loss of sensory neuron subpopulations. 周围神经损伤会导致感觉神经元亚群的偏向性丧失。

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1097/j.pain.0000000000003321

Andrew H Cooper, Allison M Barry, Paschalina Chrysostomidou, Romane Lolignier, Jinyi Wang, Magdalena Redondo Canales, Heather F Titterton, David L Bennett, Greg A Weir

{"title":"Peripheral nerve injury results in a biased loss of sensory neuron subpopulations.","authors":"Andrew H Cooper, Allison M Barry, Paschalina Chrysostomidou, Romane Lolignier, Jinyi Wang, Magdalena Redondo Canales, Heather F Titterton, David L Bennett, Greg A Weir","doi":"10.1097/j.pain.0000000000003321","DOIUrl":"10.1097/j.pain.0000000000003321","url":null,"abstract":"Abstract: There is a rich literature describing the loss of dorsal root ganglion (DRG) neurons following peripheral axotomy, but the vulnerability of discrete subpopulations has not yet been characterised. Furthermore, the extent or even presence of neuron loss following injury has recently been challenged. In this study, we have used a range of transgenic recombinase driver mouse lines to genetically label molecularly defined subpopulations of DRG neurons and track their survival following traumatic nerve injury. We find that spared nerve injury leads to a marked loss of cells containing DRG volume and a concomitant loss of small-diameter DRG neurons. Neuron loss occurs unequally across subpopulations and is particularly prevalent in nonpeptidergic nociceptors, marked by expression of Mrgprd. We show that this subpopulation is almost entirely lost following spared nerve injury and severely depleted (by roughly 50%) following sciatic nerve crush. Finally, we used an in vitro model of DRG neuron survival to demonstrate that nonpeptidergic nociceptor loss is likely dependent on the absence of neurotrophic support. Together, these results profile the extent to which DRG neuron subpopulations can survive axotomy, with implications for our understanding of nerve injury-induced plasticity and pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2863-2876"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scratching the surface: the complex interface of chronic pain and mental health treatment needs in the United States.

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-01 Epub Date: 2024-07-12 DOI: 10.1097/j.pain.0000000000003341

John A Sturgeon, Maisa Ziadni, Zina Trost, Afton L Hassett

引用次数: 0

Phenotyping peripheral neuropathies with and without pruritus: a cross-sectional multicenter study. 对伴有和不伴有瘙痒的周围神经病进行表型分析：一项横断面多中心研究。

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-01 Epub Date: 2024-06-28 DOI: 10.1097/j.pain.0000000000003300

Panoraia Baka, Daniel Segelcke, Frank Birklein, Esther M Pogatzki-Zahn, Stephan Bigalke, Ayşenur Süer, Martin Dugas, Livia Steenken, Claudia Sommer, Aikaterini Papagianni

{"title":"Phenotyping peripheral neuropathies with and without pruritus: a cross-sectional multicenter study.","authors":"Panoraia Baka, Daniel Segelcke, Frank Birklein, Esther M Pogatzki-Zahn, Stephan Bigalke, Ayşenur Süer, Martin Dugas, Livia Steenken, Claudia Sommer, Aikaterini Papagianni","doi":"10.1097/j.pain.0000000000003300","DOIUrl":"10.1097/j.pain.0000000000003300","url":null,"abstract":"Abstract: Pruritus often escapes physicians' attention in patients with peripheral neuropathy (PNP). Here we aimed to characterize neuropathic pruritus in a cohort of 191 patients with PNP (large, mixed, or small fiber) and 57 control subjects with deep phenotyping in a multicenter cross-sectional observational study at 3 German sites. All participants underwent thorough neurological examination, nerve conduction studies, quantitative sensory testing, and skin biopsies to assess intraepidermal nerve fiber density. Patients filled in a set of questionnaires assessing the characteristics of pruritus and pain, the presence of depression and anxiety, and quality of life. Based on the severity of pruritus and pain, patients were grouped into 4 groups: \"pruritus,\" \"pain,\" \"pruritus and pain,\" and \"no pruritus/no pain.\" Although 11% (21/191) of patients reported pruritus as their only symptom, further 34.6% (66/191) reported pruritus and pain. Patients with pain (with or without pruritus) were more affected by anxiety, depression, and reduced quality of life than control subjects. Patients with pruritus (with and without pain) had increases in cold detection threshold, showing Aδ-fiber dysfunction. The pruritus group had lower intraepidermal nerve fiber density at the thigh, concomitant with a more proximal distribution of symptoms compared with the other PNP groups. Stratification of patients with PNP by using cross-sectional datasets and multinominal logistic regression analysis revealed distinct patterns for the patient groups. Together, our study sheds light on the presence of neuropathic pruritus in patients with PNP and its relationship with neuropathic pain, outlines the sensory and structural abnormalities associated with neuropathic pruritus, and highlights its impact on anxiety levels.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2840-2850"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal trends and projections in the global burden of neck pain: findings from the Global Burden of Disease Study 2019. 全球颈痛负担的时间趋势和预测：2019 年全球疾病负担研究的结果。

IF 5.9 1区医学

PAIN® Pub Date : 2024-12-01 Epub Date: 2024-06-19 DOI: 10.1097/j.pain.0000000000003298

Siqing Cheng, Jin Cao, Leying Hou, Shuting Li, Weidi Sun, Shiyi Shan, Jianhui Zhao, Lingzi Yao, Xue Li, Bin He, Peige Song

{"title":"Temporal trends and projections in the global burden of neck pain: findings from the Global Burden of Disease Study 2019.","authors":"Siqing Cheng, Jin Cao, Leying Hou, Shuting Li, Weidi Sun, Shiyi Shan, Jianhui Zhao, Lingzi Yao, Xue Li, Bin He, Peige Song","doi":"10.1097/j.pain.0000000000003298","DOIUrl":"10.1097/j.pain.0000000000003298","url":null,"abstract":"Abstract: Data were obtained from the Global Burden of Disease study 2019. Joinpoint regression model was used to analyze the temporal trends from 1990 to 2019 of neck pain burden, focusing on age-standardized incidence rates, age-standardized prevalence rates, and age-standardized years lived with disability (YLDs) rates at the global, regional, and national levels. The age-period-cohort analysis was used to estimate the effects of age (5-99 years), period (1990-2019), and cohort (1893-2012) at the global, regional, and national levels. Future projections for the global burden of neck pain from 2020 to 2044 were estimated using the nordpred age-period-cohort model. From 1990 to 2019, the global incidence, prevalence cases, and YLDs counts of neck pain have increased by 71.89%, 98.21%, and 78.17%, respectively. The joinpoint analysis indicated significant shifts in the global trends of age-standardized neck pain burden, which varied across regions and nations. The age-period-cohort model indicated that the neck pain burden was predominantly concentrated in middle-aged and older age, with period and cohort effects showing minimal variation from 1990 to 2019. Compared with 2019, the incident cases, prevalent cases, and YLDs counts of neck pain were projected to increase by 134%, 142%, and 140% by 2044. The global burden of neck pain has persisted at a relatively elevated level from 1990 to 2019, with projections indicating a continuing upward trend. Future research is urgently needed to better understand the predictors and clinical course of neck pain and to enhance prevention and management strategies.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":" ","pages":"2804-2813"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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