IF 7.4 1区医学

PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003671

Andrey Bortsov,Sahel Jahangiri Esfahani,Lucas V Lima,Ru-Rong Ji,Jeffrey S Mogil,Luda Diatchenko

{"title":"How people resolve pain: insights from human transcriptomics into immune activation and therapeutic innovations.","authors":"Andrey Bortsov,Sahel Jahangiri Esfahani,Lucas V Lima,Ru-Rong Ji,Jeffrey S Mogil,Luda Diatchenko","doi":"10.1097/j.pain.0000000000003671","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003671","url":null,"abstract":"Patients with chronic pain commonly exhibit elevated inflammatory markers in the blood that correlate with reported pain and pain-related disability. Although inflammation is traditionally seen as a driver of chronic pain, recent transcriptomic data challenge this view, highlighting the beneficial role of acute inflammation in pain resolution. Here, we present evidence pointing to the overall dynamics of the inflammatory response being critical for pain resolution with the initial acute inflammatory response necessary to trigger pain resolution processes. We posit that chronic pain reflects an inability to resolve inflammation rather than its mere presence. Pharmacological or nonpharmacological reactivation of acute inflammatory pathways may thus provide novel therapeutic strategies targeting pain resolution instead of merely mitigating pain perception. This novel hypothesis regarding the effect of inflammation on pain is an example of what can be learned using unbiased approaches such as human transcriptomics. We believe that the near future will feature more examples of hypothesis generation using human genetics followed up by mechanistic experimentation in animal models.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"4 1","pages":"S60-S64"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerating discovery in pain science: the Acute to Chronic Pain Signatures program. 加速疼痛科学的发现：急性到慢性疼痛特征项目。

IF 7.4 1区医学

PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003674

Tor D Wager,Stephani P Sutherland,Martin A Lindquist,Kathleen A Sluka,

{"title":"Accelerating discovery in pain science: the Acute to Chronic Pain Signatures program.","authors":"Tor D Wager,Stephani P Sutherland,Martin A Lindquist,Kathleen A Sluka, ","doi":"10.1097/j.pain.0000000000003674","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003674","url":null,"abstract":"Chronic pain is a complex and multifaceted disease, with biological causes distributed across tissues and bodily systems and influenced by psychological and social factors. A major aim of pain research is to find better ways to measure signals associated with chronic pain and thus predict, track, and treat pain conditions. Emerging biological measures related to the metabolic, immune, and nervous systems hold promise for identifying the physiology underlying pain and developing new treatments. Developing such measures will require multimodal datasets from large samples in combination with methodological advances. The Acute to Chronic Pain Signatures (A2CPS) Program serves as a model for such an effort, and its data will provide investigational opportunities for years to come. Acute to Chronic Pain Signatures is collecting multiomics, psychosocial, functional, and neuroimaging data from 2800 individuals before and after thoracic or knee replacement surgery. In addition to evaluating the prognostic value of previously identified biomarkers for predicting the transition to chronic pain, A2CPS will use machine learning and artificial intelligence to link these multiple data types and identify multimodal biosignatures of future pain. Open sharing of large datasets like that of the A2CPS, and models derived from them, will accelerate discovery and allow researchers to model brain, metabolic, and immune relationships relevant for multiple facets of health.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"42 1","pages":"S95-S98"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimising physical rehabilitation for people with musculoskeletal pain. 优化肌肉骨骼疼痛患者的身体康复。

IF 7.4 1区医学

PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003719

Aidan G Cashin,Michele Sterling

引用次数: 0

Forward and reverse engineering the pain system: from computational neuroscience to neuro-engineering. 疼痛系统的正向和反向工程：从计算神经科学到神经工程。

IF 7.4 1区医学

PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003705

Pranav Mahajan,Ben Seymour

引用次数: 0

Moving beyond measures of pain intensity in preclinical models. 在临床前模型中超越疼痛强度的测量。

IF 7.4 1区医学

PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003688

Kathleen A Sluka,Levi P Sowers,Carolyn A Fairbanks,B Duncan X Lascelles

引用次数: 0

Allostatic load and pain: instability of a bio-social ecosystem. 适应负荷和疼痛：生物社会生态系统的不稳定性。

IF 7.4 1区医学

PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003716

David Borsook

引用次数: 0

A fireside chat with Nobel Laureates Ardem Patapoutian and David Julius. 与诺贝尔奖得主阿尔登·帕塔普提安和大卫·朱利叶斯的炉边谈话。

IF 7.4 1区医学

PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003751

Cheryl L Stucky

引用次数: 0

Caregiver-reported chronic pain among children born preterm. 护理人员报告的早产儿慢性疼痛。

IF 7.4 1区医学

PAIN® Pub Date : 2025-10-15 DOI: 10.1097/j.pain.0000000000003829

Julia Glass,Em Long-Mills,Dmitry Tumin,Juan Guillen-Hernandez

{"title":"Caregiver-reported chronic pain among children born preterm.","authors":"Julia Glass,Em Long-Mills,Dmitry Tumin,Juan Guillen-Hernandez","doi":"10.1097/j.pain.0000000000003829","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003829","url":null,"abstract":"To determine whether preterm birth or low birth weight (LBW) is associated with chronic pain in childhood and whether this association grows weaker at older attained ages. We analyzed data from children ages 0 to 17 years in the 2016 to 2022 National Survey of Children's Health. Caregivers reported prematurity, birth weight, and presence of chronic pain for 1 child per participating household. We classified children born preterm (<37 weeks) based on very low birth weight (VLBW) (<1500 g), LBW (1500-2500 g), and normal birth weight (NBW) (>2500 g), and included a comparator group of term-born NBW children. The study outcome was caregiver-reported chronic pain, which was used as a surrogate measure for child-reported chronic pain. The analysis included 242,575 children (88% term NBW, 6% preterm NBW, 5% preterm LBW, 1% preterm VLBW). On multivariable analysis, among infants attained age younger than 1 year, there were no statistically significant associations between preterm birth or (V) LBW and odds of caregiver-reported chronic pain (P = 0.056, 0.536, and 0.317 for preterm NBW, preterm LBW, and preterm VLBW, respectively). All interactions between attained age and gestational age or birth weight categories were also not statistically significant (interaction P = 0.254, 0.951, and 0.792 for preterm NBW, preterm LBW, and preterm VLBW, respectively), indicating no substantive change in the associations of preterm birth or (V) LBW with odds of chronic pain among older children. We found no evidence that (V) LBW or preterm birth was associated with increased odds of caregiver-reported chronic pain in childhood or adolescence.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"1 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic pain after decompression for degenerative cervical myelopathy: a pooled trajectory analysis of individual participant data. 退行性颈椎病减压后慢性疼痛：个体参与者数据的汇总轨迹分析。

IF 7.4 1区医学

PAIN® Pub Date : 2025-10-15 DOI: 10.1097/j.pain.0000000000003828

Alex B Bak,Ali Moghaddamjou,Paul M Arnold,James S Harrop,Michael G Fehlings

{"title":"Chronic pain after decompression for degenerative cervical myelopathy: a pooled trajectory analysis of individual participant data.","authors":"Alex B Bak,Ali Moghaddamjou,Paul M Arnold,James S Harrop,Michael G Fehlings","doi":"10.1097/j.pain.0000000000003828","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003828","url":null,"abstract":"Pain is a significant contributor to quality of life for those living with degenerative cervical myelopathy (DCM). The trajectories and factors associated with chronic pain are poorly understood. Patients with DCM were identified from a harmonized data set of the AO Spine Cervical Spondylotic Myelopathy (CSM)-North America, CSM-International, and CSM-Protect studies. Pain scores were prospectively collected using the Neck Disability Index pain intensity (NDI-PI) score preoperatively and at 6-month, 12-month, and 24-month follow-up. Patients were categorized into 3 groups of preoperative pain: severe pain (NDI-PI ≥3), moderate pain (NDI-PI = 2), and minimal pain (NDI-PI ≤1). Latent class trajectory modeling classified patients into distinct trajectories based on their NDI-PI score over 24 months postoperatively. From a total of 952 patients, 32% of patients (n = 305) presented preoperatively with severe pain, 29.1% (n = 277) with moderate pain, and 38.9% (n = 370) with minimal pain. Postoperatively, patients presenting with severe pain followed (1) complete resolution (n = 128, 42.0%), (2) moderate recovery (n = 105, 34.4%), or (3) marginal recovery (n = 72, 23.6%) trajectory. Patients presenting with moderate pain followed the trajectories of (1) pain evolution (n = 22, 7.9%), (2) marginal recovery (n = 104, 37.6%), and (3) complete resolution (n = 151, 54.5%). Patients presenting with minimal pain followed 2 trajectories: (1) no pain evolution (n = 329, 88.9%) and (2) moderate evolution (n = 41, 11.1%). At 24 months, 36.1% (n = 344) of all trajectories ended in chronic pain. Preoperative pain in DCM can be classified into distinct subpopulations with fundamentally differing clinical courses. Surgery is associated with long-term trajectories of pain reduction in painful DCM. However, some patients experience persisting chronic pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"102 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal development of peripheral neuroinflammation in whiplash-associated disorder grade II and its role in chronicity. 鞭扭伤相关疾病II级患者周围神经炎症的时间发展及其慢性作用。

IF 7.4 1区医学

PAIN® Pub Date : 2025-10-10 DOI: 10.1097/j.pain.0000000000003816

Colette Ridehalgh,Joel Fundaun,Stephen Bremner,Mara Cercignani,Soraya Koushesh,Annina B Schmid,Andrew Dilley

{"title":"Temporal development of peripheral neuroinflammation in whiplash-associated disorder grade II and its role in chronicity.","authors":"Colette Ridehalgh,Joel Fundaun,Stephen Bremner,Mara Cercignani,Soraya Koushesh,Annina B Schmid,Andrew Dilley","doi":"10.1097/j.pain.0000000000003816","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003816","url":null,"abstract":"Whiplash injuries cause considerable pain and disability. Most individuals are diagnosed with whiplash-associated disorder grade II (WADII), which is defined by the absence of frank nerve injury. However, studies indicate possible peripheral neuroinflammation in some individuals with WADII that may contribute to symptoms. The temporal changes of peripheral neuroinflammation in WADII remain unclear. This study aimed to investigate the course of peripheral neuroinflammation from acute to chronic stages and assess whether neuroinflammation in the acute stage predicts recovery 6 months postinjury. Sixty-two WADII participants, who were examined within 4 weeks of a whiplash injury, returned for a follow-up appointment at 6 months. Thirty-two percent (n = 20) of participants considered themselves to be all better at 6 months based on a global recovery question. Magnetic resonance imaging T2-weighted signal ratio of the C5 to C8 roots of the brachial plexus, associated dorsal root ganglia, and median nerve, were similar at both time points. Signs of heightened nerve mechanosensitivity reduced significantly at 6 months, as did mechanical and thermal hyperalgesia in the upper limb. Inflammatory mediator serum levels were unaltered at 6 months, except for tumour necrosis factor-α, which was reduced. Multivariable regression analysis indicated that heightened nerve mechanosensitivity (reduced elbow range of motion) in the acute stage was weakly prognostic for neuropathic pain classification at 6 months. Although many participants recovered at 6 months, the data show that peripheral neuroinflammation may persist in some individuals. These findings highlight the complexity of WADII and the contribution of neuroinflammation in both acute and chronic stages.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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