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Preclinical spontaneous pain measures may predict clinical analgesic efficacy better than von Frey assays.
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003721
Cheryl L Stucky
{"title":"Preclinical spontaneous pain measures may predict clinical analgesic efficacy better than von Frey assays.","authors":"Cheryl L Stucky","doi":"10.1097/j.pain.0000000000003721","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003721","url":null,"abstract":"","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"9 1","pages":"2445-2446"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated biopsychosocial signatures: moving beyond isolated biomarkers to predict, prevent, and treat persistent pain. 综合生物心理社会特征：超越孤立的生物标志物，预测、预防和治疗持续性疼痛。
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003635
Yenisel Cruz-Almeida
{"title":"Integrated biopsychosocial signatures: moving beyond isolated biomarkers to predict, prevent, and treat persistent pain.","authors":"Yenisel Cruz-Almeida","doi":"10.1097/j.pain.0000000000003635","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003635","url":null,"abstract":"Persistent pain affects one-fifth of the global population, creating a healthcare crisis that defies conventional treatments and understanding. This perspective examines how pain research is evolving from seeking isolated biomarkers to developing composite biomarker signatures that integrate neuroimaging, multiomics, and sensor data. The future requires further advancement toward integrated biopsychosocial signatures that combine these biological markers with psychological and social factors to create truly holistic pain characterizations. Achieving this requires shifting from siloed research to team science integrating diverse disciplines and patient perspectives. Through artificial intelligence and cross-disciplinary collaboration, we can envision making persistent pain predictable, preventable, and precisely treatable while maintaining the patient's voice as central to compassionate care.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"37 1","pages":"S99-S102"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electroencephalography, magnetoencephalography and pain: where do we stand, and where are we going. 脑电图、脑磁图和疼痛：我们现在处于什么位置，我们要去哪里。
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003689
Luis Garcia-Larrea,Nathalie André-Obadia
{"title":"Electroencephalography, magnetoencephalography and pain: where do we stand, and where are we going.","authors":"Luis Garcia-Larrea,Nathalie André-Obadia","doi":"10.1097/j.pain.0000000000003689","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003689","url":null,"abstract":"Considerable progress has been made over the past decade in the use, practicality, and clinical relevance of electroencephalography (EEG) and magnetoencephalography (MEG)-derived data, improving our understanding of cortical nociceptive processing, the transition from nociception to conscious pain, and its cognitive-emotional modulations. Multimodal responses to heat, cold, and tactile/electrical stimuli, combined with autonomic reactions, provide objective sensory tests that bypass the limitations of verbal responses, while emerging approaches to spontaneous EEG/MEG analysis are changing the game in the still elusive area of ongoing pain. We can expect that all departments involved in the assessment of chronic pain will gradually be able to access these powerful and flexible techniques.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"95 1","pages":"S65-S70"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the next 50 years of positron emission tomography can transform our understanding of chronic pain. 未来50年的正电子发射断层扫描将如何改变我们对慢性疼痛的理解。
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003665
Marco L Loggia,Pedro Brugarolas,Ciprian Catana,Jacob M Hooker
{"title":"How the next 50 years of positron emission tomography can transform our understanding of chronic pain.","authors":"Marco L Loggia,Pedro Brugarolas,Ciprian Catana,Jacob M Hooker","doi":"10.1097/j.pain.0000000000003665","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003665","url":null,"abstract":"The first modern positron emission tomography (PET) scanner was introduced in 1975-the same year during which the journal PAIN was first published. Over the past 50 years, PET imaging has driven major discoveries in human biology, offering transformative insights into chronic pain. Yet, despite its remarkable versatility, PET remains a relatively underutilized tool in pain research. In this narrative, we explore the vast potential of this imaging technique, envisioning its evolution in the upcoming decades with advancements in scanner technology, novel radioligands, sophisticated data analysis methods, and expanded accessibility. We discuss how these innovations could revolutionize our understanding, diagnosis, and treatment of chronic pain.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"16 1","pages":"S71-S74"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking the temporal dynamics of pain: from 3 months to 3 hours? 重新思考疼痛的时间动态：从3个月到3小时？
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003678
Nader Ghasemlou
{"title":"Rethinking the temporal dynamics of pain: from 3 months to 3 hours?","authors":"Nader Ghasemlou","doi":"10.1097/j.pain.0000000000003678","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003678","url":null,"abstract":"The perception of pain varies rhythmically across the day. Although early studies showed variations in pain sensitivity, mechanistic studies are only now identifying how clock genes and individual rhythms affect pain outcomes. Core clock genes, including Bmal1 and Cry1, regulate pain through neuroimmune interactions, providing potential biomarkers to understand individual variability. This rhythmicity offers a promising avenue for a precision medicine approach to identify optimal timing for pain therapies and stratification of individuals. Integrating daily rhythmic patterns with digital health tools could significantly enhance treatment strategies, moving beyond the conventional \"one-size-fits-all\" approach toward personalized pain management.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"22 1","pages":"S33-S36"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging technologies to upskill primary care providers in person-centred pain care. 利用技术提高初级保健提供者在以人为本的疼痛护理方面的技能。
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003715
Simone De Morgan,Fiona M Blyth,Helen Slater,Pippy Walker,Anne Daly,Carolyn Berryman,Anne L J Burke,Michael K Nicholas,Andrea D Furlan,Chitra Lalloo,Jennifer Stinson
{"title":"Leveraging technologies to upskill primary care providers in person-centred pain care.","authors":"Simone De Morgan,Fiona M Blyth,Helen Slater,Pippy Walker,Anne Daly,Carolyn Berryman,Anne L J Burke,Michael K Nicholas,Andrea D Furlan,Chitra Lalloo,Jennifer Stinson","doi":"10.1097/j.pain.0000000000003715","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003715","url":null,"abstract":"There is a critical need to upskill primary care providers to enable timely high-quality care for children, youth, and adults living with pain. Leveraging technologies has the potential to increase accessibility of pain education as part of continuing professional development. In this paper, we highlight 2 digitally enabled education strategies-Project Extension for Community Healthcare Outcomes (synchronous) and eLearning pain training (asynchronous). Emerging areas of interest for education and research are also highlighted including blended synchronous and asynchronous pain education; the use of artificial intelligence tools to create personalised and engaging eLearning experiences; and consumers as partners in the development, implementation, and evaluation of digitally enabled pain education.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"58 1","pages":"S37-S41"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglia, sex, and pain: even more twists and turns ahead? 小胶质细胞、性和疼痛：前方还有更多的曲折？
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003670
Eder Gambeta,Michael W Salter
{"title":"Microglia, sex, and pain: even more twists and turns ahead?","authors":"Eder Gambeta,Michael W Salter","doi":"10.1097/j.pain.0000000000003670","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003670","url":null,"abstract":"When IASP began 50 years ago, microglia were not on the radar of pain researchers. Indeed, interest only began to develop in earnest 25 years after IASP was established. Since then, there has been an explosion of information on microglia, particularly in animal models of chronic neuropathic pain. Microglia are regularly part of the conversation about neuropathic pain in animals and humans. The past 25 years has seen many unexpected twists and turns: microglia mediating neuropathic pain, profound mechanistic sex differences, helpful as well as hurtful microglia, and even microglia-independent neuropathic pain. Where will the story go in the next 50 years? Given the rapid growth in imaging of the panoply of cells, signaling molecules, and receptors in the central nervous system, it seems inevitable that the field will have determined whether microglia are intermediaries of chronic pain in humans and whether the mechanistic sex differences found in animal models exist in pain in humans. The principles of precision medicine may be applied to cell types and pathways increasingly identified in preclinical studies. However, application to humans will require advanced molecular diagnostics, not yet developed, for this approach to be successful. Alternatively, to develop safe and effective therapeutics, the field may take advantage of the points of convergence that have been revealed by studies on microglia and sex in pain. Time, and substantial efforts by passionate and talented pain researchers and clinicians, will tell. But what an exciting, and provocative journey it will be, undoubtedly full of novel twists and turns.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"53 1","pages":"S23-S26"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decolonizing pain and health-related research to advance research and optimize health. 非殖民化疼痛和健康相关研究，以推进研究和优化健康。
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003717
Carmen Renee Green,Fernando V Villalta,Esmeralda E Garcia-Almonte
{"title":"Decolonizing pain and health-related research to advance research and optimize health.","authors":"Carmen Renee Green,Fernando V Villalta,Esmeralda E Garcia-Almonte","doi":"10.1097/j.pain.0000000000003717","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003717","url":null,"abstract":"Pain and healthcare inequities persist as consequences of early colonial practices, which plague pain and health-related research today. Colonialism negatively contributes to known inequities among vulnerable marginalized communities. Scientists control overall study design and who participates in research, continuing colonial power practices. Past ethical shortcomings have fostered mistrust in communities. The model proposed advocates for decolonizing pain and health-related research to create shared understandings and collaborations to restore trust. By acknowledging the past, scientists can move from colonial structures and biases to promote integrity and trust. Centering the focus on equity allows for improved pain and health outcomes.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"1 1","pages":"S136-S139"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital twin learning health systems and multimodal biomarkers transform pain care. 数字双胞胎学习健康系统和多模态生物标志物改变了疼痛护理。
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003779
Sean Mackey,Beth Darnall,Ming-Chih Kao
{"title":"Digital twin learning health systems and multimodal biomarkers transform pain care.","authors":"Sean Mackey,Beth Darnall,Ming-Chih Kao","doi":"10.1097/j.pain.0000000000003779","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003779","url":null,"abstract":"Despite scientific advances, pain care remains fragmented, inaccessible, and imprecise. We propose a future in which Digital Twin Learning Health Systems (DT-LHS) transform pain management by integrating multimodal biomarkers, real-time data streams, and adaptive learning loops to personalize care. These systems simulate individual trajectories, forecast treatment responses, and update continuously based on outcomes. CHOIR, an open-source informatics platform, operationalizes this vision, turning routine clinical care into a scalable, continuously improving experiment. By merging biological insight with dynamic modeling and real-world feedback, DT-LHS offers a path toward truly personalized, responsive, accessible, and equitable pain care.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"1 1","pages":"S106-S110"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The future of pain research: neuromodulation and surgery. 疼痛研究的未来：神经调节和外科。
IF 7.4 1区 医学
PAIN® Pub Date : 2025-11-01 DOI: 10.1097/j.pain.0000000000003662
Daniel Ciampi de Andrade,Prasad Shirvalkar
{"title":"The future of pain research: neuromodulation and surgery.","authors":"Daniel Ciampi de Andrade,Prasad Shirvalkar","doi":"10.1097/j.pain.0000000000003662","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003662","url":null,"abstract":"By 2075, neuromodulation and surgical treatments for pain will be heavily impacted by advances in artificial intelligence, regenerative medicine, and precision diagnostics. Digital brain twins will enable patient-specific simulations to optimize intervention selection, while adaptive neuromodulatory systems will provide real-time, responsive pain management. Personalized treatments will replace the current trial-and-error approach, using genetics, neurophysiology, and AI-driven decision tools. Minimally invasive, home-based neuromodulation will increase accessibility, and ethical data governance will enhance patient autonomy. These advances will transform pain from a chronic, partially relieved condition into a precisely treatable disorder, fundamentally improving patient outcomes and healthcare efficiency.By 2075, precision diagnostics will match each pain patient to the optimal neuromodulation or surgical strategy before treatment begins. Adaptive, minimally invasive, home-based devices will deliver real-time, closed-loop stimulation, shifting therapy from trial-and-error to responsive, individualized care. Big-data guidance on timing, modality, and duration will cut failure rates, while robotics and regenerative techniques expand access and shorten recovery. Adapted ethics and data-governance frameworks will safeguard autonomy, so chronic pain becomes a precisely treatable, and hopefully curable, condition.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"95 1","pages":"S116-S120"},"PeriodicalIF":7.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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