IF 7.4 1区医学

PAIN® Pub Date : 2025-07-24 DOI: 10.1097/j.pain.0000000000003757

Jung Eun Kim,Bom Kim,Hyun Jung Kim,Jungyun Hwang,Heather Swan,Young Shin Kim,Jaewoo Cha,Taeuk Kang,Kyoung-Hoon Kim,Minjung Kim,Hoo Jae Hann,Kyeong Uoon Kim,Hyeong Sik Ahn

{"title":"Familial risk of carpal tunnel syndrome among first-degree relatives and interaction with obesity and hyperglycemia-a population-based study in Korea.","authors":"Jung Eun Kim,Bom Kim,Hyun Jung Kim,Jungyun Hwang,Heather Swan,Young Shin Kim,Jaewoo Cha,Taeuk Kang,Kyoung-Hoon Kim,Minjung Kim,Hoo Jae Hann,Kyeong Uoon Kim,Hyeong Sik Ahn","doi":"10.1097/j.pain.0000000000003757","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003757","url":null,"abstract":"Although genetic and lifestyle factors are known to be involved in carpal tunnel syndrome development, population-level familial risk and interactions between gene and environmental factors have been scarcely studied. We investigated population-based familial risk and assessed the interactions between family history and obesity or hyperglycemia. By using the National Health Insurance database, which covers the total population in Korea, we constructed a cohort of 5,524,403 individuals with information on familial relationships and lifestyle factors from 2002 to 2019. Familial risk was calculated using hazard ratios (HRs) that compare the risk of individuals with and without affected first-degree relatives (FDRs). Interactions between familial risk and obesity/hyperglycemia were assessed on an additive scale using the relative excess risk due to interaction (RERI). Individuals with affected FDRs showed a 1.99-fold increased risk of disease, with twin, brother, sister, paternal, and maternal risks (95% confidence interval) of 17.53 (9.43-32.58), 2.57 (2.20-3.00), 2.38 (2.04-2.77), 1.72 (1.60-1.86), and 1.95 (1.88-2.03), respectively. In the interaction analysis, the combined risk of positive family history and high body mass index or hyperglycemia exceeded the sum of their individual risks (HR 3.33 vs 2.55, 2.51 vs 2.28, respectively), showing statistically significant interactions (RERI 0.78, 0.23, respectively). Obese individuals with a family history (RERI 1.12) showed a more prominent interaction than overweight individuals (RERI 0.26), and similarly, excess risk was higher in severe hyperglycemic (RERI 0.82) compared with moderate hyperglycemic individuals (RERI 0.28), suggesting a dose-response interaction pattern. Our interaction findings indicate that individuals with a family history and obesity/hyperglycemia should be considered a high-risk population.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"115 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience of endometriosis pain: a qualitative study. 子宫内膜异位症疼痛的经验：一项定性研究。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-24 DOI: 10.1097/j.pain.0000000000003763

Amanda C de C Williams,Afra Azadi,Honor McGrigor

{"title":"Experience of endometriosis pain: a qualitative study.","authors":"Amanda C de C Williams,Afra Azadi,Honor McGrigor","doi":"10.1097/j.pain.0000000000003763","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003763","url":null,"abstract":"Endometriosis is a common disorder in postpubertal women and often associated with pain in the pelvis and elsewhere. Pain and related symptoms, such as fatigue, adversely affect quality of life. Surgical and hormonal treatments have limited efficacy and can cause additional problems. There are surprisingly few studies of psychologically based interventions aimed at pain management and a better quality of life, although women with endometriosis are included within mixed chronic pain populations. As studies of pain management applied to endometriosis start to emerge, it is important to ascertain whether the assumptions of the dominant psychological model of pain, fear, and avoidance (developed mainly in musculoskeletal pain) are appropriate for the population and the problems associated with pain. We conducted a qualitative study of 16 women with endometriosis, using a very open interview technique (Grid Elaboration Method) and thematic analysis of women's accounts. We elicited 6 interrelated themes: 1 on the nature of pain; 3 on impact on everyday life, social life, and relationships, and emotions; 1 on healthcare experiences; and 1 on the burden of being female. Even when describing concerns about what was causing pain, women expressed few fears about physical integrity, nor did they avoid activities with the intention of protecting themselves from damage or increased pain. This leads us to question the applicability of the fear and avoidance model, and we encourage further exploration of the psychology of endometriosis-related pain to better design effective pain management interventions.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"15 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic pain is associated with sleep apnea severity but attenuated by intermittent hypoxemia in people using opioids. 慢性疼痛与睡眠呼吸暂停严重程度有关，但在使用阿片类药物的人群中，间歇性低氧血症会减轻疼痛。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-24 DOI: 10.1097/j.pain.0000000000003760

Jeremy E Orr,Naa-Oye Bosompra,Brynn Norby,Jazmin Velazquez,Ahmed Khalaf,Pamela DeYoung,Christopher N Schmickl,Scott A Sands,Sonia Jain,Feng He,Burel Goodin,Mark Wallace,Robert L Owens,Atul Malhotra

{"title":"Chronic pain is associated with sleep apnea severity but attenuated by intermittent hypoxemia in people using opioids.","authors":"Jeremy E Orr,Naa-Oye Bosompra,Brynn Norby,Jazmin Velazquez,Ahmed Khalaf,Pamela DeYoung,Christopher N Schmickl,Scott A Sands,Sonia Jain,Feng He,Burel Goodin,Mark Wallace,Robert L Owens,Atul Malhotra","doi":"10.1097/j.pain.0000000000003760","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003760","url":null,"abstract":"Patients using long-term opioids for pain often have uncontrolled symptoms which might drive ongoing opioid use and contribute to the opioid public health crisis. Opioids also cause sleep disordered breathing (SDB), which might impact pain via arousals and hypoxemia, with potential for a vicious cycle. Adults with noncancer pain using opioids daily for >3 months were recruited. Subjects underwent pain and sleep questionnaires, pain tolerance via 10°C cold pressor testing, and polysomnography. Hypoxic burden was determined from polysomnographic signal analysis. Participants (n = 143) had a median (interquartile range) age of 60 (51, 67) years, body mass index 29 (25, 35) kg/m2. 80 (56%) subjects were female. The median daily morphine equivalent dose was 20 (10, 45). 78% had an apnea-hypopnea index (AHI) >5/hour and 41% with AHI >15/hour. PROMIS pain interference scores differed across SDB severity, with increased symptoms in mild and moderate but not severe SDB. With increasing AHI, there was worsened pain (β = 2.2 [95% confidence interval [CI]: 0.08, 4.4]; βstd = 1.3; P = 0.043), but this relationship was attenuated at higher levels of hypoxic burden (per interaction; β = -0.42 [95% CI: -0.78, -0.06]; βstd = -0.85; P = 0.023). During cold pressor testing, there was a reduced time to hand withdrawal with increasing AHI (hazard ratio [HR] 2.60 [95% CI: 1.48, 4.57]; P = 0.001), but this was also attenuated at higher hypoxic burden (HR: 0.86 [95% CI: 0.78, 0.94]; P = 0.002). Overall, SDB is linked with worsened pain in those using opioids for chronic pain, but hypoxemia attenuates the effect. Individuals with the same AHI may have different symptoms depending on hypoxic burden. Interventional studies will help elucidate mechanisms and the role for SDB treatment in pain management.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"92 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A combined activity of peripheral nociceptive and nonnociceptive neurons is necessary to trigger spinal microglial reactivity and sustained pain. 外周伤害性和非伤害性神经元的联合活动是触发脊髓小胶质反应和持续疼痛所必需的。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-23 DOI: 10.1097/j.pain.0000000000003725

Manon Isler,Paul Chu Sin Chung,Alexandru-Florian Deftu,Guylène Kirschmann,Isabelle Decosterd,Marc Rene Suter

{"title":"A combined activity of peripheral nociceptive and nonnociceptive neurons is necessary to trigger spinal microglial reactivity and sustained pain.","authors":"Manon Isler,Paul Chu Sin Chung,Alexandru-Florian Deftu,Guylène Kirschmann,Isabelle Decosterd,Marc Rene Suter","doi":"10.1097/j.pain.0000000000003725","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003725","url":null,"abstract":"Abnormal activity in injured nerve fibers triggers spinal microglial reactivity, a critical step in the development of chronic postoperative pain. It remains unclear whether spinal microglia respond to inputs from nociceptive fibers alone or require combined activity from nociceptors and nonnociceptors. Using electrical and optogenetic approaches, we selectively activated different fiber subtypes without causing neuronal injury. Our findings demonstrate that only simultaneous activation of both nociceptive and nonnociceptive fibers induces sustained hypersensitivity and a spinal microglia response. This response is characterized by increased cell proliferation, altered electrophysiological profile with hyperpolarized membrane potential, increased potassium currents, and a less ramified morphology. In contrast, activation of nociceptive or nonnociceptive fibers alone does not induce these changes. In addition, inhibiting spinal microglia with minocycline prevents those changes. Overall, our study suggests that both types of peripheral sensory input are necessary to elicit microglial reactivity in the spinal cord and the subsequent development of sustained pain-related behavior.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"114 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent information regulator sirtuin 1-mediated neuronal excitation-inhibition imbalance in the central amygdala is involved in peripheral nerve injury-induced depression-related behavior in mice. 沉默信息调节器sirtuin 1介导的中央杏仁核神经元兴奋抑制失衡参与小鼠周围神经损伤诱导的抑郁相关行为。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-23 DOI: 10.1097/j.pain.0000000000003744

Jia-Tao Lin,Xiao-Bao Ding,Wei Dong,Wei-Feng Wu,Yu-Wen Lin,Chen-Rui Zhou,Chu-Di Zhang,Chen Chen,Yi-Man Sun,Qiang Liu,Yan-Ping Liu,Cheng-Hua Zhou,Yu-Qing Wu

{"title":"Silent information regulator sirtuin 1-mediated neuronal excitation-inhibition imbalance in the central amygdala is involved in peripheral nerve injury-induced depression-related behavior in mice.","authors":"Jia-Tao Lin,Xiao-Bao Ding,Wei Dong,Wei-Feng Wu,Yu-Wen Lin,Chen-Rui Zhou,Chu-Di Zhang,Chen Chen,Yi-Man Sun,Qiang Liu,Yan-Ping Liu,Cheng-Hua Zhou,Yu-Qing Wu","doi":"10.1097/j.pain.0000000000003744","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003744","url":null,"abstract":"Chronic pain often coexists with depression. We have found that histone deacetylase Silent information regulator sirtuin 1 (SIRT1) is involved in peripheral nerve injury-induced depression-related behavior in mice. However, the underlying mechanism is still unclear. In this study, using a mouse spared nerve injury (SNI) model, we found that SIRT1 was downregulated in both glutamatergic and GABAergic neurons in the central amygdala (CeA) of mice with peripheral nerve injury-induced depression-related behavior. SIRT1 overexpression in CeA glutamatergic or GABAergic neurons effectively alleviated peripheral nerve injury-induced depression-related behavior in mice. Moreover, peripheral nerve injury induced significant neuronal excitation-inhibition (E-I) imbalance in CeA, manifested by the increased glutamatergic neuronal excitability and decreased GABAergic neuronal excitability in SNI mice. SIRT1 overexpression in CeA glutamatergic neurons decreased glutamatergic neuronal activity without influence on GABAergic neuronal activity, while SIRT1 overexpression in CeA GABAergic neurons increased GABAergic neuronal activity and reduced glutamatergic neuronal activity in SNI mice. Moreover, optogenetic induction of neuronal E-I imbalance in CeA by activating glutamatergic neurons or inhibiting GABAergic neurons reversed the improvement of peripheral nerve injury-induced depression-related behavior by SIRT1 overexpression. These findings suggest that the dysfunction of SIRT1 is related to the development of peripheral nerve injury-induced depression-related behavior by decreasing GABAergic neuronal excitability and enhancing glutamatergic neuronal excitability, leading to the neuronal E-I imbalance in CeA. These results demonstrate that SIRT1 is a key regulator in peripheral nerve injury-induced depression-related behavior.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"23 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the untreated course of adults with chronic pain seeking psychological intervention: a systematic review and meta-analysis. 了解未治疗的成人慢性疼痛寻求心理干预的过程：系统回顾和荟萃分析。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-23 DOI: 10.1097/j.pain.0000000000003702

Zoe Morgan,Amelia Scott,Madelyne A Bisby,Shianika Chandra,Taylor Hathway,Ashleigh B Correa,Blake F Dear

{"title":"Understanding the untreated course of adults with chronic pain seeking psychological intervention: a systematic review and meta-analysis.","authors":"Zoe Morgan,Amelia Scott,Madelyne A Bisby,Shianika Chandra,Taylor Hathway,Ashleigh B Correa,Blake F Dear","doi":"10.1097/j.pain.0000000000003702","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003702","url":null,"abstract":"The untreated course of chronic pain is not well understood, despite the importance of this information for treatment planning and benchmarking. This study examined symptom change over time and potential moderators in control groups of people seeking psychological pain management for chronic pain. After preregistration, we conducted a systematic literature search for RCTs of psychologically based treatment for chronic pain, which included a control condition whereby participants do not receive treatment (ie, waitlist control or no-treatment control). Meta-analyses were performed to determine that magnitude of symptom change across the control period for pain intensity, disability/interference, depression, and anxiety. Several potential moderators were also analysed. Data were extracted from 52 eligible studies (n = 2190), and the average control period was 13.5 weeks (range: 3-34). Overall, untreated participants demonstrated very small but statistically significant improvements in pain intensity (g = -0.07; CI: -0.13, -0.01) and disability/interference (g = -0.07; CI: -0.12, -0.01) over the control period. No significant change in depression (g = -0.06; CI: -0.11, 0.00) and anxiety (g = -0.05; CI: -0.11, 0.01) symptoms were observed. Some moderators were found. The findings suggest that people with chronic pain do not deteriorate or improve while waiting short periods of time for psychologically based pain management programs, contrary to some previous reports. Instead, the findings suggest that symptoms are relatively stable. These findings may be helpful for treatment and service planning as well as benchmarking activities concerning psychologically based pain management.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"14 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immersion in nature through virtual reality attenuates the development and spread of mechanical secondary hyperalgesia: a role for insulo-thalamic effective connectivity. 通过虚拟现实沉浸在大自然中，可以减弱机械性继发性痛觉过敏的发展和传播：脑岛-丘脑有效连接的作用。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-23 DOI: 10.1097/j.pain.0000000000003701

Sonia Medina,Sam W Hughes

{"title":"Immersion in nature through virtual reality attenuates the development and spread of mechanical secondary hyperalgesia: a role for insulo-thalamic effective connectivity.","authors":"Sonia Medina,Sam W Hughes","doi":"10.1097/j.pain.0000000000003701","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003701","url":null,"abstract":"Nature-based social prescribing has been shown to improve physical and mental health and is increasingly used to manage chronic pain. However, the mechanisms of nature-based analgesia remain unclear. In this study, we used immersive virtual reality (VR) alongside pain psychophysics, functional magnetic resonance imaging, and psychometric assessments to assess the brain-based mechanisms of nature-based pain relief. Specifically, we experimentally induced sensitisation within central nociceptive pathways using the high frequency stimulation model of pain in 30 healthy participants and tracked the development of secondary mechanical hyperalgesia across 3 conditions: immersive VR nature, nonimmersive 2D nature video, and no intervention. Immersive nature VR significantly reduced the development and spread of mechanical secondary hyperalgesia, with sustained analgesic effects correlating with perceived presence. Bayesian modelling of neuroimaging end points collected separately revealed that nature VR-induced analgesic effects correlated with insulo-thalamic effective connectivity. We propose that the analgesic effects of nature are likely mediated through top-down endogenous analgesic systems which could be working to reduce the development and spread of heterotopic plasticity in the spinal cord.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"133 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ribosomes under stress: GCN2 integrates translational dysfunction and pain signaling. 应激下的核糖体：GCN2整合了翻译功能障碍和疼痛信号。

IF 5.5 1区医学

PAIN® Pub Date : 2025-07-21 DOI: 10.1097/j.pain.0000000000003762

Erick J Rodríguez-Palma, Rajesh Khanna

引用次数: 0

Upregulated natriuretic peptide B expression as a hallmark of chronic itch. 利钠肽B表达上调是慢性瘙痒的标志。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-21 DOI: 10.1097/j.pain.0000000000003742

Pang-Yen Tseng,Huey Ling Liew,Matthias Ringkamp,Keisuke Nagao,Mark A Hoon

{"title":"Upregulated natriuretic peptide B expression as a hallmark of chronic itch.","authors":"Pang-Yen Tseng,Huey Ling Liew,Matthias Ringkamp,Keisuke Nagao,Mark A Hoon","doi":"10.1097/j.pain.0000000000003742","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003742","url":null,"abstract":"Chronic itch can arise from a variety of etiologies, ranging from dermatological conditions like eczema and psoriasis to systemic diseases such as liver disease and kidney failure. However, it remains unclear whether there are common molecular features associated with chronic itch, and whether these features are selective for chronic itch compared to chronic pain. To identify potential genes or molecular characteristics that are specifically associated with chronic itch, we examined transcriptomic data from sensory neurons collected from 3 mouse models of chronic itch and a monkey model of contact dermatitis. We compared these data to transcriptomic data from 3 mouse models of pain and clinical data from patients with neuropathic pain. Our analyses revealed that the upregulation of Nppb expression in sensory neurons is consistently associated with models of itch, but not with models of pain. Further, our cellular characterization showed that the increased expression of Nppb arises from increased cell-autonomous expression rather than the recruitment of Nppb expression in other classes of sensory neurons. Given that Nppb is a well-established itch neurotransmitter, our findings suggest that the increased expression of Nppb in sensory neurons may contribute to chronic itch. In addition, based on our results, we propose that Nppb could serve as a conserved biomarker for chronic itch.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"214 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic benefits of pharmacological and nonpharmacological sleep interventions for adults with fibromyalgia: a systematic review and meta-analyses. 成人纤维肌痛患者的药物和非药物睡眠干预的镇痛效果：一项系统综述和荟萃分析。

IF 7.4 1区医学

PAIN® Pub Date : 2025-07-21 DOI: 10.1097/j.pain.0000000000003708

Shokouh Abolhosseini,Ava Malatesta,Aleiia Jocelyn Noelle Asmundson,Ian Gilron,Tim Vaughn Salomons

{"title":"Analgesic benefits of pharmacological and nonpharmacological sleep interventions for adults with fibromyalgia: a systematic review and meta-analyses.","authors":"Shokouh Abolhosseini,Ava Malatesta,Aleiia Jocelyn Noelle Asmundson,Ian Gilron,Tim Vaughn Salomons","doi":"10.1097/j.pain.0000000000003708","DOIUrl":"https://doi.org/10.1097/j.pain.0000000000003708","url":null,"abstract":"Fibromyalgia is a chronic musculoskeletal pain condition affecting 2% to 8% of the population. Most people with fibromyalgia experience poor sleep, and sleep problems consistently predict pain severity. Given the bidirectional relationship between sleep and pain, improving sleep may reduce fibromyalgia pain. This review identified trials of sleep-focused pharmacological and nonpharmacological interventions to evaluate whether they improved pain outcomes for adults with fibromyalgia. A systematic search of 7 electronic databases, 2 trial registries, and the reference lists of related studies retrieved 5728 records. Three independent reviewers completed study screening, data extraction, and risk of bias assessments. Nineteen studies met the inclusion criteria. Sleep interventions were evaluated against inactive and active control groups in a total of 10 trials with self-reported pain outcomes. Sodium oxybate significantly improved pain compared with placebo (4.5 g: MD = -9.55, 95% CI [-11.97, -7.12]; 6.0 g: SMD = -3.41, 95% CI [-6.49, -0.32]) at postintervention. Cognitive behavioural therapy (CBT) for insomnia also significantly improved pain compared with usual care (MD = -5.47, 95% CI [-9.64, -1.30]) at postintervention. Comparisons of CBT for insomnia with sleep hygiene training, and combined CBT for insomnia and pain with CBT for pain showed no significant postintervention differences. Other interventions (eg, melatonin and zopiclone) were identified but had insufficient data to allow meta-analysis. This review provided preliminary support for the analgesic benefits of some sleep interventions for adults with fibromyalgia. Long-term effects of sleep interventions on pain should be investigated to further inform treatment planning efforts.","PeriodicalId":19921,"journal":{"name":"PAIN®","volume":"1 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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