Pharmacological research最新文献_第2页

Elucidation of the anti-arthritic mechanism of Guizhi-Shaoyao-Zhimu decoction by reshaping circadian rhythm 桂枝少药直木汤调节昼夜节律抗关节炎机制的研究

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-22 DOI: 10.1016/j.phrs.2025.107787

Xizi He , Runze Li , Xiaohong He , Fan He , Yao Xiao , Xianghong Chen , Yu Lai , Wanyi Guo , Peiyu Liu , Xiao Cai , Xiaonan Yang , Yongkang Shu , Jie Shao , Yulian Chen , Danli Chen , Minqi Quan , Jiaqi Wu , Leyao Xian , Jiayan He , Hong Ren , Hudan Pan

{"title":"Elucidation of the anti-arthritic mechanism of Guizhi-Shaoyao-Zhimu decoction by reshaping circadian rhythm","authors":"Xizi He , Runze Li , Xiaohong He , Fan He , Yao Xiao , Xianghong Chen , Yu Lai , Wanyi Guo , Peiyu Liu , Xiao Cai , Xiaonan Yang , Yongkang Shu , Jie Shao , Yulian Chen , Danli Chen , Minqi Quan , Jiaqi Wu , Leyao Xian , Jiayan He , Hong Ren , Hudan Pan","doi":"10.1016/j.phrs.2025.107787","DOIUrl":"10.1016/j.phrs.2025.107787","url":null,"abstract":"<div><div>Rheumatoid Arthritis (RA) exhibits pronounced circadian oscillations, with variations in joint stiffness, pain, and swelling following rhythmic patterns. Our preliminary research suggests that inflammatory cytokines in RA serum display rhythmicity closely associated with circadian rhythms. Additionally, circadian clock genes show a tendency towards disordered expression in RA, suggesting potential new therapeutic avenues from a circadian perspective. Traditional Chinese Medicine's Guizhi-Shaoyao-Zhimu Decoction (GSZD) has demonstrated clinical efficacy in RA, yet its underlying mechanism remains elusive. Our study confirms the effectiveness of GSZD in alleviating arthritis symptoms, reducing bone destruction, and lowering the expression of related inflammatory cytokines. Notably, we found that GSZD modulates the core circadian gene NR1D1 in a dose-dependent and time-selective manner. The administration of GSZD at 10 AM demonstrated enhanced anti-arthritic effects, which were mediated by regulating NR1D1 and suppressing the NLRP3-IL-18/IL-1β inflammatory signaling pathway. Moreover, silencing of NR1D1 significantly upregulated the expression of NLRP3, IL-18, and IL-1β. In NR1D1-deficient macrophages, GSZD failed to inhibit the NLRP3 inflammasome and inflammatory cytokines such as IL-18, and IL-1β. Overall, GSZD exerts therapeutic benefits for RA patients via activating NR1D1 and the interplay between molecular-based circadian rhythms and immune balance develop new avenues for targeted RA treatments, offering innovative strategies for the timing and administration of therapies.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"216 ","pages":"Article 107787"},"PeriodicalIF":9.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted role of zipper-interacting protein kinase beyond cell death: Implication of ZIPK dysregulation in neuronal and vascular injuries 拉链相互作用蛋白激酶在细胞死亡之外的多方面作用：神经元和血管损伤中ZIPK失调的含义

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-21 DOI: 10.1016/j.phrs.2025.107793

Fei She, Tao Zhang, Tae Ho Lee

{"title":"Multifaceted role of zipper-interacting protein kinase beyond cell death: Implication of ZIPK dysregulation in neuronal and vascular injuries","authors":"Fei She, Tao Zhang, Tae Ho Lee","doi":"10.1016/j.phrs.2025.107793","DOIUrl":"10.1016/j.phrs.2025.107793","url":null,"abstract":"<div><div>Zipper-interacting protein kinase (ZIPK) belongs to the death-associated protein kinase (DAPK) family and is a serine/threonine kinase. ZIPK is ubiquitously expressed in different types of tissues and cells. ZIPK is involved in many cellular functions, including cell death, smooth muscle contraction, transcriptional regulation, inflammatory signaling and the regulation of angiogenesis. The dysregulation of ZIPK has been shown to be involved in multiple diseases, including cancer, neurological diseases such as stroke, and cardiovascular diseases such as hypertension. The molecular mechanisms by which ZIPK inhibits the development of cancer have been well studied, but less is known about how ZIPK dysregulation is involved in vascular and neurological diseases. In this review, we summarize the current knowledge about the cellular processes in which ZIPK is involved and the pathological relevance of ZIPK dysregulation in diseases, with a focus on the role of ZIPK in vascular and neuronal functions. The molecular mechanisms by which ZIPK dysregulation contributes to cancer and vascular and neuronal diseases are discussed. We also review recent advances in the development of ZIPK modulators and their potential in treating vascular damage and neurological disorders. Multiple findings support that ZIPK has important functions in regulating vascular homeostasis and serves as a novel therapeutic target for alleviating neurological diseases.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"216 ","pages":"Article 107793"},"PeriodicalIF":9.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases 肠道微生物衍生代谢物苯乙酰谷氨酰胺在心血管和代谢性疾病中的作用。

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-21 DOI: 10.1016/j.phrs.2025.107794

Wan Chen , Mei-Ling Li , Guang Zeng , Xiang-Yu Xu , Shan-Hui Yin , Can Xu , Linlin Li , Kaikai Wen , Xiao-Hua Yu , Gang Wang

引用次数: 0

Gut microbiota and well-being: A comprehensive summary of the special issue. 肠道菌群与健康：特刊综合综述。

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-21 DOI: 10.1016/j.phrs.2025.107791

Utpal Sen

{"title":"Gut microbiota and well-being: A comprehensive summary of the special issue.","authors":"Utpal Sen","doi":"10.1016/j.phrs.2025.107791","DOIUrl":"10.1016/j.phrs.2025.107791","url":null,"abstract":"<p><p>Gut microbes play an immense role in digesting ingested food, providing nutrients to the host, and producing several bioactive metabolites that not only help maintain health but can also elicit disease during dysbiotic conditions. The bioactive compounds derived from gut microbiota metabolites include trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids, lipopolysaccharide - to name a few. Once these compounds enter the host cells, tissues, and organs they can cause diseases such as epigenetic, metabolic, neurodegenerative, psychiatric, cardiovascular, hypertension, respiratory, gastrointestinal, kidney, bone, cancer, and others. Regulating healthy gut microbiota thus provides a potential option for the prevention, reversal, or even treatment of these diseases. Towards this end, various interventional strategies are postulated in this field of emerged and rapidly expanding health research arena that includes fecal microbiota transplantation, prebiotics, and probiotics, and to introduce the concept that correcting gut dysbiosis can ameliorate disease symptoms, thus offering a new approach towards dysbiosis-related disease mitigation and treatment. In the special issue of Pharmacological Research titled \"Gut Microbiota and Well-Being,\" several outstanding research findings and review articles are published, covering a broad spectrum of topics related to the influence of gut microbiota on health and disease. This editorial summarizes each of these contributions, prioritizing research findings before discussing the review articles. The summaries are restructured abstracts of relevant articles focusing on major findings or thematic topics.</p>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":" ","pages":"107791"},"PeriodicalIF":9.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical regulation of CaMKII in Alzheimer’s disease: A review of molecular mechanisms and therapeutic potential CaMKII在阿尔茨海默病中的植物化学调控：分子机制和治疗潜力的综述

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-21 DOI: 10.1016/j.phrs.2025.107790

Zhongying Lin , Miao Sun

{"title":"Phytochemical regulation of CaMKII in Alzheimer’s disease: A review of molecular mechanisms and therapeutic potential","authors":"Zhongying Lin , Miao Sun","doi":"10.1016/j.phrs.2025.107790","DOIUrl":"10.1016/j.phrs.2025.107790","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is a common neurodegenerative disorder that leads to cognitive decline. CaMKII is a calcium-regulated kinase that is crucial for synaptic plasticity and memory. Phytochemicals with diverse origins, safety, and biological activity have attracted considerable attention in AD research. This systematic analysis of phytochemicals targeting CaMKII reveals their neuroprotective mechanisms against AD pathogenesis, highlighting CaMKII as a promising therapeutic target that warrants further preclinical investigation and drug development. We conducted a comprehensive review of the literature of phytochemicals that target CaMKII as a protective mechanism against AD. The search was conducted across multiple databases, including PubMed, Web of Science, China National Knowledge Internet, and Google Scholar, and covered the period from January 2000 to October 2024. A total of 301 articles were retrieved, of which 22 articles were included. The results showed that flavonoid, glycoside, terpene, and polyphenol analogs positively regulated CaMKII expression, whereas alkaloid analogs negatively regulated CaMKII expression. Different components of traditional Chinese medicine played different roles in CaMKII expression. Flavonoid compounds upregulated the expression of SYN, PSD-95, MAP2, and GluR1 to exert neuroprotective effects. Alkaloid and glycoside analogs inhibited Aβ deposition and tau hyperphosphorylation. Terpene analogs upregulated the SYN, PSD-95, NMDAR, BDNF, and PI3K/Akt signaling pathways to exert neuroprotection. Polyphenol analogs upregulated PSD-95, Munc18–1, SNAP25, SYN, and BDNF to exert neuroprotective effects. Emerging evidence demonstrates that select phytochemicals and traditional Chinese medicine compounds exert neuroprotective effects in AD by modulating CaMKII activity, thereby reducing Aβ accumulation, attenuating tau hyperphosphorylation, and enhancing synaptic plasticity, suggesting promising therapeutic potential.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"216 ","pages":"Article 107790"},"PeriodicalIF":9.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terpenoids: A promising traditional chinese medicine for neuropathic pain relief 萜类：一种有前途的缓解神经性疼痛的中药。

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-20 DOI: 10.1016/j.phrs.2025.107789

Hui-Si Yang , David H. Mauki , Yue-Xiang Zheng , Ting-Hua Wang , Xiu-Ying He

{"title":"Terpenoids: A promising traditional chinese medicine for neuropathic pain relief","authors":"Hui-Si Yang , David H. Mauki , Yue-Xiang Zheng , Ting-Hua Wang , Xiu-Ying He","doi":"10.1016/j.phrs.2025.107789","DOIUrl":"10.1016/j.phrs.2025.107789","url":null,"abstract":"<div><div>Neuropathic pain (NPP) is a prevalent chronic condition characterized by spontaneous pain, hyperalgesia, allodynia, and sensory abnormalities, severely impacting patients' quality of life. Despite various guided treatments, their clinical efficacy remains limited, often accompanied by adverse reactions. Traditional Chinese medicine (TCM) offers unique advantages in disease treatment through its holistic approach (balancing the body as a unified system) and syndrome differentiation principle (personalized medicine). Recent research has highlighted terpenoids for their analgesic effects and minimal side effects. This review summarizes the role of terpenoids in NPP and their underlying molecular mechanisms. Terpenoids, natural products found in plants, are categorized into monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids, and tetraterpenoids based on isoprene units. These compounds alleviate NPP by: inhibiting neuroinflammation and oxidative stress, regulating mitochondrial function, modulating ion channels, and influencing the cannabinoid and opioid receptor systems. This review aims to deepen our understanding of terpenoids and provide crucial evidence and mechanistic insights for their application in NPP therapy.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"216 ","pages":"Article 107789"},"PeriodicalIF":9.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The regulation of microglia by aging and autophagy in multiple sclerosis 衰老和自噬对多发性硬化症小胶质细胞的调节。

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-19 DOI: 10.1016/j.phrs.2025.107786

Xiying Wang, Ye Sun, Haojun Yu, Chunran Xue, Xuzhong Pei, Yi Chen, Yangtai Guan

{"title":"The regulation of microglia by aging and autophagy in multiple sclerosis","authors":"Xiying Wang, Ye Sun, Haojun Yu, Chunran Xue, Xuzhong Pei, Yi Chen, Yangtai Guan","doi":"10.1016/j.phrs.2025.107786","DOIUrl":"10.1016/j.phrs.2025.107786","url":null,"abstract":"<div><div>Multiple sclerosis (MS) is an inflammatory disease that is often characterized by the development of irreversible clinical disability. Age is a strong risk factor that is strongly associated with the clinical course and progression of MS. Several lines of evidence suggest that with aging, microglia have an aging-related gene expression signature and are close to disease-associated microglia (DAM), which exhibit decreased phagocytosis but increased production of inflammatory factors. The gene expression signatures of microglia in MS overlap with those in aging, inflammation and DAM. Moreover, the clearance of damaged myelin by microglia is impaired in the aged brain. Autophagy is a cellular process that decreases in activity with age. In this review, we provide an overview of the role of autophagy and aging in MS. We describe the impact of autophagy and aging on microglial activation in MS and the molecules involved in autophagy and aging, which are related to the phagocytosis and activation of microglia. We propose that a decrease in autophagy in microglia occurs with aging, leading to a decrease in phagocytosis. Decreases in phagocytosis and increases in the production of inflammatory factors by microglia contribute to chronic inflammation in the aged brain and disease progression in MS. Thus, the modulation of autophagy in microglia serves as a potential therapeutic target for MS.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"216 ","pages":"Article 107786"},"PeriodicalIF":9.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma. 敲除SIN3B可调节皮肤黑色素瘤的转录程序和细胞存活。

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-18 DOI: 10.1016/j.phrs.2025.107785

Larissa Satiko Alcantara Sekimoto Matsuyama, Victoria Harle, Victoria Offord, Alastair Droop, Roy Rabbie, Manik Garg, Martha Estefania Vázquez-Cruz, Carla Daniela Robles-Espinoza, Gemma Turner, David Fraser, Erica Aparecida de Oliveira, Danielle Goncalves de Carvalho, Natasha Andressa Nogueira Jorge, Mariana Boroni, Patricia A Possik, David J Adams, Silvya Stuchi Maria-Engler

{"title":"Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma.","authors":"Larissa Satiko Alcantara Sekimoto Matsuyama, Victoria Harle, Victoria Offord, Alastair Droop, Roy Rabbie, Manik Garg, Martha Estefania Vázquez-Cruz, Carla Daniela Robles-Espinoza, Gemma Turner, David Fraser, Erica Aparecida de Oliveira, Danielle Goncalves de Carvalho, Natasha Andressa Nogueira Jorge, Mariana Boroni, Patricia A Possik, David J Adams, Silvya Stuchi Maria-Engler","doi":"10.1016/j.phrs.2025.107785","DOIUrl":"https://doi.org/10.1016/j.phrs.2025.107785","url":null,"abstract":"<p><p>SIN3 is a critical component of the histone deacetylase complex. Utilizing whole transcriptome data from melanoma patient samples we reveal that elevated levels of SIN3B are associated with poor survival outcomes with in vitro studies showing increased SIN3B expression in BRAF-mutant metastatic melanoma cell lines. The generation of isogenic SIN3B knockout cell lines indicated that SIN3B disruption led to a decrease in pathways associated with tumor invasion, migration, and cell-cell interactions. Moreover, pooled genome-wide CRISPR/Cas9 screens highlighted POLE4 and STK11 as crucial for the fitness and survival of SIN3B-knockout melanoma cells suggesting a role for these genes in epistasis with SIN3B. In summary, our findings suggest that SIN3B plays a pivotal role in modulating the behavior of melanoma cells, with implications for tumor growth and response to therapy.</p>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":" ","pages":"107785"},"PeriodicalIF":9.1,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms 诱导型一氧化氮合酶（iNOS）：不仅仅是一种诱导酶？NOS亚型分类的再思考。

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-17 DOI: 10.1016/j.phrs.2025.107781

Aryan Farahani , Arman Farahani , Khosrow Kashfi , Asghar Ghasemi

{"title":"Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms","authors":"Aryan Farahani , Arman Farahani , Khosrow Kashfi , Asghar Ghasemi","doi":"10.1016/j.phrs.2025.107781","DOIUrl":"10.1016/j.phrs.2025.107781","url":null,"abstract":"<div><div>Nitric oxide (NO) is a critical signaling molecule synthesized from <em>L</em>-arginine by nitric oxide synthase (NOS). The three NOS isoforms—neuronal NOS (nNOS; NOS1), inducible NOS (iNOS; NOS2), and endothelial NOS (eNOS; NOS3)—have traditionally been classified as either constitutive (nNOS and eNOS) or inducible (iNOS). However, this binary classification oversimplifies their functions, particularly by neglecting the physiological roles of iNOS and misrepresenting its involvement in pathological processes. Increasing evidence demonstrates that all three isoforms can exhibit both constitutive and inducible expression. Notably, iNOS is constitutively expressed at low levels in several tissues, including blood, heart, bone marrow, lung, brain, spinal cord, retina, colonic mucosa, liver, ileum, skeletal muscle, epidermis, adipose tissue, endometrium, ovary, and kidney under normal physiological conditions, a form we refer to as <em>constitutive iNOS</em> (ciNOS). This basal expression contributes to essential functions such as heart rate regulation, respiratory exchange, and microbiome balance in the gut. Moreover, in certain pathological contexts, iNOS may exert protective rather than harmful effects, challenging the prevailing view that it is solely a pro-inflammatory mediator. Current drug development strategies targeting NOS are largely based on the outdated dichotomy of constitutive “physiologic” versus inducible “pathologic” isoforms, focusing primarily on iNOS inhibition. The failure of iNOS inhibitors in most clinical trials highlights the limitations of this approach. To address these gaps, we propose a revised nomenclature that incorporates both gene expression mode (constitutive vs. inducible) and discovery order, offering a more nuanced framework for understanding NOS isoforms in both health and disease.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"216 ","pages":"Article 107781"},"PeriodicalIF":9.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease 探讨芒果在调节炎症性肠病免疫反应和疼痛持续性中的双重作用。

IF 9.1 2区医学

Pharmacological research Pub Date : 2025-05-17 DOI: 10.1016/j.phrs.2025.107773

Elena Lucarini , Anna Schettino , Noemi Marigliano , Clara Ciampi , Martina Smimmo , Francesca Romano , Antonio Paolillo , Luana Izzo , Jenefa Begum , Adel Abo Mansour , Nunzia Iaccarino , Antonio Randazzo , Karin Vicente Greco , Raffaele Scarpa , Francesco Caso , Asif Jilani Iqbal , Mariarosaria Bucci , Carla Ghelardini , Lorenzo Di Cesare Mannelli , Anella Saviano , Francesco Maione

{"title":"Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease","authors":"Elena Lucarini , Anna Schettino , Noemi Marigliano , Clara Ciampi , Martina Smimmo , Francesca Romano , Antonio Paolillo , Luana Izzo , Jenefa Begum , Adel Abo Mansour , Nunzia Iaccarino , Antonio Randazzo , Karin Vicente Greco , Raffaele Scarpa , Francesco Caso , Asif Jilani Iqbal , Mariarosaria Bucci , Carla Ghelardini , Lorenzo Di Cesare Mannelli , Anella Saviano , Francesco Maione","doi":"10.1016/j.phrs.2025.107773","DOIUrl":"10.1016/j.phrs.2025.107773","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn’s disease, is characterized by chronic intestinal inflammation and immune dysregulation, driven mainly by Th1 and Th17 cells and sustained by pro-inflammatory cyto-chemokines. This inflammatory milieu is associated with visceral pain, a key symptom affecting patient quality of life. Addressing both gut inflammation/immunity and visceral pain is crucial for improving IBD therapy. This study assessed the therapeutic potential of <em>Mangifera indica</em> L. extract (MIE), a mangiferin-rich formulation, in a DNBS-induced colitis model in rats. MIE treatment administered either simultaneously or post-DNBS induction, significantly reduced pathogenic Th1 and Th17 cell infiltration, along with pro-inflammatory cytokines (IL-1β, TNF-α) and chemokines (CXCL1, CXCL2), though histopathology showed no significant improvements in tissue healing. Additionally, MIE restored microbiota–derived short-chain fatty acids (acetate and butyrate) in colon and faecal samples. Importantly, MIE alleviated post-inflammatory visceral hypersensitivity, reducing the abdominal withdrawal reflex (AWR) to colorectal distension (CRD), after either acute or repeated treatment. These findings suggest that MIE, in the context of nutraceuticals and functional foods, shows promise as a dual-action therapeutic strategy for complementary and/or adjuvant therapy in IBD.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"217 ","pages":"Article 107773"},"PeriodicalIF":9.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0