Terpenoids: A promising traditional chinese medicine for neuropathic pain relief

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2025-05-20 DOI:10.1016/j.phrs.2025.107789

Hui-Si Yang , David H. Mauki , Yue-Xiang Zheng , Ting-Hua Wang , Xiu-Ying He

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引用次数: 0

Abstract

Neuropathic pain (NPP) is a prevalent chronic condition characterized by spontaneous pain, hyperalgesia, allodynia, and sensory abnormalities, severely impacting patients' quality of life. Despite various guided treatments, their clinical efficacy remains limited, often accompanied by adverse reactions. Traditional Chinese medicine (TCM) offers unique advantages in disease treatment through its holistic approach (balancing the body as a unified system) and syndrome differentiation principle (personalized medicine). Recent research has highlighted terpenoids for their analgesic effects and minimal side effects. This review summarizes the role of terpenoids in NPP and their underlying molecular mechanisms. Terpenoids, natural products found in plants, are categorized into monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids, and tetraterpenoids based on isoprene units. These compounds alleviate NPP by: inhibiting neuroinflammation and oxidative stress, regulating mitochondrial function, modulating ion channels, and influencing the cannabinoid and opioid receptor systems. This review aims to deepen our understanding of terpenoids and provide crucial evidence and mechanistic insights for their application in NPP therapy.

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萜类：一种有前途的缓解神经性疼痛的中药。

神经性疼痛（NPP）是一种常见的慢性疾病，以自发性疼痛、痛觉过敏、异常性疼痛和感觉异常为特征，严重影响患者的生活质量。尽管有多种指导治疗，但其临床疗效仍然有限，往往伴有不良反应。中医以其整体疗法（平衡身体作为一个统一的系统）和辨证原则（个性化医疗）在疾病治疗方面具有独特的优势。最近的研究强调了萜类化合物的镇痛作用和最小的副作用。本文综述了萜类化合物在NPP中的作用及其潜在的分子机制。萜类化合物是植物中发现的天然产物，根据异戊二烯的单位分为单萜类、倍半萜类、二萜类、三萜类和四萜类。这些化合物通过抑制神经炎症和氧化应激，调节线粒体功能，调节离子通道，影响大麻素和阿片受体系统来减轻NPP。本文综述旨在加深我们对萜类化合物的认识，并为其在NPP治疗中的应用提供重要的证据和机制见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.