肠道微生物衍生代谢物苯乙酰谷氨酰胺在心血管和代谢性疾病中的作用。

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2025-05-21 DOI:10.1016/j.phrs.2025.107794

Wan Chen , Mei-Ling Li , Guang Zeng , Xiang-Yu Xu , Shan-Hui Yin , Can Xu , Linlin Li , Kaikai Wen , Xiao-Hua Yu , Gang Wang

{"title":"肠道微生物衍生代谢物苯乙酰谷氨酰胺在心血管和代谢性疾病中的作用。","authors":"Wan Chen , Mei-Ling Li , Guang Zeng , Xiang-Yu Xu , Shan-Hui Yin , Can Xu , Linlin Li , Kaikai Wen , Xiao-Hua Yu , Gang Wang","doi":"10.1016/j.phrs.2025.107794","DOIUrl":null,"url":null,"abstract":"<div><div>The aging of population coupled with unhealthy dietary habits among residents has led to a rise in the incidence of cardiovascular and metabolic diseases (CVMDs). Extensive research has highlighted the role of gut microbiota-derived metabolites in CVMDs. Among these metabolites, phenylacetylglutamine (PAGln), a meta-organismal prothrombotic metabolite, has been proved to promote the progression of CVMDs. This bacterial derived metabolite is a byproduct of amino acid comes from phenylalanine (Phe) in the diet. There are increasing evidence showing that the level of PAGln is associated with the risk of developing CVMDs. To provide a comprehensive understanding of the role of PAGln in CVMDs, this review delves into the production and metabolic pathways of PAGln and discusses the links of PAGln and the pathogenesis of CVMDs.</div></div>","PeriodicalId":19918,"journal":{"name":"Pharmacological research","volume":"217 ","pages":"Article 107794"},"PeriodicalIF":9.1000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases\",\"authors\":\"Wan Chen , Mei-Ling Li , Guang Zeng , Xiang-Yu Xu , Shan-Hui Yin , Can Xu , Linlin Li , Kaikai Wen , Xiao-Hua Yu , Gang Wang\",\"doi\":\"10.1016/j.phrs.2025.107794\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The aging of population coupled with unhealthy dietary habits among residents has led to a rise in the incidence of cardiovascular and metabolic diseases (CVMDs). Extensive research has highlighted the role of gut microbiota-derived metabolites in CVMDs. Among these metabolites, phenylacetylglutamine (PAGln), a meta-organismal prothrombotic metabolite, has been proved to promote the progression of CVMDs. This bacterial derived metabolite is a byproduct of amino acid comes from phenylalanine (Phe) in the diet. There are increasing evidence showing that the level of PAGln is associated with the risk of developing CVMDs. To provide a comprehensive understanding of the role of PAGln in CVMDs, this review delves into the production and metabolic pathways of PAGln and discusses the links of PAGln and the pathogenesis of CVMDs.</div></div>\",\"PeriodicalId\":19918,\"journal\":{\"name\":\"Pharmacological research\",\"volume\":\"217 \",\"pages\":\"Article 107794\"},\"PeriodicalIF\":9.1000,\"publicationDate\":\"2025-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1043661825002191\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1043661825002191","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

摘要

人口老龄化加上居民不健康的饮食习惯导致心血管代谢疾病（CVMDs）的发病率上升。大量研究强调了肠道微生物衍生代谢物在CVMDs中的作用。在这些代谢物中，苯乙酰谷氨酰胺（PAGln），一种元机体的血栓前代谢物，已被证明可促进CVMDs的进展。这种细菌衍生的代谢物是饮食中苯丙氨酸（Phe）氨基酸的副产品。越来越多的证据表明，PAGln水平与发生心血管疾病的风险有关。为了全面了解PAGln在CVMDs中的作用，本文深入探讨了PAGln的产生和代谢途径，并讨论了PAGln与CVMDs发病机制的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases

The aging of population coupled with unhealthy dietary habits among residents has led to a rise in the incidence of cardiovascular and metabolic diseases (CVMDs). Extensive research has highlighted the role of gut microbiota-derived metabolites in CVMDs. Among these metabolites, phenylacetylglutamine (PAGln), a meta-organismal prothrombotic metabolite, has been proved to promote the progression of CVMDs. This bacterial derived metabolite is a byproduct of amino acid comes from phenylalanine (Phe) in the diet. There are increasing evidence showing that the level of PAGln is associated with the risk of developing CVMDs. To provide a comprehensive understanding of the role of PAGln in CVMDs, this review delves into the production and metabolic pathways of PAGln and discusses the links of PAGln and the pathogenesis of CVMDs.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.