Journal of Pineal Research最新文献

{"title":"Correction to “Melatonin Attenuates (-)-Epigallocatehin-3-Gallate-Triggered Hepatotoxicity Without Compromising Its Downregulation of Hepatic Gluconeogenic and Lipogenic Genes in Mice”","authors":"","doi":"10.1111/jpi.70164","DOIUrl":"10.1111/jpi.70164","url":null,"abstract":"<p>Wang D, Wei Y, Wang T, et al. Melatonin attenuates (-)-epigallocatehin-3-gallate-triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice. J Pineal Res. 2015;59(4):497-507. https://doi.org/10.1111/jpi.12281</p><p>Upon the publication of the article, the splicing and deletion problems in Figures 3A and Figure 5C were originally flagged by a concerned reader. Specifically, due to the first author's nonstandard practices during figure assembly, splicing and deletion issues appeared in Figures 3A and Figure 5C. It is important to emphasize that these adjustments by the first author do not compromise the scientific integrity of the study's conclusions. The authors unanimously support this corrigendum and sincerely apologize for any inconvenience caused by this oversight and declare that the correction does not affect the description, interpretation, or conclusions detailed in the original published manuscript. The accurate images, obtained during the repeat experimental procedures, are provided below.</p><p>We apologize for these error.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Melatonin Promotes the Proliferation of Primordial Germ Cell-Like Cells Derived From Porcine Skin-Derived Stem Cells: A Mechanistic Analysis”","authors":"","doi":"10.1111/jpi.70162","DOIUrl":"10.1111/jpi.70162","url":null,"abstract":"<p>Liu WX, Tan SJ, Wang YF, Zhang FL, Feng YQ, Ge W, Dyce PW, Reiter RJ, Shen W, Cheng SF. Melatonin promotes the proliferation of primordial germ cell-like cells derived from porcine skin-derived stem cells: A mechanistic analysis. <i>J Pineal Res</i>. 2022 Nov;73(4):e12833. doi: 10.1111/jpi.12833. Epub 2022 Sep 22. PMID: 36106819.</p><p>The authors regret to report errors in Figures 1D and 5B of the article. Concerns of image duplication in Figure 5B were brought to our attention by a concerned reader, and our subsequent review identified an additional error in Figure 1D. In Figure 5B, the fluorescent images for the 5 μM MLT group and the 100 μM MLT group partially overlapped, and the correct image for the 100 μM MLT group has now been provided. In Figure 1D, an incorrect fluorescent image was inadvertently used for c-MYC staining and has now been replaced with the correct image in the revised figure. We have confirmed that these corrections do not affect the overall results and conclusions of the article.</p><p><b>Correction text:</b></p><p>We apologize for this error.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148373968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Histone Deacetylase 9 Regulates Disease Resistance Through Fine-Tuning Histone Deacetylation of Melatonin Biosynthetic Genes and Melatonin Accumulation in Cassava”","authors":"","doi":"10.1111/jpi.70161","DOIUrl":"10.1111/jpi.70161","url":null,"abstract":"<p>H. Zhao, Z. Ge, M. Zhou, et al. “Histone Deacetylase 9 Regulates Disease Resistance Through Fine-Tuning Histone Deacetylation of Melatonin Biosynthetic Genes and Melatonin Accumulation in Cassava,” <i>Journal of Pineal Research</i> 74, no. 3 (2023):e12861. https://doi.org/10.1111/jpi.12861.</p><p>Figure 6D presents the data for the subcellular localization of 35S::GFP-MePP2C12. It incorrectly featured a template base-layer image, due to an inadvertent deletion of the correct result layer during figure preparation. The corrected Figure 6D appears below. The correction does not compromise the scientific integrity of the study's conclusions.</p><p>We apologize for this error.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148373975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Identification, Transcriptional and Functional Analysis of Heat-Shock Protein 90s in Banana (Musa acuminata L.) Highlight Their Novel Role in Melatonin-Mediated Plant Response to Fusarium Wilt”","authors":"","doi":"10.1111/jpi.70160","DOIUrl":"10.1111/jpi.70160","url":null,"abstract":"<p>Y. Wei, W. Hu, Q. Wang, et al. “Identification, Transcriptional and Functional Analysis of Heat-Shock Protein 90s in Banana (<i>Musa acuminata</i> L.) Highlight Their Novel Role in Melatonin-Mediated Plant Response to Fusarium Wilt,” <i>Journal of Pineal Research</i> 62, no. 1 (2017): e12367. https://doi.org/10.1111/jpi.12367.</p><p>Figure 7A presents the effect of <i>MaHSP90s</i> in melatonin-mediated disease resistance in response to <i>Foc4</i> infection. The third image of Control at 12 hpi and the first image of Mel+GDA at 24 hpi were incorrectly displayed due to repeatedly saved images. The correct images, obtained following the original experimental procedures, are now used for the corrected Figure 7A. The corrected Figure is shown below.</p><p>We apologize for this error.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin-Mediated Alleviation of Plant Response to Heavy Metals: From Integrative Mechanisms to Potential Applications.","authors":"X Cheng, H Shi","doi":"10.1111/jpi.70150","DOIUrl":"10.1111/jpi.70150","url":null,"abstract":"<p><p>Global heavy metal (HM) stresses pose serious threats to environmental plants and animals. Melatonin has shown potent effects on improving plant stress resistance and phytoremediation upon HM stress, however, the systematic discussion of these extensive mechanisms and the gaps to practical applications remain elusive. This review aims to systemically provide the mechanistic understanding and environmental implication of melatonin integrative effects on alleviating HM toxicity. On the one hand, melatonin modulates HM homeostasis, induces HM detoxification, keeps photosynthesis and nutrient balance, and activates antioxidant defense systems to improve plant defense resistance to HM. On the other hand, melatonin triggers multiple transcriptional gene networks and extensive phytohormone crosstalks in plant defense responses. Notably, melatonin and melatonin-producing microbes exhibit potential applications in keeping plant growth and improving phytoremediation under HM conditions, indicating their effects on plant-microbiome-soil synergistic feedbacks. Finally, the current challenges and future perspectives of melatonin integrative mechanisms and applications are elucidated, highlighting that basic scientific questions and combined technologies should be further integrated to promote its practical applications. In summary, this review clarifies the multifaceted mechanisms of melatonin-integrated plant responses and potential remediation applications for environmental HMs, providing relative broad-spectrum and long-term strategies.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":"e70150"},"PeriodicalIF":7.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Light-Dark Cycles Promote Osteoclast Activity and Decrease Bone Density in Mice: The Modulatory Role of Melatonin and Sirt3-SOD2 Signaling.","authors":"Qian Wang, Mian Zhang, Jun Sun, Shu Zhang, Jianda Xie, Zhaokai Yin, Shuo Yang, Shenqiang Qiu","doi":"10.1111/jpi.70148","DOIUrl":"10.1111/jpi.70148","url":null,"abstract":"<p><p>The circadian rhythm system plays an essential role in maintaining skeletal homeostasis, yet the precise impact of circadian rhythm abnormalities on bone mineral density (BMD) remains poorly understood. In this study, we systematically investigated the effects of rhythm disruption on bone metabolism by establishing murine models exposed to winter-simulated extended darkness (8-h light:16-h dark) and severe non-24-h light-dark cycles (8L:8D, 6L:6D, and 4L:4D). Our structural and histological analyses revealed that abnormal circadian rhythms profoundly uncouple bone remodeling, leading to a precipitous decline in trabecular bone mass. Crucially, we demonstrated that enhanced osteoclast activity due to the extended period of darkness in winter increases the risk of fractures, and this skeletal deterioration is further exacerbated under increasingly fragmented non-24-h rhythms. Mechanistically, circadian misalignment induced a severe downregulation of the Sirt3-SOD2 signaling pathway in bone tissue, which released physiological constraints on RANKL expression and subsequently drove rampant osteoclastogenesis. Pharmacological intervention with the endogenous circadian synchronizer melatonin partially mitigated this rhythm-disrupted bone loss by restoring Sirt3 expression and predominantly enhancing osteoblast anabolism; however, its capacity to directly suppress rhythm-induced osteoclast hyperactivation was limited. Furthermore, co-treatment with the Sirt3 inhibitor 3-TYP abolished the osteoprotective effects of melatonin by concurrently impairing osteoblast function. Collectively, these findings identify circadian rhythm disruption as a critical intrinsic driver of BMD decline. This chronobiological perspective elucidates that photoperiod-induced circadian disruptions may act as a risk factor for diminished bone density by driving osteoclastogenesis, warranting further translational research in humans.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":"e70148"},"PeriodicalIF":7.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Inhibiting MT2-TFE3-Dependent Autophagy Enhances Melatonin-Induced Apoptosis in Tongue Squamous Cell Carcinoma.","authors":"","doi":"10.1111/jpi.70171","DOIUrl":"10.1111/jpi.70171","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Retraction: &lt;/strong&gt;T. Fan, H. Pi, M. Li, Z. Ren, Z. He, F. Zhu, L. Tian, M. Tu, J. Xie, M. Liu, Y. Li, M. Tan, G. Li, W. Qing, R. J. Reiter, Z. Yu, H. Wu, and Z. Zhou, \"Inhibiting MT2-TFE3-Dependent Autophagy Enhances Melatonin-Induced Apoptosis in Tongue Squamous Cell Carcinoma,\" Journal of Pineal Research 64, no. 2 (2018): e12457, https://doi.org/10.1111/jpi.12457. The above article, published online on 08 May 2017 in Wiley Online Library (wileyonlinelibrary.com) and its corrigendum (https://doi.org/10.1111/jpi.12645), has been retracted by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party brought the publisher's attention to a report on PubPeer [1] which suggested that the row of BAX bands in Figure 7E had been duplicated in Figure 8E and represented as CL-PARP following a vertical flip, while the row of GAPDH bands in Figure 7E had also likely been duplicated with further brightness changes and vertical resizing. Additionally, the row of CL-PARP bands in Figure 1B had been duplicated in Figure 2B and represented as SQSTM1 following a horizontal flip, while the row of GAPDH bands had also been duplicated between those same figures. While the corrigendum published online on 28 March 2020 corrected the duplication in Figure 2B, the corrigendum did not address how the mistake was made and did not address the duplications between Figure 7E and 8E. Further investigation by the publisher also found that most of the row of p-TFE3 bands in Figure 6A had been potentially duplicated from another article which shares one of the same authors [Chen et al. 2016 (https://doi.org/10.18632/oncotarget.12894)]. Both articles represented the data as being from different samples. Additionally, one further potential duplication between the c-TFEB and Histone H3 bands in Figure 4B was also detected. The authors responded to an inquiry by the publisher and presented original data as well as original experimental documentation. A review of these data by the publisher found that, while some of the bands in question were not duplicated, there were further discrepancies between the labeling of the original data and the data presented in the article. There were also further discrepancies between the presentation of the original data and the data included in the corrigendum. Following contact with the authors, an additional round of checks found further evidence of image duplication in the supplementary data. Part of the MT2 band in Figure S2A was potentially shared with the p-P70S6K band in Supplementary Figure S4B. Part of the GAPDH band in Figure S3A was shared with the GAPDH band in Figure S3B. A portion of the GAPDH band in Figure S4A was duplicated and represented as P70S6K in Figure S4C. Lastly, a portion of the row of GAPDH bands in Figure S3A was duplicated in Figure 6B in the main article text and represented as Histone H3 while the BAX band in Figure S5 was duplicated in Figure 4B in the main ar","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":"e70171"},"PeriodicalIF":7.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronomedicine: The Need to Bridge Chronobiology to Clinical Medicine","authors":"Gianluigi Ubaldo Mazzoccoli,&nbsp;Filippo Pigazzani","doi":"10.1111/jpi.70159","DOIUrl":"10.1111/jpi.70159","url":null,"abstract":"","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level Regulation","authors":"Doris Loh,&nbsp;Luiz Gustavo de Almeida Chuffa,&nbsp;Fábio Rodrigues Ferreira Seiva,&nbsp;Russel J. Reiter","doi":"10.1111/jpi.70156","DOIUrl":"10.1111/jpi.70156","url":null,"abstract":"<p>Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive. Here, we introduce a sovereign singularity framework, presenting a deductive biophysical model that positions the indoleamine melatonin as a master regulator of biological phase separation. A systematic synthesis and integrative bioinformatics analysis were performed to identify the intersection between melatonin-responsive genes and the phase-separation proteome. We identified a core 26-gene regulatory signature—including <i>AR, BCL2, CGAS, CTNNB1, EP300, EZH2, EGFR, IKBKG (</i>NEMO<i>), KEAP1, KDM1A</i> (LSD1), <i>LEF1, MYC, NANOG, PRNP (</i>PRP^c), <i>SMAD3, SOX9, SQSTM1, TFEB, TFAM, TP53, TWIST1</i>, USP10, <i>WWTR1</i> (TAZ), <i>VIM, YAP1</i>, and <i>YTHDF3</i>—at the intersection of melatonin signaling and condensate architecture. We propose that melatonin utilizes a tri-lever framework of redox tuning (Lever I), multivalent plasticization (Lever II), and dielectric recalibration (Lever III) to render oncogenic programs biophysically untenable. This model provides a mechanical basis for high-resolution regulatory outcomes that modulate the organizational logic of nuclear decision-making (Axis I), state-transition (Axis II), and stress-adaptation (Axis III) condensates. Our results define a strategic platform for disrupting condensate-driven malignancy through the systemic modulation of the cellular biophysical landscape.</p>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jpi.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Omics Analysis Reveals Melatonin-Mediated Chilling-Responsive Physiological, Antioxidant, and Metabolic Mechanisms Underlying Cold Resistance in Wampee","authors":"Shujun Peng,&nbsp;Yongyan Huang,&nbsp;Xiaoyue Zhu,&nbsp;Zhechong Ling,&nbsp;Jiayi Chen,&nbsp;Xinglong Hu,&nbsp;Guibing Hu,&nbsp;Yonghua Qin,&nbsp;Irfan Ali Sabir","doi":"10.1111/jpi.70155","DOIUrl":"10.1111/jpi.70155","url":null,"abstract":"<div>\u0000 \u0000 <p>Wampee (<i>Clausena lansium</i>) is a tropical and southern subtropical fruit tree whose productivity is limited by low-temperature stress (LTS). This study investigated the physiochemical and ‌molecular mechanisms by which melatonin (MLT) enhances chilling tolerance in wampee. MLT treatment improved membrane stability and reduced oxidative damage by enhancing antioxidant capacity and osmotic adjustment. Metabolomic and transcriptomic analyses revealed that differentially expressed genes and metabolites were primarily associated with flavonoid biosynthesis and starch and sucrose metabolism pathways. Eleven key candidate genes were identified, including sucrose synthase, granule-bound starch synthase, trehalose-6-phosphate synthase, chalcone-flavonone isomerase, flavonoid 3′,5′-hydroxylase, and UDP-glycosyltransferase. MLT treatment also increased soluble carbohydrate levels, such as sucrose and fructose, and enhanced sucrose phosphate synthase activity. Transcription factors ClbHLH2 and ClNAC1 enhanced wampee's cold tolerance by activating the sucrose-biosynthetic genes <i>ClSUS2</i> and <i>ClSPS1</i>, respectively. These findings provide insights into the molecular and physiological mechanisms underlying wampee adaptation to LTS and highlight MLT as a potential tool to improve wampee's cold tolerance.</p>\u0000 </div>","PeriodicalId":198,"journal":{"name":"Journal of Pineal Research","volume":"78 4","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}