Philosophical Transactions of the Royal Society B: Biological Sciences最新文献_第7页

Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study. 改善执行功能的迷幻剂辅助神经反馈：随机半自然实验室可行性研究。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-02 Epub Date: 2024-10-21 DOI: 10.1098/rstb.2023.0095

S Enriquez-Geppert, J Krc, F J O'Higgins, M Lietz

{"title":"Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study.","authors":"S Enriquez-Geppert, J Krc, F J O'Higgins, M Lietz","doi":"10.1098/rstb.2023.0095","DOIUrl":"10.1098/rstb.2023.0095","url":null,"abstract":"Executive function deficits, common in psychiatric disorders, hinder daily activities and may be linked to diminished neural plasticity, affecting treatment and training responsiveness. In this pioneering study, we evaluated the feasibility and preliminary efficacy of psilocybin-assisted frontal-midline theta neurofeedback (NF), a neuromodulation technique leveraging neuroplasticity, to improve executive functions (EFs). Thirty-seven eligible participants were randomized into an experimental group (n = 18) and a passive control group (n = 19). The experimental group underwent three microdose sessions and then three psilocybin-assisted NF sessions, without requiring psychological support, demonstrating the approach's feasibility. NF learning showed a statistical trend for increases in frontal-midline theta from session to session with a large effect size and non-significant but medium effect size dynamical changes within sessions. Placebo effects were consistent across groups, with no tasks-based EF improvements, but significant self-reported gains in daily EFs-working memory, shifting, monitoring and inhibition-showing medium and high effect sizes. The experimental group's significant gains in their key training goals underscored the approach's external relevance. A thorough study with regular sessions and an active control group is crucial to evaluate EFs improvement and their specificity in future. Psilocybin-enhanced NF could offer significant, lasting benefits across diagnoses, improving daily functioning. This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1915","pages":"20230095"},"PeriodicalIF":5.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semantic fMRI neurofeedback of emotions: from basic principles to clinical applications. 情绪的语义 fMRI 神经反馈：从基本原理到临床应用。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-02 Epub Date: 2024-10-21 DOI: 10.1098/rstb.2023.0084

Rainer Goebel, Michael Lührs, Assunta Ciarlo, Fabrizio Esposito, David E Linden

{"title":"Semantic fMRI neurofeedback of emotions: from basic principles to clinical applications.","authors":"Rainer Goebel, Michael Lührs, Assunta Ciarlo, Fabrizio Esposito, David E Linden","doi":"10.1098/rstb.2023.0084","DOIUrl":"10.1098/rstb.2023.0084","url":null,"abstract":"During fMRI neurofeedback participants learn to self-regulate activity in relevant brain areas and networks based on ongoing feedback extracted from measured responses in those regions. This closed-loop approach has been successfully applied to reduce symptoms in mood disorders such as depression by showing participants a thermometer-like display indicating the strength of activity in emotion-related brain areas. The hitherto employed conventional neurofeedback is, however, 'blind' with respect to emotional content, i.e. patients instructed to engage in a specific positive emotion could drive the neurofeedback signal by engaging in a different (positive or negative) emotion. In this future perspective, we present a new form of neurofeedback that displays semantic information of emotions to the participant. Semantic information is extracted online using real-time representational similarity analysis of emotion-specific activity patterns. The extracted semantic information can be provided to participants in a two-dimensional semantic map depicting the current mental state as a point reflecting its distance to pre-measured emotional mental states (e.g. 'happy', 'content', 'sad', 'angry'). This new approach provides transparent feedback during self-regulation training, and it has the potential to enable more specific training effects for future therapeutic applications such as clinical interventions in mood disorders.This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1915","pages":"20230084"},"PeriodicalIF":5.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding and modifying dynamic attentional bias in gaming disorder. 解码和修正游戏障碍中的动态注意偏差。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-02 Epub Date: 2024-10-21 DOI: 10.1098/rstb.2023.0090

Taiki Oka, Takatomi Kubo, Nao Kobayashi, Misa Murakami, Toshinori Chiba, Aurelio Cortese

{"title":"Decoding and modifying dynamic attentional bias in gaming disorder.","authors":"Taiki Oka, Takatomi Kubo, Nao Kobayashi, Misa Murakami, Toshinori Chiba, Aurelio Cortese","doi":"10.1098/rstb.2023.0090","DOIUrl":"10.1098/rstb.2023.0090","url":null,"abstract":"With the spread of smartphones and computer games, concerns have escalated regarding the rising prevalence of gaming disorder. Patients often display attentional biases, unconsciously turning their attention towards gaming-related stimuli. However, attempts to discover and ameliorate these attentional deficits have yielded inconsistent outcomes, potentially due to the dynamic nature of attentional bias. This study investigated neural mechanisms underlying attentional bias state by combining neuroimaging (functional magnetic resonance imaging -fMRI) with an approach-avoidance task tailored to an individual's gaming preference. We conducted a multivariate pattern analysis of endogenous brain activity in 21 participants with probable gaming disorder. Our analyses revealed that activity patterns in the insula tracked temporal attentional bias states specific to gaming stimuli. A broad network of frontal and parietal regions instead appeared to predict a general temporal attentional bias state. Finally, we conducted a proof-of-concept study for 'just-in-time' attentional bias training through fMRI-decoded neurofeedback of insula activity patterns, named decoded attentional bias training (DecABT). Our preliminary results suggest that DecABT may help to decrease the attractiveness of gaming stimuli via a insula- and precuneus-based neural mechanism. This work provides new evidence for the insula as an endogenous regulator of attentional bias states in gaming disorder and a starting point to develop novel, individualized therapeutic approaches to treat addiction.This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1915","pages":"20230090"},"PeriodicalIF":5.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of fMRI neurofeedback of right inferior frontal cortex on inhibitory brain activation in children with ADHD. 右下额皮层的 fMRI 神经反馈对多动症儿童大脑抑制激活的影响。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-02 Epub Date: 2024-10-21 DOI: 10.1098/rstb.2023.0097

Steve Lukito, Sheut-Ling Lam, Marion Criaud, Samuel Westwood, Olivia S Kowalczyk, Sarah Curran, Nadia Barrett, Christopher Abbott, Holan Liang, Emily Simonoff, Gareth J Barker, Vincent Giampietro, Katya Rubia

{"title":"Effects of fMRI neurofeedback of right inferior frontal cortex on inhibitory brain activation in children with ADHD.","authors":"Steve Lukito, Sheut-Ling Lam, Marion Criaud, Samuel Westwood, Olivia S Kowalczyk, Sarah Curran, Nadia Barrett, Christopher Abbott, Holan Liang, Emily Simonoff, Gareth J Barker, Vincent Giampietro, Katya Rubia","doi":"10.1098/rstb.2023.0097","DOIUrl":"10.1098/rstb.2023.0097","url":null,"abstract":"We aimed to replicate previous effects of functional magnetic resonance imaging neurofeedback (fMRI-NF) in right inferior frontal cortex (rIFC) on IFC activation during a Stop Task in a larger group of boys with attention-deficit/hyperactivity disorder (ADHD). The present double-blind, randomized controlled trial tested the effects of 15 runs of active versus sham fMRI-NF of rIFC on performance and activation associated with successful and failed inhibition versus Go trials during a tracking Stop task in 88 boys with ADHD (44 active; 44 sham), controlling for age and medication status. No significant group-by-time interaction effects were observed for performance or brain activation during the successful stop trials, and post hoc analysis showed very low numbers of active fMRI-NF learners. Nevertheless, during error monitoring, there was a significant group-by-time interaction effect on post-error reaction time slowing and in left IFC activation, which were both increased after active compared to sham fMRI-NF. The findings are in line with our previous observation of left IFC upregulation after fMRI-NF of rIFC relative to active fMRI-NF of parahippocampal gyrus. This highlights the potentially wider regional effects that fMRI-NF of a particular self-control target region has on other self-regulatory regions in ADHD. This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1915","pages":"20230097"},"PeriodicalIF":5.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurorights in the Constitution: from neurotechnology to ethics and politics. 宪法中的神经权利：从神经技术到伦理和政治。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-02 Epub Date: 2024-10-21 DOI: 10.1098/rstb.2023.0098

Sergio Ruiz, Luca Valera, Paulina Ramos, Ranganatha Sitaram

{"title":"Neurorights in the Constitution: from neurotechnology to ethics and politics.","authors":"Sergio Ruiz, Luca Valera, Paulina Ramos, Ranganatha Sitaram","doi":"10.1098/rstb.2023.0098","DOIUrl":"10.1098/rstb.2023.0098","url":null,"abstract":"Neuroimaging technologies such as brain-computer interfaces and neurofeedback have evolved rapidly as new tools for cognitive neuroscience and as potential clinical interventions. However, along with these developments, concern has grown based on the fear of the potential misuse of neurotechnology. In October 2021, Chile became the first country to include neurorights in its Constitution. The present article is divided into two parts. In the first section, we describe the path followed by neurorights that led to its inclusion in the Chilean Constitution, and the neurotechnologies usually involved in neurorights discussions. In the second part, we discuss two potential problems of neurorights. We begin by pointing out some epistemological concerns regarding neurorights, mainly referring to the ambiguity of the concepts used in neurolegislations, the difficult relationship between neuroscience and politics and the weak reasons for urgency in legislating. We then describe the dangers of overprotective laws in medical research, based on the detrimental effect of recent legislation in Chile and the potential risk posed by neurorights to the benefits of neuroscience development. This article aims to engage with the scientific community interested in neurotechnology and neurorights in an interdisciplinary reflection of the potential consequences of neurorights.This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1915","pages":"20230098"},"PeriodicalIF":5.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating subjective pain perception with decoded Montreal Neurological Institute-space neurofeedback: a proof-of-concept study. 通过蒙特利尔神经研究所空间神经反馈解码调节主观疼痛感：概念验证研究。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-02 Epub Date: 2024-10-21 DOI: 10.1098/rstb.2023.0082

Taryn Berman, Cody Cushing, Shawn Manuel, Etienne Vachon-Presseau, Aurelio Cortese, Mitsuo Kawato, Choong-Wan Woo, Tor Dessart Wager, Hakwan Lau, Mathieu Roy, Vincent Taschereau-Dumouchel

{"title":"Modulating subjective pain perception with decoded Montreal Neurological Institute-space neurofeedback: a proof-of-concept study.","authors":"Taryn Berman, Cody Cushing, Shawn Manuel, Etienne Vachon-Presseau, Aurelio Cortese, Mitsuo Kawato, Choong-Wan Woo, Tor Dessart Wager, Hakwan Lau, Mathieu Roy, Vincent Taschereau-Dumouchel","doi":"10.1098/rstb.2023.0082","DOIUrl":"10.1098/rstb.2023.0082","url":null,"abstract":"Pain is a complex emotional experience that still remains challenging to manage. Previous functional magnetic resonance imaging (fMRI) studies have associated pain with distributed patterns of brain activity (i.e. brain decoders), but it is still unclear whether these observations reflect causal mechanisms. To address this question, we devised a new neurofeedback approach using real-time decoding of fMRI data to test if modulating pain-related multivoxel fMRI patterns could lead to changes in subjective pain experience. We first showed that subjective pain ratings can indeed be accurately predicted using a real-time decoding approach based on the stimulus intensity independent pain signature (SIIPS) and the neurologic pain signature (NPS). Next, we trained participants (n = 16) in a double-blinded decoded fMRI neurofeedback experiment to up- or downregulate the SIIPS. Our results indicate that participants can learn to downregulate the expression of SIIPS independently from NPS expression. Importantly, the success of this neurofeedback training was associated with the perceived intensity of painful stimulation following the intervention. Taken together, these results indicate that closed-loop brain imaging can be efficiently conducted using a priori fMRI decoders of pain, potentially opening up a new range of applications for decoded neurofeedback, both for clinical and basic science purposes. This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1915","pages":"20230082"},"PeriodicalIF":5.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of craving for real-time fMRI neurofeedback based on individual classification. 基于个体分类的实时 fMRI 神经反馈渴求调节。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-12-02 Epub Date: 2024-10-21 DOI: 10.1098/rstb.2023.0094

Dong-Youl Kim, Jonathan Lisinski, Matthew Caton, Brooks Casas, Stephen LaConte, Pearl H Chiu

{"title":"Regulation of craving for real-time fMRI neurofeedback based on individual classification.","authors":"Dong-Youl Kim, Jonathan Lisinski, Matthew Caton, Brooks Casas, Stephen LaConte, Pearl H Chiu","doi":"10.1098/rstb.2023.0094","DOIUrl":"10.1098/rstb.2023.0094","url":null,"abstract":"In previous real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) studies on smoking craving, the focus has been on within-region activity or between-region connectivity, neglecting the potential predictive utility of broader network activity. Moreover, there is debate over the use and relative predictive power of individual-specific and group-level classifiers. This study aims to further advance rtfMRI-NF for substance use disorders by using whole-brain rtfMRI-NF to assess smoking craving-related brain patterns, evaluate the performance of group-level or individual-level classification (n = 31) and evaluate the performance of an optimized classifier across repeated NF runs. Using real-time individual-level classifiers derived from whole-brain support vector machines, we found that classification accuracy between crave and no-crave conditions and between repeated NF runs increased across repeated runs at both individual and group levels. In addition, individual-level accuracy was significantly greater than group-level accuracy, highlighting the potential increased utility of an individually trained whole-brain classifier for volitional control over brain patterns to regulate smoking craving. This study provides evidence supporting the feasibility of using whole-brain rtfMRI-NF to modulate smoking craving-related brain responses and the potential for learning individual strategies through optimization across repeated feedback runs. This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1915","pages":"20230094"},"PeriodicalIF":5.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biotic interactions, evolutionary forces and the pan-plant specialized metabolism. 生物相互作用、进化力量和泛植物特化代谢。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-11-18 Epub Date: 2024-09-30 DOI: 10.1098/rstb.2023.0362

Sophie de Vries, Ivo Feussner

{"title":"Biotic interactions, evolutionary forces and the pan-plant specialized metabolism.","authors":"Sophie de Vries, Ivo Feussner","doi":"10.1098/rstb.2023.0362","DOIUrl":"10.1098/rstb.2023.0362","url":null,"abstract":"Plant specialized metabolism has a complex evolutionary history. Some aspects are conserved across the green lineage, but many metabolites are unique to certain lineages. The network of specialized metabolism continuously diversified, simplified or reshaped during the evolution of streptophytes. Many routes of pan-plant specialized metabolism are involved in plant defence. Biotic interactions are recalled as major drivers of lineage-specific metabolomic diversification. However, the consequences of this diversity of specialized metabolism in the context of plant terrestrialization and land plant diversification into the major lineages of bryophytes, lycophytes, ferns, gymnosperms and angiosperms remain only little explored. Overall, this hampers conclusions on the evolutionary scenarios that shaped specialized metabolism. Recent efforts have brought forth new streptophyte model systems, an increase in genetically accessible species from distinct major plant lineages, and new functional data from a diversity of land plants on specialized metabolic pathways. In this review, we will integrate the recent data on the evolution of the plant immune system with the molecular data of specialized metabolism and its recognition. Based on this we will provide a contextual framework of the pan-plant specialized metabolism, the evolutionary aspects that shape it and the impact on adaptation to the terrestrial environment.This article is part of the theme issue 'The evolution of plant metabolism'.","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1914","pages":"20230362"},"PeriodicalIF":5.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary trajectory of transcription factors and selection of targets for metabolic engineering. 转录因子的进化轨迹和代谢工程目标的选择。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-11-18 Epub Date: 2024-09-30 DOI: 10.1098/rstb.2023.0367

Yun Sun Lee, Edward L Braun, Erich Grotewold

引用次数: 0

Current and future perspectives for enhancing our understanding of the evolution of plant metabolism. 增进我们对植物新陈代谢进化的了解的当前和未来展望。

IF 5.4 2区生物学

Philosophical Transactions of the Royal Society B: Biological Sciences Pub Date : 2024-11-18 Epub Date: 2024-09-30 DOI: 10.1098/rstb.2024.0253

Jan de Vries, Sophie de Vries, Alisdair R Fernie

引用次数: 0