Pediatric Infectious Disease Journal最新文献

{"title":"Gradenigo's Syndrome Conservative Management Remains an Option Despite Complications: A Case Report.","authors":"Samer Ali, Abdulla Aloteiby, Ingi Elsaid, Jehan AlRayahi, Andres Perez, Mohammad Janahi","doi":"10.1097/INF.0000000000004656","DOIUrl":"10.1097/INF.0000000000004656","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e147-e148"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Impact of Rapid Molecular Microbiologic Diagnosis for Mechanically Ventilated Children in Intensive Care With Suspected Pneumonia.","authors":"Robyn Silcock, Vanessa Clifford, Joshua Osowicki, Ben Gelbart","doi":"10.1097/INF.0000000000004629","DOIUrl":"10.1097/INF.0000000000004629","url":null,"abstract":"<p><strong>Background: </strong>Lower respiratory tract infections (LRTIs) remain a leading cause of community-acquired and nosocomial infection in children and a common indication for antimicrobial use and intensive care admission. Determining the causative pathogen for LRTIs is difficult and traditional culture-based methods are labor- and time-intensive. Emerging molecular diagnostic tools may identify pathogens and detect antimicrobial resistance more quickly, to enable earlier targeted antimicrobial therapy.</p><p><strong>Methods: </strong>This is a single-center, prospective observational laboratory study evaluating the use of the Biofire FilmArray pneumonia panel (FA-PP) (BioFire Diagnostics, Salt Lake City, UT) for bronchoalveolar lavage specimens from mechanically ventilated children admitted with suspected or presumed pneumonia. We aimed to determine its feasibility and utility for identifying pathogens, antimicrobial resistance and its potential influence on antibiotic prescribing.</p><p><strong>Results: </strong>We analyzed 50 samples taken from 41 children with a median age of 6 months. Positive agreement between culture and FA-PP was 83% and negative agreement was 76%. Agreement between FA-PP ( mecA/C or MREJ ) and culture was high for methicillin-resistant Staphylococcus aureus . In 3 cases, extended-spectrum beta-lactamase-producing Gram-negative organisms were detected by culture and not FA-PP. Hypothetically, FA-PP results would have affected antimicrobial prescribing in approximately half the cases (24, 48%).</p><p><strong>Conclusions: </strong>FA-PP is a useful adjunct to traditional culture methods in mechanically ventilated children with LRTIs and may influence clinical decision-making regarding antibiotic escalation or stewardship.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"371-375"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Invasive Group A Streptococcal Infections.","authors":"Gülsüm İclal Bayhan","doi":"10.1097/INF.0000000000004640","DOIUrl":"https://doi.org/10.1097/INF.0000000000004640","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":"44 4","pages":"e143-e144"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 Pandemic on the Follow-up of Children and Adolescents With HIV Infection in Guatemala.","authors":"Santiago Alonso Yáñez, Julio Werner Juárez Lorenzana, Luis Prieto Tato, Sara Guillén Martín, Elisa Cristina Salazar Alarcón, Luisa Navarro Gómez","doi":"10.1097/INF.0000000000004674","DOIUrl":"10.1097/INF.0000000000004674","url":null,"abstract":"<p><p>We conducted a retrospective study to assess the effect of the COVID-19 pandemic on children living with HIV in Guatemala. A reduction in physical consultations and laboratory tests was observed in prepandemic versus pandemic period. However, immunovirological status of the children showed no differences. The mitigation measures implemented were important to reduce the impact of the pandemic on the follow-up of children living with HIV.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"330-332"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Rates of \"Watch\" and \"Reserve\" Class Antibiotics Used to Treat Infections in Neonates and Infants in Southeast Asia.","authors":"Michelle L Harrison, Benjamin F R Dickson, Maria Esterlita T Villanueva-Uy, Nina Dwi Putri, Riyadi Adrizain, Leny Kartina, Gayana P S Gunaratna, Nambage Shirani Chandrasiri, Hoang T Tran, Huong X Nguyen, Siew M Fong, Erena S Kasahara, Chau H M Le, Distyayu Soekardja, Dominicus Husada, Ng Boon Hong, Phoebe C M Williams","doi":"10.1097/INF.0000000000004614","DOIUrl":"10.1097/INF.0000000000004614","url":null,"abstract":"<p><p>We evaluated antibiotic prescribing practices for neonates and infants hospitalized with infections in resource-constrained healthcare settings, where antimicrobial resistance is responsible for significant neonatal morbidity and mortality. A point prevalence survey of 667 admitted infants across 10 clinical sites in Southeast Asia revealed a total of 405 antibiotics were prescribed to 218 infants, with high use of World Health Organization-classified \"Watch,\" \"Reserve\" and \"Not Recommended\" antibiotics.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e113-e116"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply: A Rare Cause of Extended-spectrum Beta-lactamase Positive Escherichia coli Meningitis in a Child: Spinal Canal Cyst.","authors":"Chiara Campone, Giacomo Tardini, Marina Francesca Strati, Carlotta Pepino, Simona Matarese, Carla Debbia, Giacomo Brisca, Emanuela Piccotti, Daniela Pirlo","doi":"10.1097/INF.0000000000004627","DOIUrl":"https://doi.org/10.1097/INF.0000000000004627","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":"44 4","pages":"e141-e142"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Epidemiology in Pediatric Invasive Group A Streptococcal Infections in Ireland During the 2022-2023 Outbreak.","authors":"Deirdre J Foley, Orla Cotter, Lucy Davidson, Marguerite Lawler, Aaron M Walsh, Fiona Cloak, Mary Ward, Mary Meehan, Robert Cunney, Ciara Martin, Paul McKeown, Una Fallon, Cilian Ó Maoldomhnaigh","doi":"10.1097/INF.0000000000004746","DOIUrl":"10.1097/INF.0000000000004746","url":null,"abstract":"<p><strong>Background: </strong>From October 2022 to June 2023, there was a 4-fold increase in pediatric invasive group A streptococcus cases (iGAS) in the Republic of Ireland. This project aimed to better understand the clinical characteristics and disease course of iGAS in children in Ireland to inform Public Health interventions and messaging for carers, clinicians and the public.</p><p><strong>Methods: </strong>All cases of iGAS notified to Public Health under 16 years from October 2022 to June 2023 inclusive were collated. A clinical case review of every death and hospitalization was performed under the auspices of the National Incident Management team using an online questionnaire. Analysis was performed using a 2-sided Fischer's exact test and 1-way analysis of variance.</p><p><strong>Results: </strong>Of 180 cases of iGAS in children, 167 had clinical data collected; 33 of 49 with skin and soft tissue infection had active varicella, and 69 of 167 had at least 1 respiratory viral coinfection. Seventy-four of 167 required therapeutic procedural intervention, and 34 of 167 required pediatric intensive care unit admission. Ten of 12 patients who died had necrotizing pneumonia, and 8 had an out-of-hospital cardiac arrest. Compared with historical data, significant changes in iGAS epidemiology in children were seen, with an increase in respiratory diagnoses, a decrease in musculoskeletal disease and an increased need for procedural intervention.</p><p><strong>Conclusions: </strong>The rapidity and severity of secondary deterioration and death in children with iGAS highlight the importance of sepsis awareness in primary and secondary care. The high prevalence of viral coinfection emphasizes the importance of current vaccine uptake and expansion of the national schedule to include varicella zoster virus.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: The Corruption of Medical Literature.","authors":"Stanley A Plotkin","doi":"10.1097/INF.0000000000004808","DOIUrl":"https://doi.org/10.1097/INF.0000000000004808","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Attributable Risk of Wheeze in 2-<6-Year-old Children, Following a Respiratory Syncytial Virus Lower Respiratory Tract Infection in The First 2 Years of Life.","authors":"Shabir A Madhi, Ana Ceballos, Luis Cousin, Joseph B Domachowske, Joanne M Langley, Emily Lu, Thanyawee Puthanakit, Mika Rämet, Amy Tan, Khalequ Zaman, Bruno Anspach, Agustin Bueso, Elisa Cinconze, Jo Ann Colas, Ulises D'Andrea, Ilse Dieussaert, Janet A Englund, Sanjay Gandhi, Lisa Jose, Joon Hyung Kim, Nicola P Klein, Outi Laajalahti, Runa Mithani, Martin O C Ota, Mauricio Pinto, Peter Silas, Sonia K Stoszek, Auchara Tangsathapornpong, Jamaree Teeratakulpisarn, Miia Virta, Rachel A Cohen","doi":"10.1097/INF.0000000000004447","DOIUrl":"10.1097/INF.0000000000004447","url":null,"abstract":"<p><strong>Background: </strong>There is limited evidence regarding the proportion of wheeze in young children attributable to respiratory syncytial virus lower respiratory tract infections (RSV-LRTI) occurring early in life. This cohort study prospectively determined the population attributable risk (PAR) and risk percent (PAR%) of wheeze in 2-<6-year-old children previously surveilled in a primary study for RSV-LRTI from birth to their second birthday (RSV-LRTI<2Y).</p><p><strong>Methods: </strong>From 2013 to 2021, 2-year-old children from 8 countries were enrolled in this extension study (NCT01995175) and were followed through quarterly surveillance contacts until their sixth birthday for the occurrence of parent-reported wheeze, medically-attended wheeze or recurrent wheeze episodes (≥4 episodes/year). PAR% was calculated as PAR divided by the cumulative incidence of wheeze in all participants.</p><p><strong>Results: </strong>Of 1395 children included in the analyses, 126 had documented RSV-LRTI<2Y. Cumulative incidences were higher for reported (38.1% vs. 13.6%), medically-attended (30.2% vs. 11.8%) and recurrent wheeze outcomes (4.0% vs. 0.6%) in participants with RSV-LRTI<2Y than those without RSV-LRTI<2Y. The PARs for all episodes of reported, medically-attended and recurrent wheeze were 22.2, 16.6 and 3.1 per 1000 children, corresponding to PAR% of 14.1%, 12.3% and 35.9%. In univariate analyses, all 3 wheeze outcomes were strongly associated with RSV-LRTI<2Y (all global P < 0.01). Multivariable modeling for medically-attended wheeze showed a strong association with RSV-LRTI after adjustment for covariates (global P < 0.0001).</p><p><strong>Conclusions: </strong>A substantial amount of wheeze from the second to sixth birthday is potentially attributable to RSV-LRTI<2Y. Prevention of RSV-LRTI<2Y could potentially reduce wheezing episodes in 2-<6-year-old children.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fever in the Returning Pediatric Traveler.","authors":"Nina Vaezipour, Michael Buettcher, Nicole Ritz","doi":"10.1097/INF.0000000000004783","DOIUrl":"https://doi.org/10.1097/INF.0000000000004783","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}