Pediatric Infectious Disease Journal最新文献_第4页

Cytokine Profile in Children Following SARS-CoV-2 Infection: Preliminary Findings. 儿童感染 SARS-CoV-2 后的细胞因子谱：初步研究结果

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 DOI: 10.1097/INF.0000000000004558

Danilo Buonsenso, Anna Camporesi, Gabriele Di Sante, Michela Sali, Maria Del Carmen Pereyra Boza, Rosa Morello, Piero Valentini, Francesca Raffaelli, Lucie Rodriguez, Laura Gonzalez, Anette Johnsson, Constantin Habimana Mugabo, Tadepally Lakshmikanth, Petter Brodin

引用次数: 0

Clinical Significance of Mucor in Airway Culture of Immunocompetent Patients With Chronic Lung Disease. 免疫功能正常的慢性肺病患者气道培养物中粘菌的临床意义。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-06-11 DOI: 10.1097/INF.0000000000004427

Suha Rizik, Lea Bentur, Ronen Bar-Yoseph, Moran Szwarcwort, Dina Pollak, Michal Gur, Michal Meir

{"title":"Clinical Significance of Mucor in Airway Culture of Immunocompetent Patients With Chronic Lung Disease.","authors":"Suha Rizik, Lea Bentur, Ronen Bar-Yoseph, Moran Szwarcwort, Dina Pollak, Michal Gur, Michal Meir","doi":"10.1097/INF.0000000000004427","DOIUrl":"10.1097/INF.0000000000004427","url":null,"abstract":"Objectives: Mucor within the airways of immunocompromised patients often signifies an invasive life-threatening infection. However, its significance in immunocompetent patients with chronic lung diseases is less clear. We aimed to assess the clinical implication of mucor in airway-secretion cultures of these patients.Methods: A single-center retrospective cohort study was performed. Patients with cystic fibrosis (CF), primary ciliary dyskinesia (PCD) or non-CF/non-PCD bronchiectasis followed in our Pediatric Pulmonary Institute, with sputum or bronchoalveolar lavage cultures growing Mucorales molds in the years 2010-2022, were included. Demographic and clinical parameters such as body mass index and spirometry values (forced expiratory volume at 1 second) were collected and compared with values up to 12 months prior to and following the index (positive culture) visit.Results: A total of 27 patients of whom 22 (82%) patients were with CF, 3 with PCD (11%) and 2 (7%) with non-CF/non-PCD bronchiectasis were included. Median age was 21.8 (14.9-32.1) years, with forced expiratory volume at 1 second of 62.8% ± 21.9% at the index visit. None of the patients developed disseminated disease, none had clinical or radiological evidence of fungal disease and none required antifungal therapy. Throughout the 12 months prior to and following the positive cultures, no significant changes were noted in body mass index, forced expiratory volume at 1 second, frequency of pulmonary exacerbations, days of hospitalization or days of antibiotic treatment.Conclusions: Evidence of mucor in airway cultures of immunocompetent patients with chronic lung disease does not necessarily signify clinical deterioration nor suggests invasive fungal disease. Larger, long-term prospective studies are required to obviate the need for a thorough evaluation in these patients.","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Disease Course of COVID-19 and Seasonal Coronavirus Infections in Children. 儿童感染 COVID-19 和季节性冠状病毒的病程比较。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-06-14 DOI: 10.1097/INF.0000000000004423

Kubra Aykac, Melike Demir, Merve Kasikci, Ali Bulent Cengiz, Yasemin Ozsurekci

引用次数: 0

A Rare Pediatric Case of Spondylodiscitis Caused by Oral Flora. 口腔菌群引起脊柱盘炎的罕见儿科病例

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-06-19 DOI: 10.1097/INF.0000000000004436

Quynh Pham, Rachel Downey, Sharwin Khot, Danielle Glade, Sarmistha B Hauger

引用次数: 0

Blood Cultures in Children: Maximizing Their Usefulness. 儿童血培养：最大限度地发挥其作用。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-07-02 DOI: 10.1097/INF.0000000000004453

Thao T Truong, Jacky Lu, Jennifer Dien Bard

引用次数: 0

Bone and Joint Infections in Children With Sickle Cell Disease in French Guiana: A 13-Year Retrospective Multicenter Review. 法属圭亚那镰状细胞病患儿的骨与关节感染：13年回顾性多中心研究。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-07-09 DOI: 10.1097/INF.0000000000004416

Apolline Furgier, Juliette Goutines, Succes Dobian, Magaly Zappa, Magalie Demar, Nadjia Aigoun, Bruno Oubda, Albert Faye, Narcisse Elenga, Lindsay Osei

{"title":"Bone and Joint Infections in Children With Sickle Cell Disease in French Guiana: A 13-Year Retrospective Multicenter Review.","authors":"Apolline Furgier, Juliette Goutines, Succes Dobian, Magaly Zappa, Magalie Demar, Nadjia Aigoun, Bruno Oubda, Albert Faye, Narcisse Elenga, Lindsay Osei","doi":"10.1097/INF.0000000000004416","DOIUrl":"10.1097/INF.0000000000004416","url":null,"abstract":"Introduction: Sickle cell disease (SCD) is a genetic disorder with a high infectious morbidity and mortality and a heterogeneous distribution in France. One of the challenges is to differentiate a bone and joint infection (BJI) from a vaso-occlusive crisis. This challenge is particularly prevalent in French Guiana, an overseas territory with the highest incidence of SCD in France. The aim of this study was to describe the epidemiology of BJI in children with SCD in French Guiana.Method: This was a retrospective multicentric descriptive study of SCD patients living in French Guiana aged under 18 and diagnosed with a BJI between 2010 and 2022. These BJI were divided into 2 groups: those with microbiological documentation (d-BJI) and those without microbiological identification (ud-BJI).Results: A total of 53 episodes of BJI in 42 patients (mean age 7.2 years) were reported. Clinical symptoms on arrival were comparable between the d-BJI and ud-BJI groups. Patients in the d-BJI group had longer average hospital stays (40.4 days vs. 16.8 days, P = 0.01) and Salmonella spp. were the most identified bacteria (n = 8/13). White blood cell count was greater in the d-BJI group (30.3 G/L vs. 18.G/L, P = 0.01) and a collection was more frequently identified on imaging (11/13 vs. 16/40, P = 0.01) in this group. Initial in-hospital antibiotic therapy was longer in the d-BJI group (17.2 days vs. 12.8, P = 0.02), as were infection-related complications (9/13 vs. 12/40 P = 0.01).Conclusion: BJI in children with SCD is not sufficiently microbiologically documented. Progress must be made to improve the documentation of BJI.","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Syphilis Leading to High Efficiency In Utero Transmission of Antiretroviral Resistant HIV: Intersection of Two Pandemics. 孕产妇梅毒导致抗逆转录病毒耐药艾滋病病毒在子宫内的高效传播：两种流行病的交汇。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-06-12 DOI: 10.1097/INF.0000000000004414

James Homans, Carla Blieden

{"title":"Maternal Syphilis Leading to High Efficiency In Utero Transmission of Antiretroviral Resistant HIV: Intersection of Two Pandemics.","authors":"James Homans, Carla Blieden","doi":"10.1097/INF.0000000000004414","DOIUrl":"10.1097/INF.0000000000004414","url":null,"abstract":"Background: Testing for syphilis and HIV is indicated in prenatal care in the United States. Effective antiretroviral therapy during pregnancy reduces mother-to-child HIV transmission (MTCT) to less than 1%. Syphilis infection in pregnant women with unsuppressed HIV increases the risk of MTCT, usually in utero. The incidences of syphilis in women of childbearing age and corresponding congenital syphilis are increasing in the United States.Methods: We report 3 cases of in utero HIV transmission associated with maternal syphilis that occurred during the ongoing syphilis epidemic.Results: All 3 women had untreated HIV infection and active syphilis with placentitis during late pregnancy. Their newborns were found to have symptomatic congenital syphilis and HIV infection from in utero transmission. The babies' antiretroviral resistance patterns were nearly identical to their mothers'.Conclusions: When untreated syphilis and uncontrolled HIV coincide in pregnancy, there is a high likelihood of in utero mother-to-child HIV transmission. The current syphilis epidemic in the United States may lead to an increase in MTCT.","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burden of Invasive Group B Streptococcus Infection Among Omani Infants Less Than 90 Days Old: A Multicenter Study. 阿曼 90 天以下婴儿感染侵袭性 B 群链球菌的负担：一项多中心研究。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-05-29 DOI: 10.1097/INF.0000000000004412

Rajaa Al Aamri, Laila Al Yazidi, Hilal Al Hashami, Amal Al Jabri, Rahma Al Haddabi, Badriya Al Adawi

{"title":"Burden of Invasive Group B Streptococcus Infection Among Omani Infants Less Than 90 Days Old: A Multicenter Study.","authors":"Rajaa Al Aamri, Laila Al Yazidi, Hilal Al Hashami, Amal Al Jabri, Rahma Al Haddabi, Badriya Al Adawi","doi":"10.1097/INF.0000000000004412","DOIUrl":"10.1097/INF.0000000000004412","url":null,"abstract":"Background: Group B Streptococcus (GBS) infection is the leading cause of neonatal morbidity and mortality worldwide. This study aims to investigate the incidence of invasive GBS disease among infants less than 90 days old in Oman and to describe their risk factors, clinical presentations and clinical outcomes.Methods: We retrospectively collected the data of less than 90-day-old Omani infants with culture-positive GBS from sterile samples. This study was conducted in 3 tertiary hospitals in Oman from 2009 to 2018.Results: Over 10 years, we identified 92 cases of culture-confirmed invasive GBS infection from 178,285 live births in the 3 hospitals, giving an overall incidence of 0.53 per 1000 live births [95% confidence interval (CI): 0.4-0.7)]. Of those, 59 (64.1%) had early-onset neonatal GBS disease and 33 (35.9%) had late-onset neonatal GBS disease. The incidence of invasive GBS disease was significantly higher in the last 5 years from 2014 to 2018 (0.69 per 1000 live births, 95% CI: 0.5-0.9) compared to the previous years from 2009 to 2013 (0.36 per 1000 live births, 95% CI: 0.2‒0.5), ( P = 0.004). Infants with late-onset neonatal GBS disease had a higher risk of meningitis compared to infants with early-onset neonatal GBS disease (30.3% vs. 10.2%, P = 0.021). The mortality rate was 13.5%.Conclusions: The incidence of invasive GBS disease in Oman is similar to what was reported worldwide, however, the burden of the disease in terms of mortality is high. In addition, a significant increase in the annual incidence of invasive GBS disease in Omani infants was found over the study period.","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grouped Indurated Papules on the Arm of a Healthy Child Following Skin Trauma. 皮肤外伤后健康儿童手臂上的成群凹陷性丘疹。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-09-16 DOI: 10.1097/INF.0000000000004383

Álvaro Guerra-Amor, Trinidad Repiso-Montero, María Espiau

引用次数: 0

Neurodevelopmental Outcomes Following Childhood Viral Meningitis in Canterbury New Zealand. 新西兰坎特伯雷儿童病毒性脑膜炎后的神经发育结果。

IF 2.9 4区医学

Pediatric Infectious Disease Journal Pub Date : 2024-10-01 Epub Date: 2024-05-15 DOI: 10.1097/INF.0000000000004398

Natalie G Martin, Jonathan Williman, Tony Walls, Manish Sadarangani, Cameron C Grant

{"title":"Neurodevelopmental Outcomes Following Childhood Viral Meningitis in Canterbury New Zealand.","authors":"Natalie G Martin, Jonathan Williman, Tony Walls, Manish Sadarangani, Cameron C Grant","doi":"10.1097/INF.0000000000004398","DOIUrl":"10.1097/INF.0000000000004398","url":null,"abstract":"Background: Most childhood meningitis is viral in countries with widespread conjugate vaccine use. This study assessed clinical features and neurodevelopmental outcomes in preschool children following enteroviral and parechoviral meningitis.Methods: Children 18-42 months of age in Canterbury, New Zealand were included, who had enterovirus (EV) or parechovirus (HPEV) meningitis from 2015 to 2021. Comprehensive neurodevelopmental assessments were completed by a psychologist using the Bayley Scale for Infant Development-3 (BSID-3). Mean composite and scaled scores and proportion below the cutoff were assessed in each domain. Clinical data was analyzed.Results: There were 79 children 18-42 months old with previous EV or HPEV meningitis. BSID assessments were completed for 33 children (55% male), median age 32 months, from 2019 to 2022 including 23 with EV and 10 HPEV meningitis. At diagnosis, 32 (97%) received intravenous/intramuscular antibiotics, and 6 received a fluid bolus. Parents reported developmental speech concerns in 6 children, and delayed motor milestones in 1 child. There was no reported sensorineural hearing loss. BSID mean composite scores were in the expected range for cognition 102 (confidence interval: 98-106), language 96 (93-100) and motor 102 (98-106) domains. Overall, 12/33 (36%) children had below expected scores in 1 developmental domain, including scores 1-2 SD below the normative mean for cognition (2/33; 6%), receptive language (6/33; 18%), expressive language (5/33; 15%) and gross motor (6/33; 18%). There were no differences between scores in EV and HPEV meningitis.Conclusion: Following viral meningitis, more than a third of preschool children had a mild developmental delay with comprehensive neurodevelopmental assessment, suggesting targeted follow-up should be considered.","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0