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Patologicheskaia fiziologiia i eksperimental'naia terapiia最新文献

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[Current status of vascular remodeling and angiogenesis in chronic liver diseases]. [慢性肝病血管重构和血管生成的研究现状]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
A S Batyrova, M I Bakanov, A N Surkov
{"title":"[Current status of vascular remodeling and angiogenesis in chronic liver diseases].","authors":"A S Batyrova,&nbsp;M I Bakanov,&nbsp;A N Surkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The review focuses on the analysis of researches on the pathophysiology of liver vascular bed, mesenteric vessels, as well as the characteristics of angiogenesis in CLD. The results of this review shows that one of the most important areas of research is soluble vascular endothelial growth factor receptors, disclosing their importance for prognosis and treatment of diseases that occur with severe disorders of angiogenesis, including in CLD.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35232268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Registration of the protein in the serum with a field-effect nanotransistor biosensor]. [用场效应纳米晶体管生物传感器记录血清中的蛋白质]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
Yu D Ivanov, K A Malsagova, T O Pleshakova, I D Shumov, A L Kaysheva, V P Popov, O V Naumova, B I Fomin, D A Nasimov, A V Latyshev, A L Aseev, V Yu Tatur, N D Ivanova, G M Konovalova, A I Archakov
{"title":"[Registration of the protein in the serum with a field-effect nanotransistor biosensor].","authors":"Yu D Ivanov,&nbsp;K A Malsagova,&nbsp;T O Pleshakova,&nbsp;I D Shumov,&nbsp;A L Kaysheva,&nbsp;V P Popov,&nbsp;O V Naumova,&nbsp;B I Fomin,&nbsp;D A Nasimov,&nbsp;A V Latyshev,&nbsp;A L Aseev,&nbsp;V Yu Tatur,&nbsp;N D Ivanova,&nbsp;G M Konovalova,&nbsp;A I Archakov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A method for detection of cancer-associated protein D-NFATc1 in serum using nanowire (NW) biosensor based on field-effect nanotransistor is developed. Field-effect nanotransistor was fabricated on the basis of «silicon-on-insulator» structures. For the biospecific detection of target protein, the NW surface was modified with aptamers against the target protein. Using the 3 um-NW enabled to obtain stable source-drain characteristics and to register D-NFATc1 in serum at concentration of 2.5 x 1014 M in the mode of drain-source current vs. gate voltage characteristics measurements. Data collection in the mode of drain-source current vs. gate voltage characteristics measurements was carried out with the use of high-speed data collection system running TURBO NBS software.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"94-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35232272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Expression of vascular endothelial growth factor (VEGF) in uterine tissues as one of the mechanisms of algogenezis in adenomyosis, associated with chronic pelvic pain]. [血管内皮生长因子(VEGF)在子宫组织中的表达是子宫腺肌病致痛的机制之一，与慢性盆腔疼痛相关]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
V E Radzinskiy, M R Orazov, O M Nosenko
{"title":"[Expression of vascular endothelial growth factor (VEGF) in uterine tissues as one of the mechanisms of algogenezis in adenomyosis, associated with chronic pelvic pain].","authors":"V E Radzinskiy,&nbsp;M R Orazov,&nbsp;O M Nosenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Methods. For morphological studies it were using fragments of walls 60 uterus, received after hysterectomy in patients with pelvic pain on a background of diffuse adenomyosis II-III degree, and 30 uterus of women with painless form of adenomyosis. Expression of vascular endothelial growth factor (VEGF) was measured in endometrial and myometrial tissues using immunohistochemistry. The results showed a significantly higher expression of VEGF in patients with adenomyosis pain phenotype compared to the same in women with silent form in the epithelial cells of ectopic endometrium (14,7 ± 1,6 vs. 10,7 ± 1,6%, p<0,01) in the smooth muscle cells of the myometrium (12,6 ± 1,4 vs. 9,6 ± 1,2%, p<0,01), in the stromal cells of the myometrium (10,1 ± 1,9 vs. 7,4 ± 1,8%, p <0,01).</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"32-5"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35231838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hemoglobin oxygen transport capacity in surgical endotoxicosis ]. [手术内毒素中毒的血红蛋白氧运输能力]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
G V Poryadin, A P Vlasov, V A Trofimov, T I Vlasova, O V Kamkina, A G Grigoryev, P A Vlasov
{"title":"[Hemoglobin oxygen transport capacity in surgical endotoxicosis ].","authors":"G V Poryadin,&nbsp;A P Vlasov,&nbsp;V A Trofimov,&nbsp;T I Vlasova,&nbsp;O V Kamkina,&nbsp;A G Grigoryev,&nbsp;P A Vlasov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In surgical endointoxication hemoglobin oxygen transport capacity of red blood cells (hemoglobin affinity ligands: the ability to bind and release ligands) is reduced and is associated with the severity of endogenous intoxication. Violation of oxygen transport function of hemoglobin at endogenous intoxication is associated with conformational changes of a biomolecule, and its possible influence on reactive oxygen species, which confirmed in experiments in vitro: under the influence of oxygen-iron ascorbate ability of hemoglobin deteriorates. Largely similar structural and functional changes in hemoglobin occur in patients with surgical endotoxicosis.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"23-7"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35231834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role of lipoprotein-associated enzyme paraoxonase 1 and its polymorphisms in the pathogenesis of endothelial dysfunction and somatic complications in patients with alcoholism: Review ]. [脂蛋白相关酶对氧磷酶1及其多态性在酒精中毒患者内皮功能障碍和躯体并发症发病机制中的作用:综述]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
L F Panchenko, V Yu Baronets, T A Naumova, S V Pyrozhkov, N N Terebilina, B B Shoibonov
{"title":"[The role of lipoprotein-associated enzyme paraoxonase 1 and its polymorphisms in the pathogenesis of endothelial dysfunction and somatic complications in patients with alcoholism: Review ].","authors":"L F Panchenko,&nbsp;V Yu Baronets,&nbsp;T A Naumova,&nbsp;S V Pyrozhkov,&nbsp;N N Terebilina,&nbsp;B B Shoibonov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A review of recent data on the role of the multifunctional enzyme, associated with high density lipoproteins - paraoxonase 1 (PON1) in maintaining healthy endothelial function by detoxifying both oxidized low density lipoproteins and homocysteine thiolactone. The additional contribution to the protection of the endothelium against damage makes organophosphatase activity of PON1 involved in the detoxification products of tobacco smoke. The reduction of antioxidant activity of PON1 promotes the differentiation of monocytes into macrophages and the development of inflammation. The reduction of thiolactonase activity of PON1 is accompanied by a decrease of methionine re-synthesis from homocysteine causing DNA- hypomethylation and alteratioin of the expression patterns of pro- and anti-atherogenic genes. Global hypomethylation of the genome is regarded as one of the three most important mechanisms of the increased risk of somatic complications of alcoholism. The accumulation of homocysteine thiolactone serving agonist of glutamate receptors and antagonist of dopamine receptors is a prerequisite to increased alcohol abuse. Clinical observations focusing on gene polymorphisms of PON indicate that three different genotypes of polymorphism PON1Q192R have unequal degrees atheroprotective properties.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"50-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35232264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume]. [循环血容量实验改变后通过传递函数估计全身动脉压的系统性误差]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
V O Erkudov, A P Pugovkin, N A Verlov, I V Sergeev, S A Ievkov
{"title":"[Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume].","authors":"V O Erkudov,&nbsp;A P Pugovkin,&nbsp;N A Verlov,&nbsp;I V Sergeev,&nbsp;S A Ievkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of the experimental studies reveal the decrease of vascular rigidity with the increase of systemic error of the arterial pressure values estimated via implication of transfer functions following haemorrhage modeling in rats. Compensation of the circulating blood volume by means of dextran infusion resulted in restoration of both vascular rigidity and systemic error of estimated arterial pressure. The results can be put into medical practice as an approach for testing of non-invasive methods in cardiovascular research.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"45-9"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35231842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Macrophage activation in atherosclerosis. Message 2. Effects of factors on macrophage activation]. 巨噬细胞在动脉粥样硬化中的激活。信息2。因子对巨噬细胞活化的影响[j]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
N G Nikiforov, N V Elizova, N A Nikitina, V P Karagodin, A N Orekhov
{"title":"[Macrophage activation in atherosclerosis. Message 2. Effects of factors on macrophage activation].","authors":"N G Nikiforov,&nbsp;N V Elizova,&nbsp;N A Nikitina,&nbsp;V P Karagodin,&nbsp;A N Orekhov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In atherosclerosis, macrophages demonstrate phenotypic plasticity to rapidly adjust to changing microenvironmental conditions. In the plaque, serum lipids, serum lipoproteins and various pro- or anti-inflammatory stimuli such as cytokines, chemokines and small bioactive molecules could greatly influence the macrophage phenotype inducing switch towards more proinflammatory or anti-inflammatory properties. Dynamic plasticity of macrophages is achieved by up-regulation and down-regulation of overlapping set of transcription factors that drive macrophage polarization. Understanding of mechanisms of macrophage plasticity and resolving functional characteristics of distinct macrophage phenotypes should help in the development of new strategies for treatment of chronic inflammation in cardiovascular disease.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35232266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Melatonin as a universal modulator of any pathological processes ]. [褪黑素是任何病理过程的普遍调节剂]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
E B Arushanian, E V Schetinin
{"title":"[Melatonin as a universal modulator of any pathological processes ].","authors":"E B Arushanian,&nbsp;E V Schetinin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In paper reviewed own and numerous literary data about of universal modulated and limited influences of melatonin, which produced by pineal gland and peripheral tissues cells, on any pathological processes in the cerebral brain and internal organs. Cellular and systemic mechanisms of its protective and modulated properties were observed.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"79-88"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35232270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chronic ischemia of the brain: state structurally functional properties of erythrocytes ]. [脑慢性缺血:红细胞的结构功能特性]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
A I Konoplya, A A Shulginova
{"title":"[Chronic ischemia of the brain: state structurally functional properties of erythrocytes ].","authors":"A I Konoplya,&nbsp;A A Shulginova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>At patients with a chronic ischemia of a brain against an idiopathic hypertensia of the II stage development intra erythrocyte «an oxidative stress», depression of sorption ability of erythrocytes, change in a membrane of cells of a ratio of fractions of lipids due to decrease of the maintenance of glitserophospholipid and a sphingomyelin, augmentation of a lizophosphatidilkholin, cholesterol is taped. Change of presentability of the membranous proteins responsible for structurization and stabilization of a membrane of erythrocytes, a shaping, flexibility of a membrane and an intracellular metabolism is established. The important role of erythrocytes at a chronic ischemia of a brain based on the concept of their participation in a chain of the adaptive mechanisms supporting a homeostasis is noted.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35624980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chronic exposure to cold is adaptation without stress ]. [长期暴露在寒冷中是一种没有压力的适应]。
Patologicheskaia fiziologiia i eksperimental'naia terapiia Pub Date : 2016-01-01
L N Maslov, S Yu Tsibulnikov, N V Naryzhnaia, V V Ivanov, M R Tsibulnikova
{"title":"[Chronic exposure to cold is adaptation without stress ].","authors":"L N Maslov,&nbsp;S Yu Tsibulnikov,&nbsp;N V Naryzhnaia,&nbsp;V V Ivanov,&nbsp;M R Tsibulnikova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has been established that prolonged continuous cold exposure (+4°C for 24 hours/day, four weeks) causes an increase in brown fat weight, hypertrophy of the adrenal gland, spleen and did not affect cortisol and corticosterone levels in the blood serum in rats. Gastric ulcers were not observed in the rats. Chronic intermittent exposure to cold (+4°C, 8 hours/day, 4 weeks) promoted an increase in the weight of brown fat, spleen, kidneys and heart, stomach ulcers and an alteration of cortisol and corticosterone levels were did observed. Short-term intermittent exposure to cold (+4°C, 1.5 hours/day, 4 weeks) did not affect the weight of brown fat, but promoted an increases in the weight of body, spleen, kidneys and heart, stomach ulcers were not found, cortisol and corticosterone levels was not changed.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35231835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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