Yu D Ivanov, K A Malsagova, T O Pleshakova, I D Shumov, A L Kaysheva, V P Popov, O V Naumova, B I Fomin, D A Nasimov, A V Latyshev, A L Aseev, V Yu Tatur, N D Ivanova, G M Konovalova, A I Archakov
{"title":"[Registration of the protein in the serum with a field-effect nanotransistor biosensor].","authors":"Yu D Ivanov, K A Malsagova, T O Pleshakova, I D Shumov, A L Kaysheva, V P Popov, O V Naumova, B I Fomin, D A Nasimov, A V Latyshev, A L Aseev, V Yu Tatur, N D Ivanova, G M Konovalova, A I Archakov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A method for detection of cancer-associated protein D-NFATc1 in serum using nanowire (NW) biosensor based on field-effect nanotransistor is developed. Field-effect nanotransistor was fabricated on the basis of «silicon-on-insulator» structures. For the biospecific detection of target protein, the NW surface was modified with aptamers against the target protein. Using the 3 um-NW enabled to obtain stable source-drain characteristics and to register D-NFATc1 in serum at concentration of 2.5 x 1014 M in the mode of drain-source current vs. gate voltage characteristics measurements. Data collection in the mode of drain-source current vs. gate voltage characteristics measurements was carried out with the use of high-speed data collection system running TURBO NBS software.</p>","PeriodicalId":19857,"journal":{"name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","volume":"60 1","pages":"94-8"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A method for detection of cancer-associated protein D-NFATc1 in serum using nanowire (NW) biosensor based on field-effect nanotransistor is developed. Field-effect nanotransistor was fabricated on the basis of «silicon-on-insulator» structures. For the biospecific detection of target protein, the NW surface was modified with aptamers against the target protein. Using the 3 um-NW enabled to obtain stable source-drain characteristics and to register D-NFATc1 in serum at concentration of 2.5 x 1014 M in the mode of drain-source current vs. gate voltage characteristics measurements. Data collection in the mode of drain-source current vs. gate voltage characteristics measurements was carried out with the use of high-speed data collection system running TURBO NBS software.
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