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Short-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies. 环境空气污染与心率变异性之间的短期关联:基于人群的KORA S4和FF4研究结果
IF 8.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-10-17 DOI: 10.1186/s12989-025-00645-6
Yujiao Li, Susanne Breitner-Busch, Wayne E Cascio, Siqi Zhang, Kathrin Wolf, Ina-Maria Rückert-Eheberg, Stefan Kääb, Georg Schmidt, Alexander Strom, Annette Peters, Alexandra Schneider
{"title":"Short-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies.","authors":"Yujiao Li, Susanne Breitner-Busch, Wayne E Cascio, Siqi Zhang, Kathrin Wolf, Ina-Maria Rückert-Eheberg, Stefan Kääb, Georg Schmidt, Alexander Strom, Annette Peters, Alexandra Schneider","doi":"10.1186/s12989-025-00645-6","DOIUrl":"https://doi.org/10.1186/s12989-025-00645-6","url":null,"abstract":"<p><strong>Background: </strong>Ambient air pollution is a major risk factor for CVDs, and a plausible mechanism is speculated to be alteration of autonomic nervous system (ANS) function. Yet, the short-term effects of air pollution on heart rate variability (HRV), a measure of ANS balance are inconsistent.</p><p><strong>Objective: </strong>This study aimed to evaluate the short-term effects of ambient PM<sub>2.5</sub> and NO<sub>2</sub> on cardiovascular autonomic function, and to determine vulnerable subgroups and temporal trends from repeated HRV and HR measurements over 14 years in the KORA cohort.</p><p><strong>Methods: </strong>We analyzed data from 4,032 participants in KORA S4 (1999-2001) and 1,912 in KORA FF4 (2013-2014). Air pollution data were from fixed monitoring stations, and HRV indices were derived from 5-minute ECG recordings. Generalized additive models (GAMs) and generalized additive mixed models (GAMMs) were used to assess associations.</p><p><strong>Results: </strong>In S4, each IQR increase in PM<sub>2.5</sub> at the 14-day moving average was associated with a 2.32% (95% CI: - 4.41, - 0.19) decrease in SDNN and a 1.20% (95% CI: 0.16, 2.26) increase in HR. By contrast, KORA FF4 showed opposite associations, with a 0.86% (95% CI: 0.02, 1.70) increase in SDNN at lag 4 for PM<sub>2.5</sub>. Effect modifications by age and smoking status were observed in S4. No statistically significant associations were found in the longitudinal analysis, however, the observed trends were consistent with the effects identified in S4.</p><p><strong>Conclusion: </strong>Short-term exposure to PM<sub>2.5</sub> and NO<sub>2</sub> impacts cardiac autonomic function, with varying effects across study waves due to aging, smoking, medication, and lower pollution levels. Even at low ambient concentrations, these exposures impaired autonomic function via inflammation and oxidative stress, underscoring the importance of stringent air quality standards and lifestyle interventions in reducing cardiovascular risk.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"26"},"PeriodicalIF":8.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerium dioxide nanoparticles coated with benzo[a]pyrene modify aryl hydrocarbon receptor activity, trophoblast differentiation and mitochondrial network phenotype in human placenta. 以苯并[a]芘包被的二氧化铈纳米颗粒改变人胎盘中芳烃受体活性、滋养细胞分化和线粒体网络表型。
IF 8.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-10-14 DOI: 10.1186/s12989-025-00640-x
Séverine A Degrelle, Gaëlle Deval, Arnaud Tête, Claire Mikolajczak, Frank Giton, Marie-Léone Vignaud, Sonja Boland, Céline J Guigon, Xavier Coumoul, Amal Zerrad-Saadi, Marie-Pierre Golinelli-Cohen, Thierry Fournier, Ioana Ferecatu
{"title":"Cerium dioxide nanoparticles coated with benzo[a]pyrene modify aryl hydrocarbon receptor activity, trophoblast differentiation and mitochondrial network phenotype in human placenta.","authors":"Séverine A Degrelle, Gaëlle Deval, Arnaud Tête, Claire Mikolajczak, Frank Giton, Marie-Léone Vignaud, Sonja Boland, Céline J Guigon, Xavier Coumoul, Amal Zerrad-Saadi, Marie-Pierre Golinelli-Cohen, Thierry Fournier, Ioana Ferecatu","doi":"10.1186/s12989-025-00640-x","DOIUrl":"10.1186/s12989-025-00640-x","url":null,"abstract":"<p><p>A growing body of epidemiological evidence links maternal exposure to air pollution with an increased risk of adverse pregnancy outcomes, such as preterm birth and low birth weight. Cerium dioxide nanoparticles (CeO<sub>2</sub> NPs or nanoceria) are emerging pollutants, used as additives in diesel fuels and cigarettes for their catalytic properties, and released into the environment. Due to their high surface-to-volume ratio and reactivity, CeO<sub>2</sub> NPs develop a surface coating during combustion, which may incorporate other released fuel-borne chemicals, such as benzo[a]pyrene (BaP), a known carcinogen, mutagen and reprotoxicant, raising concerns about their combined impacts on human health. To better reflect environmental reality, we produced BaP-coated CeO<sub>2</sub> NPs and exposed primary human trophoblasts and chorionic villi. Our findings show that BaP-coated CeO<sub>2</sub> NPs activate the aryl hydrocarbon receptor (AhR) pathway, enhancing trophoblast differentiation and syncytium formation, with effects distinct from those of BaP or CeO₂ NPs alone, or their unbound mixture. Additionally, exposure to CeO<sub>2</sub> NPs alone altered homeostasis of mitochondria, affecting their phenotype and function. While individual exposures or BaP-coated CeO<sub>2</sub> NPs had no detectable impact, parallel co-exposure resulted in a slight but significant reduction in basal respiration. Finally, uncoated CeO<sub>2</sub> NPs altered placental steroidogenesis, increasing estrone level while decreasing dehydroepiandrosterone level, with sex-specific effects. These findings suggest that CeO<sub>2</sub> NPs can influence the biological effects of BaP in the human placenta, including modulating trophoblast differentiation, as well as disrupting mitochondria homeostasis and steroid production, with potential implications for pregnancy outcomes in polluted environments.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"25"},"PeriodicalIF":8.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms. 更正:大鼠吸入毒理学研究证实氧化锌纳米形式的分组。
IF 8.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-09-02 DOI: 10.1186/s12989-025-00635-8
Tizia Thoma, Lan Ma-Hock, Steffen Schneider, Naveed Honarvar, Silke Treumann, Sibylle Groeters, Volker Strauss, Heike Marxfeld, Dorothee Funk-Weyer, Svenja Seiffert, Wendel Wohlleben, Martina Dammann, Karin Wiench, Noömi Lombaert, Christine Spirlet, Marie Vasquez, Nicole Dewhurst, Robert Landsiedel
{"title":"Correction: Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms.","authors":"Tizia Thoma, Lan Ma-Hock, Steffen Schneider, Naveed Honarvar, Silke Treumann, Sibylle Groeters, Volker Strauss, Heike Marxfeld, Dorothee Funk-Weyer, Svenja Seiffert, Wendel Wohlleben, Martina Dammann, Karin Wiench, Noömi Lombaert, Christine Spirlet, Marie Vasquez, Nicole Dewhurst, Robert Landsiedel","doi":"10.1186/s12989-025-00635-8","DOIUrl":"10.1186/s12989-025-00635-8","url":null,"abstract":"","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"24"},"PeriodicalIF":8.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice. 柴烟对老年雌性C57BL/6J小鼠神经代谢组学的影响及抗衰老药物的保护作用
IF 8.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-09-01 DOI: 10.1186/s12989-025-00639-4
David Scieszka, Jonathan Hulse, Haiwei Gu, Amanda Barkley-Levenson, Ed Barr, Marcus Garcia, Jessica G Begay, Guy Herbert, Mark McCormick, Jonathan Brigman, Andrew Ottens, Barry Bleske, Kiran Bhaskar, Matthew J Campen
{"title":"Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice.","authors":"David Scieszka, Jonathan Hulse, Haiwei Gu, Amanda Barkley-Levenson, Ed Barr, Marcus Garcia, Jessica G Begay, Guy Herbert, Mark McCormick, Jonathan Brigman, Andrew Ottens, Barry Bleske, Kiran Bhaskar, Matthew J Campen","doi":"10.1186/s12989-025-00639-4","DOIUrl":"10.1186/s12989-025-00639-4","url":null,"abstract":"<p><strong>Background: </strong>Wildland fires in the United States have increased in frequency and scale over the past 30 years exposing millions of people to hazardous air pollutants. Among others, aging individuals are particularly vulnerable to the effects of wildfire smoke. In this study, we assessed the neurobiological impacts of wood smoke (WS) on aged mice and the potential of anti-aging therapeutics to mitigate these impacts.</p><p><strong>Methods: </strong>Female C57BL/6 J mice, aged 18 months, were divided into 10 groups and exposed to either filtered air (FA; 5 groups) or biomass derived WS (5 groups) for 4 h/day, every other day, for 14 days (7 exposures total) with an average particulate matter (PM) concentration of 448 µg/m<sup>3</sup> per exposure. One FA control group and one WS exposed group were euthanized 24 h after the last exposure. The remaining 8 groups (4 FA and 4 WS exposed) were treated with either vehicle control, resveratrol and nicotinamide mononucleotide (RNMN), dasatinib and quercetin (DQ), or both RNMN and DQ (RNDQ) for 10 weeks.</p><p><strong>Results: </strong>A significant reduction in NAD + within the prefrontal cortex was observed following the 14-day exposure to WS along with a reduction in serotonin. Serotonin reductions were observed up to 10 weeks post-exposure and co-occurred with neuroinflammation and behavioral alterations, including increased immobility in a forced swim test. RNMN conferred the greatest mitigating effect after WS exposure, while RNDQ treatment resulted in an upregulation of markers associated with aging in the brain. While the metabolic shift in the PFC following WS exposure was relatively modest, mice exposed to FA and vehicle control (10 weeks of natural aging) exhibited the greatest metabolic shift, including perturbed nicotinamide metabolism.</p><p><strong>Conclusion: </strong>Taken together, these findings highlight that subacute (14-day) exposure to WS results in persistent neurometabolomic and behavioral alterations in an aged mouse model and that intervention with RNMN may be a useful strategy to mitigate the adverse neurological outcomes observed. Further studies are needed to assess the specific impact of either resveratrol or NMN in isolation and to fully elucidate age-specific, as well as sex- and species-determinant, WS exposure response pathways.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"23"},"PeriodicalIF":8.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Pulmonary effects of exposure to indium and its compounds: cross-sectional survey of exposed workers and experimental findings in rodents. 修正:暴露于铟及其化合物的肺部影响:暴露工人的横断面调查和啮齿动物的实验结果。
IF 8.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-08-13 DOI: 10.1186/s12989-025-00634-9
Nan Liu, Yi Guan, Yan Yu, Gai Li, Ling Xue, Weikang Li, Xiaoyu Qu, Ning Li, Sanqiao Yao
{"title":"Correction: Pulmonary effects of exposure to indium and its compounds: cross-sectional survey of exposed workers and experimental findings in rodents.","authors":"Nan Liu, Yi Guan, Yan Yu, Gai Li, Ling Xue, Weikang Li, Xiaoyu Qu, Ning Li, Sanqiao Yao","doi":"10.1186/s12989-025-00634-9","DOIUrl":"10.1186/s12989-025-00634-9","url":null,"abstract":"","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"22"},"PeriodicalIF":8.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combustion products of burn pit constituents induce more changes in asthmatic than non-asthmatic murine lungs. 烧伤坑成分的燃烧产物引起哮喘小鼠肺比非哮喘小鼠肺更多的变化。
IF 8.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-07-29 DOI: 10.1186/s12989-025-00625-w
Lanazha Belfield-Simpson, Jessica R Martin, Matthew K McPeek, Alessandra Livraghi-Butrico, Hong Dang, Yong Ho Kim, M Ian Gilmour, Claire M Doerschuk
{"title":"Combustion products of burn pit constituents induce more changes in asthmatic than non-asthmatic murine lungs.","authors":"Lanazha Belfield-Simpson, Jessica R Martin, Matthew K McPeek, Alessandra Livraghi-Butrico, Hong Dang, Yong Ho Kim, M Ian Gilmour, Claire M Doerschuk","doi":"10.1186/s12989-025-00625-w","DOIUrl":"10.1186/s12989-025-00625-w","url":null,"abstract":"<p><strong>Background: </strong>Burn pits, a method for disposal of military waste outside the United States, produce toxic substances, to which 3.5 million military personnel have been and continue to be exposed. Mild asthma (persistent or intermittent symptoms of asthma but no change in pulmonary function tests) is found among military personnel. We investigated whether burn pit combustion products (CPs) are more detrimental to the airways of asthmatic than non-asthmatic mice.</p><p><strong>Methods: </strong>Mice were exposed to house dust mite antigen (HDM) or phosphate-buffered saline (PBS) 5 times over 2 weeks to initiate asthma-like airway injury. Condensates of CPs or saline were generated by flaming combustion of military cardboard, plastic and military plywood. CPs were aspirated oropharyngeally at 24 h after the final HDM or PBS instillation. The lungs were studied 24 h later.</p><p><strong>Results: </strong>HDM increased recruitment of eosinophils and mucus projection, both Muc5ac and Muc5b mRNAs and protein. Following exposure to CPs, mice exposed to HDM had a greater inflammatory response and injury, as measured by increased neutrophil recruitment and the concentration of protein in the bronchoalveolar lavage (BAL), than control mice exposed to PBS. Expression of neutrophil chemokines was enhanced. CPs had no effect on HDM-induced eosinophil recruitment or expression of Th2 cytokines. CPs had no effect on mucus production in PBS or HDM mice. However, CPs increased intraluminal mucus, as revealed by AB-PAS staining, only in HDM mice, suggesting that CPs impaired mucociliary clearance (MCC), the lung's primary defense system, only in asthmatic airways. Lung RNA sequencing revealed that CPs increased genes and gene pathways describing inflammatory processes and impaired structure and function of cilia to a greater degree in HDM mice.</p><p><strong>Conclusions: </strong>These data indicate that asthmatic mice are more susceptible to CP-induced lung remodeling and dysfunction than non-asthmatic mice. Enhanced chemokine expression suggests that the CXCL1,2,5/CXCR2 axis may be the mechanism of the increased neutrophil recruitment. A potential mechanism of mucus accumulation is that inhalation of CPs amplifies the changes in cilia and MCC caused by asthma and triggers a positive feedback loop of enhanced inflammation induced by this accumulating mucus.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"21"},"PeriodicalIF":8.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to ambient air pollution over developmental stages induced neurodevelopmental impairment in mice offspring via microbiome-gut-brain axis. 在发育阶段暴露于环境空气污染通过微生物群-肠-脑轴诱导小鼠后代神经发育损伤。
IF 7.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-07-14 DOI: 10.1186/s12989-025-00637-6
Zijun Yang, Yi Zhang, Shanshan Ran, Jingyi Zhang, Yonggui Gao, Yali Zhang, Xinyue Li, Baozhuo Ai, Shengtao Wei, Fei Tian, Guang Jia, Hualiang Lin, Zhangjian Chen, Zilong Zhang
{"title":"Exposure to ambient air pollution over developmental stages induced neurodevelopmental impairment in mice offspring via microbiome-gut-brain axis.","authors":"Zijun Yang, Yi Zhang, Shanshan Ran, Jingyi Zhang, Yonggui Gao, Yali Zhang, Xinyue Li, Baozhuo Ai, Shengtao Wei, Fei Tian, Guang Jia, Hualiang Lin, Zhangjian Chen, Zilong Zhang","doi":"10.1186/s12989-025-00637-6","DOIUrl":"10.1186/s12989-025-00637-6","url":null,"abstract":"<p><p>Exposure to air pollution has been increasingly recognized as a risk factor for neurodevelopmental disorders, and gut microbiome may play a critical role. However, current evidence still remains scarce. In the present study, mice were exposed to real-time ambient air pollution from conception through young adulthood, with neurobehavioral performance and gut microbiome being assessed across different developmental stages. Neurodevelopmental changes including emotional and cognitive impairments were observed in behavioral tests, accompanied by pathological and inflammation changes in brain, which were more pronounced in adolescence than in young adulthood. Alterations in the compositions and functions of gut microbiome were also revealed by fecal metagenomic sequencing. Mediation analysis showed that gut microbiome alterations significantly contributed to the observed neurodevelopmental changes induced by air pollution. Furthermore, after antibiotic (ABX) intervention, the observed neurobehavioral, pathological and inflammatory differences between the exposed and control groups diminished. These findings indicate that the gut microbiome mediates the neurodevelopmental damage caused by exposure to air pollution during developmental stages, adding novel insights on the underlying mechanisms linking air pollution and neurodevelopmental disorders.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"20"},"PeriodicalIF":7.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopersistence of man-made vitreous fibres (MMVF) / synthetic vitreous fibres (SVF): advancing from animal models to acellular testing. 人造玻璃体纤维(MMVF) /合成玻璃体纤维(SVF)的生物持久性:从动物模型到脱细胞试验的进展
IF 7.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-07-11 DOI: 10.1186/s12989-025-00636-7
Craig A Poland, Léa Hiéronimus, Denis V Okhrimenko, John W Hoffman
{"title":"Biopersistence of man-made vitreous fibres (MMVF) / synthetic vitreous fibres (SVF): advancing from animal models to acellular testing.","authors":"Craig A Poland, Léa Hiéronimus, Denis V Okhrimenko, John W Hoffman","doi":"10.1186/s12989-025-00636-7","DOIUrl":"10.1186/s12989-025-00636-7","url":null,"abstract":"<p><p>The field of fibre toxicology highlights a significant connection between the physicochemical properties of fibres-such as diameter, length, and durability-and their toxicity when inhaled. Among these properties, durability, particularly in terms of biopersistence and retention time in the lungs, is crucial in determining chronic toxicity. This understanding of fibre biopersistence is especially relevant to the regulation and safety assessment of Man-Made Vitreous Fibres (MMVF), also referred to in North American literature as Synthetic Vitreous Fibres (SVF). Despite its importance, current practices rely heavily on in vivo testing methods for evaluating biopersistence, which conflicts with the movement towards reducing animal testing and utilising new approach methodologies (NAMs) for hazard and risk assessment. In vitro assessments of biodurability have long been employed by the research community and industry alike to investigate the persistence of fibres in the lung, offering an alternative to reduce animal testing to evaluate this critical mediator of fibre toxicity. Here, we explore recent developments in acellular in vitro biodurability approaches for assessing fibre durability in the lung, addressing the variations and key challenges associated with using these methods to determine the safety of bio-soluble MMVF.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"19"},"PeriodicalIF":7.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of subway air particles on healthy adults: a randomized controlled trial in a Chinese city. 地铁空气颗粒对健康成人的影响:中国城市随机对照试验
IF 8.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-07-08 DOI: 10.1186/s12989-025-00638-5
Yuan Sun, Yuting Xiang, Yuwei Chen, Dan Xu, Tianyun Wang, Fanmei Zeng, Yu Bao, Luwei Zhao, Yifei Li, Qing Xia, Ye Deng, Jiamei Chen, Yuting Wang, Wen Peng, Guanhua Pang, Miao He
{"title":"Impacts of subway air particles on healthy adults: a randomized controlled trial in a Chinese city.","authors":"Yuan Sun, Yuting Xiang, Yuwei Chen, Dan Xu, Tianyun Wang, Fanmei Zeng, Yu Bao, Luwei Zhao, Yifei Li, Qing Xia, Ye Deng, Jiamei Chen, Yuting Wang, Wen Peng, Guanhua Pang, Miao He","doi":"10.1186/s12989-025-00638-5","DOIUrl":"10.1186/s12989-025-00638-5","url":null,"abstract":"<p><strong>Background: </strong>Subway systems reduce traffic congestion, air pollution, and carbon dioxide emissions in cities but the impacts of subway air pollution on the health of subway users remain obscure. We conducted a randomized controlled trial involving 83 healthy adults, with 80 included in the final analysis, randomly grouped to spend 2 h daily for 5 consecutive days either in an office or on a subway platform. The fine (PM<sub>2.5</sub>) and thoracic (PM<sub>10</sub>) particles concentrations, temperature, and humidity were monitored. Measurements of health parameters were assessed, including lung function and levels of fractional exhaled nitric oxide (FeNO), inflammatory and oxidative stress biomarkers, and metabolites in serum.</p><p><strong>Results: </strong>The subway platform exhibited significantly high pollutant levels, with mean PM<sub>2.5</sub> and PM<sub>10</sub> concentrations of 193.4 ± 39.4 µg/m<sup>3</sup> and 311.5 ± 64.3 µg/m<sup>3</sup> respectively. After the 5-day subway exposure, significant declines were observed in lung-function index values, including forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC), maximal voluntary ventilation (MVV) and peak expiratory flow rate (PEFR) as well as serum levels of glutathione peroxidase (GPX)-1 (p < 0.05). Conversely, somatosensory symptom scores, FeNO levels, and serum levels of tumor necrosis factor (TNF)-α and interleukin (IL)-8 were strongly elevated (p < 0.05). Results indicated increased arsenic and cobalt and decreased selenium in urine after the subway exposure (p < 0.05). Finally, the subway exposure was associated with disruptions in seven metabolic pathways and nine metabolites, particularly the depletion of L-cysteine, pretyrosine and O-acetyl-L-serine.</p><p><strong>Conclusions: </strong>This study provides the first evidence that repeated exposure to subway airborne particles is associated with reduced lung function and increased respiratory and systemic inflammation in healthy adults. Our results underscore the need to develop strategies to mitigate exposure risks, ultimately protecting public health in urban environments.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"18"},"PeriodicalIF":8.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of environmental microplastic exposure on HepG2 cells: unraveling proliferation, mitochondrial dynamics and autophagy activation. 环境微塑料暴露对HepG2细胞的影响:解开增殖,线粒体动力学和自噬激活。
IF 7.2 1区 医学
Particle and Fibre Toxicology Pub Date : 2025-06-17 DOI: 10.1186/s12989-025-00632-x
Hana Najahi, Nicola Alessio, Massimo Venditti, Ida Lettiero, Domenico Aprile, Gea Oliveri Conti, Tiziana Cappello, Giovanni Di Bernardo, Umberto Galderisi, Sergio Minucci, Margherita Ferrante, Mohamed Banni
{"title":"Impact of environmental microplastic exposure on HepG2 cells: unraveling proliferation, mitochondrial dynamics and autophagy activation.","authors":"Hana Najahi, Nicola Alessio, Massimo Venditti, Ida Lettiero, Domenico Aprile, Gea Oliveri Conti, Tiziana Cappello, Giovanni Di Bernardo, Umberto Galderisi, Sergio Minucci, Margherita Ferrante, Mohamed Banni","doi":"10.1186/s12989-025-00632-x","DOIUrl":"10.1186/s12989-025-00632-x","url":null,"abstract":"<p><p>The rise of microplastic (MPs) pollution presents a pressing environmental issue, raising concerns about its potential health impacts on human populations. Given the critical role of the liver in detoxification and metabolism, understanding the effects of MPs on the human hepatoma cell line HepG2 cells is essential for comprehensively assessing the dangers associated with MPs pollution to human health. Until now, the assessment of the harmful impact of polyethylene (PE) and polyethylene terephthalate (PET) on HepG2 has been incomplete and lacks certain essential data points. In this particular setting, we examined parameters such as cell viability, oxidative stress, mtDNA integrity, mitochondrial membrane potential, and autophagy in HepG2 cells exposed for 72 h to PET and PE at a concentration of 10 µg/mL. Our data revealed that exposure of HepG2 to MPs causes an increase in cell viability accompanied by a heightened ROS and altered mitochondrial function, as revealed by decreased mtDNA integrity and membrane potential. In addition, results demonstrated that exposure to PET and PE activated autophagic events, as suggested by the increased levels of the specific markers LC3 and p62. This last point was further confirmed using bafilomycin, a specific blocker that hinders the merging of autophagosomes and lysosomes, thereby blocking autophagic degradation processes. Given the increasing evidence of food chain MPs contamination and its possible harmful effects, our data should be carefully considered.</p>","PeriodicalId":19847,"journal":{"name":"Particle and Fibre Toxicology","volume":"22 1","pages":"17"},"PeriodicalIF":7.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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