Jonathan S Okereke, Alan D Kaye, Nathan Lien, Landyn Johnson, Austin S Thomassenm, Sahar Shekoohi, Brian E Bernhardt, Varsha Allampalli, Azem A Chami
{"title":"Clinical Effectiveness, Disability, and Outcomes of Genicular Nerve Ablation for Chronic Knee Pain.","authors":"Jonathan S Okereke, Alan D Kaye, Nathan Lien, Landyn Johnson, Austin S Thomassenm, Sahar Shekoohi, Brian E Bernhardt, Varsha Allampalli, Azem A Chami","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic knee (CK) pain has various underlying etiologies with several available therapeutic options that differ in effectiveness, duration, and complication rate. For the past decade, a minimally invasive ablation relying upon genicular radiofrequency has been gaining popularity as a treatment for the condition. To date, however, the literature contains only limited data supporting the effectiveness of this procedure, leading to insurance companies labeling it as \"experimental\" and denying claims. Benefits described include reduced adverse outcomes and complications, quicker recovery and longer duration of analgesia, and broader scope of applicability when compared to other, traditional treatments.</p><p><strong>Objectives: </strong>The present investigation focused on genicular radiofrequency ablation (GRFA) and its outcomes, including disability (e.g., stiffness, physical function), pain, and improvement in patients' quality of life.</p><p><strong>Study design: </strong>This retrospective, single-center study was conducted to evaluate the safety and effectiveness of GRFAs, plus their associated radiofrequency generators and electrode systems. The equipment consisted of the MultiGen® 2 Radiofrequency Generator (Stryker Corporation) and the RFA Solutions Generator System (Avanos Medical, Inc.).</p><p><strong>Methods: </strong>Selected patient age ranged between 26 and 92 years, with a mean age of 56.5 years. Thirty-four (34) individuals were enrolled at LSU Health Shreveport, which was the sole investigational site, between March 2021 and 2025. The Stryker SERFAS Energy Platform (Stryker Corporation) was the primary radiofrequency generator selected for genicular ablation (61.9%), with the Avanos RFA Solutions Generator System (Avanos Medical, Inc.) selected for the remaining cases. As for the outcome measures, scores on the visual analog scale (VAS), disability changes measured on the Western Ontario and McMaster Universities Arthritis Index (WOMAC), adverse outcomes, quality of improvement, and ratings recorded in the Quality of Life subsection of the Knee Injury and Osteoarthritis Outcome Score (KOOS) were compared after GRFA.</p><p><strong>Results: </strong>Mean VAS scores for CK pain intensity decreased significantly, dropping by 3.1 cm from a baseline score of 9.0 cm by the specified end (March 18th, 2025). Furthermore, 66.7% of the patients experienced a 20% or greater improvement in pain, 33.3% of the patients experienced a 40% or greater improvement in pain, and 19.1% of the patients experienced a 60% or greater improvement in pain. Zero (0) procedure-related adverse events or intra- or post-procedural complications occurred during the investigation.</p><p><strong>Limitations: </strong>The study was retrospective and had no sham operation to determine placebo response. The relatively small sample size (34 total ablations, 21 patients) could have limited the generalizability of the results. Furthermore, the","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"389-399"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Repsonse to Comments on \"The Effects of Ultrasound-Guided Genicular Nerve Blocks Used with Local Anesthetics Alone or in Combination with Corticosteroids on Patients with Knee Osteoarthritis\".","authors":"Claudia de la Fuente-Escudero","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E447-E448"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inadequate Reporting of Intervention and Statistical Methods in a Trial of Chromium for Steroid-Induced Hyperglycemia.","authors":"Mohammad Erfan Lotfi, Aysan Valinejad","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E443"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Application of the Balloon Pre-Inflating Technique in Percutaneous Balloon Compression for Primary Trigeminal Neuralgia: A Retrospective Study.","authors":"Wei Gao, Wu Di, Wei Zhang, Canying Li, Yaping Wang, Dingquan Zou, Xinghua Jiang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous balloon compression (PBC) is a safe and effective surgical technique for treating trigeminal neuralgia. The filling balloon can compress the trigeminal ganglion in Meckel's cave to achieve the interruption of pain signals. The core of the operation is the successful placement of a balloon catheter into Meckel's cave so that effective compression of the trigeminal ganglion can be achieved after the balloon is inflated.</p><p><strong>Objective: </strong>In this article, we try to determine the application value of the balloon pre-inflating technique (using contrast agents as guides during positioning) by studying its effect on the ideal balloon formation rate in PBC.</p><p><strong>Study design: </strong>A retrospective study.</p><p><strong>Setting: </strong>A single center.</p><p><strong>Methods: </strong>To compare the small-dose balloon pre-inflating technique with traditional techniques during PBC surgery, we conducted a retrospective study on the clinical data of patients who had primary trigeminal neuralgia and underwent PBC surgery at the Department of Pain Management of the Second Xiangyi Hospital at Central South University in Changsha from January 2018 to January 2024. In total, 170 patients underwent the pre-inflating technique (pre-inflating group), and 199 patients underwent the traditional non-pre-inflating technique (control group).</p><p><strong>Results: </strong>A total of 369 patients were included in the study, with a follow-up period of 12 months. When the initial balloon morphology was suboptimal, the success rate of re-catheterization to obtain the ideal balloon shape in the pre-inflating group and the non-pre-inflating group was 84.3% and 58.9%, respectively. The success rate in the pre-inflating group was significantly higher than in the non-pre-inflated group (P < 0.001). The numbers of re-punctures and re-catheterizations were significantly lower than in the non-pre-inflating group, as was the radiation dose. The instances of re-punctures in the pre-inflating group and the non-pre-inflating group were 0.41(ranging from 0.23 to 0.59 instances) and 0.71 (0.55-0.87 instances), respectively; and the re-catheterizations in the pre-inflating group and the non-pre-inflating group took place a respective 1.08 (0.77-1.40 instances) and 1.59 (1.28-1.90) instances. The radiation dose was 5.59 mGy (4.88-6.38 mGy) in the pre-inflating group and 7.69 mGy (6.86-8.52 mGy) in the non-pre-inflating group.</p><p><strong>Limitations: </strong>This single-center investigation may be subject to institution-specific protocols and potential physician biases, with the generalizability of findings further constrained by the limited sample size.</p><p><strong>Conclusion: </strong>We found that using the low-dose balloon pre-inflating technique in PBC surgery significantly improved the success rate of subsequent balloon deployment when the initial balloon morphology was suboptimal. This pre-inflating techni","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E395-E405"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fan Feng, Yongzhi Fan, Qianqian Xu, Xianbao Yao, Yi Cai
{"title":"Bibliometric Analysis of Global Research on Radiofrequency in Chronic Pain Treatment.","authors":"Fan Feng, Yongzhi Fan, Qianqian Xu, Xianbao Yao, Yi Cai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic pain is a significant global health challenge, often resistant to conventional treatments, which has led to increased interest in minimally invasive interventions such as radiofrequency (RF) techniques. Over the past 2 decades, clinicians and researchers have extensively studied and utilized RF for chronic pain management. Despite its growing clinical use, the evidence supporting the efficacy of RF remains inconsistent, with outcomes varying due to differences in study design, patient selection, and procedural techniques. To improve the understanding of the current research landscape, this study conducts a bibliometric analysis with the aim of summarizing and visualizing the evolution of, research hot spots within, and future trends in the use of RF for chronic pain treatment. The findings aim to inform directions for future research and optimize the application of RF techniques in clinical practice.</p><p><strong>Objective: </strong>This research endeavors to perform a comprehensive bibliometric analysis of global research on the use of RF in chronic pain treatment, focusing on identifying major contributing countries, institutions, journals, and authors, assessing the knowledge base, tracking trends in research hot spots, and exploring emerging topics within the field.</p><p><strong>Study design: </strong>A bibliometric analysis.</p><p><strong>Methods: </strong>We searched the Web of Science (WoS) database for articles published between January 1, 2004, and December 31, 2024. CiteSpace and VOSviewer were utilized to perform bibliometric analysis and visualization.</p><p><strong>Results: </strong>After all the data were gathered, 719 documents in total were classified and subjected to a detailed analysis that employed the aforementioned tools. The annual number of publications about the use of RF in chronic pain treatment showed a continuous growth trend that reached its peak in 2020. The United States, China, and South Korea were recognized as the most productive countries. Key institutions driving advancements included Yeungnam University, the University of Wisconsin, and Harvard Medical School. Among the authors, Min Cheol Chang and Alaa Abd-Elsayed led in productivity, while Steven P. Cohen stood as the most influential co-cited author, reflecting his foundational contributions to RF clinical applications and guidelines. Among all the journals, Pain Physician and Pain Medicine published the greatest number of relevant papers. Keyword bursts included \"radiofrequency ablation,\" \"pain management,\" and \"postherpetic neuralgia,\" which were hot topics and frontiers in the research field.</p><p><strong>Limitations: </strong>We analyzed only publications indexed in the WoS because most indicators required for bibliometric analysis could be extracted efficiently from its Web site.</p><p><strong>Conclusion: </strong>This bibliometric analysis synthesizes 2 decades of global research on the use of RF for chronic ","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E383-E394"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comments on \"The Effects of Ultrasound-Guided Genicular Nerve Blocks Used with Local Anesthetics Alone or in Combination with Corticosteroids on Patients with Knee Osteoarthritis: A Placebo-Controlled Randomized Clinical Trial\".","authors":"Jiang-Yuan Luo, Bi-Xin Zheng","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E453-E454"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: In Response to Comment on \"Is Fibromyalgia a Nociplastic or a Mixed-pain Condition?\" are Conflating Empirics with Theory, Theory with Empirics.","authors":"Shiloh Plaut","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E449-E451"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Evaluating the Efficacy of GCSB-5 in Lumbar Disc Herniation: A Randomized Controlled Trial\".","authors":"Gonca Yazici Sacaklidir","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E437"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Methodological Notes on a Placebo-Controlled Trial of GCSB-5 in Lumbar Disc Herniation.","authors":"Zeinab Sinaeifar, Mohammad Erfan Lotfi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"29 5","pages":"E439"},"PeriodicalIF":3.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}