Pediatric Research最新文献

{"title":"Congenital diaphragmatic hernia outcomes: navigating center-to-center variability in level 4 NICUs in the Children's Hospitals Neonatal Consortium.","authors":"Yigit S Guner, Isabella Zaniletti, Theresa R Grover, Sharada H Gowda, Nicolas F M Porta, Michael A Padula, Sarah Keene, Burhan Mahmood, Jacquelyn R Evans, Holly L Hedrick, Karna Murthy","doi":"10.1038/s41390-025-03829-0","DOIUrl":"https://doi.org/10.1038/s41390-025-03829-0","url":null,"abstract":"<p><strong>Background: </strong>This study examined inter-center variation (ICV) in inpatient outcomes for infants with congenital diaphragmatic hernia (CDH), aiming to contribute to quality metrics and clinical benchmarks in neonatal care.</p><p><strong>Methods: </strong>We retrospectively analyzed CDH cases from the Children's Hospitals Neonatal Consortium (CHNC) database (2010-2022), focusing on infants without prior surgical repair or discharge. Our outcomes of interest included inpatient survival, survival without ECMO, and hospital length of stay (LOS). We incorporated centers with ≥30 cases into multivariable models to adjust for patient and clinical factors.</p><p><strong>Results: </strong>Analysis of 3639 infants revealed significant ICV. Unadjusted inpatient survival rate was 76.5%, with ICV ranging from 55.4% to 90.7%. The composite outcome of survival without ECMO was 63.3% (ICV: 38.6-87.9%). The median LOS for survivors was 50 days (ICV: 29-68 days). Multivariable analyses confirmed these trends, indicating an 18-fold variation in survival, a 35-fold variation in survival without ECMO, and a 3.3-fold variation in LOS across centers (p < 0.001 for all).</p><p><strong>Conclusion: </strong>The treating center was a significant predictor of risk-adjusted inpatient outcomes for infants with CDH. These findings highlight substantial disparities in care and support the integration of these metrics into future research and quality improvement efforts in level IV NICUs.</p><p><strong>Impact statement: </strong>This study reveals considerable inter-center differences in CDH outcomes, contributing extensive, multicenter data to the existing body of literature. It underscores how center-specific practices affect survival and ECMO use, suggesting that organized high-level care could enhance outcomes for CDH patients. These insights lay the groundwork for center-specific quality improvement initiatives to elevate the standard of care.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between physical fitness, physical activity, sedentary behavior and executive function in preschoolers.","authors":"Yesenia García-Alonso, Robinson Ramírez-Vélez, Gaizka Legarra-Gorgoñon, Mikel Izquierdo, Alicia M Alonso-Martínez","doi":"10.1038/s41390-025-03946-w","DOIUrl":"https://doi.org/10.1038/s41390-025-03946-w","url":null,"abstract":"<p><strong>Background: </strong>This study examined the association between individual physical fitness (PF) components, overall fitness scores, and executive function (EF) indicators in preschoolers. Additionally, it explored the relationship between objectively measured physical activity (PA), sedentary behavior (SB), and EF.</p><p><strong>Methods: </strong>This cross-sectional study included 241 preschoolers (121 males, 50%) aged 3-5 years from two different schools. Physical fitness was assessed using the PREFIT battery, which measures lower- and upper-body muscular strength (handgrip strength [HGS] and standing long jump [SLJ]), speed/agility (4 × 10 m), and cardiorespiratory fitness (CRF). The test scores for each student were standardized by age and sex. Individual z-scores were then calculated, and the sum of these z-scores constituted the overall PF. EF (including visual-spatial working memory, phonological working memory, inhibition, and cognitive shifting) was assessed using the one-on-one iPad-based Early Year Toolbox. Total PA, SB, and SB were objectively measured using a tri-axial GENEActiv Original accelerometer worn for six consecutive days.</p><p><strong>Results: </strong>Preschoolers with higher overall PF showed significantly better performance in visual-spatial working memory (β = 0.574, p < 0.001), phonological working memory (β = 0.317, p < 0.001), inhibition (β = 0.379, p < 0.001) and cognitive shifting (β = 0.395, p < 0.001). Similarly, greater engagement in total PA was associated with higher scores in visual-spatial working memory (β = 0.179, p = 0.016), phonological working memory (β = 0.237, p = 0.036), and inhibition (β = 0.148, p = 0.045), which had higher scores on inhibitory control and working memory tasks.</p><p><strong>Conclusion: </strong>These findings highlight the significant influence of PF and PA levels on cognitive performance. Therefore, educational and public health programs must implement strategies to encourage regular PA and improve PF. Such efforts could contribute to better cognitive development and overall health outcomes.</p><p><strong>Impact: </strong>This study emphasizes the importance of physical fitness, particularly muscular strength, speed agility, and cardiorespiratory fitness, in supporting executive function (EF) development in preschool-aged children. Early childhood education policies should prioritize structured physical activity programs to enhance cognitive functions such as working memory, inhibition, and cognitive flexibility. A direct inverse relationship between sedentary behavior and EF was observed. Limiting sedentary activities and encouraging movement in early childhood settings may yield significant cognitive benefits, suggesting that teachers and caregivers should promote more active environments for children. The findings indicate that overall physical fitness supports cognitive abilities rather than isolated fitness components.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life growth is related to pubertal growth and adult height - a QEPS-model analysis.","authors":"Carin Skogastierna, Anton Holmgren, Aimon Niklasson, Andreas F M Nierop, Aldina Pivodic, Anders Elfvin, Diana Swolin-Eide, Kerstin Albertsson-Wikland","doi":"10.1038/s41390-025-03939-9","DOIUrl":"https://doi.org/10.1038/s41390-025-03939-9","url":null,"abstract":"<p><strong>Background: </strong>The early life growth period, from conception to ~2 years of age, has proven crucial for later health. We hypothesized that early life growth could explain variations in pubertal growth and timing, and adult height.</p><p><strong>Methods: </strong>This retrospective, population-based study was conducted in Sweden. A subgroup, including individuals of all gestational ages and birth sizes (n = 4700, 50% males), from the longitudinal GrowUp_1974&1990Gothenburg cohorts was used. QEPS variables were analyzed in univariate and multivariate linear regression models, separately per sex; Q-function throughout all growth periods, and specific E- and P-functions, for early life growth and pubertal growth, respectively.</p><p><strong>Results: </strong>In multivariate models, early life growth explained 37-38% of the variability in specific pubertal growth, but less so the variability in pubertal timing. Variability in adult height was explained by birth size (57-62%), early growth (66-67%), childhood growth (65-69%), and to a lesser degree by mid-parental height (35-39%). The change in height during puberty explained 8-9% of the variation in adult height.</p><p><strong>Conclusion: </strong>This study indicates that early life growth is strongly associated with the variability in pubertal growth, and adult height, but not with the timing of pubertal growth.</p><p><strong>Impact: </strong>Early life growth is important as it can serve as a marker for future growth, development, and health. The association between length growth during fetal life and infancy and pubertal growth and timing, and adult height, is only partly understood. Using the QEPS growth model, specific early life growth (E-function) and specific pubertal growth (P-function), including individual variations in tempo and amplitude, can be studied separately from ongoing basic growth (Q-function). This study showed that early life growth is strongly associated with and explains specific pubertal height gain and adult height but less so the timing of pubertal growth.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation.","authors":"Jan W van der Scheer, Victoria Komolafe, Kirstin Webster, Stamatina Iliodromiti, Charles C Roehr, Asma Khalil, Tim Draycott, Louise Dewick, George Dunn, Rachel Walsh, Philip Steer, Alessandra Giusti, Mark L Cabling, Nick Fahy, Mary Dixon-Woods","doi":"10.1038/s41390-025-03949-7","DOIUrl":"10.1038/s41390-025-03949-7","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab successfully controlled eczema in Wiskott-Aldrich Syndrome over 52 weeks.","authors":"Changhua Zhu, Yaxuan Zheng, Lianming Liao, Jincong Chen, Lihang Lin, Huichun Su","doi":"10.1038/s41390-025-03941-1","DOIUrl":"https://doi.org/10.1038/s41390-025-03941-1","url":null,"abstract":"<p><strong>Impact statement: </strong>Wiskott-Aldrich syndrome (WAS) is a rare genetic disorder characterized by immunodeficiency, thrombocytopenia, and eczema. The Management of eczema remains still a major clinical challenge. We present a rare case of eczema associated with WAS in an 8-year-old boy whose lesions significantly improve after a 4-week treatment of dupilumab, a interleukin(IL)-4α receptor monoclonal antibody. Although eczema relapsed after stopping dupilumab, and alleviated after dupilumab was resumed. Finally, the Eczema Area and Severity Index (EASI) score decreased to less than 7 after the patient receive dupilumab 300 mg every 4 weeks over 52 weeks. This case suggests that dupilumab is a promising therapy alternative for patient with eczema in WAS.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hirschsprung's disease may increase the incidence of inflammatory bowel disease through alterations in CA1.","authors":"Enyang He, Bowen Shi, Miao Jia, Wenjing Sun, Kaili Chang, Hongyv Jiang, Wei Zhao, Hailan Zhao, Liang Dong, Xiaohong Die, Wei Feng, Hualei Cui","doi":"10.1038/s41390-025-03938-w","DOIUrl":"https://doi.org/10.1038/s41390-025-03938-w","url":null,"abstract":"<p><strong>Background: </strong>The role of Hirschsprung's disease (HSCR) for the development of inflammatory bowel disease (IBD) and the common pathogenesis of the diseases remains unclear. The objective is to investigate the relationship between HSCR and IBD.</p><p><strong>Methods: </strong>In our study, the Mendelian randomization approach was employed to analyze the causal relationships. A further search was conducted for differentially expressed genes (DEGs) between disease and control tissues in HSCR and IBD. Subsequently, the potential pathway mechanisms were subjected to an enrichment analysis. Furthermore, the molecular docking was employed to investigate the binding relationship between potential therapeutic targets and drugs.</p><p><strong>Results: </strong>The results show HSCR have an increased risk of developing IBD (IVW: OR = 1.048, P < 0.05; weighted median: OR = 1.065, P < 0.05). A total of 111 DEGs were identified in IBD, while 471 DEGs were observed in HSCR. CA1 was identified as core gene and exhibited lower expression levels in IBD (P < 0.05). Concomitantly, CA1 exhibited reduced expression levels in inflamed tissues. And the TNF and IL17 signaling pathway were found closely related to CA1 expression.</p><p><strong>Conclusion: </strong>In total, our study shows HSCR promote the occurrence of IBD and reveals pathogenesis. Our results suggest CA1 may provide novel insight for the treatment of HSCR complicated with IBD.</p><p><strong>Impact: </strong>Individuals with HSCR are at a higher risk of developing IBD (IVW: OR = 1.048, P < 0.05; Weighted median: OR = 1.065, P < 0.05). Patients with IBD exhibited lower expression levels of CA1 (P < 0.05). Furthermore, CA1 expression was found to be lower in inflamed tissues (P < 0.05). CA1 may provide novel insight for the treatment of HSCR complicated with IBD.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readability of paediatric participant information leaflets in research studies.","authors":"Cian P O'Halloran, Abhishek Agarwal, Daniel B Hawcutt, Louise Oni, James Moss","doi":"10.1038/s41390-025-03943-z","DOIUrl":"https://doi.org/10.1038/s41390-025-03943-z","url":null,"abstract":"<p><strong>Background: </strong>Information leaflets in research studies should be age-appropriate to be understood, however the formal readability of children's participant information leaflets (PILs) for research studies has not been assessed.</p><p><strong>Methods: </strong>A single-centre cross-sectional study assessing paediatric PILs. Six readability tests were applied (Gunning Fog Index (GFI), Simple Measure of Gobbledygook (SMOG), Flesch Kincaid Grade Level (FKGL), Coleman-Liau Index (CLI), Automated Readability Index (ARI) and Flesch Reading Ease score (FRE). Results were compared between age groups, and whether the PIL was from either a commercially sponsored or investigator led study.</p><p><strong>Results: </strong>191 paediatric PILs were included. Age categories; <10 years (n = 65), ≤12 (n = 73), ≤15 (n = 73) and ≥16 (n = 61); were used for analysis. There were 39 commercial PILs and 226 non-commercial PILs. For the ≤10 and ≤12 age bands, all 6 median readability scores exceeded the target age group (thus hard to read, p < 0.005), and there was no difference in readability scores between these two age bands. Four scores from the readability tests were considered age-appropriate in the ≤15 year category, and all median scores were age-appropriate in the ≥16 years age groups. Readability scores for children's PILs were significantly higher in commercially sponsored versus non-commercial studies (P < 0.005).</p><p><strong>Conclusion: </strong>Improvements are required to make children's PILs readable for the target audience, particularly in commercially sponsored research studies.</p><p><strong>Impact: </strong>Paediatric participant information leaflets may not be readable in research studies, especially in younger age groups. PILs for children participating in commercially sponsored studies were less readable than non-commercial studies. Research teams writing PILs for a paediatric study need to consider the use of readability tools to ensure that the information they are providing is readable by the target audience.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical impedance tomography in neonates: a review.","authors":"Ako A Ako, Ahmed Ismaiel, Shantanu Rastogi","doi":"10.1038/s41390-025-03929-x","DOIUrl":"https://doi.org/10.1038/s41390-025-03929-x","url":null,"abstract":"<p><p>Appropriate interventions informed by real-time assessment of pulmonary function in mechanically ventilated critically ill neonates can reduce the incidence of bronchopulmonary dysplasia, pneumothorax, intraventricular hemorrhage and other complications of newborn life. The respiratory system in neonates is uniquely different from older children, and its physiological and anatomic attributes increase neonatal vulnerability to respiratory distress and eventual failure. While significant advancements have been made in developing respiratory support for neonates, such support is accompanied by inherent risks to their delicate lungs. Ventilator-associated lung injury poses a critical concern that can be potentially decreased with more precise, non-invasive, non-radiating, bedside methods for assessing neonatal pulmonary function in real time. Electrical impedance tomography (EIT) is one such tool, with immense potential for real-time pulmonary function monitoring in neonates. Still relatively new and in the earliest stages of clinical adoption, EIT use in neonatal critical care has been reported in several studies. This review discusses the basic features of EIT, its distinct advantages over traditional pulmonary function monitoring tools, the scope of its adoption in neonatal clinical practice, challenges associated with clinical adoption, and prospects for future applications. IMPACT: 1. Individualized care assisted by bedside pulmonary function monitoring can positively impact neonatal critical care and outcomes. 2. Electrical impedance tomography (EIT) has the potential to improve neonatal pulmonary function monitoring and treatment outcomes. 3. Electrical impedance tomography can be adopted as a part of routine neonatal respiratory critical care, especially in the population of patients most at risk for bronchopulmonary dysplasia and acute respiratory complications.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between screen use and internalizing/externalizing problems among preschoolers: the mediation of circadian rhythm.","authors":"Jia Zhao, Naixue Cui, Yan Li, Guanghai Wang, Shunpeng Hu, Yinjun Hao, Jianghong Liu","doi":"10.1038/s41390-025-03944-y","DOIUrl":"https://doi.org/10.1038/s41390-025-03944-y","url":null,"abstract":"<p><strong>Background: </strong>Circadian disruption has been proposed as an etiological mechanism for psychopathology, yet its role in the relationship between screen use and emotional and behavioral problems remains under-investigated. This study aimed to examine the mediating effect of circadian rhythm in this relationship among young children.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 1111 children aged 2 to 7 years recruited from six kindergartens between March 2022 and June 2024. Parents reported children's screen time and use before sleep. Parents and teachers assessed internalizing and externalizing problems using the Strengths and Difficulties Questionnaire. Circadian rhythm, including chronotype and midsleep on free days corrected for sleep debt (MSF_sc), was measured using the Children's ChronoType Questionnaire. In a subsample, MSF_sc was also measured using actigraphy and sleep diaries.</p><p><strong>Results: </strong>Screen use was significantly associated with parent-reported internalizing and externalizing problems. Chronotype significantly mediated the relationships between screen use and parent-reported outcomes, whereas the results were not reproducible using MSF_sc derived from survey, actigraphy and sleep diaries.</p><p><strong>Conclusion: </strong>The mediation of delayed circadian phase in the relationship between screen use and internalizing and externalizing problems in young children may be negligible. Future research should explore the role of other circadian parameters in this relationship.</p><p><strong>Impact statement: </strong>Circadian disruption has been suggested as a potential mechanism linking screen-based media exposure to psychopathology. Using a triangulation approach that combined multiple data sources-survey, actigraphy, and sleep diaries-we found that the mediating effects of delayed circadian phase in the relationships between screen use and internalizing and externalizing problems were minimal in children aged 2 to 7 years. Future research should explore alternative circadian pathways and examine the long-term developmental effects of screen use during early childhood.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific evolution from the definition of Hirschsprung disease to the present: a bibliometric analysis (1980-2023).","authors":"Nurcan Çoşkun, Mehmet Metin","doi":"10.1038/s41390-025-03927-z","DOIUrl":"https://doi.org/10.1038/s41390-025-03927-z","url":null,"abstract":"<p><strong>Background: </strong>The primary objective of this study is to define the global productivity of Hirschsprung disease (HSCR), identify influential studies, determine research directions focused on both historical and contemporary perspectives.</p><p><strong>Methods: </strong>The study obtained 2816 articles published between 1980 and 2023 related to HSCR from the Web of Science database, and comprehensive bibliometric analysis were conducted.</p><p><strong>Results: </strong>The top three most productive countries were the USA (n = 1283), China (n = 1167), and Japan (n = 587). The most productive institution was Université Paris Cité (n = 149), and the most productive author was Prem Puri (n = 99). The most frequently used keywords in the articles were enterocolitis (n = 191), enteric nervous system (n = 136), and transanal endorectal pull-through (n = 129).</p><p><strong>Conclusion: </strong>Academic interest in HSCR began in 1887-1888, significantly increased in 1948 and 1964, and reached its highest peak in 1994. The findings indicate that key topics such as enterocolitis, enteric nervous system, surgical techniques, and genetic factors have been prominent in HSCR research. Previous studies, which often focused on molecular and genetic mechanisms, have shifted towards clinical and surgical applications in the last decade. Factor analysis reveals the complexity and diversity of HSCR research, with various topics examined, including clinical features, surgical treatments, pathological findings, and genetic bases.</p><p><strong>Impact statement: </strong>This study presents a comprehensive bibliometric analysis of global research trends and future directions in Hirschsprung disease, revealing significant changes and developments in the study of the disease. The study provides an important contribution to the existing literature by detailing the historical development, main research topics, and thematic evolution of Hirschsprung disease research. The findings indicate that future research focus in Hirschsprung disease may increasingly prioritize innovative approaches, such as stem cell therapy, alongside clinical and surgical advancements. These advancements have the potential to enhance patient quality of life and guide future research strategies.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}