Pediatric Research最新文献

{"title":"Electrical impedance tomography in neonates: a review.","authors":"Ako A Ako, Ahmed Ismaiel, Shantanu Rastogi","doi":"10.1038/s41390-025-03929-x","DOIUrl":"https://doi.org/10.1038/s41390-025-03929-x","url":null,"abstract":"<p><p>Appropriate interventions informed by real-time assessment of pulmonary function in mechanically ventilated critically ill neonates can reduce the incidence of bronchopulmonary dysplasia, pneumothorax, intraventricular hemorrhage and other complications of newborn life. The respiratory system in neonates is uniquely different from older children, and its physiological and anatomic attributes increase neonatal vulnerability to respiratory distress and eventual failure. While significant advancements have been made in developing respiratory support for neonates, such support is accompanied by inherent risks to their delicate lungs. Ventilator-associated lung injury poses a critical concern that can be potentially decreased with more precise, non-invasive, non-radiating, bedside methods for assessing neonatal pulmonary function in real time. Electrical impedance tomography (EIT) is one such tool, with immense potential for real-time pulmonary function monitoring in neonates. Still relatively new and in the earliest stages of clinical adoption, EIT use in neonatal critical care has been reported in several studies. This review discusses the basic features of EIT, its distinct advantages over traditional pulmonary function monitoring tools, the scope of its adoption in neonatal clinical practice, challenges associated with clinical adoption, and prospects for future applications. IMPACT: 1. Individualized care assisted by bedside pulmonary function monitoring can positively impact neonatal critical care and outcomes. 2. Electrical impedance tomography (EIT) has the potential to improve neonatal pulmonary function monitoring and treatment outcomes. 3. Electrical impedance tomography can be adopted as a part of routine neonatal respiratory critical care, especially in the population of patients most at risk for bronchopulmonary dysplasia and acute respiratory complications.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between screen use and internalizing/externalizing problems among preschoolers: the mediation of circadian rhythm.","authors":"Jia Zhao, Naixue Cui, Yan Li, Guanghai Wang, Shunpeng Hu, Yinjun Hao, Jianghong Liu","doi":"10.1038/s41390-025-03944-y","DOIUrl":"https://doi.org/10.1038/s41390-025-03944-y","url":null,"abstract":"<p><strong>Background: </strong>Circadian disruption has been proposed as an etiological mechanism for psychopathology, yet its role in the relationship between screen use and emotional and behavioral problems remains under-investigated. This study aimed to examine the mediating effect of circadian rhythm in this relationship among young children.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 1111 children aged 2 to 7 years recruited from six kindergartens between March 2022 and June 2024. Parents reported children's screen time and use before sleep. Parents and teachers assessed internalizing and externalizing problems using the Strengths and Difficulties Questionnaire. Circadian rhythm, including chronotype and midsleep on free days corrected for sleep debt (MSF_sc), was measured using the Children's ChronoType Questionnaire. In a subsample, MSF_sc was also measured using actigraphy and sleep diaries.</p><p><strong>Results: </strong>Screen use was significantly associated with parent-reported internalizing and externalizing problems. Chronotype significantly mediated the relationships between screen use and parent-reported outcomes, whereas the results were not reproducible using MSF_sc derived from survey, actigraphy and sleep diaries.</p><p><strong>Conclusion: </strong>The mediation of delayed circadian phase in the relationship between screen use and internalizing and externalizing problems in young children may be negligible. Future research should explore the role of other circadian parameters in this relationship.</p><p><strong>Impact statement: </strong>Circadian disruption has been suggested as a potential mechanism linking screen-based media exposure to psychopathology. Using a triangulation approach that combined multiple data sources-survey, actigraphy, and sleep diaries-we found that the mediating effects of delayed circadian phase in the relationships between screen use and internalizing and externalizing problems were minimal in children aged 2 to 7 years. Future research should explore alternative circadian pathways and examine the long-term developmental effects of screen use during early childhood.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific evolution from the definition of Hirschsprung disease to the present: a bibliometric analysis (1980-2023).","authors":"Nurcan Çoşkun, Mehmet Metin","doi":"10.1038/s41390-025-03927-z","DOIUrl":"https://doi.org/10.1038/s41390-025-03927-z","url":null,"abstract":"<p><strong>Background: </strong>The primary objective of this study is to define the global productivity of Hirschsprung disease (HSCR), identify influential studies, determine research directions focused on both historical and contemporary perspectives.</p><p><strong>Methods: </strong>The study obtained 2816 articles published between 1980 and 2023 related to HSCR from the Web of Science database, and comprehensive bibliometric analysis were conducted.</p><p><strong>Results: </strong>The top three most productive countries were the USA (n = 1283), China (n = 1167), and Japan (n = 587). The most productive institution was Université Paris Cité (n = 149), and the most productive author was Prem Puri (n = 99). The most frequently used keywords in the articles were enterocolitis (n = 191), enteric nervous system (n = 136), and transanal endorectal pull-through (n = 129).</p><p><strong>Conclusion: </strong>Academic interest in HSCR began in 1887-1888, significantly increased in 1948 and 1964, and reached its highest peak in 1994. The findings indicate that key topics such as enterocolitis, enteric nervous system, surgical techniques, and genetic factors have been prominent in HSCR research. Previous studies, which often focused on molecular and genetic mechanisms, have shifted towards clinical and surgical applications in the last decade. Factor analysis reveals the complexity and diversity of HSCR research, with various topics examined, including clinical features, surgical treatments, pathological findings, and genetic bases.</p><p><strong>Impact statement: </strong>This study presents a comprehensive bibliometric analysis of global research trends and future directions in Hirschsprung disease, revealing significant changes and developments in the study of the disease. The study provides an important contribution to the existing literature by detailing the historical development, main research topics, and thematic evolution of Hirschsprung disease research. The findings indicate that future research focus in Hirschsprung disease may increasingly prioritize innovative approaches, such as stem cell therapy, alongside clinical and surgical advancements. These advancements have the potential to enhance patient quality of life and guide future research strategies.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant sleep EEG features at 4 months as biomarkers of neurodevelopment at 18 months.","authors":"Soraia Ventura, Sean R Mathieson, John M O'Toole, Vicki Livingstone, Deirdre M Murray, Geraldine B Boylan","doi":"10.1038/s41390-025-03893-6","DOIUrl":"https://doi.org/10.1038/s41390-025-03893-6","url":null,"abstract":"<p><strong>Background: </strong>Sleep parameters evolve in parallel with neurodevelopment. Sleep participates in synaptic homeostasis and memory consolidation and infant sleep parameters correlate with later aspects of early childhood cognition.</p><p><strong>Methods: </strong>Typically developing, term-born infants had a diurnal sleep-EEG at 4 months and Griffiths III developmental assessment at 18 months. EEG analysis included sleep macrostructure (i.e. durations of total sleep and sleep stages, and latencies to sleep and REM), sleep spindle features, and quantitative EEG features (qEEG): interhemispheric connectivity and spectral power. We assessed the correlations between these EEG features and Griffiths III quotients.</p><p><strong>Results: </strong>Sleep recordings from 92 infants were analyzed. Sleep latency was positively associated with the Griffiths III Foundations of Learning subscale and N3 sleep duration was positively correlated with the Personal-Social-Emotional subscale. Sleep spindle synchrony was negatively associated with Eye and Hand Coordination, Personal-Social-Emotional, Gross Motor, and General Development quotients. Sleep spindle duration was negatively associated with the Personal-Social-Emotional and Gross Motor subscales. In some sleep states, delta 1 and 2 EEG spectral power and interhemispheric coherence measures were correlated with subscale quotients.</p><p><strong>Conclusion: </strong>Certain sleep features in the EEG of 4-month-old infants are associated with neurodevelopment at 18 months and may be useful early biomarkers of neurodevelopment.</p><p><strong>Impact: </strong>This study shows that the EEG during infant sleep may provide insights into later neurodevelopmental outcomes. We have examined novel EEG sleep spindle features and shown that spindle duration and synchrony may help predict neurodevelopmental outcomes. Sleep macrostructure elements such as latency to sleep, N3 duration, and qEEG features such as interhemispheric coherence and spectral power measures at 4 months may be useful for the assessment of future neurodevelopmental outcomes. Due to exceptional neuroplasticity in infancy, EEG biomarkers of neurodevelopment may support early and targeted intervention to optimize outcomes.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child somatic growth and neurodevelopment: effects of pregnancy lifestyle intervention.","authors":"Kristina Geyer, Roxana Raab, Monika Spies, Johanna Knoke, Dorothy Meyer, Stephanie Brandt-Heunemann, Hans Hauner","doi":"10.1038/s41390-025-03936-y","DOIUrl":"10.1038/s41390-025-03936-y","url":null,"abstract":"<p><strong>Objective: </strong>Maternal health behavior influences offspring health and obesity risk. This study examined the long-term effects of an antenatal lifestyle intervention on somatic growth and neurodevelopment of preschool-aged children.</p><p><strong>Methods: </strong>We followed children born to women in the cluster-randomized GeliS trial who received usual care (CG) or lifestyle counseling (IG). Anthropometrics and neurodevelopment data for children aged 4 and 5 were collected from routine health examinations and the Ages-and-Stages Questionnaire (ASQ).</p><p><strong>Results: </strong>Of 2 286 women initially enrolled, 1 403 reported on their child's development. The intervention had no effect on weight, height, head circumference, BMI, or percentiles and z-scores at ages 4 and 5. In IG compared to CG, the proportion of children with underweight was lower (4 years: 7.8% vs. 10.9%; 5 years: 8.1% vs. 8.9%), while overweight (4 years: 6.5% vs. 4.2%; 5 years: 5.1% vs. 3.4%) and obesity proportions (4 years: 1.0% vs. 1.1%; 5 years: 2.7% vs. 1.6%) were higher. IG children were more likely to fall into a higher weight category at 4 (p = 0.017) and 5 years (p = 0.075). ASQ scores were similar across both groups.</p><p><strong>Conclusion: </strong>Despite slight weight differences, the pregnancy lifestyle intervention had no meaningful impact on child somatic growth or neurodevelopment up to age 5.</p><p><strong>Impact: </strong>This comprehensive antenatal lifestyle intervention, executed as a large-scale real-world effectiveness trial, did not demonstrate any long-term effect on children's anthropometry or their risk of overweight or obesity up to 5 years of age. No discernible intervention effects were observed concerning children's neurodevelopment outcomes. Personalized antenatal interventions targeting the individual risk profiles of pregnant women may be needed to substantially modify lifestyle behaviors and achieve sustainable impacts on child development and obesity risk.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathiazol induces neuronal-like differentiation in neuroblastoma cells via upregulation of PEG5.","authors":"Hao Xu, Fei Zhang, Yi Xu, Tianpeng Chen, Fenqian Yuan, Qihong Nie","doi":"10.1038/s41390-025-03925-1","DOIUrl":"https://doi.org/10.1038/s41390-025-03925-1","url":null,"abstract":"<p><strong>Background: </strong>Differentiation therapy is emerging as a promising strategy for treating neuroblastoma. However, the effects of neuropathiazol, a small molecule known to induce neuronal differentiation, have not been explored in neuroblastoma.</p><p><strong>Procedure: </strong>Neuroblastoma cell lines were used to investigate the effects of neuropathiazol and retinoic acid on cell morphology, proliferation, and invasion in vitro. In vivo, neuroblastoma cells were implanted in nude mice to assess neuropathiazol's therapeutic potential. Silver staining and markers of mature neurons were employed to evaluate neuropathiazol's ability to promote neuronal differentiation.</p><p><strong>Results: </strong>Neuropathiazol significantly inhibited the proliferation and invasion of neuroblastoma cells in vitro. It also enhanced synaptic growth and increased the expression of mature neuron markers more effectively than retinoic acid. Neuropathiazol treatment upregulated PEG5 expression, suggesting its role in promoting neuronal differentiation. Silencing PEG5 reversed these differentiation effects, reducing neuronal features. In vivo, neuropathiazol suppressed tumor growth and induced neuron-like differentiation in tumor tissues. However, its efficacy was diminished when PEG5 was knocked down. Additionally, neuropathiazol synergized with cyclophosphamide, enhancing its anti-neuroblastoma effects.</p><p><strong>Conclusion: </strong>Neuropathiazol induces neuroblastoma differentiation, partly through PEG5 upregulation. As a promising differentiating agent for neuroblastoma, the combination of neuropathiazol and cyclophosphamide offers a potential treatment strategy for the disease.</p><p><strong>Impact: </strong>Neuropathiazol significantly inhibits neuroblastoma cell proliferation and invasion in vitro. Neuropathiazol promotes synaptic growth and upregulates mature neuronal marker expression more effectively than retinoic acid. Neuropathiazol induces significant neuronal-like differentiation of neuroblastoma cells in vivo, leading to tumor growth suppression. PEG5 is identified as a critical mediator of neuropathiazol's differentiation-inducing effects. Knockdown of PEG5 reverses these effects, underscoring its pivotal role. The combination of neuropathiazol with cyclophosphamide synergistically enhances anti-neuroblastoma effects, offering a compelling pharmacotherapeutic strategy.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Human milk feeding to drive impactful immune health and outcomes in vulnerable preterm infants should evaluate maternal confounders.","authors":"Christina J Valentine","doi":"10.1038/s41390-025-03932-2","DOIUrl":"https://doi.org/10.1038/s41390-025-03932-2","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-oriented, hospital level genetics: a new approach to improve access for underserved communities.","authors":"Yoel Gofin, Fadel Tibi, Eliana Fanous, Shay Ben-Shachar, Rivka Sukenik-Halevy","doi":"10.1038/s41390-025-03908-2","DOIUrl":"https://doi.org/10.1038/s41390-025-03908-2","url":null,"abstract":"<p><strong>Background: </strong>Certain populations are at increased risk for genetic syndromes but have limited access to genetic testing.</p><p><strong>Methods: </strong>We founded a community-based, pediatric genetics clinic in the Muslim-Arab city of Tayibe, Israel. Children with suspected genetic conditions of consanguineous parents, or families with two or more affected siblings were referred by local staff. The clinic was staffed by a Meir Medical Center (MMC) clinical geneticist. Blood samples were collected during the initial visit. Tests were publicly funded, with no parental involvement in administrative procedures required. A control group consisted of MMC pediatric genetics clinic patients.</p><p><strong>Results: </strong>During the first year, 30 children were assessed. No patients were lost to follow-up, compared to 8 (28%) in the MMC control group. The average time to test results was shorter in the Tayibe group and the diagnostic rate was higher, with 27.6% receiving a diagnosis (42.9%, excluding autism cases).</p><p><strong>Conclusion: </strong>Our first-year experience shows the success and promising results of this model, with advantages in almost all parameters, compared to the traditional, hospital-based clinic. Factors such as faster time-to-results, greater family adherence and satisfaction, and zero lost to follow-up rate suggest considering implementing this model for providing genetic services to other underserved populations.</p><p><strong>Impact: </strong>A community-oriented approach for a pediatric genetics clinic allowed reaching high-risk populations, with increased adherence, faster results and a higher yield. Our clinic relied solely on available public funding and staff, requiring no additional contributions. The current dogma of hospital-based genetics services should be reconsidered.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega and heart rate variability in overweight and obese schoolchildren.","authors":"Hoda Atef Abdelsattar Ibrahim, Rodina Sobhi, Nouran Khaled Farouk, Faten Mohamed AbdelAziz","doi":"10.1038/s41390-025-03913-5","DOIUrl":"https://doi.org/10.1038/s41390-025-03913-5","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obese children are risky for developing chronic cardiovascular disorders. Heart rate variability is a valuable indicator of the cardiovascular health.</p><p><strong>Aim: </strong>To outline the impact of supplementation of omega-3 on the variability of the heart rate.</p><p><strong>Methods: </strong>A randomized interventional control study has been done on 60 overweight and obese children; 30 children were assigned to the interventional group who received omega-3 with the standard recommendations and 30 children were assigned to the control group who received the standard recommendations only. Resting 10 min Holter ECG was done at the start and after 3 months of omega-3 supplementation in both groups to observe and compare the difference in the heart rate variability. In addition, lipid profiles were investigated and compared.</p><p><strong>Results: </strong>Difference in measures of the heart rate variability; RMSSD, SDNN, and pNN50 were increased significantly in cases compared to the controls (P value = 0.017, 0.009, and 0.043 respectively). Differences in measures of the lipid profiles differed only in triglycerides which decreased significantly in cases and HDL which increased significantly in the cases (P value = 0.006, 0.005 respectively).</p><p><strong>Conclusion: </strong>Our results suggested that omega-3 supplementation might improve cardiovascular health in overweight and obese children.</p><p><strong>Impact: </strong>This study discloses the importance of supplementation of omega-3 fatty acids as a cardioprotective dietary supplement. Omega-3 fatty acids can improve heart rate variability in overweight and obese children. Omega-3 fatty acids can also improve the lipid profiles in overweight and obese children.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between heat exposure and intussusception in children in Japan from 2011 to 2022.","authors":"Nobutoshi Nawa, Hisaaki Nishimura, Kiyohide Fushimi, Takeo Fujiwara","doi":"10.1038/s41390-025-03930-4","DOIUrl":"https://doi.org/10.1038/s41390-025-03930-4","url":null,"abstract":"<p><strong>Background: </strong>Exposure to heat may increase the risk of intussusception through various mechanisms, including alterations in dietary intake. However, no nationwide studies have examined the association between daily heat exposure and intussusception in children. This study aims to examine the association between higher daily ambient temperatures and intussusception in children.</p><p><strong>Methods: </strong>The daily number of intussusception hospitalizations among children up to 5 years old from 2011 to 2022 was extracted from Japan's nationwide administrative claims database. Daily mean temperature data were obtained from the Japan Meteorological Agency. Since the focus is on heat exposure, the analysis examines hospitalizations that occurred during the five warmest months (May to September). A time-stratified case-crossover design with conditional quasi-Poisson regression analysis was applied to estimate the relative risk of heat exposure on intussusception with a lag of 0-4 days.</p><p><strong>Results: </strong>There were 13,083 cases of intussusception hospitalizations. Higher daily mean temperatures were associated with an elevated risk of intussusception hospitalizations. Specifically, exposure to extremely high daily mean temperatures at the 99th percentile was associated with a 39% increase in hospitalization risk (95% CI: 1.05, 1.83).</p><p><strong>Conclusion: </strong>The study found the association between higher daily mean temperatures and an increased risk of hospitalization for intussusception. Future research should clarify the mechanisms of the association between higher daily mean temperatures and the increased risk of intussusception hospitalizations.</p><p><strong>Impact: </strong>While exposure to heat may increase the risk of intussusception through mechanisms such as alterations in dietary intake and intestinal motility, no nationwide studies have investigated the association between daily heat exposure and intussusception in children. The study found the association between higher daily mean temperatures and an increased risk of hospitalization for intussusception. Both caregivers and healthcare providers should be aware of a potential increase in pediatric intussusception cases during warmer days, which may become even more critical as climate change results in more frequent and severe heat events.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}