Pathophysiology of Haemostasis and Thrombosis最新文献_第3页

The influence of tissue factor and tissue factor pathway inhibitor polymorphisms on thrombin generation in stable coronary artery disease. 组织因子及组织因子通路抑制剂多态性对稳定型冠状动脉疾病凝血酶生成的影响。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2011-05-10 DOI: 10.1159/000327491

Trine B Opstad, Alf-Aage R Pettersen, Vibeke Bratseth, Harald Arnesen, Ingebjørg Seljeflot

{"title":"The influence of tissue factor and tissue factor pathway inhibitor polymorphisms on thrombin generation in stable coronary artery disease.","authors":"Trine B Opstad, Alf-Aage R Pettersen, Vibeke Bratseth, Harald Arnesen, Ingebjørg Seljeflot","doi":"10.1159/000327491","DOIUrl":"https://doi.org/10.1159/000327491","url":null,"abstract":"In patients with stable coronary heart disease (n = 1,001) we investigated the influence of tissue factor (TF) and TF pathway inhibitor (TFPI) polymorphisms on thrombin generation in vivo, measured by prothrombin fragment (F) 1 and 2, and the potential to generate thrombin ex vivo, measured by the calibrated automated thrombogram assay. Additionally, circulating levels of TF and TFPI were correlated to the different parameters of thrombin generation. The TF 5466 and TFPI -399 polymorphisms associated with higher thrombin generation in vivo, the latter also with a prolonged lag time of the thrombin generation ex vivo(p < 0.05 for all).The TF -1812 TT and the TF -603 GG genotypes were associated with lower peak thrombin and a decreased average net rate of thrombin activation during the propagation phases (p ≤ 0.05), and the TFPI -33 TC genotype with prolonged lag time (p < 0.05) and additionally time to peak (p = 0.06). Strong correlations between TFPI levels, prothrombin fragment 1 and 2 as well as calibrated automated thrombogram parameters were observed.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 2-4","pages":"98-103"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000327491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29869309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The start of a new era-antithrombotic agents. Abstracts from the 21st International Congress on Thrombosis. July 6-9, 2010. Milan, Italy. 一个新时代的开始——抗血栓药物。第21届国际血栓形成大会摘要。2010年7月6日至9日。米兰,意大利。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-06-29 DOI: 10.1159/000318089

引用次数: 0

Effects of short-term streptozotocin-induced diabetes and vitamin C on platelet non-enzymatic glycation. 短期链脲佐菌素诱导的糖尿病和维生素C对血小板非酶糖化的影响。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2011-01-20 DOI: 10.1159/000322916

Saime Batırel, Ayşen Yarat, Nesrin Emekli

{"title":"Effects of short-term streptozotocin-induced diabetes and vitamin C on platelet non-enzymatic glycation.","authors":"Saime Batırel, Ayşen Yarat, Nesrin Emekli","doi":"10.1159/000322916","DOIUrl":"https://doi.org/10.1159/000322916","url":null,"abstract":"Diabetes mellitus is one of the most prevalent metabolic syndromes worldwide. Glycation, a chemical modification of proteins with reducing sugars, indicates a possible explanation for the association between hyperglycemia and the wide variety of tissue pathologies. Non-enzymatic glycation (NEG) of platelet proteins is one of the key mechanisms in the pathogenesis of diabetic complications and may be significant in diabetic atherothrombosis. The aim of this study was to investigate the effects of streptozotocin (STZ)-induced short-term experimental diabetes on the glycation of platelets and to find out if vitamin C affected this glycation. A total of 40 male Wistar albino rats, 200-250 g, were randomly divided into 4 groups (2 diabetic and 2 control groups). The diabetic groups were made diabetic by intraperitoneal injection of STZ (65 mg/kg, citrate buffer pH 4.5). By daily intraperitoneal injection, 80 mg/kg vitamin C (Roche, Turkey) was administered until the end of the experiment. Blood glucose levels of the diabetic groups were significantly higher than those at day 0 and also higher than those of the non-diabetic control groups. The changes in total protein, NEG and vitamin C levels were not statistically significant. Although the differences among the groups were not statistically significant, vitamin C administration increased NEG levels in the diabetic group. The results of this study demonstrate that 8 days of STZ-induced short-term diabetes did not cause a significant increase in NEG of platelets. However, the effect of vitamin C on platelet NEG needs to be further investigated.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 2-4","pages":"72-6"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000322916","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29614154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Impact of chemotherapy on thrombin generation and on the protein C pathway in breast cancer patients. 化疗对乳腺癌患者凝血酶生成及蛋白C通路的影响

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2011-03-23 DOI: 10.1159/000324166

Som D Mukherjee, Laura L Swystun, Nigel Mackman, Jian-Guo Wang, Gregory Pond, Mark N Levine, Patricia C Liaw

{"title":"Impact of chemotherapy on thrombin generation and on the protein C pathway in breast cancer patients.","authors":"Som D Mukherjee, Laura L Swystun, Nigel Mackman, Jian-Guo Wang, Gregory Pond, Mark N Levine, Patricia C Liaw","doi":"10.1159/000324166","DOIUrl":"https://doi.org/10.1159/000324166","url":null,"abstract":"Although thromboembolism is a problematic complication of chemotherapy, the pathogenic mechanisms by which chemotherapeutic agents exert prothrombotic effects in vivo are unclear.The objective of this study was to examine the effects of adjuvant chemotherapy on thrombin generation, the protein C anticoagulant pathway, and microparticle tissue factor (MP TF) activity in 26 breast cancer patients (stages I to III). The patients received cyclophosphamide, 5-fluorouracil, and methotrexate, epirubicin, or doxorubicin. Plasma samples were collected on day 1 (baseline), day 2, and day 8 for the first 2 cycles of chemotherapy. Levels of thrombin-antithrombin (TAT) complexes, MP TF activity, and components of the protein C anticoagulant pathway, including protein C, activated protein C (APC), soluble thrombomodulin (sTM), and soluble endothelial protein C receptor (sEPCR), were measured. Compared to prechemotherapy baseline levels, plasma TAT, protein C, and APC were significantly different following the administration of chemotherapy (p < 0.01 for each). Plasma TAT was higher in cycle 1, day 2, and cycle 2, day 8, compared to baseline. Plasma protein C levels were lower in cycle 2, day 8, whereas plasma APC levels were lower in cycle 2, day 1, and cycle 2, day 8. No significant changes were found in plasma sEPCR, sTM, or MP TF activity. This study suggests that adjuvant chemotherapy in women with breast cancer increases thrombin generation and impairs the endothelium-based protein C anticoagulant pathway.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 2-4","pages":"88-97"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000324166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29763780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Levels of C-reactive protein and protein C in periodontitis patients with and without cardiovascular disease. 伴有和不伴有心血管疾病的牙周炎患者的C反应蛋白和C蛋白水平

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-07-03 DOI: 10.1159/000318189

Ezgi Malali, Isik Basar, Ebru Emekli-Alturfan, Eser Elemek, Sehkar Oktay, Faruk Ayan, Nesrin Emekli, Ulku Noyan

{"title":"Levels of C-reactive protein and protein C in periodontitis patients with and without cardiovascular disease.","authors":"Ezgi Malali, Isik Basar, Ebru Emekli-Alturfan, Eser Elemek, Sehkar Oktay, Faruk Ayan, Nesrin Emekli, Ulku Noyan","doi":"10.1159/000318189","DOIUrl":"https://doi.org/10.1159/000318189","url":null,"abstract":"Since periodontitis is a chronic and inflammatory disease, a number of hypotheses have proposed that it has an etiological or modulating role in cardiovascular disease (CVD). This study aimed to ascertain the changes in the plasma levels of C-reactive protein (CRP) and protein C (PC), a natural anticoagulant also having an anti-inflammatory effect, in patients who have mild-to-severe periodontitis with or without CVD. The test group consisted of 26 patients with CVD and chronic periodontitis and the control group consisted of 26 patients with chronic periodontitis and no systemic disease. In both groups Community Periodontal Index of Treatment Needs scores were recorded and blood samples were collected. CRP levels were significantly high and PC activity was significantly low in the test group compared to the control group (p < 0.001). There was a negative correlation between tooth loss and PC and between CRP and PC. How PC is affected by the inflammatory events and its association with CRP is an active area of investigation.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000318189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29104408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va. 在Va因子失活过程中，V因子是活化蛋白C的一种抗凝辅因子。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-05-22 DOI: 10.1159/000315141

Thomas J Cramer, John H Griffin, Andrew J Gale

引用次数: 29

Splenomegaly in primary antiphospholipid syndrome without accompanying portal hypertension or comorbidity. 原发性抗磷脂综合征伴脾肿大，无门静脉高压或合并症。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2011-05-10 DOI: 10.1159/000327506

Mehmet Ali Cikrikcioglu, Mehmet Hursitoglu, Hafize Erkal, Bekir Inan, Turkan Ozturk, Mustafa Cakirca, Fatih Canpolat, Serdar Erkal, Ismet Bahtiyar, Ilker Cordan, Tufan Tukek

{"title":"Splenomegaly in primary antiphospholipid syndrome without accompanying portal hypertension or comorbidity.","authors":"Mehmet Ali Cikrikcioglu, Mehmet Hursitoglu, Hafize Erkal, Bekir Inan, Turkan Ozturk, Mustafa Cakirca, Fatih Canpolat, Serdar Erkal, Ismet Bahtiyar, Ilker Cordan, Tufan Tukek","doi":"10.1159/000327506","DOIUrl":"https://doi.org/10.1159/000327506","url":null,"abstract":"Objective: To demonstrate the presence of splenomegaly in primary antiphospholipid syndrome (PAPS) patients without accompanying portal hypertension or comorbidity.Methods: Twelve patients (7 women) aged 23-65 years followed upon the diagnosis of PAPS were enrolled in the study. We documented the identified causes of splenomegaly in patients with PAPS, and searched for the potential causes of splenomegaly in patients with spleen enlargement. PAPS patients with or without splenomegaly were evaluated in terms of demographic and clinical findings.Results: Splenomegaly was present in 6 of the 12 patients. In these patients, there were no infections, hematological disorders, portal hypertension or malignancy that might lead to splenomegaly. The long axis of spleen was found to be in the range of 137-155 mm in patients with splenomegaly. Splenomegaly was more frequently determined in female PAPS patients. The splenomegaly group had a longer duration of disease (median 5.5 vs. 0.75 years) and a higher number of thrombotic events (median 3 vs. 1.5). The splenomegaly group was especially composed of patients who never received any anticoagulant and acetylsalicylic acid, or who used these agents irregularly for very short periods.Conclusion: Splenomegaly was observed in association with disease duration, frequency of thrombotic events and irregular antiaggregant or anticoagulant treatment in patients with PAPS, in the absence of comorbidity or portal hypertension.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 2-4","pages":"104-9"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000327506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29869308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Statin treatment for primary and secondary prevention of pulmonary embolism: A population based case-control study 他汀类药物治疗一级和二级预防肺栓塞:一项基于人群的病例对照研究

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 DOI: 10.1159/000318095

S. Biere-Rafi, V. Gerdes, B. Hutten, A. Squizzato, W. Ageno, P. Souverein, A. Boer, H. Büller, P. Kamphuisen

引用次数: 1

Platelet function and spontaneous thrombolytic activity of patients with cerebral infarction assessed by the global thrombosis test. 脑梗死患者血小板功能和自发溶栓活性的全球血栓试验评估。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-05-28 DOI: 10.1159/000315494

Katsushi Taomoto, Hideyuki Ohnishi, Yoshihiro Kuga, Kazuya Nakashima, Tsugumichi Ichioka, Yuuji Kodama, Hisashi Kubota, Takashi Tominaga, Tomofumi Hirose, Masato Hayashi, Chifumi Kinugasa, Tsutomu Yamashita, Junichiro Yamamoto

{"title":"Platelet function and spontaneous thrombolytic activity of patients with cerebral infarction assessed by the global thrombosis test.","authors":"Katsushi Taomoto, Hideyuki Ohnishi, Yoshihiro Kuga, Kazuya Nakashima, Tsugumichi Ichioka, Yuuji Kodama, Hisashi Kubota, Takashi Tominaga, Tomofumi Hirose, Masato Hayashi, Chifumi Kinugasa, Tsutomu Yamashita, Junichiro Yamamoto","doi":"10.1159/000315494","DOIUrl":"https://doi.org/10.1159/000315494","url":null,"abstract":"Measurements of platelet reactivity and assessment of the efficacy of antiplatelet drugs are widely recognized as pre-requisite for the diagnosis and treatment of stroke patients. A recently established shear-induced platelet reactivity test using non-anticoagulated blood (the Global Thrombosis Test) has facilitated measurements of physiologically relevant platelet function and thrombolytic activity. 195 healthy volunteers, not taking antiplatelet drugs or anticoagulants, and 185 patients with acute cerebrovascular diseases were enrolled. The effect of antiplatelet drugs on platelet function and thrombolytic activity was assessed using the Global Thrombosis Test after 14 days of medication. The occlusion time (OT), an index of platelet reactivity, in healthy controls was 284.9 ± 92.2 s. The lysis time (LT), an index of thrombolytic activity, in healthy controls was 2,231 ± 1,223 s. Both times had no significant difference between males and females. The OT of all stroke patients was 210.3 ± 140.8 s and was shorter than that of the healthy controls (284.9 ± 92.2, p < 0.0001). The LT of all stroke patients was 3,159 ± 1,549 s and was longer than that of the controls (2,231 ± 1,223, p < 0.0001). Medication significantly prolonged the OT from 184.5 ± 150.6 s (before) to 295.3 ± 208.1 s (after) in all patients, indicating a reversal of the hyper-platelet reactivity. In addition, medication shortened the LT from 3,924 ± 1,718 s (before) to 3,107 ± 1,794 s (after) in all patients. A prothrombotic state exists in stroke patients due to enhanced platelet function and suppressed thrombolytic activity. Medication improved these physiological parameters of haemostasis.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 1","pages":"43-8"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000315494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29029292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

New insight into the mechanism of Lonomia obliqua envenoming: toxin involvement and molecular approach. 新见解对机制的斜凤尾:毒素参与和分子途径。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-08-14 DOI: 10.1159/000320067

M P Alvarez Flores, M Zannin, A M Chudzinski-Tavassi

{"title":"New insight into the mechanism of Lonomia obliqua envenoming: toxin involvement and molecular approach.","authors":"M P Alvarez Flores, M Zannin, A M Chudzinski-Tavassi","doi":"10.1159/000320067","DOIUrl":"https://doi.org/10.1159/000320067","url":null,"abstract":"Despite the nearly worldwide distribution of Lepidoptera, there are few species with clear documentation of adverse reactions in humans. Most syndromes caused by Lepidoptera are consequences of direct contact with the hairs or setae of caterpillars. In most instances, the adverse effects caused by moth and caterpillars are self-limited and the treatment is based on the removal of hairs, application of topical antipruritics and, in some cases, the use of oral antihistamines. However, in the case of envenoming by South American Lonomiaobliqua caterpillars, the antilonomic serum produced at Instituto Butantan in Brazil is the only effective treatment to re-establish the physiological coagulation parameters in poisoned patients and to abolish the complications seen in severe cases (e.g. consumptive coagulopathy, intracerebral hemorrhage, and acute renal failure). Many studies have been carried out to understand the pathophysiological mechanism of envenoming by L. obliqua. Several toxic principles were found in bristle extract and the hemolymph, probably related to the envenoming. An interesting fact is that some toxins from the venom usually have more than one function. With the advent of molecular biology techniques it has become possible to analyze these processes at a molecular level, thus giving rise to hypotheses on the molecular basis of envenomation. This review contributes to enhance our understanding of the dramatic alterations that hemorrhagic syndrome causes in patients, current treatment, and the diversity of the molecules involved in this pathology.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 1","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000320067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29192102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17