Pathophysiology of Haemostasis and Thrombosis最新文献_第10页

Contents Vol. 34, 2005 目录2005年第34卷

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-06-01 DOI: 10.1159/000093990

Katherine Schulz-Heik, Jaimohan Ramachandran, W. Ageno, R. Strey, T. Siegemund, Christine Schubert, G. Schuster, Karin Wulff, F. Herrmann, M. Šabovič, Vida Bojec, D. Imberti, J. Jesty, A. Siegemund, L. Mattar, I. C. Ferrari, Guareide Carelli, I. Zupan, D. Bluestein, L. Carvalho, I. A. Thomazini-Santos, B. Salobir, F. Maffei, A. Ihara, Kengo Matsumoto, T. Kawamoto, S. Shouno, J. Kawamoto, Akira Katayama, M. Yoshitatsu, H. Izutani, Petra Bratina, J. Ponikvar, M. Fouassier, D. Moreau, F. Thiolliére, C. Frère, A. Marquès-Verdier, B. Souweine

引用次数: 0

Subject Index Vol. 34, 2005 主题索引，2005年第34卷

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-06-01 DOI: 10.1159/000093989

Katherine Schulz-Heik, Jaimohan Ramachandran, W. Ageno, R. Strey, T. Siegemund, Christine Schubert, G. Schuster, Karin Wulff, F. Herrmann, M. Šabovič, Vida Bojec, D. Imberti, J. Jesty, A. Siegemund, L. Mattar, I. C. Ferrari, Guareide Carelli, I. Zupan, D. Bluestein, L. Carvalho, I. A. Thomazini-Santos, B. Salobir, F. Maffei, A. Ihara, Kengo Matsumoto, T. Kawamoto, S. Shouno, J. Kawamoto, Akira Katayama, M. Yoshitatsu, H. Izutani, Petra Bratina, J. Ponikvar, M. Fouassier, D. Moreau, F. Thiolliére, C. Frère, A. Marquès-Verdier, B. Souweine

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Title Page / Table of Contents 标题页/目录

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-05-01 DOI: 10.1159/000093465

引用次数: 0

Subject Index Vol. 34, No. 4–5, 2005 专题索引第34卷，2005年第4-5期

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-05-01 DOI: 10.1159/000093467

引用次数: 0

Author Index Vol. 34, No. 4–5, 2005 作者索引，第34卷，2005年第4-5期

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-05-01 DOI: 10.1159/000093466

引用次数: 0

Oral and Poster Presentations 口头及海报演讲

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-05-01 DOI: 10.1159/000093567

Redakcja Nt

引用次数: 2

Aspirin resistance. 阿司匹林抵抗。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-01-01 DOI: 10.1159/000093570

Alan D Michelson

引用次数: 1

Procoagulant microparticles: 'criminal partners' in atherothrombosis and deleterious cellular exchanges. 促凝微粒:动脉粥样硬化血栓形成和有害细胞交换中的“犯罪伙伴”。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-01-01 DOI: 10.1159/000093538

Olivier Morel, Florence Toti, Babé Bakouboula, Lélia Grunebaum, Jean-Marie Freyssinet

{"title":"Procoagulant microparticles: 'criminal partners' in atherothrombosis and deleterious cellular exchanges.","authors":"Olivier Morel, Florence Toti, Babé Bakouboula, Lélia Grunebaum, Jean-Marie Freyssinet","doi":"10.1159/000093538","DOIUrl":"https://doi.org/10.1159/000093538","url":null,"abstract":"Procoagulant microparticles (MP) constitute valuable hallmarks of vascular cell damage at the crossroad of atherothrombosis processes. Detectable at low concentrations in the blood flow of healthy individuals, elevated levels of procoagulant microparticles are characteristic features of most cardiovascular risk factors. Circulating MP support cellular cross-talk leading to vascular inflammation, endothelial dysfunction, leukocyte adhesion and recruitment possibly contributing to plaque growth with consecutive development of local thrombosis and altered vasomotion. Within the plaque, MP shed by apoptotic monocytes and smooth muscle cells are major determinant of plaque thrombogenicity mainly through the presence of tissue factor (TF) activity. Besides this procoagulant potential, trapped MP could contribute to plaque vulnerability through multiple pathways including angiogenesis, extracellular matrix proteolysis, recruitment of inflammatory cells, smooth muscle cell and endothelial apoptosis. Having long been considered sufficient to initiate coagulation following plaque disruption, the role assigned to plaque-bound TF does not appear physically realistic at a macroscopic scale, the swift growth of the thrombus probably involving blood-borne TF conveyed by circulating MP. As participants in crucial steps of atherosclerotic disease, MP can now be viewed as \"partners in crime\" in acute ischemic syndromes.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"35 1-2","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000093538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26153387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

HDL--associated paraoxonase 1 (PON1) and dietary antioxidants attenuate lipoprotein oxidation, macrophage foam cells formation and atherosclerosis development. HDL相关的对氧磷酶1 (PON1)和膳食抗氧化剂可减弱脂蛋白氧化、巨噬细胞泡沫细胞形成和动脉粥样硬化的发展。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-01-01 DOI: 10.1159/000093558

Michael Aviram

{"title":"HDL--associated paraoxonase 1 (PON1) and dietary antioxidants attenuate lipoprotein oxidation, macrophage foam cells formation and atherosclerosis development.","authors":"Michael Aviram","doi":"10.1159/000093558","DOIUrl":"https://doi.org/10.1159/000093558","url":null,"abstract":"Dietary antioxidants act as a first line of defense against lipids peroxidation in lipoproteins and in arterial cells, including macrophage foam cells. A second line of defense by antioxidants could be related to stimulation of paraoxonases (PONs). PON1 is associated in serum with high density lipoprotein (HDL). The activity of serum PON1 was shown to be inversely associated with the risk for atherosclerosis development and this phenomenon could be related to the ability of PON 1 to protect lipids in LDL, HDL and arterial cells against oxidation, secondary to its hydrolytic action on specific oxidized lipids. PON1 was shown to play a major role in protecting against oxidative stress and its consequent cardiovascular diseases development. Dietary intervention with appropriate nutraceuticals, with most potent and diverse antioxidative properties most efficiently attenuate cardiovascular diseases progression. Major risk factors for atherosclerosis development include the quantity and quality of low density lipoprotein (LDL, “The bad cholesterol”) and that of high density lipoprotein (HDL, “the good cholesterol”). High","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"35 1-2","pages":"146-51"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000093558","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26154350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Modified low-density lipoproteins and high-density lipoproteins. From investigation tools to real in vivo players. 改性低密度脂蛋白和高密度脂蛋白。从调查工具到真实的活体玩家。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2006-01-01 DOI: 10.1159/000093225

Elisabeth Koller, Ivo Volf, Aner Gurvitz, Franz Koller

{"title":"Modified low-density lipoproteins and high-density lipoproteins. From investigation tools to real in vivo players.","authors":"Elisabeth Koller, Ivo Volf, Aner Gurvitz, Franz Koller","doi":"10.1159/000093225","DOIUrl":"https://doi.org/10.1159/000093225","url":null,"abstract":"It has long been known that the oxidative state of the various plasma lipoproteins modulates platelet aggregability, thereby contributing to atherogenesis. Low-density lipoprotein (LDL), occurring in vivo both in the native and oxidised forms, interacts directly with platelets, by binding to specific receptors. While the identity of the receptors for native LDL and some subfractions of high-density lipoproteins (HDL) remains disputed, apoE-containing HDL(2) binds to LRP8. The nature of these interactions as well as the distinction between candidate receptor proteins was elucidated using covalently modified apolipoproteins, which pointed to the participation of apolipoproteins in high affinity binding. However, the platelet effects initiated by binding of native lipoproteins remain controversial. Some of this ambiguity can be traced to the fact that native LDL inevitably undergoes substantial oxidisation upon modification, including by radiolabelling. The platelet-activating effects provoked by oxidised LDL are irrefutable, but many details remain unknown. The role of CD36 in platelet binding by oxidised LDL is well established, although additional receptors may exist. Much less is known about the interaction of oxidised HDL with platelets, since platelet activation was observed in some, but not all studies. Various frequently applied in vitro oxidation methods produce modified lipoprotein species that may not be relevant in vivo. Based on the reported modifications obtained by in vitro oxidation of LDL, early investigations focused mainly on the formation and the eventual effects of oxidised lipids. More recently, alterations to lipoproteins performed using hypochloric acid and myeloperoxidase redirected the attention to the role of modified apoproteins in triggering platelet responses.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"35 3-4","pages":"322-45"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000093225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26172118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9