Pathophysiology of Haemostasis and Thrombosis最新文献_第2页

Subject Index Vol. 36, 2007–08 主题索引第36卷，2007-08

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-05-01 DOI: 10.1159/000314972

M. Fodor, A. Facskó, E. Berényi, I. Sziklai, A. Berta, G. Pfliegler, E. Emekli-Alturfan, I. Basar, A. Alturfan, F. Ayan, L. Koldaş, H. Balcı, N. Emekli, C. Yatagai, Tatsuya Singu, M. Maruyama, H. Sumi, Takefumi Matsuo, Miyako Matsuo, T. Sugimoto, K. Wanaka, R. Ravindran, L. Krishnan

引用次数: 0

Author Index Vol. 36, 2007–08 作者索引卷36,2007-08

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-05-01 DOI: 10.1159/000314971

Giorgi Pierfranceschi

引用次数: 0

The effect of chronic cadmium toxicity on blood pressure and plasma viscosity. 慢性镉中毒对血压和血浆粘度的影响。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2011-03-10 DOI: 10.1159/000323702

Mehtap Kacar Kocak, Nuray Yazihan, Ethem Akcil, Meltem Bay, Onder Aslan

{"title":"The effect of chronic cadmium toxicity on blood pressure and plasma viscosity.","authors":"Mehtap Kacar Kocak, Nuray Yazihan, Ethem Akcil, Meltem Bay, Onder Aslan","doi":"10.1159/000323702","DOIUrl":"https://doi.org/10.1159/000323702","url":null,"abstract":"Cadmium (Cd) is a heavy metal which affects many systems in humans and animals as a consequence of environmental and industrial pollution. The aim of this study was to investigate the effect of chronic Cd toxicity on blood pressure and plasma viscosity. Experimental group rats were given doses that contained 15 ppm CdCl(2) in drinking water for 8 weeks. The systolic blood pressure and heart rate were measured from rats' tails and recorded by plethysmography every two weeks. Blood samples were drawn, Cd levels were determined by atomic absorption spectrophotometer and plasma viscosity values by viscometer. Blood Cd levels were found to be significantly higher in the experimental group compared to the control group (p < 0.001). The whole blood analysis was made by an analyzer. Polymorphonuclear leukocytes and monocytes increased (p < 0.01) and lymphocyte number (p < 0.05) decreased in the experimental group. Viscosity values were 2.21 ± 0.54 and 1.62 ± 0.31 centipoises in the experimental and control groups, respectively (p < 0.001). In the experimental group, changes in systolic blood pressure between weeks were significant (p < 0.001) and were found to be correlated with plasma viscosity (p < 0.001). In the experimental group, changes in heart rate between weeks were significant (p < 0.001). According to our findings, Cd toxicity may lead to an increase in blood pressure by increasing plasma viscosity.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 2-4","pages":"82-7"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000323702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29729712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Venous thromboembolism and port-related thrombosis in metastatic colorectal cancer patients: a monocenter experience. 转移性结直肠癌患者的静脉血栓栓塞和端口相关血栓形成:单中心经验。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-10-20 DOI: 10.1159/000319552

Elisabetta Nobili, Roberto Di Cicilia, Monica Di Battista, Antonio Maria Morselli-Labate, Marco Paragona, Jody Corbelli, Marina Macchini, Paolo Prandoni, Guido Biasco, Giovanni Brandi

{"title":"Venous thromboembolism and port-related thrombosis in metastatic colorectal cancer patients: a monocenter experience.","authors":"Elisabetta Nobili, Roberto Di Cicilia, Monica Di Battista, Antonio Maria Morselli-Labate, Marco Paragona, Jody Corbelli, Marina Macchini, Paolo Prandoni, Guido Biasco, Giovanni Brandi","doi":"10.1159/000319552","DOIUrl":"https://doi.org/10.1159/000319552","url":null,"abstract":"Venous thromboembolism (VTE) may occur during the natural history of neoplastic disease and is a common cause of mortality and morbidity in cancer patients. Major risk factors for VTE in cancer patients include surgery, immobilization, hospitalization, and the administration of granulopoietic and/or erythropoietic (stimulatory) agents. Chemotherapy is a supplementary independent risk factor for VTE and the use of central venous catheters (CVC) in clinical practice has increased the risk of thromboembolic events. We conducted a retrospective study to evaluate CVC-related thrombosis and the VTE rate in 145 consecutive metastatic colorectal cancer patients. We observed only 2 cases of symptomatic CVC- related thrombotic events (1.38%) and 10 cases of thromboembolic events (6.9%) in our series. Only surgery for metastases was found to be significantly related to the development of VTE, with an incidence of 16.1% vs. 4.4 in patients who did not undergo surgery (p = 0.037). In addition, a history of VTE seems to be a supplementary risk factor for CVC-related thrombosis (p = 0.055).","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 1","pages":"30-4"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000319552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29364428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Prediction of venous thrombosis in cancer patients using a microparticle based clotting test 用微粒凝血试验预测癌症患者静脉血栓形成

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 DOI: 10.1159/000318099

A. Kleinjan, F. F. V. Doormaal, R. Berckmans, M. Nisio, A. Sturk, P. Kamphuisen, R. Nieuwland, H. Büller

{"title":"Prediction of venous thrombosis in cancer patients using a microparticle based clotting test","authors":"A. Kleinjan, F. F. V. Doormaal, R. Berckmans, M. Nisio, A. Sturk, P. Kamphuisen, R. Nieuwland, H. Büller","doi":"10.1159/000318099","DOIUrl":"https://doi.org/10.1159/000318099","url":null,"abstract":"Background: Although in patients with cancer the risk of venous thromboembolism (VTE) is increased, the incidence is too low to routinely give prophylactic treatment. Procoagulant microparticles (MPs), especially tissue factor (TF)-bearing MPs, contribute to the risk of VTE in cancer patients. In the present study, we assessed the MP-associated procoagulant activity using a functional assay, the fibrin generation test (FGT), to identify cancer patients prone to develop VTE. Methods: As an ongoing study, plasma was collected from cancer patients, mainly with stage III or IV pancreatic, gastro-intestinal, breast or lung cancer. The MPassociated procoagulant activity was determined via the FGT with the addition of an inhibitory antibody to factor VII. The prolongation of the clotting time in the presence of anti-factor VII is a measure for the contribution of TF-bearing MPs to the clotting time. Patients were followed up for 6 months. Results: 100 patients were included, of which 77 have completed follow-up until now. The first 43 patients were used to establish a cut-off value of the FGT. Receiver operating characteristics showed that a prolongation of the clotting time of 13% after addition of anti-factor VII, was the optimal cut-off value. In the entire group, 8 of 77 patients (10%) developed VTE, of which 7 could have been predicted by the FGT. Using this cut-off value, 23 patients (30%) had a FGT-result above the cut-off (positive test) and 54 patients had a FGT-result below the cut-off (negative test). The prevalence of VTE was 30% in the FGT-positive patients and 2% in the FGTnegative patients (sensitivity 88%, specificity 77%). Conclusions: The FGT seems an excellent predictor for VTE in cancer patients. The next step will be to test the efficacy of prophylactic anticoagulants in patients with cancer and a high thrombosis risk based on the FGT.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000318099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64438363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature. V - leiden因子、凝血酶原G20210A突变、MTHFR C677T突变、PAI-1突变纯合1例17岁女孩避孕相关深静脉血栓形成及肺栓塞:多遗传危险因素家族报告及文献复习

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-07-20 DOI: 10.1159/000319051

Jasna Lenicek Krleza, Gordana Jakovljevic, Ana Bronic, Désirée Coen Herak, Aleksandra Bonevski, Jasminka Stepan-Giljevic, Goran Roic

{"title":"Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature.","authors":"Jasna Lenicek Krleza, Gordana Jakovljevic, Ana Bronic, Désirée Coen Herak, Aleksandra Bonevski, Jasminka Stepan-Giljevic, Goran Roic","doi":"10.1159/000319051","DOIUrl":"https://doi.org/10.1159/000319051","url":null,"abstract":"We present the case of a 17-year-old girl who suddenly woke up with localized pain in the left groin and the inability to twist her leg. After comprehensive physician and laboratory examinations, deep venous thrombosis with consequent pulmonary embolism was ascertained. She had not experienced any recent trauma, but she had started to take oral contraceptives 6 months prior to the onset of the symptoms. Her parents and sisters had been asymptomatic throughout their lives, but the family history revealed a few thromboembolic accidents. Using DNA analysis, heterozygosity for factor V Leiden, prothrombin gene mutation G20210A and methylenetetrahydrofolate reductase C677T, as well as the homozygous 4G/4G genotype in the plasminogen activator inhibitor 1 were identified in our patient. Subsequently, DNA analysis was performed in all living family members, and multiple factors associated with thrombophilia were discovered. Our case confirms the multifactorial cause of thromboembolic events and emphasizes the importance of oral contraceptive use in the onset of venous thrombosis, especially in teenage females. In addition, this case indicates that teenage females with a family history of thrombosis who are making choices about contraception could most likely benefit from advanced thrombophilia testing.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 1","pages":"24-9"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000319051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29149156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Serum and saliva sialic acid in periodontitis patients with and without cardiovascular disease. 有无心血管疾病的牙周炎患者血清唾液唾液酸测定。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2011-03-02 DOI: 10.1159/000321377

Sehkar Oktay, Isık Basar, Ebru Emekli-Alturfan, Ezgi Malali, Eser Elemek, Faruk Ayan, Lale Koldas, Ulku Noyan, Nesrin Emekli

{"title":"Serum and saliva sialic acid in periodontitis patients with and without cardiovascular disease.","authors":"Sehkar Oktay, Isık Basar, Ebru Emekli-Alturfan, Ezgi Malali, Eser Elemek, Faruk Ayan, Lale Koldas, Ulku Noyan, Nesrin Emekli","doi":"10.1159/000321377","DOIUrl":"https://doi.org/10.1159/000321377","url":null,"abstract":"Serum total sialic acid (sTSA) has recently been shown to be a cardiovascular risk factor. However, there is little information about the role of sTSA and TSA in saliva in periodontitis, a chronic and inflammatory disease known to be a risk factor for cardiovascular disease (CVD). We aimed to investigate the changes in sTSA and TSA levels in saliva in patients having both periodontitis and CVD versus periodontitis patients without diagnosed CVD. The study group consisted of 26 patients with proven periodontitis and 26 controls with no diagnosed systemic disease but periodontitis. sTSA and saliva TSA levels were determined by the thiobarbituric acid method, and C-reactive protein (CRP) was evaluated by the nephelometric method. The severity of periodontitis has been determined by the community periodontal index of treatment needs (CPITN). TSA in blood and saliva and CRP levels in blood were significantly increased in CVD patients compared with the control group. CPITN ranged from 2 to 4 in both groups. Significant and positive correlations were found between sTSA and saliva SA levels in patients and controls and between tooth loss and TSA both in blood and saliva. Therefore, TSA in saliva may be a useful marker similar to sTSA in CVD patients.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 2-4","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000321377","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29714901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Curcumin facilitates fibrinolysis and cellular migration during wound healing by modulating urokinase plasminogen activator expression. 姜黄素通过调节尿激酶纤溶酶原激活物的表达促进伤口愈合过程中的纤维蛋白溶解和细胞迁移。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-11-12 DOI: 10.1159/000321375

R Madhyastha, H Madhyastha, Y Nakajima, S Omura, M Maruyama

引用次数: 36

Plasma tissue factor levels and salivary tissue factor activities of periodontitis patients with and without cardiovascular disease. 伴有和不伴有心血管疾病的牙周炎患者血浆组织因子水平和唾液组织因子活性。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2011-02-04 DOI: 10.1159/000323418

E Emekli-Alturfan, I Basar, E Malali, E Elemek, S Oktay, F Ayan, N Emekli, U Noyan

{"title":"Plasma tissue factor levels and salivary tissue factor activities of periodontitis patients with and without cardiovascular disease.","authors":"E Emekli-Alturfan, I Basar, E Malali, E Elemek, S Oktay, F Ayan, N Emekli, U Noyan","doi":"10.1159/000323418","DOIUrl":"https://doi.org/10.1159/000323418","url":null,"abstract":"The association between periodontal and cardiovascular disease has received considerable attention. Studies have demonstrated a higher incidence of atherosclerotic complications in patients with periodontal disease. Tissue factor (TF) has been known as a key initiator of the coagulation cascade, and the TF pathway is the primary physiological mechanism of initiation of blood coagulation. Recently, it has been shown that the circulating pool of TF in blood is associated with increased blood thrombogenicity in patients with coronary artery disease (CAD). Various tissues and saliva have been known to have TF activity. Consequently, the aim of this study was to investigate plasma TF levels and TF activity of saliva in periodontitis patients with and without diagnosed CAD. Twenty-six patients with a diagnosis of CAD and 26 systemically healthy patients were examined in the dental clinic, and the Community Periodontal Index Treatment Needs (CPITN) scores were recorded. Plasma TF levels were determined using commercially available ELISA kit. Salivary TF activities were determined according to Quick's one-stage method. Plasma TF levels were significantly increased in patients with CAD when compared with the control group. There was no difference in salivary TF activities between the 2 groups, but there was a strong and negative correlation between salivary TF activities and CPITN indexes in both groups. In order to determine the possible role of TF activity as a salivary marker in CAD and periodontitis and to fully understand the negative correlation between salivary TF activities and CPITN, TF activity of gingival crevicular fluid that may also affect saliva can be evaluated.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 2-4","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000323418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29648585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Platelet density distribution in essential thrombocythemia. 原发性血小板增多症的血小板密度分布。

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2010-01-01 Epub Date: 2010-05-19 DOI: 10.1159/000314964

Micha Milovanovic, Kourosh Lotfi, Tomas Lindahl, Claes Hallert, Petter Järemo

{"title":"Platelet density distribution in essential thrombocythemia.","authors":"Micha Milovanovic, Kourosh Lotfi, Tomas Lindahl, Claes Hallert, Petter Järemo","doi":"10.1159/000314964","DOIUrl":"https://doi.org/10.1159/000314964","url":null,"abstract":"Essential thrombocythemia (ET) is characterized by high platelet counts and a slightly increased bleeding risk. Why severe hemorrhage does not occur more frequently is not known. Variations of platelet density (kg/l) depend mainly on cell organelle content in that high-density platelets contain more α and dense granules. This study compares ET patients (n = 2) and healthy volunteers (n = 2) with respect to platelet density subpopulations. A linear Percoll™ gradient containing prostaglandin E1 was employed to separate platelets according to density. The platelet population was subsequently divided by density into 16 or 17 subpopulations. Determination of platelet counts was carried out. In each density fraction, platelet in vivo activity, i.e. platelet-bound fibrinogen, was measured using a flow cytometer. To further characterize platelet subpopulations, we determined intracellular concentrations of CD40 ligand (CD40L) and P-selectin in all fractions. Patients and controls demonstrated similar density distributions, i.e. 1 density peak. High-density platelets had more surface-bound fibrinogen in conjunction with signs of platelet release reactions, i.e. with few exceptions they contained less CD40L and P-selectin. Peak density platelets showed less surface-bound fibrinogen. These platelets contained less CD40L and P-selectin than nearby denser populations. The light platelets had more surface-bound fibrinogen than peak platelets together with elevated concentrations of CD40L. In ET, the malignant platelet production could exist together with platelets originating from normal megakaryocytes. It is also possible that clonal megakaryocytes produce platelets covering the entire density span. The ‘normal’ density distribution offers a tenable explanation as to why serious bleedings do not occur more frequently.","PeriodicalId":19817,"journal":{"name":"Pathophysiology of Haemostasis and Thrombosis","volume":"37 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000314964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29001656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15