Pharmacognosy Research最新文献

{"title":"Anti-inflammatory Effect of Squalene Isolated from Simarouba glauca in Experimental Animal Model","authors":"Svenia Periyapurath Jose, Sandya Sukumaran, Ratheesh Mohanan, Sangeeth Saji, Aditya Asish, Sajeev Martin George","doi":"10.5530/pres.15.4.069","DOIUrl":"https://doi.org/10.5530/pres.15.4.069","url":null,"abstract":"Pharmacognosy Research,2023,15,4,658-666.DOI:10.5530/pres.15.4.069Published:October 2023Type:Original ArticleAuthors:Svenia Periyapurath Jose, Sandya Sukumaran, Ratheesh Mohanan, Sangeeth Saji, Aditya Asish, and Sajeev Martin George Author(s) affiliations:Svenia Periyapurath Jose1, Sandya Sukumaran1,*, Ratheesh Mohanan2, Sangeeth Saji2, Aditya Asish1, Sajeev Martin George3 1Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, Karnataka, INDIA. 2Department of Biochemistry, St. Thomas College, Palai, Kerala, INDIA. 3Department of Chemistry, St. Thomas College, Palai, Kerala, INDIA. Abstract:Background: Most dynamic area of scientific investigation is to identify the bioactive compounds and establish their potential health effects against chronic diseases. Multi-targeted compounds with fewer side effects has shown to be potential therapeutic agents. Objectives: To evaluate the anti-inflammatory effect of isolated Squalene (SQ), a triterpenoid from Simarouba glauca in carrageenan-induced acute inflammation. Materials and Methods: Squalene (SQ), a triterpenoid fraction was isolated from Simarouba glauca and characterized by FT-IR and NMR. Experimental animals were categorized into five groups, group I was control (0.5% DMSO in normal saline), group II received Carrageenan (Carr), group III received SQ and Carr, whereas group IV received diclofenac and Carr. After 1 hr, SQ and diclofenac (20mg/kg) were administered (i.p.). Carrageenan suspension was injected into the sub-plantar tissue of the right hind paw. Paw edema was determined 3 hours post-carrageenan administration. Rats were sacrificed and mRNA expression of TNF-α and IL-6, levels of PGE-2 and TBARS, activities of COX-2, SOD, catalase, GPx, MPO, and the level of nitrite were measured. Results: SQ at a dose of 5.0 mg/kg body weight was found to be the minimal dose for maximum edema inhibition. Serum levels of TNF-α, IL-6, PGE-2, NO, COX-2 and levels of TBARS and MPO were significantly reduced (p < 0.05). Antioxidant markers such as SOD, Catalse and GPx were increased significantly (p < 0.05). Conclusion: These results suggest the anti-inflammatory properties of SQ and its multi-targeted mechanism of action, meriting its potential therapeutic efficacy in various inflammatory diseases. Keywords:Antioxidants, Inflammation, MPO, PGE2, SqualeneView:PDF (520.4 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"31 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis","authors":"Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani Shivani S, Vikas Kumar Pal","doi":"10.5530/pres.15.4.088","DOIUrl":"https://doi.org/10.5530/pres.15.4.088","url":null,"abstract":"Pharmacognosy Research,2023,15,4,831-840.DOI:10.5530/pres.15.4.088Published:October 2023Type:Original ArticleAuthors:Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, and Vikas Kumar Pal Author(s) affiliations:Arun Kumar, Saurabh Singh*, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, Vikas Kumar Pal School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, INDIA. Abstract:Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, and Woodfordia fruticosa. Materials and Methods: The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results: Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion: These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments. Keywords:Azadirachta indica, Curcuma longa, haCaT cells, Pongamia pinnata, Psoralea corylifolia, Woodfordia fruticosaView:PDF (349.84 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo Investigation to Validate the Traditional Usage of Sorbaria tomentosa (Lindley) Reh. Root Extract against Alloxan-induced Diabetic Rats","authors":"Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani","doi":"10.5530/pres.15.4.071","DOIUrl":"https://doi.org/10.5530/pres.15.4.071","url":null,"abstract":"Pharmacognosy Research,2023,15,4,671-678.DOI:10.5530/pres.15.4.071Published:October 2023Type:Original ArticleAuthors:Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, and Sushila Rani Author(s) affiliations:Monika Mehta*, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani Department of Botany, Panjab University, Chandigarh, INDIA. Abstract:Background: DM is a complicated condition that impacts the handling of sugar, fat, and protein metabolism in our bodies. Medicinal herbs play a significant role in diabetes care. As a result, we focused on the plant components traditionally employed by regional medical professionals. Objectives: The current research was carried out to check if Sorbaria tomentosa (Lindley) Reh. (ST) the ethanolic root extracts anti-diabetic potential. ST is a member of the Rosaceae family commonly known by the common name \"false spirae.\" The root extract of ST is used by the locals in the Kinnaur district of Himachal Pradesh to effectively treat diabetes. Materials and Methods: Plant ethanolic extracts were evaluated for their potential on alloxan-induced diabetic rats for 14 days. The animals were put into one of four treatment groups at random: a normal control group, not treated diabetic control group (150 mg/kg bw), a drug control group that got glibenclamide (5 mg/kg bw), and the last treatment group medicated with ST root extract (50 mg/kg BW). Liver, pancreas, and kidney histopathology were analyzed to correlate biochemical findings with histological changes. Results: Our results showed that the extract and medication-treated diabetic groups gained statistically significant weight (p≤0.001) and that their BGL went back to normal. Along with more common biological markers such as SGOT, SGPT, ALP, TC, TG, HDL, LDL, VLDL, creatinine level, uric acid, urea, and uric acid were measured. After the extract treated hyperglycaemic rats, all biochemical markers came under the normal range (p≤0.001). Improvement of the damaged structure of the liver, pancreas, and kidneys was observed after treatment with standard medication and root extracts of ST. Conclusion: Based on the data gathered from the tribal research area, to the best of our capacity, we have uncovered for the very first time the anti-diabetic efficacy of the plant parts. The empirical knowledge of previous generations is typically the basis for the traditional utilization of medicinal plants for controlling diabetes. Nevertheless, in vivo, research has assisted to discover the anti-diabetic potential of ST's ethanolic root extract and provides scientific proof to back up these claims. The plant component may also be used to create natural antidiabetic drugs that are effective. Keywords:Alloxan, Diabetes mellitus, Kinnaur, Sorbaria tomentosa, Traditional knowledge, Wistar ratsView:PDF (1.41 MB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"32 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Urolithiasis Activity of Tridax procumbens Methanolic Extract on Calcium Oxalate Crystals Prepared by Precipitation Method","authors":"Aithamraju Satishchandra, Alagarsamy V Alagarsamy, Radhika V Radhika, V Ravi Kumar, Bandi Narendhar, P Subhash Chandra Bose","doi":"10.5530/pres.15.4.070","DOIUrl":"https://doi.org/10.5530/pres.15.4.070","url":null,"abstract":"Pharmacognosy Research,2023,15,4,667-670.DOI:10.5530/pres.15.4.070Published:October 2023Type:Original ArticleAuthors:Aithamraju Satishchandra, V. Alagarsamy, V. Radhika, V Ravi Kumar, Bandi Narendhar, and P. Subhash Chandra Bose Author(s) affiliations:Aithamraju Satishchandra1,*, V. Alagarsamy2, V. Radhika2, V Ravi Kumar1, Bandi Narendhar2, P. Subhash Chandra Bose3 1Department of Pharmacology, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. 2Department of Pharmaceutical Chemistry, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. 3Department of Pharmaceutics, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. Abstract:Background: The main purpose of present to reduce the kidney stone with herbal drugs due increase in incidence rate of kidney stones significantly with change in life style from the last two decades. Aim and Methodology: The present study aimed to evaluate in vitro urolithiasis activity of Tridax procumbens on experimentally prepared calicium oxalate crystals. Calcium oxalate crystals were prepared by homogenous ppt method by using calium chloride and sodium oxalate. The crude extract was prepared by the simple maceration with methanol 1:3 ratio and the solvent was evaporated by rotary evaporator and two doses of extract selected i.e 10mg and 20 mg and compared against standard cytosine all were assayed against calcium oxalate crystals which were incubated in semi-permeable membrane with sulphuric acid. Results and Conclusion: The results were 68.02% (10 mg), 72.41% (20 mg) and 90% and we conclude that the Tridax procumbens was showed significant effect of urolithiasis. Keywords:Calcium oxalate crystals, Cytosine, PPT, Tridax procumbensView:PDF (197.05 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"32 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive Effects of High Fructose Corn Syrup (HFCS) in Experimental Oral Carcinogenesis","authors":"Kavitha Kalimuthu, Sindhu Ganapathy, Balamurugan Elumalai, Asha Kumarasamypillai Radha Thayammal, Veeran Veeravarmal, Vijayalakshmi Annamalai","doi":"10.5530/pres.15.4.087","DOIUrl":"https://doi.org/10.5530/pres.15.4.087","url":null,"abstract":"Pharmacognosy Research,2023,15,4,819-830.DOI:10.5530/pres.15.4.087Published:October 2023Type:Original ArticleAuthors:Kavitha Kalimuthu, Sindhu Ganapathy, Balamurugan Elumalai, Asha Kumarasamypillai Radha Thayammal, Veeran Veeravarmal, and Vijayalakshmi Annamalai Author(s) affiliations:Kavitha Kalimuthu1, Sindhu Ganapathy1,2,*, Balamurugan Elumalai1, Asha Kumarasamypillai Radha Thayammal3, Veeran Veeravarmal4, Vijayalakshmi Annamalai5 1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA. 2Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamil Nadu, INDIA. 3Department of Biochemistry, Government Arts College, Paramakudi, Tamil Nadu, INDIA. 4Department of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College and Hospital, Annamalai Nagar, Tamil Nadu, INDIA. 5Plant Head, Galileovasan Offshore and Research and Development Private Limited, Nagapattinam, Tamil Nadu, INDIA. Abstract:Introduction: Nowadays, fructose uses dramatically increased in form of High-Fructose Corn Syrup (HFCS) found in juices and packed food. Sustained fructose utilization is detrimental to long-term human health. Objectives: To assess the additive effects of HFCS during 7,12-Dimethylbenz(a)Anthracene (DMBA)-induced Hamster Buccal Pouch Carcinogenesis (HBPCs) model. Materials and Methods: The animals were separated into eight groups: Group I; vehicle control; Group II (0.5% DMBA); Group III and IV (HFCS 8% and 25%); Group V (Sucrose 10%); Group VI and VII (0.5% DMBA+HFCS 8 and 25%) and VIII group (0.5% DMBA+Sucrose 10%) respectively for 14 weeks. After the 14th week of treatment; the tumor morphology, buccal histopathology, and biochemical markers were measured and compared with carcinogenic control as well as vehicle control. Observations and Results: The buccal pouch of golden Syrian hamsters developed well-differentiated squamous cell carcinoma after getting topical applications of 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Although DMBA treatment alone caused 100% tumor development in hamsters, drinking water administration of HFCS at a concentration of 25%/kg body weight (b.w.) to DMBA-treated hamster greatly accelerated the development of oral tumors. Additionally, during DMBA-induced oral carcinogenesis, HFCS moderatingly increased the lipid peroxidation by-products, decreased the status of enzymatic and non-enzymatic antioxidants, modulated the levels of phase I and phase II detoxification agents, and favored the excretion of carcinogenic metabolite. Conclusion: The present study concludes that the additive effect of HFCS relies on its altered peroxidative and antioxidant function as well as effects on phase I and II detoxification enzymes during DMBA-induced hamster buccal pouch carcinogenesis. Taken together the current study described that HFCS induced oral tumour development. From this study we suggested HFCS usage to be curtaile","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is COVID-19 Related to the Recent Surge in Research on Houttuynia cordata (Thunb)?","authors":"Poonam Singh Deo, Sweety Angelirie Kharumnuid, Moses M Naga, Hangsing P Hangsing","doi":"10.5530/pres.15.4.074","DOIUrl":"https://doi.org/10.5530/pres.15.4.074","url":null,"abstract":"Pharmacognosy Research,2023,15,4,693-704.DOI:10.5530/pres.15.4.074Published:October 2023Type:Original ArticleAuthors:Poonam Singh Deo, Sweety Angelirie Kharumnuid, Moses M. Naga, and P. Hangsing Author(s) affiliations:Poonam Singh Deo*, Sweety Angelirie Kharumnuid, Moses M. Naga, P. Hangsing Department of Library and Information Science, North Eastern Hill University, Library and Information Science, Umshing Mawkynroh, Shillong, Meghalaya, INDIA. Abstract:Background of the Study: Houttuynia cordata is an herbal medicinal plant with a variety of ethnomedicinal properties. The plant extract has potent anti-inflammatory and antioxidant effects, which may help to reduce the complications associated with diabetes. Additionally, it is used as an anti-inflammation, antidote, astringent, anti-bacterial, and anti-viral. Objectives: The present study is a scientometric analysis of Houttuynia cordata during 1992-2021 as covered in the SCOPUS database to find out the citation impact, growth rate, and research output of Houttuynia cordata research during a three-decade period. Materials and Methods: SCOPUS database was used to download data for three decades. The information gathered was quantified using bibliometrics; further, VOS viewer was used for visualizing the keyword network. Results: The study revealed that from 2005 onwards, there was an increase in Houttuynia cordata research and publication. China turns out to be at the top with the maximum number of research publications on Houttuynia cordata. Pharmacology, Toxicology, and Pharmaceutics were the top subject areas that constituted the leading publication. Keywords 'Traditional Medicine' and 'Medicinal Plants' were used mainly during the year 1992-2018, however, from 2019-2021 there is a tremendous shift from the keywords such as 'Traditional Medicine', and 'Medicinal Plants' to keywords such as 'Coronavirus' 'COVID-19' and 'Pandemic', indicating that research on Houttuynia cordata relating to COVID-19 and Pandemic has become an extensive area of research from 2019 onwards. Conclusion: This study concludes that research on Houttuynia cordata has been slow since the early years, with a significant surge during the COVID-19 pandemic. The onset of the COVID-19 pandemic has certainly reconfirmed the relevance of Houttuynia cordata as a medicinal herb. Additionally, this study will help researchers understand the current state of the Houttuynia cordata research and can act as an information road map to further explore research on its medicinal importance which may benefit humanity in the future. Keywords:Coronavirus, COVID-19, Houttuynia cordata, Medicinal plants, Scientometric Analysis, Traditional medicineView:PDF (1.12 MB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"31 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar","authors":"Omilla Ragavan, Sze Cheng Chan, Yi En Goh, Vuanghao Lim, Yoke Keong Yong","doi":"10.5530/pres.15.4.067","DOIUrl":"https://doi.org/10.5530/pres.15.4.067","url":null,"abstract":"Pharmacognosy Research,2023,15,4,636-652.DOI:10.5530/pres.15.4.067Published:October 2023Type:Review ArticleAuthors:Omilla Ragavan, Sze Cheng Chan, Yi En Goh, Vuanghao Lim, and Yoke Keong Yong Author(s) affiliations:Omilla Ragavan1, Sze Cheng Chan1,2, Yi En Goh1,2, Vuanghao Lim3, Yoke Keong Yong1,* 1Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, MALAYSIA. 2School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, MALAYSIA. 3Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, MALAYSIA. Abstract:The weed Alternanthera sessilis, having Green (ASG) and Red (ASR) cultivars, is a member of the Amaranthaceae. Both cultivars are known to possess high medicinal and nutraceutical values as they are widely utilized in traditional medicine. Populations from various Asian regions commonly consume this medicinal weed as part of diet and as therapeutic agent. In general, both cultivars have been employed for treating a broad range of human ailments including cardiovascular diseases, diabetes, hypertension, and inflammatory disorders such as asthma, bronchitis and hepatitis apart from its administration as a painkiller. Following its ethnomedicinal uses, an attempt was made to review and consolidate the phytochemical constituents of ASG and ASR discovered from previous studies that utilized advanced technologies, respective traditional application among different ethnicities of Asia and their established pharmacological properties. All the information in this study was acquired through a literature search of research databases, namely ScienceDirect, Scopus, PubMed and Google Scholar using keywords such as Alternanthera sessilis, Alternanthera sessilis red, dwarf copperleaf and sessile joyweed. The results of each study were reviewed to identify its relevance and the cultivar that was being investigated. All relevant studies were collected and its subsequent results were reported and discussed to provide insights into the health enhancing qualities of ASG and ASR. Inspection of phytoconstituents in ASG and ASR showed the presence of polyphenol, flavonoid, carotenoid, terpenes and alkaloid with polyphenol being the major chemical group found in both cultivars. It was also revealed that whilst ASR is traditionally consumed in China, Malaysia, Singapore, and Taiwan, indigenous usage of ASG is more common in nations such as Sri Lanka, India, and Indonesia. Both ASG and ASR showed potent anti-oxidant, anti-hyperglycemic, antimicrobial, antifungal and hepatoprotective effects while the anti-inflammatory, anti-cancer and analgesic properties were disclosed in ASG only. Further processing and commercialization of this remedial weed as a product benefiting the wellbeing of humans is recommended as Alternanthera sessilis has high potential to be utilized as a curative agent while being a vital ingredient that can be included in ","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Use of Medicinal Plants against ENT Diseases by the Tribals of Purulia District, West Bengal, India","authors":"Rajani Kanta Mahato, Ghanashyam Mahato","doi":"10.5530/pres.15.4.073","DOIUrl":"https://doi.org/10.5530/pres.15.4.073","url":null,"abstract":"Pharmacognosy Research,2023,15,4,687-692.DOI:10.5530/pres.15.4.073Published:October 2023Type:Original ArticleAuthors:Rajani Kanta Mahato, and Ghanashyam Mahato Author(s) affiliations:Rajani Kanta Mahato, Ghanashyam Mahato* Department of Botany, Achhruram Memorial College, Jhalda, West Bengal, INDIA. Abstract:Background: Since ancient times natural plant parts were extensively used for the treatment and prevention of Ear, Nose and Throat related diseases. ENT related diseases are caused by various types of micro-organism. Eleven ethnic groups (Bhumij, Birhor, Gond, Sabar, Kharwar, Kurmi, Lodha, Malpaharya, Sardar, Oraon, Santal) present in Purulia district. Objectives: This study aims to record herbal plants used in the traditional treatment of ENT related ailments in Purulia district of West Bengal. Materials and Methods: Semi-structured questionnaire, interviews with traditional healers and focused group discussion were used to gather ethnobotanical data Results: This investigation listed 24 species in 20 plant families that are beneficial for treating ENT disorders in the Purulia district of West Bengal. Conclusion: The primary source of information on therapeutic plants is traditional healers. This information has been passed down orally from one generation to the next, but it appears that it is fading from modern society since young people are not interested to continue this tradition. So, the traditional wisdom on ethnobotanicals should be digitized for future references in India. Keywords:ENT, Ethnobotany, PuruliaView:PDF (292.56 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"34 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats","authors":"Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, Saddala Rajeswara Reddy","doi":"10.5530/pres.15.4.086","DOIUrl":"https://doi.org/10.5530/pres.15.4.086","url":null,"abstract":"Pharmacognosy Research,2023,15,4,813-818.DOI:10.5530/pres.15.4.086Published:October 2023Type:Original ArticleAuthors:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, and Saddala Rajeswara Reddy Author(s) affiliations:Thopireddy Lavanya1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4,* 1Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA. 2Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA. 3Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA. 4Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA. Abstract:Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future. Keywords:Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensisView:PDF (1.78 MB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crassocephalum crepidioides (Asteraceae) Benth S. Moore Leaves Fractions Attenuate Dyslipidemia and Atherogenic Indices in Diabetic Rats","authors":"Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, Omolaja Osoniyi","doi":"10.5530/pres.15.4.080","DOIUrl":"https://doi.org/10.5530/pres.15.4.080","url":null,"abstract":"Pharmacognosy Research,2023,15,4,761-770.DOI:10.5530/pres.15.4.080Published:October 2023Type:Original ArticleAuthors:Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, and Omolaja Osoniyi Author(s) affiliations:Opeyemi Oluwayemisi Ayodele1,2,*, Funmilayo Dorcas Onajobi2, Emeka Emea Okoro1, Omolaja Osoniyi2,3 1Department of Biochemistry, College of Basic and Applied Sciences, Mountain Top University, Prayer, Ogun, NIGERIA. 2Department of Biochemistry, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ilishan-Remo, Ogun, NIGERIA. 3Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun, NIGERIA. Abstract:Background: Diabetes mellitus, a metabolic and endocrine disorder, is associated with an impaired lipid profile that can result in increased atherogenic indices. The effects of the aqueous and hexane fractions of C. crepidioides leaves on the lipid profile and atherogenic indices of diabetic rats were investigated in this study. Materials and Methods: Varied concentrations (50-200 mg/kg body weight) of the aqueous (CAF) and hexane (CHF) fractions of C. crepidioides were assayed against streptozotocin-induced diabetic rats. Histological examinations of the pancreas were carried out using hematoxylin and eosin staining procedures. Experimental rats were randomly divided into 9 groups of 6 rats each and orally treated for 14 days. Results: The tested concentrations (50, 100 and 200 mg/kg) of CAF and CHF significantly (p < 0.05) reduced plasma glucose (51.3-62.2%), plasma and liver triglycerides (up to 50.5% in plasma; 66.1% in the liver), total cholesterol (up to 49.0% in plasma; 35.3% in the liver), low-density lipoprotein-cholesterol (up to 96.0 and 91.0% in the plasma and liver), very low-density lipoprotein-cholesterol (up to 50.5% in plasma; 55.0% in the liver), and the atherogenic indices elevated by diabetes induction. The high-density lipoprotein-cholesterol concentrations were significantly increased (plasma: 73.60-127.60%; liver: 108.70-152.5%) in CAF and CHF-treated diabetic rats compared to the diabetic control. Histological examination showed improved tissue architecture in the pancreas of the diabetic-treated rats compared to the diabetic control. Conclusion: C. crepidioides leaf fractions possess hypolipidemic and anti-atherogenic activities. Therefore, the plant could be useful in managing diabetes, dyslipidemia, and cardiovascular conditions. Keywords:Atherogenic indices, Diabetes mellitus, Dyslipidemia, Histological, Solvent fractionsView:PDF (619.52 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}