Physicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis

IF 0.7 Q4 PHARMACOLOGY & PHARMACY

Pharmacognosy Research Pub Date : 2023-11-08 DOI:10.5530/pres.15.4.088

Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani Shivani S, Vikas Kumar Pal

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Abstract

Pharmacognosy Research,2023,15,4,831-840.DOI:10.5530/pres.15.4.088Published:October 2023Type:Original ArticleAuthors:Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, and Vikas Kumar Pal Author(s) affiliations:Arun Kumar, Saurabh Singh*, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, Vikas Kumar Pal School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, INDIA. Abstract:Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, and Woodfordia fruticosa. Materials and Methods: The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results: Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion: These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments. Keywords:Azadirachta indica, Curcuma longa, haCaT cells, Pongamia pinnata, Psoralea corylifolia, Woodfordia fruticosaView:PDF (349.84 KB)

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中药籼米、龙葵、桄榔子、茯苓子对银屑病潜在疗效的理化及体外分析

出版日期:2023年10月类型:原创文章作者:Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani和Vikas Kumar Pal作者:Arun Kumar, Saurabh Singh*， Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, Vikas Kumar Pal Pharmaceutical Sciences School of medicine;可爱的专业大学，帕格瓦拉，旁遮普，印度。摘要/ Abstract摘要:背景:姜黄(姜科)、印楝科(楝科)、补骨脂(豆科)、桄榔子(豆科)和木足草(莱草科)是印度著名的药用植物。传统上，这些植物的不同部分被用于治疗，特别是在治疗牛皮癣和各种其他疾病的背景下。这催化了我们对这些植物药潜在的抗银屑病特性的研究。目的:对姜黄、印楝、补骨脂、凤尾草和木荆的丙酮、乙醇和水提取物进行初步的植物化学分析和体外抗银屑病能力的评价。材料和方法:利用HaCaT细胞，通过MTT法评估这些提取物的抗银屑病潜能。此外，我们进行了LDH测定，并利用共聚焦显微镜获得了进一步的见解。结果:我们的研究揭示了这些植物对皮肤角质形成细胞有良好的抗增殖活性。值得注意的是，与对照组相比，化合物A、B和C的细胞活力明显下降。相比之下，化合物D和E与对照组相比没有显着差异。讨论和结论:这些发现证实了这些植物在治疗银屑病中的传统用途，并强调了它们作为寻求有效抗银屑病治疗的宝贵资源的潜力。关键词:印楝，姜黄，haCaT细胞，凤尾莲，补骨脂，木果

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Pharmacognosy Research PHARMACOLOGY & PHARMACY-

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期刊介绍： Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.