Pharmacognosy Research最新文献

{"title":"Nutrition and Therapeutic Potential of the Dragon Fruit: A Qualitative Approach","authors":"K. M. Rathi, Shaktikumar Lawlesh Singh, Godwin Geo Gigi, S. V. Shekade","doi":"10.5530/pres.16.1.1","DOIUrl":"https://doi.org/10.5530/pres.16.1.1","url":null,"abstract":"","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"124 S1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of Five Colombian Propolis Extracts on the Expression of Genes Associated with Cell Cycle and Inflammation in a Canine Osteosarcoma Cell Line","authors":"Oscar Julian Murillo Torres, Dolly Patricia Pardo Mora, Orlando Torres García, Mauricio Rey Buitrago","doi":"10.5530/pres.16.1.22","DOIUrl":"https://doi.org/10.5530/pres.16.1.22","url":null,"abstract":"","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"84 8","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Therapeutic Potential of Herbal Plants in Managing Blood Sugar Levels: A Comprehensive Evaluation","authors":"A. Katrolia, Ved Pal, Vikesh Kumar Shukla, Rohit Singh","doi":"10.5530/pres.16.1.2","DOIUrl":"https://doi.org/10.5530/pres.16.1.2","url":null,"abstract":"","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"26 11","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPTLC, Physico-chemical, Phytochemical, Macroscopic, Microscopic Analysis of Seeds of a Nutri Cereal-Finger Millet/Ragi [(Eleusine coracana (L.) Gaertn.]","authors":"Sinimol Peethambaran, Soumya Mohanan Chandrika, Sree Deepthi Girija Nalinakshan, Meghna Pooleriveettil Padikkal, Reena Viswam Lilly, Neethu Kannan Bhagyanathan, Ghanthikumar Subramanian","doi":"10.5530/pres.16.1.14","DOIUrl":"https://doi.org/10.5530/pres.16.1.14","url":null,"abstract":"","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"50 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-Derived Selected Bioactive Saponins and Tannins: An Overview of their Multi-Target Mechanisms and Diverse Biological Activities","authors":"Dudday Venkata Vyshnavi, Sunkara Sivananda Swaroop, Akkiraju Sudheer, Somasekhar Reddy Kanala, Ramavath Muralidhar Naik, Onamala Varalakshmi","doi":"10.5530/pres.15.4.066","DOIUrl":"https://doi.org/10.5530/pres.15.4.066","url":null,"abstract":"Pharmacognosy Research,2023,15,4,623-635.DOI:10.5530/pres.15.4.066Published:October 2023Type:Review ArticleAuthors:Dudday Venkata Vyshnavi, Sunkara Sivananda Swaroop, Akkiraju Sudheer, Somasekhar Reddy Kanala, Ramavath Muralidhar Naik, and Onamala Varalakshmi Author(s) affiliations:Dudday Venkata Vyshnavi1, Sunkara Sivananda Swaroop1, Akkiraju Sudheer1,*, Somasekhar Reddy Kanala1, Ramavath Muralidhar Naik2, Onamala Varalakshmi1 1Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Chiyyedu, Anantapuram, Andhra Pradesh, INDIA. 2Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Chiyyedu, Anantapuram, Andhra Pradesh, INDIA. Abstract:An extensive variety of ailments have been treated using medicinal herbs for ages. Recent research has revealed that many of these plants possess multiple therapeutic activities, rendering them interesting candidates for the creation of novel medicines. This review examines the current state of knowledge regarding the multi targeted activities of medicinal plants, including their potential for treating multiple diseases like anti-inflammatory, anti-microbial, anti-hyperglycaemic and anti-cancer activities, their ability to modulate multiple pathways, enzymes, genes and proteins. Finally, the review highlights the potential of naturally derived substances from plant material, for the development of multitargeted drugs and suggests strategies for further research. The multi-target activities will be thoroughly explored in this review of ginsenosides, platycodon D, dioscin, soyasaponins and aescin were chosen as saponins, whereas methyl gallate, chebulinic acid, tannic acid, theaflavin and punicalagins were chosen as tannins. This overview gives a brief history of the isolated natural compounds, their structures, multi-target activity, and their suggested mechanisms of action. Keywords:Bioactive compounds, Biological activities, Medicinal plants, Multi targets, saponins, TanninsView:PDF (711.79 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"32 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piper pedicellatum C. DC. Leaf Methanol Extract Inhibits Edema and Granuloma and Modulates Mediators and Cytokines in Rats","authors":"Dev Jyoti Kalita, Kangkan Deka, Ngurzampuii Sailo, Sanjoy Das, Bibhuti Bhusan Kakoti","doi":"10.5530/pres.15.4.072","DOIUrl":"https://doi.org/10.5530/pres.15.4.072","url":null,"abstract":"Pharmacognosy Research,2023,15,4,679-686.DOI:10.5530/pres.15.4.072Published:October 2023Type:Original ArticleAuthors:Dev Jyoti Kalita, Kangkan Deka, Ngurzampuii Sailo, Sanjoy Das, and Bibhuti Bhusan Kakoti Author(s) affiliations:Dev Jyoti Kalita1,2,*, Kangkan Deka1,3, Ngurzampuii Sailo1, Sanjoy Das1, Bibhuti Bhusan Kakoti1 1Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh, Assam, INDIA. 2Department of Medicine, Assam Medical College and Hospital, Dibrugarh, Assam, INDIA. 3Department of Pharmacognosy, NETES Institute of Pharmaceutical Science, Guwahati. Assam, INDIA. Abstract:Background: Piper pedicellatum is an ethnomedicinal plant used in various inflammatory conditions by many ethnic groups and exploration of its therapeutic potentials is imperative. Objective: This study was carried out to assess anti-inflammatory potential of the methanol extract of the plant leaves using in vivo experiments to validate the traditional uses. Materials and Methods: Carrageenan-induced paw edema and Cotton pellet-induced granuloma models were used to investigate into the anti-inflammatory potential of the plant extract in rats at 200 mg/kg and 400 mg/kg dose. Indomethacin (10 mg/kg) is used as reference standard. Serum levels of inflammatory markers and cytokines, hematological and serum hepatic enzyme indices were analyzed in granuloma-induced model. Results: The methanol extract suppressed Carrageenan-induced paw edema significantly at different time intervals. The highest percentage inhibition was observed at 3rd hr after Carrageenan injection, which was 42.67% and 49.33% for 200 mg/kg and 400 mg/kg dose of the extract respectively. In granuloma-induced model, the methanol extract at 200 mg/kg and 400 mg/kg dose inhibited exudate formation by 28.58% and 41.27%, respectively and inhibition of granuloma tissue was 32.45% and 43.71%, respectively along with significant decrement in serum C-reactive protein, Prostaglandin E2, Tumor necrosis factor-α, Interleukin-6 while increases in Interleukin-10 levels. Also, the results showed hematological and serum hepatic enzyme levels were rectified to near normal levels in treated rats. Conclusion: The outcome of the investigation reveals the potential of extract as possible anti-inflammatory agent, which can be develop into therapeutic agent or supplement and also necessitates further pharmacological studies on the plant. Keywords:Cytokines, Edema, Granuloma, Interleukins, Piper pedicellatum C. DCView:PDF (693.95 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Ursolic Acid in Methanolic Extract of Momordica dioica by HPTLC Method","authors":"Jui Darbhe, Vrushali Neve, Vrushali Bhalchim, Ashwini Tonpe, Pritam Khandave, Suchita Mane, Rupali Yewale","doi":"10.5530/pres.15.4.077","DOIUrl":"https://doi.org/10.5530/pres.15.4.077","url":null,"abstract":"Pharmacognosy Research,2023,15,4,727-732.DOI:10.5530/pres.15.4.077Published:October 2023Type:Original ArticleAuthors:Jui Darbhe, Vrushali Neve, Vrushali Bhalchim, Ashwini Tonpe, Pritam Khandave, Suchita Mane, and Rupali Yewale Author(s) affiliations:Jui Darbhe1, Vrushali Neve1,*, Vrushali Bhalchim1, Ashwini Tonpe1, Pritam Khandave2, Suchita Mane3, Rupali Yewale4 1Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune, Maharashtra, INDIA. 2Department of Pharmaceutical Chemistry, Sterling Institute of Pharmacy, Nerul, Navi Mumbai, Maharashtra, INDIA. 3Department of Pharmaceutics, Ideal College of Pharmacy, Kalyan, Mumbai, Maharashtra, INDIA. 4Department of Pharmaceutical Chemistry, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Raigad, Maharashtra, INDIA. Abstract:Background: A number of nonsteroidal anti-inflammatory medications have been shown to lessen pain and inflammation. Unfortunately, there are numerous side effects connected with their use. There are, however, medicinal plants that have anti-inflammatory therapeutic effects with little to no side effects. Momordica dioica is a herb that belongs to the Cucurbitaceae family. There are numerous phytoconstituents in it. Ursolic acid is one of them and a pentacyclic terpenoid that is found in nature and has a number of therapeutic benefits. The current study looked at Ursolic Acid's activities (UA), a secondary plant metabolite, for its anti-inflammatory properties in the Momordica dioica plant. The current study's objective was to create and validate an HPTLC method that was quick, accurate, precise, and specific for determining ursolic acid from Momordica dioica herbal extract. Methodology/Conclusion/Significance: For quick analysis of Ursolic acid determination, The High Performance Thin Layer Chromatography (HPTLC) was established and confirmed. On an aluminium HPTLC plate (60 F254) coated with precoated silica gel with formic acid, ethyl acetate, and toluene (7:3:0,1), chromatographic separation was accomplished. The detection process was carried out at 530 nm. Ursolic acid's Rf value was discovered to be 0.795%. In the 400ng/band concentration range, linearity for ursolic acid was detected. The limits of detection and quantitation for ursolic acid were observed to be 0.04 ng/ band and 0.14 ng/band, respectively. The mean % recovery of rosmarinic acid was (0.54). The method's specificity, robustness, linearity, precision, and accuracy have all been validated in compliance with ICH standards. The created method can be used to evaluate the regularity of ursolic acid in herbal extracts. Keywords:Chromatography, Herbal extract, HPTLC, Inflammation, Methanol, momordica dioica, Rf value, Ursolic acidView:PDF (637.24 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"32 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Screening, in vitro Anti-bacterial, and Antioxidant Efficacy of Solanum virginianum L. Aerial Vegetative Parts Extracted in Four Solvents","authors":"Preety Rohilla, Ashmita Chhikara, Pushpa Dahiya","doi":"10.5530/pres.15.4.084","DOIUrl":"https://doi.org/10.5530/pres.15.4.084","url":null,"abstract":"","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"13 s3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Crosstalk in Indian Gooseberry Preparation to Explain Therapeutic Potentials of Dietary Supplements","authors":"Md Rafi Uz Zama Khan, Vishal Trivedi","doi":"10.5530/pres.15.4.076","DOIUrl":"https://doi.org/10.5530/pres.15.4.076","url":null,"abstract":"Pharmacognosy Research,2023,15,4,716-726.DOI:10.5530/pres.15.4.076Published:October 2023Type:Original ArticleAuthors:Md Rafi Uz Zama Khan, and Vishal Trivedi Author(s) affiliations:Md Rafi Uz Zama Khan, Vishal Trivedi* Department of Biosciences and Bioengineering, Malaria Research Group, Indian Institute of Technology-Guwahati, Guwahati, Assam, INDIA. Abstract:Background: The therapeutic properties of phytochemicals found in medicinal plants, as well as in dietary plants and herbs, have had a significant impact on the development of several herbal remedies for a range of ailments. Amalaki churna, a well-known ayurvedic composition, has been traditionally used to treat a number of disorders and has been shown to have anti-inflammatory, anti-diabetic, and anti-cancer properties, among others. The presence of large number of phytochemicals in this ayurvedic formulation seems to be responsible for its diverse actions. However, little is known about the precise molecular interaction between phytochemicals and their protein targets. This study puts forward a methodical and structured approach to determine the targets for the phytochemicals recovered from the aqueous extract of Amalaki churna and to establish the phytochemical-protein cross talk occurring at the molecular level. Materials and Methods: Various phytochemicals were identified from AMCAE using spectroscopic techniques such as HPLC, NMR (1H, 13C, and 2D NMR), and UPLC-MS analysis. The phytochemical-protein cross talk was discovered utilizing network-based pharmacology, with phytochemicals serving as core nodes. Seven hub proteins were considered most important from the string network of the protein targets using variable parameters such as Degree Centrality (DCY), Closeness Centrality (CCY) and Betweenness Centrality (BCY). Molecular docking and molecular dynamic simulations were carried out to ascertain the stability of the best docked phytochemical-protein complexes. The in silico findings were further validated using c-Src kinase protein as a model. Results: In this study, we have fractionated and identified 8 phytochemicals from Amalaki churna. We were able to find a total of 387 protein targets from the Drug bank and Binding DB by using structural similarity search. A network with 273 nodes and 417 edges that was acquired from Drug Bank demonstrated the substantial cross talk between phytochemicals and their protein targets. In a similar manner, phytochemical similarity search from Binding data bank resulted in a protein-phytochemical network with 143 nodes and 275 edges. Further, seven hub proteins with most interconnectedness were selected as the top most protein targets of the phytochemicals. Molecular modelling and docking experiments show that phytochemicals fit well into the target proteins' active sites. Molecular dynamic studies were used to further demonstrate the durability and stability of the protein phytochemical complexes. Phytochemicals were also shown to alter cell cycle","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyto-mediated Synthesis of Silver Nanoparticles with Afrohybanthus travancoricus Leaf Aqueous Extract and Screening of their in vitro Antioxidant, Anti-Inflammatory, and Anti-diabetic Activities","authors":"Balrajmani Davidson Raja, Devaraj Sathiya Sheela, Elumalai Shanthi Priya, Ammasaikutty Vanitha, Kandasamy Kalimuthu, Periannan Viswanathan","doi":"10.5530/pres.15.4.079","DOIUrl":"https://doi.org/10.5530/pres.15.4.079","url":null,"abstract":"Pharmacognosy Research,2023,15,4,751-760.DOI:10.5530/pres.15.4.079Published:October 2023Type:Original ArticleAuthors:Balrajmani Davidson Raja, Devaraj Sathiya Sheela, Elumalai Shanthi Priya, Ammasaikutty Vanitha, Kandasamy Kalimuthu, and Periannan Viswanathan Author(s) affiliations:Balrajmani Davidson Raja1, Devaraj Sathiya Sheela1, Elumalai Shanthi Priya1, Ammasaikutty Vanitha2, Kandasamy Kalimuthu1, Periannan Viswanathan1,* 1Department of Botany, Government Arts College (Autonomous), Coimbatore, Tamil Nadu, INDIA. 2Department of Botany, Namakkal Kavignar Ramalingam Government Arts College for Women, Namakkal, Tamil Nadu, INDIA. Abstract:Aim: There are many uses for silver nanoparticles in the field of biomedicine due to their exceptional properties. A major application of silver nanoparticles is the increase of antibiotics that are clinically helpful against microbes and drug-resistant bacteria. However, environmentally friendly methods for their synthesis must be developed. Objectives: Current study, the major objective of this research is concentrated on to suggest an easy and well-organized biosynthesis of silver nanoparticles by confirmed antioxidant, anti-inflammatory and anti-diabetic activities. The ATSNPs (Afrohybanthus travancoricus silver nanoparticles) was biosynthesized with A. travancoricus plant like capping and reducing agent. Materials and Methods: The ATSNPs aqueous extract were mixed by water extract of 1mM AgNO3 solution led to appearance of greenish brown to dark brown colour indicates the synthesis of SNPs. The silver nanoparticles were characterized by UV-visible spectroscopy, FT-IR, SEM, XRD, and EDX analysis. Antioxidant assay was tested through DPPH and ABTS+ assays, anti-inflammatory assay through albumin denaturation and antidiabetic assay by α-amylase and α-glucosidase activities. Results: A colour change of solution from dark brown to light brown, absorption peak of ATSNPs as 290 to 300 nm in UV-vis spectroscopy. ATSNPs showed 6 intense peaks in FTIR analysis and functional groups like phenols, alcohols, 1° amines, alkynes, aliphatic amines, aromatics, and alkyl halides were identified. In XRD analysis showed 5 intense peaks at 20.8°, 30.3°, 40.1°, 40.9°, 60°. The EDX analysis the presence of Ag at 3 kev and SEM analysis showed the size of ATSNPs ranges between 88 μm – 242 μm. Antioxidant activity was observed the dose dependent manner in both assays. Anti-inflammatory activity of ATSNPs proved maximum inhibition through egg albumin denaturation. Antidiabetic activity exhibits maximum inhibition percentage of α-amylase and α- glucosidase at 10 μg/mL. The lowest IC50 value was noted in α amylase (170 μg/mL) and α glucosidase (134 μg/mL). Conclusion: The obtained results recommended that using ATSNPs, it is likely to represented silver nanoparticles with controlled characteristics and important pharmacological activities. Keywords:Afrohybanthus travancoricus, Anti-diabetic activity, Anti-inflammatory, Antioxidant, Gre","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"34 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}