Pharmacological research communications最新文献

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Autoradiographic visualization of the GABA-A receptor agonist,3H-muscimol in the rat uterus GABA-A受体激动剂3H-muscimol在大鼠子宫中的放射自显像
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90003-3
Francesco Amenta , Carlo Cavallotti , Fabio Ferrante , Sandor L. Erdo¨
{"title":"Autoradiographic visualization of the GABA-A receptor agonist,3H-muscimol in the rat uterus","authors":"Francesco Amenta ,&nbsp;Carlo Cavallotti ,&nbsp;Fabio Ferrante ,&nbsp;Sandor L. Erdo¨","doi":"10.1016/0031-6989(88)90003-3","DOIUrl":"10.1016/0031-6989(88)90003-3","url":null,"abstract":"<div><p>In the present study the distribution of specific binding sites for the GABA-A receptor agonist, <sup>3</sup>H-muscimol, was studied in the rat uterus using an autoradiographic technique. Specific binding sites were present in both myometrium and endometrium suggesting a dual role for GABA in this organ.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 863-868"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90003-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13990811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Personnel placement 人员安置
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90009-4
{"title":"Personnel placement","authors":"","doi":"10.1016/0031-6989(88)90009-4","DOIUrl":"https://doi.org/10.1016/0031-6989(88)90009-4","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Page 918"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90009-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91658150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substance p as a transmitter in the human ciliary muscle 在人的睫状肌中作为递质的p物质
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90006-9
Marcello D. Lograno, Eugenia Daniele
{"title":"Substance p as a transmitter in the human ciliary muscle","authors":"Marcello D. Lograno,&nbsp;Eugenia Daniele","doi":"10.1016/0031-6989(88)90006-9","DOIUrl":"10.1016/0031-6989(88)90006-9","url":null,"abstract":"<div><p>The present experiments, carried out on the human fresh cilliary muscle, were undertaken to define whether substance P is involved as an excitatory transmitter in the contractile response evoked by electrical stimulation. Our results show that, following cholinergic and adrenergic blockade, the resistant component of contraction was completely abolished by (D-Pro<sup>2</sup>-D--Trp<sup>7,9</sup>)-SP, a synthetic analogue of substance P with antagonistic activity. Moreover the effects of exogenous substance P were investigated.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 901-905"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90006-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13612346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Streptococcus faecalis susceptibility to amiloride depends on medium pH 粪链球菌对阿米洛利的敏感性取决于培养基的pH值
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90002-1
Sergio Giunta, Luciano Galeazzi, Gianni Turchetti, Giordano Grilli, Giuseppe Groppa
{"title":"Streptococcus faecalis susceptibility to amiloride depends on medium pH","authors":"Sergio Giunta,&nbsp;Luciano Galeazzi,&nbsp;Gianni Turchetti,&nbsp;Giordano Grilli,&nbsp;Giuseppe Groppa","doi":"10.1016/0031-6989(88)90002-1","DOIUrl":"10.1016/0031-6989(88)90002-1","url":null,"abstract":"<div><p>Amiloride is one of the major molecular probes in basic and applied investigations on the physiology of cation transport in animal cells. In these cells the drug also exerts growth inhibitory activity. Recently, we discovered that amiloride causes growth inhibition also on bacterial cells. In this paper we report that medium pH influences amiloride activity on <u>Streptococcus faecalis</u>. The lowering of external pH causes a drop in the susceptibility of this bacterium to amiloride up to an almost complete resistance. This finding, constitutes a novel aspect of the in vitro experimental pharmacology of this diuretic potentially useful also in clinical pharmacology and in animal cell investigations.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 853-861"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90002-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14280506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Behavioral teratology and toxicology: A brief review 行为畸形学和毒理学:简要综述
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90001-X
Z. Annau , V. Cuomo
{"title":"Behavioral teratology and toxicology: A brief review","authors":"Z. Annau ,&nbsp;V. Cuomo","doi":"10.1016/0031-6989(88)90001-X","DOIUrl":"10.1016/0031-6989(88)90001-X","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 841-852"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90001-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14202836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Influence of urapidil on in vitro platelet response to adrenaline and other aggregating agents 乌拉地尔对体外血小板对肾上腺素和其他聚集剂反应的影响
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90005-7
Emanuelli G. , Anfossi G. , Lanzio M. , Mularoni E. , Calcamuggi G. , Brunello F. , Busca G.P. , Ciani D.
{"title":"Influence of urapidil on in vitro platelet response to adrenaline and other aggregating agents","authors":"Emanuelli G. ,&nbsp;Anfossi G. ,&nbsp;Lanzio M. ,&nbsp;Mularoni E. ,&nbsp;Calcamuggi G. ,&nbsp;Brunello F. ,&nbsp;Busca G.P. ,&nbsp;Ciani D.","doi":"10.1016/0031-6989(88)90005-7","DOIUrl":"10.1016/0031-6989(88)90005-7","url":null,"abstract":"<div><p>The effects of hypotensive drug urapidil on human platelet functions were investigated.</p><p>Urapidil failed to evidence direct aggregating properties or potentiating effects. Furthermore, drug high concentrations inhibited the platelet response to ADP, PAF, collagen, adrenaline and bovine thrombin, and influenced the platelet release reaction induced by ADP and PAF.</p><p>Data indicate that urapidil possesses negligible agonistic effects on human platelet alpha 2-adrenoceptors and interferes at high concentrations with the platelet activation, as evidenced for other anti-aggregating compounds.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 883-899"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90005-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14110965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
5th international colloquium on lecithin cannes 第五届戛纳卵磷脂国际学术研讨会
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90008-2
{"title":"5th international colloquium on lecithin cannes","authors":"","doi":"10.1016/0031-6989(88)90008-2","DOIUrl":"https://doi.org/10.1016/0031-6989(88)90008-2","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Page 917"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90008-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137263172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physostigmine and metoclopramide in oesophageal peristaltic spread in man 毒豆碱和甲氧氯普胺在人食管蠕动扩散中的作用
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90004-5
Tolu E., Mameli O., Soro P. , Muretti P. , Melis F., Caria M.A., Bresadola F.
{"title":"Physostigmine and metoclopramide in oesophageal peristaltic spread in man","authors":"Tolu E.,&nbsp;Mameli O.,&nbsp;Soro P. ,&nbsp;Muretti P. ,&nbsp;Melis F.,&nbsp;Caria M.A.,&nbsp;Bresadola F.","doi":"10.1016/0031-6989(88)90004-5","DOIUrl":"10.1016/0031-6989(88)90004-5","url":null,"abstract":"<div><p>Simultaneous recordings of electrical and mechanical activities at different levels of the oesophagus were performed in normal men before and after physostigmine and metoclopramide injections. Various parameters of the basal oesophageal peristalsis were significantly modified following drug treatment. In particular, physostigmine injections induced a shortening of electromechanical coupling time and a reduction of the propagation velocities of the electrical and mechanical oesophageal events. Metoclopramide shortened the electromechanical coupling time but increased the electrical and mechanical propagation velocities along the oesophagus.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 869-882"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90004-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14366897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Reduction rate of14C-carmoisine by resting cell bacterial suspension from human and rat faeces 人类和大鼠粪便中静息细胞细菌悬浮液对14c -卡莫辛的还原率
Pharmacological research communications Pub Date : 1988-10-01 DOI: 10.1016/0031-6989(88)90007-0
L.M. Flaminio , E. Tragni , A. De Giorgi , T. Brusa , C.L. Galli
{"title":"Reduction rate of14C-carmoisine by resting cell bacterial suspension from human and rat faeces","authors":"L.M. Flaminio ,&nbsp;E. Tragni ,&nbsp;A. De Giorgi ,&nbsp;T. Brusa ,&nbsp;C.L. Galli","doi":"10.1016/0031-6989(88)90007-0","DOIUrl":"10.1016/0031-6989(88)90007-0","url":null,"abstract":"<div><p><sup>14</sup>C-Carmoisine (250/gmg; 1.25 × 10<sup>6</sup> dpm) was incubated under strictly anaerobic conditions with resting cell suspension from stool specimens collected from male rats and human male healthy adults.</p><p>The kinetics of azoreduction was determined as amount of naphthionic acid (NA), the stable metabolite of Carmoisine produced by the activity of the anaerobic bacteria. The analytical determinations were performed by radio-HPLC technique.</p><p>There were no significant qualitative differences in the radiochro-matographic profiles of samples obtained from human and rat flora suspensions.</p><p>The calculated reduction rates were 5.03 ± 0.18 nmoles of NA/250 /ug protein/min, and 1.72 ± 0.12 nmoles of NA/250 /ug protein/min for rat and human faecal resting cells respectively. From our results it seems that the enzymatic reaction, following zero order kinetics, is similar for the two species and only the reduction rate is different.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 907-916"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90007-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14366898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effect of the PAF antagonists, CV-3988 and L-652, 731 on the pulmonary and hematological responses to guinea pig anaphylaxis PAF拮抗剂CV-3988和l - 652,731对豚鼠过敏反应肺和血液学反应的影响
Pharmacological research communications Pub Date : 1988-09-01 DOI: 10.1016/S0031-6989(88)80717-3
Gisela Danko, Joseph E. Sherwood, Beverly Grissom, William Kreutner, Richard W. Chapman
{"title":"Effect of the PAF antagonists, CV-3988 and L-652, 731 on the pulmonary and hematological responses to guinea pig anaphylaxis","authors":"Gisela Danko,&nbsp;Joseph E. Sherwood,&nbsp;Beverly Grissom,&nbsp;William Kreutner,&nbsp;Richard W. Chapman","doi":"10.1016/S0031-6989(88)80717-3","DOIUrl":"10.1016/S0031-6989(88)80717-3","url":null,"abstract":"<div><p>To define the role of PAF in the acute phase of guinea pig anaphylaxis, we have measured the pulmonary (bronchoconstrictor) and hematological (thrombocytopenia, leukopenia, hemoconcentration, plasma TxB<sub>2</sub> increase) responses to PAF infusion and compared these responses to the effect of antigen exposure in actively and passively sensitized guinea pigs. We have also determined the effect of the structurally unrelated PAF antagonists, CV-3988 and L-652, 731 on these responses. Intravenous administration of PAF (50–400 ng/kg) caused a dose-related bronchoconstriction, thrombocytopenia, leukopenia, hemoconcentration and increase in plasma TxB<sub>2</sub>. These PAF-induced responses were inhibited, to a variable degree, by pretreatment with CV-3988 (3 and 10 mg/kg, i.v.) and L-652, 731 (3 mg/kg, i.v.). Intravenous administration of ovalbumin to actively or passively sensitized guinea pigs caused bronchoconstriction, thrombocytopenia, leukopenia and hemoconcentration, but there was no increase in TxB<sub>2</sub>. Moreover, the anaphylactic bronchoconstriction, thrombocytopenia, leukopenia (actively sensitized) and hemoconcentration were not inhibited by CV-3988 (10 mg/kg, i.v.) and L-652, 731 (3 mg/kg, i.v.). The different profile of changes produced by PAF and allergic anaphylaxis and the failure to alter the responses to allergic anaphylaxis with PAF antagonists suggest that PAF is not an important mediator of the acute phase of guinea pig anaphylaxis.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 9","pages":"Pages 785-798"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80717-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14304373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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