{"title":"在人的睫状肌中作为递质的p物质","authors":"Marcello D. Lograno, Eugenia Daniele","doi":"10.1016/0031-6989(88)90006-9","DOIUrl":null,"url":null,"abstract":"<div><p>The present experiments, carried out on the human fresh cilliary muscle, were undertaken to define whether substance P is involved as an excitatory transmitter in the contractile response evoked by electrical stimulation. Our results show that, following cholinergic and adrenergic blockade, the resistant component of contraction was completely abolished by (D-Pro<sup>2</sup>-D--Trp<sup>7,9</sup>)-SP, a synthetic analogue of substance P with antagonistic activity. Moreover the effects of exogenous substance P were investigated.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 901-905"},"PeriodicalIF":0.0000,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90006-9","citationCount":"11","resultStr":"{\"title\":\"Substance p as a transmitter in the human ciliary muscle\",\"authors\":\"Marcello D. Lograno, Eugenia Daniele\",\"doi\":\"10.1016/0031-6989(88)90006-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The present experiments, carried out on the human fresh cilliary muscle, were undertaken to define whether substance P is involved as an excitatory transmitter in the contractile response evoked by electrical stimulation. Our results show that, following cholinergic and adrenergic blockade, the resistant component of contraction was completely abolished by (D-Pro<sup>2</sup>-D--Trp<sup>7,9</sup>)-SP, a synthetic analogue of substance P with antagonistic activity. Moreover the effects of exogenous substance P were investigated.</p></div>\",\"PeriodicalId\":19810,\"journal\":{\"name\":\"Pharmacological research communications\",\"volume\":\"20 10\",\"pages\":\"Pages 901-905\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0031-6989(88)90006-9\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0031698988900069\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological research communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0031698988900069","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Substance p as a transmitter in the human ciliary muscle
The present experiments, carried out on the human fresh cilliary muscle, were undertaken to define whether substance P is involved as an excitatory transmitter in the contractile response evoked by electrical stimulation. Our results show that, following cholinergic and adrenergic blockade, the resistant component of contraction was completely abolished by (D-Pro2-D--Trp7,9)-SP, a synthetic analogue of substance P with antagonistic activity. Moreover the effects of exogenous substance P were investigated.
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