Emanuelli G. , Anfossi G. , Lanzio M. , Mularoni E. , Calcamuggi G. , Brunello F. , Busca G.P. , Ciani D.
{"title":"乌拉地尔对体外血小板对肾上腺素和其他聚集剂反应的影响","authors":"Emanuelli G. , Anfossi G. , Lanzio M. , Mularoni E. , Calcamuggi G. , Brunello F. , Busca G.P. , Ciani D.","doi":"10.1016/0031-6989(88)90005-7","DOIUrl":null,"url":null,"abstract":"<div><p>The effects of hypotensive drug urapidil on human platelet functions were investigated.</p><p>Urapidil failed to evidence direct aggregating properties or potentiating effects. Furthermore, drug high concentrations inhibited the platelet response to ADP, PAF, collagen, adrenaline and bovine thrombin, and influenced the platelet release reaction induced by ADP and PAF.</p><p>Data indicate that urapidil possesses negligible agonistic effects on human platelet alpha 2-adrenoceptors and interferes at high concentrations with the platelet activation, as evidenced for other anti-aggregating compounds.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 10","pages":"Pages 883-899"},"PeriodicalIF":0.0000,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0031-6989(88)90005-7","citationCount":"6","resultStr":"{\"title\":\"Influence of urapidil on in vitro platelet response to adrenaline and other aggregating agents\",\"authors\":\"Emanuelli G. , Anfossi G. , Lanzio M. , Mularoni E. , Calcamuggi G. , Brunello F. , Busca G.P. , Ciani D.\",\"doi\":\"10.1016/0031-6989(88)90005-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effects of hypotensive drug urapidil on human platelet functions were investigated.</p><p>Urapidil failed to evidence direct aggregating properties or potentiating effects. Furthermore, drug high concentrations inhibited the platelet response to ADP, PAF, collagen, adrenaline and bovine thrombin, and influenced the platelet release reaction induced by ADP and PAF.</p><p>Data indicate that urapidil possesses negligible agonistic effects on human platelet alpha 2-adrenoceptors and interferes at high concentrations with the platelet activation, as evidenced for other anti-aggregating compounds.</p></div>\",\"PeriodicalId\":19810,\"journal\":{\"name\":\"Pharmacological research communications\",\"volume\":\"20 10\",\"pages\":\"Pages 883-899\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0031-6989(88)90005-7\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0031698988900057\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological research communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0031698988900057","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Influence of urapidil on in vitro platelet response to adrenaline and other aggregating agents
The effects of hypotensive drug urapidil on human platelet functions were investigated.
Urapidil failed to evidence direct aggregating properties or potentiating effects. Furthermore, drug high concentrations inhibited the platelet response to ADP, PAF, collagen, adrenaline and bovine thrombin, and influenced the platelet release reaction induced by ADP and PAF.
Data indicate that urapidil possesses negligible agonistic effects on human platelet alpha 2-adrenoceptors and interferes at high concentrations with the platelet activation, as evidenced for other anti-aggregating compounds.
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