Pathology International最新文献_第9页

Abstracts of presentation by the winners of The Japanese Society of Pathology; Japan Pathology Award in 2024 (in program order). 日本病理学会 2024 年日本病理学奖获奖者演讲摘要（按节目顺序排列）。

IF 2.2 4区医学

Pathology International Pub Date : 2024-03-01 DOI: 10.1111/pin.13401

引用次数: 0

Molecular pathological demonstration of an unusual angiosarcoma-like dedifferentiation pattern in hepatocellular carcinoma. 分子病理学显示肝细胞癌存在不寻常的血管肉瘤样去分化模式。

IF 2.2 4区医学

Pathology International Pub Date : 2024-03-01 Epub Date: 2024-02-06 DOI: 10.1111/pin.13412

Keigo Murakami, Taito Itoh, Yasunobu Okamura, Kengo Kinoshita, Hideki Ota, Michiaki Unno, Takashi Kamei, Toru Furukawa

引用次数: 0

CSF3R-, ASXL1-, and SETBP1-mutated chronic neutrophilic leukemia with monoclonal gammopathy of undetermined significance in a patient who developed severe ascites due to sinusoidal neutrophilic infiltration. CSF3R、ASXL1 和 SETBP1 基因突变的慢性中性粒细胞白血病伴有意义不明的单克隆抗体病，患者因窦状中性粒细胞浸润而出现严重腹水。

IF 2.2 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2023-12-05 DOI: 10.1111/pin.13394

Naonori Harada, Daiki Mukai, Yuto Izuta, Ikumi Shibano, Yusuke Kizawa, Hiroshi Shiragami, Nobuhiko Ohnishi, Naoki Hosaka, Atsuko Mugitani

引用次数: 0

HER2 staining of breast cancer is reduced under the current protocol of Ventana PATHWAY anti-HER-2/neu (4B5). 在目前的 Ventana PATHWAY 抗 HER-2/neu (4B5) 方案中，乳腺癌的 HER2 染色减少。

IF 2.2 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2024-01-10 DOI: 10.1111/pin.13404

Yoshiya Horimoto, Hiroko Onagi, Junichiro Watanabe, Takuo Hayashi

引用次数: 0

Is the endomyocardial biopsy in giant cell myocarditis of some help for the rapid indication for heart transplantation? 巨细胞心肌炎的心内膜活检是否有助于快速确定心脏移植指征？

IF 2.2 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2023-12-27 DOI: 10.1111/pin.13400

Andrea Marzullo, Gabriella Serio, Gerardo Cazzato, Marialessandra Capuzzolo, Carla Nardelli, Cecilia Salzillo

引用次数: 0

Decoding the DNA methylome of central nervous system tumors: An emerging modality for integrated diagnosis. 解码中枢神经系统肿瘤的 DNA 甲基组：综合诊断的新兴模式。

IF 2.2 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2024-01-15 DOI: 10.1111/pin.13402

Kaishi Satomi, Koichi Ichimura, Junji Shibahara

{"title":"Decoding the DNA methylome of central nervous system tumors: An emerging modality for integrated diagnosis.","authors":"Kaishi Satomi, Koichi Ichimura, Junji Shibahara","doi":"10.1111/pin.13402","DOIUrl":"10.1111/pin.13402","url":null,"abstract":"The definitive diagnosis and classification of individual cancers are crucial for patient care and cancer research. To achieve a robust diagnosis of central nervous system (CNS) tumors, a genotype-phenotype integrated diagnostic approach was introduced in recent versions of the World Health Organization classification, followed by the incorporation of a genome-wide DNA methylome-based classification. Microarray-based platforms are widely used to obtain DNA methylome data, and the German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]) has a webtool for a DNA methylation-based classifier (DKFZ classifier). Integration of DNA methylome will further enhance the precision of CNS tumor classification, especially in diagnostically challenging cases. However, in the clinical application of DNA methylome-based classification, challenges related to data interpretation persist, in addition to technical caveats, regulations, and limited accessibility. Dimensionality reduction (DMR) can complement integrated diagnosis by visualizing a profile and comparing it with other known samples. Therefore, DNA methylome-based classification is a highly useful research tool for auxiliary analysis in challenging diagnostic and rare disease cases, and for establishing novel tumor concepts. Decoding the DNA methylome, especially by DMR in addition to DKFZ classifier, emphasizes the capability of grasping the fundamental biological principles that provide new perspectives on CNS tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"51-67"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma that deteriorated after COVID-19 vaccination. 首例接种 COVID-19 疫苗后病情恶化的 Epstein-Barr 病毒阳性边缘区淋巴瘤尸检病例。

IF 2.2 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI: 10.1111/pin.13398

Ziyao Wang, Reiji Muto, Hiroaki Miyoshi, Mikiko Aoki, Noriko Uesugi, Hiroyuki Murayama, Kosuke Masutani, Makoto Hamasaki

{"title":"The first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma that deteriorated after COVID-19 vaccination.","authors":"Ziyao Wang, Reiji Muto, Hiroaki Miyoshi, Mikiko Aoki, Noriko Uesugi, Hiroyuki Murayama, Kosuke Masutani, Makoto Hamasaki","doi":"10.1111/pin.13398","DOIUrl":"10.1111/pin.13398","url":null,"abstract":"This is the first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma (EBV + MZL) with an other iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPD) (methotrexate [MTX]-associated LPD) that deteriorated after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. This case had a unique immunophenotype. A 71-year-old female patient with rheumatoid arthritis receiving MTX presented with fatigue 1 week after the SARS-CoV-2 vaccination. She was hospitalized due to hepatorenal dysfunction and pancytopenia. Computed tomography revealed systemic lymphadenopathy. Her physical condition deteriorated, and the patient died. The autopsy revealed systemic lymphadenopathy comprising medium-sized atypical lymphocytes and scattered Hodgkin/Reed-Sternberg (H/RS)-like cells. An immunohistochemical examination showed that atypical lymphocytes were positive for CD79a and MUM-1 and some were positive for CD20 and IRTA-1. H/RS-like cells were immunoreactive for CD30 and CD15 and ringed by T cells. Both cell types were positive for EBV-encoded small RNA. The majority of H/RS-like cells were positive for CD20, whereas a small number of CD3-positive cells were admixed. We herein presented the first autopsy case of EBV + MZL that deteriorated after the SARS-CoV-2 vaccination.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"87-92"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the quality of resected thyroid cancer tissue sample on next-generation sequencing testing. 切除甲状腺癌组织样本的质量对新一代测序检测的影响。

IF 2.5 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2024-01-16 DOI: 10.1111/pin.13399

Kanako C Hatanaka, Kenichi Nakamura, Ryohei Katoh, Koichi Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Yoshihiro Matsuno, Satoshi Kano, Yui Okada, Joji Mori, Yoichi M Ito, Yutaka Hatanaka

{"title":"Impact of the quality of resected thyroid cancer tissue sample on next-generation sequencing testing.","authors":"Kanako C Hatanaka, Kenichi Nakamura, Ryohei Katoh, Koichi Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Yoshihiro Matsuno, Satoshi Kano, Yui Okada, Joji Mori, Yoichi M Ito, Yutaka Hatanaka","doi":"10.1111/pin.13399","DOIUrl":"10.1111/pin.13399","url":null,"abstract":"Activating rearranged during transfection (RET) proto-oncogene alterations can be identified using next-generation sequencing (NGS) of tumor DNA/RNA. We assessed factors associated with NGS (Oncomine Dx Target Test [ODxTT]) success for resected thyroid cancer (TC) specimens, including sample age, processing conditions, and DNA/RNA quality. TC samples were from three Japanese hospitals, with sample age <1-<10 years, fixative 10%/15% neutralized buffered formalin (NBF), and fixation time ≤48 h/>48 h-≤72 h. NGS success rate was defined as the percentage of samples returning validated NGS results (RET fusion-positive/negative [RNA] or RET mutation-positive/negative [DNA], detected using ODxTT). DNA/RNA quality was assessed with indexes based on electrophoresis (DNA/RNA integrity number, DV200 ) and quantitative polymerase chain reaction (DNA/RNA integrity score [ddCq/ΔCq]). NGS success rate (N = 202) was 90%/93% (DNA/RNA) overall, 98%-100% (DNA and RNA) for samples <3 years old, and 91% (DNA and RNA) for samples ≥3-<5 years old fixed in 10% NBF for ≤48 h. Multivariate logistic regression analysis identified ddCq and ΔCq as significant predictors of DNA and RNA NGS success rates, respectively. Quality assessment of nucleic acid extracted from archival tissue samples is important for achieving high NGS success rates in clinical practice, especially for samples ≥3 years old.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"77-86"},"PeriodicalIF":2.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelioid granulomas with proliferating T-lymphocytes in bone marrow in a patient with infectious mononucleosis modified by secondary hemophagocytic lymphohistiocytosis. 继发性噬血细胞性淋巴组织细胞增多症改变的传染性单核细胞增多症患者骨髓上皮样肉芽肿伴增殖t淋巴细胞。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-11-17 DOI: 10.1111/pin.13388

Haruo Ohtani, Yoshihiro Sato, Isho Izumi, Keisuke Kato, Masahiro Tsuchida

引用次数: 0

Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers. 通过五种免疫细胞标记物的分层聚类分析来表征结直肠癌。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-12-05 DOI: 10.1111/pin.13391

Sunao Ito, Akira Koshino, Masayuki Komura, Shunsuke Kato, Takahiro Otani, Chengbo Wang, Akane Ueki, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma

{"title":"Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers.","authors":"Sunao Ito, Akira Koshino, Masayuki Komura, Shunsuke Kato, Takahiro Otani, Chengbo Wang, Akane Ueki, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma","doi":"10.1111/pin.13391","DOIUrl":"10.1111/pin.13391","url":null,"abstract":"The present study analyzed the expression of five independent immunohistochemical markers, CD4, CD8, CD66b, CD68, and CD163, on immune cells within the colorectal cancer (CRC) tumor microenvironment (TME). Using hierarchical clustering, patients were successfully classified according to significant associations with clinicopathological features and/or survival. Patients with mismatch repair-proficient (pMMR) CRC were categorized into four groups with survival differences (p = 0.0084): CD4Low , CD4High , MΦHigh , and CD8Low . MΦHigh tumors showed significantly higher expression of CD47 (p < 0.0001), a phagocytosis checkpoint molecule. These tumors contained significantly greater numbers of PD-1+ (p < 0.0001), TIM-3+ (p < 0.0001), and SIRPA+ (p < 0.0001) immune cells. Notably, 10% of the patients with pMMR CRC expressed PD-L1 (CD274) on tumor cells with significantly worse survival (p = 0.00064). The Cox proportional hazards model identified MΦ High (hazard ratio [HR] = 2.02, 95%, p = 0.032), CD8Low (HR = 2.45, p = 0.011), and tumor PD-L1 expression (HR = 2.74, p = 0.0061) as potential risk factors. PD-L1-PD-1 and/or CD47-SIRPA axes targeting immune checkpoint therapies might be considered for patients with pMMR CRC according to their tumor cells and tumor immune microenvironment characteristics.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"13-25"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0