Pathology International最新文献_第9页

The first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma that deteriorated after COVID-19 vaccination. 首例接种 COVID-19 疫苗后病情恶化的 Epstein-Barr 病毒阳性边缘区淋巴瘤尸检病例。

IF 2.2 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI: 10.1111/pin.13398

Ziyao Wang, Reiji Muto, Hiroaki Miyoshi, Mikiko Aoki, Noriko Uesugi, Hiroyuki Murayama, Kosuke Masutani, Makoto Hamasaki

{"title":"The first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma that deteriorated after COVID-19 vaccination.","authors":"Ziyao Wang, Reiji Muto, Hiroaki Miyoshi, Mikiko Aoki, Noriko Uesugi, Hiroyuki Murayama, Kosuke Masutani, Makoto Hamasaki","doi":"10.1111/pin.13398","DOIUrl":"10.1111/pin.13398","url":null,"abstract":"This is the first autopsy case of Epstein-Barr virus-positive marginal zone lymphoma (EBV + MZL) with an other iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPD) (methotrexate [MTX]-associated LPD) that deteriorated after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. This case had a unique immunophenotype. A 71-year-old female patient with rheumatoid arthritis receiving MTX presented with fatigue 1 week after the SARS-CoV-2 vaccination. She was hospitalized due to hepatorenal dysfunction and pancytopenia. Computed tomography revealed systemic lymphadenopathy. Her physical condition deteriorated, and the patient died. The autopsy revealed systemic lymphadenopathy comprising medium-sized atypical lymphocytes and scattered Hodgkin/Reed-Sternberg (H/RS)-like cells. An immunohistochemical examination showed that atypical lymphocytes were positive for CD79a and MUM-1 and some were positive for CD20 and IRTA-1. H/RS-like cells were immunoreactive for CD30 and CD15 and ringed by T cells. Both cell types were positive for EBV-encoded small RNA. The majority of H/RS-like cells were positive for CD20, whereas a small number of CD3-positive cells were admixed. We herein presented the first autopsy case of EBV + MZL that deteriorated after the SARS-CoV-2 vaccination.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the quality of resected thyroid cancer tissue sample on next-generation sequencing testing. 切除甲状腺癌组织样本的质量对新一代测序检测的影响。

IF 2.5 4区医学

Pathology International Pub Date : 2024-02-01 Epub Date: 2024-01-16 DOI: 10.1111/pin.13399

Kanako C Hatanaka, Kenichi Nakamura, Ryohei Katoh, Koichi Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Yoshihiro Matsuno, Satoshi Kano, Yui Okada, Joji Mori, Yoichi M Ito, Yutaka Hatanaka

{"title":"Impact of the quality of resected thyroid cancer tissue sample on next-generation sequencing testing.","authors":"Kanako C Hatanaka, Kenichi Nakamura, Ryohei Katoh, Koichi Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Yoshihiro Matsuno, Satoshi Kano, Yui Okada, Joji Mori, Yoichi M Ito, Yutaka Hatanaka","doi":"10.1111/pin.13399","DOIUrl":"10.1111/pin.13399","url":null,"abstract":"Activating rearranged during transfection (RET) proto-oncogene alterations can be identified using next-generation sequencing (NGS) of tumor DNA/RNA. We assessed factors associated with NGS (Oncomine Dx Target Test [ODxTT]) success for resected thyroid cancer (TC) specimens, including sample age, processing conditions, and DNA/RNA quality. TC samples were from three Japanese hospitals, with sample age <1-<10 years, fixative 10%/15% neutralized buffered formalin (NBF), and fixation time ≤48 h/>48 h-≤72 h. NGS success rate was defined as the percentage of samples returning validated NGS results (RET fusion-positive/negative [RNA] or RET mutation-positive/negative [DNA], detected using ODxTT). DNA/RNA quality was assessed with indexes based on electrophoresis (DNA/RNA integrity number, DV200 ) and quantitative polymerase chain reaction (DNA/RNA integrity score [ddCq/ΔCq]). NGS success rate (N = 202) was 90%/93% (DNA/RNA) overall, 98%-100% (DNA and RNA) for samples <3 years old, and 91% (DNA and RNA) for samples ≥3-<5 years old fixed in 10% NBF for ≤48 h. Multivariate logistic regression analysis identified ddCq and ΔCq as significant predictors of DNA and RNA NGS success rates, respectively. Quality assessment of nucleic acid extracted from archival tissue samples is important for achieving high NGS success rates in clinical practice, especially for samples ≥3 years old.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelioid granulomas with proliferating T-lymphocytes in bone marrow in a patient with infectious mononucleosis modified by secondary hemophagocytic lymphohistiocytosis. 继发性噬血细胞性淋巴组织细胞增多症改变的传染性单核细胞增多症患者骨髓上皮样肉芽肿伴增殖t淋巴细胞。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-11-17 DOI: 10.1111/pin.13388

Haruo Ohtani, Yoshihiro Sato, Isho Izumi, Keisuke Kato, Masahiro Tsuchida

引用次数: 0

Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers. 通过五种免疫细胞标记物的分层聚类分析来表征结直肠癌。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-12-05 DOI: 10.1111/pin.13391

Sunao Ito, Akira Koshino, Masayuki Komura, Shunsuke Kato, Takahiro Otani, Chengbo Wang, Akane Ueki, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma

{"title":"Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers.","authors":"Sunao Ito, Akira Koshino, Masayuki Komura, Shunsuke Kato, Takahiro Otani, Chengbo Wang, Akane Ueki, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma","doi":"10.1111/pin.13391","DOIUrl":"10.1111/pin.13391","url":null,"abstract":"The present study analyzed the expression of five independent immunohistochemical markers, CD4, CD8, CD66b, CD68, and CD163, on immune cells within the colorectal cancer (CRC) tumor microenvironment (TME). Using hierarchical clustering, patients were successfully classified according to significant associations with clinicopathological features and/or survival. Patients with mismatch repair-proficient (pMMR) CRC were categorized into four groups with survival differences (p = 0.0084): CD4Low , CD4High , MΦHigh , and CD8Low . MΦHigh tumors showed significantly higher expression of CD47 (p < 0.0001), a phagocytosis checkpoint molecule. These tumors contained significantly greater numbers of PD-1+ (p < 0.0001), TIM-3+ (p < 0.0001), and SIRPA+ (p < 0.0001) immune cells. Notably, 10% of the patients with pMMR CRC expressed PD-L1 (CD274) on tumor cells with significantly worse survival (p = 0.00064). The Cox proportional hazards model identified MΦ High (hazard ratio [HR] = 2.02, 95%, p = 0.032), CD8Low (HR = 2.45, p = 0.011), and tumor PD-L1 expression (HR = 2.74, p = 0.0061) as potential risk factors. PD-L1-PD-1 and/or CD47-SIRPA axes targeting immune checkpoint therapies might be considered for patients with pMMR CRC according to their tumor cells and tumor immune microenvironment characteristics.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large cell neuroendocrine carcinoma with discohesive growth pattern of the sigmoid colon resembling undifferentiated carcinoma. 乙状结肠的大细胞神经内分泌癌具有类似未分化癌的不粘附生长模式。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-10-27 DOI: 10.1111/pin.13384

Rin Yamada, Osamu Nakahara, Hiroshi Takamori, Yoshihiro Komohara, Minako Fujiwara

引用次数: 0

The enigmatic occurrence of Pacinian corpuscles in the prostate gland: Report of a case with pericorpuscular and intracorpuscular growth of prostatic acinar adenocarcinoma. 前列腺中太平洋小体的神秘发生:前列腺腺泡癌的胞周和胞内生长1例报告。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-12-05 DOI: 10.1111/pin.13392

João Lobo, Paula Lopes, Rui Henrique, Ângelo Rodrigues

引用次数: 0

Colostomy-site carcinoma with primitive phenotype in a rectal cancer patient after achieving pathological complete response with neoadjuvant chemoradiotherapy. 一名直肠癌患者在接受新辅助化放疗并获得病理完全反应后，出现带有原始表型的结肠造口部位癌。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-12-22 DOI: 10.1111/pin.13396

Takayuki Kodama, Maki Kanzawa, Hiroshi Hasegawa, Shuichi Tsukamoto, Mari Nishio, Manabu Shigeoka, Yu-Ichiro Koma, Tomoo Itoh, Hiroshi Yokozaki

{"title":"Colostomy-site carcinoma with primitive phenotype in a rectal cancer patient after achieving pathological complete response with neoadjuvant chemoradiotherapy.","authors":"Takayuki Kodama, Maki Kanzawa, Hiroshi Hasegawa, Shuichi Tsukamoto, Mari Nishio, Manabu Shigeoka, Yu-Ichiro Koma, Tomoo Itoh, Hiroshi Yokozaki","doi":"10.1111/pin.13396","DOIUrl":"10.1111/pin.13396","url":null,"abstract":"Herein, we report a rare case of a carcinoma with primitive phenotype (enteroblastic and/or hepatoid differentiation) occurring at a colostomy site. The patient was an elderly male who underwent neoadjuvant chemoradiotherapy for rectal cancer, followed by abdominoperineal resection. A biopsy specimen for the rectal carcinoma before neoadjuvant chemoradiotherapy was conventional tubular adenocarcinoma. Moreover, a pathological complete response was confirmed in the proctectomy specimen. However, a colostomy-site tumor appeared 6 months after the proctectomy, and it was resected 1 year after the initial proctectomy. The colostomy-site tumor comprised solid to focal glandular growth of atypical polygonal cells with clear to pale eosinophilic cytoplasm and was immunohistochemically positive for cytokeratin, spalt-like transcription factor 4, glypican-3, caudal type homeobox 2, and special AT-rich sequence-binding protein 2. Thus, the tumor was diagnosed as poorly differentiated adenocarcinoma with primitive phenotype, with suggested origin from the colorectal epithelium. Additionally, a multilocular cystic lesion comprising various types of epithelia was found adjacent to the tumor, suggestive of metaplasia or heterotopia. Changes in the histology and immunophenotype, and the findings of an adjacent cystic lesion suggest a metachronous tumor rather than a recurrence of the primary tumor.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The CAP: Your resource for artificial intelligence information. CAP:您的人工智能信息资源。

IF 2.2 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-12-01 DOI: 10.1111/pin.13390

Emily E Volk

引用次数: 0

Prevalence and diagnostic significance of non-invasive follicular thyroid neoplasm with papillary-like nuclear features in Japan-A multi-institutional study. 日本具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤的患病率及诊断意义——一项多机构研究

IF 2.5 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-12-05 DOI: 10.1111/pin.13393

Mitsuyoshi Hirokawa, Masahiro Ito, Noriko Motoi, Tomohiro Chiba, Yoshiaki Imamura, Hironao Yasuoka, Rumi Hino, Miyoko Higuchi, Akira Miyauchi, Takashi Akamizu

{"title":"Prevalence and diagnostic significance of non-invasive follicular thyroid neoplasm with papillary-like nuclear features in Japan-A multi-institutional study.","authors":"Mitsuyoshi Hirokawa, Masahiro Ito, Noriko Motoi, Tomohiro Chiba, Yoshiaki Imamura, Hironao Yasuoka, Rumi Hino, Miyoko Higuchi, Akira Miyauchi, Takashi Akamizu","doi":"10.1111/pin.13393","DOIUrl":"10.1111/pin.13393","url":null,"abstract":"This multi-institutional study investigated non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) frequency and its diagnostic significance in Japan. We reviewed 4008 thyroid nodules resected in six institutions before NIFTP was proposed. Overall, 26 cases diagnosed as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) and 145 cases of follicular thyroid adenoma (FTA) were included. Of these nodules, 80.8% and 31.0%, respectively, were NIFTPs. In five institutions, NIFTPs were more commonly found in FTA than in PTC nodules. When NIFTP was included with PTC, the overall prevalence was 2.3%, with rates in five institutions below 5.0% (0.8%-4.4%). One NIFTP case with nuclear score 3 revealed nodal metastasis 2.5 years post-resection, and the carcinoma cells were immunohistochemically positive for BRAF. FTAs or NIFTPs with nuclear score 2 did not metastasize. NIFTP was more common among FTA than among PTC nodules, possibly due to underdiagnosis of PTC on nuclear findings. Considering the clinical findings, molecular pathogenesis, and therapeutic strategy in Japan, NIFTP with nuclear score 2 is not different from FTA, and use of this entity terminology is not meaningful. In contrast, NIFTP with nuclear score 3 has potential for metastasis and BRAFV600E mutation. Therefore, in NIFTP cases, nuclear scores 2 and 3 should be separately reported.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution of proteinase K-resistant anti-α-synuclein immunoreactive axons in the cardiac plexus is unbiased to the left ventricular anterior wall. 抗α-突触核蛋白免疫反应性轴突在心脏丛的分布与左心室前壁无关。

IF 2.5 4区医学

Pathology International Pub Date : 2024-01-01 Epub Date: 2023-12-01 DOI: 10.1111/pin.13389

Nei Fukasawa, Miku Maeda, Yoshifumi Sugiyama, Takahiro Fukuda, Masayuki Shimoda

{"title":"Distribution of proteinase K-resistant anti-α-synuclein immunoreactive axons in the cardiac plexus is unbiased to the left ventricular anterior wall.","authors":"Nei Fukasawa, Miku Maeda, Yoshifumi Sugiyama, Takahiro Fukuda, Masayuki Shimoda","doi":"10.1111/pin.13389","DOIUrl":"10.1111/pin.13389","url":null,"abstract":"Lewy body disease (LBD) is characterized by the appearance of Lewy neurites and Lewy bodies, which are predominantly composed of α-synuclein. Notably, the cardiac plexus (CP) is one of the main targets of LBD research. Although previous studies have reported obvious differences in the frequency of Lewy body pathology (LBP) in the CP, none of them have confirmed whether LBP preferably appears in any part of the CP. Thus, we aimed to clarify the emergence and/or propagation of LBP in the CP. In this study, 263 consecutive autopsy cases of patients aged ≥50 years were included, with one region per case selected from three myocardial perfusion areas (MPAs) and subjected to proteinase K and then immunohistochemically stained with anti-α-synuclein antibodies to assess LBP. We stained all three MPAs in 17 cases with low-density LBP and observed the actual distribution of LBP. LBP were identified in the CP in 20.2% (53/263) of patients. Moreover, we found that LBP may appear in only one region of MPAs, mainly in the young-old group (35.3% (6/17) of patients). These findings suggest that it is possible to underestimate LBP in the CP, especially in the young-old group, by restricting the search to only one of the three MPAs.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138461506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0