PeerJ最新文献

{"title":"Studying turn performance, trunk control, and mobility in acute stroke subjects: a cross-sectional study.","authors":"Mahima Vasyani, Akshatha Nayak, K Vijaya Kumar, Zulkifli Misri, Pema Choezom, Rinita Mascarenhas, Jaya Shanker Tedla, Srikant Natarajan","doi":"10.7717/peerj.18501","DOIUrl":"10.7717/peerj.18501","url":null,"abstract":"<p><strong>Background: </strong>Stroke leads to various impairments like motor deficits, impaired trunk control and restricted mobility. However, rehabilitation professionals often underestimate the fundamental function of turning, which is essential for daily living activities like walking, cooking, or performing household chores. Impaired turning can be attributed to motor deficits post-stroke, resulting in restricted mobility and impaired trunk movement. Therefore, the present study aimed to determine the relationship between turn performance, trunk control, and mobility in stroke patients.</p><p><strong>Materials and methods: </strong>A total of 63 first-time supratentorial stroke (<i>i.e</i>., anterior circulation stroke) patients aged 18-90 years were recruited for the study. Turn performance was assessed by asking patients to walk for 10 feet comfortably, then take a 180° turn and return to the starting position. In addition, the duration and number of steps were recorded. Following this, the Trunk Impairment Scale (TIS) and Stroke Rehabilitation Assessment of Movement (STREAM) were used to assess trunk impairment and mobility, respectively. The group turn performance was analyzed using the Kruskal-Wallis test with a <i>post hoc</i> Mann-Whitney U test for between-group comparisons. The turn duration and turn steps were correlated with age, trunk control, and mobility using Spearman's rank correlation. A regression analysis was performed to determine the association of turn performance with age, trunk control, and mobility among stroke patients.</p><p><strong>Results: </strong>Thirty stroke patients had turning difficulty, and 33 did not. Hence, they were categorized into the turning difficulty (TD) and non-turning difficulty (NTD) groups. When correlated with turn duration and the number of steps taken by the stroke patients while turning, the STREAM and TIS scores revealed a significant negative correlation (<i>p</i> < 0.001). The subjects' age showed a significant positive correlation with the turn duration and number of steps taken by stroke patients while turning (<i>p</i> < 0.001). A significant association was also found between turn performance and age and trunk control. However, there was no significant association between turn performance and mobility.</p><p><strong>Conclusion: </strong>The observed associations highlight the complexity of turning ability and trunk control necessary to complete a turn safely. Additionally, with advancing age, turn performance and turning movement are compromised in stroke patients. This indicates that turning difficulty is more pronounced in older individuals with stroke.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18501"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery-induced neuroinflammatory transcriptional programs in medial prefrontal cortex of mice during early phase of perioperative neurocognitive disorders.","authors":"Xiaodong Tang, Xuwu Xiang, Yang Yu, Shuyuan Huang, Caifei Pan, Shuyuan Gan, Yongxing Yao","doi":"10.7717/peerj.18664","DOIUrl":"10.7717/peerj.18664","url":null,"abstract":"<p><p>Patients receiving anesthesia and surgery may experience cognitive dysfunction, memory deficits, and mental disturbances, which are referred to as perioperative neurocognitive disorders (PND). The function of the medial prefrontal cortex (mPFC) is disrupted during early phase of PND. To gain insight into the mechanisms of PND, we collected mouse mPFC tissues 6 h post-surgery and performed RNA sequencing analysis. In total, 178 differentially expressed genes (DEGs) were identified, including 105 upregulated and 73 downregulated genes. Bioinformatic analysis highlighted the significant enrichment of these DEGs in several immune-related biological processes and signaling pathways, suggesting that pronounced neuroinflammatory transcriptional programming in the mPFC was evoked during early phase of PND. Interleukin-6 level increased in both serum and mPFC, while the mRNA levels of <i>Il-6</i>, <i>Tnf-α</i>, and <i>Il-1β</i> remained unchanged. Taken together, our findings suggest that a distinct and acute neuroinflammatory response in the mPFC is evoked after peripheral surgery, which might play a key role in the development of PND.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18664"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of mulching and organic manure on maize yield, water, and nitrogen use efficiency in the Loess Plateau of China.","authors":"Yingying Xing, Jintao Fu, Xiukang Wang","doi":"10.7717/peerj.18644","DOIUrl":"10.7717/peerj.18644","url":null,"abstract":"<p><p>Current agricultural practices prioritize intensive food production, often at the expense of environmental sustainability. This approach results in greenhouse gas emissions and groundwater pollution due to over-fertilization. In contrast, organic agriculture promotes a more efficient use of non-renewable energy, improves soil quality, and reduces ecological damage. However, the effects of mulching and organic manure on maize yield, water use efficiency (WUE), and nitrogen use efficiency (NUE) in China's Loess Plateau have not been sufficiently researched. In 2017 and 2018, an experiment utilizing a randomized complete block design with two factors (two mulching levels × three organic nitrogen application rates) was conducted. The water content of the upper soil layer was found to be 12.6% to 19.4% higher than that of the subsoil layer. Across all soil depths and years, the soil nitrate-N content in mulched treatments was 10% to 31.8% greater than in non-mulched treatments with varying organic nitrogen rates. Additionally, mulching resulted in an increase in grain yield of 9.4% in 2017 and 8.9% in 2018 compared to non-mulched treatments. A significant interaction was observed between mulching and organic nitrogen application rate concerning WUE, alongside a negative correlation between WUE and NUE. These findings suggest that the application of 270 kg N ha^-1 of sheep manure in conjunction with mulching is a highly recommended practice for the Loess Plateau, thereby supporting sustainable agricultural strategies.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18644"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA shuffling to improve crude-water interfacial activity in biosurfactants with OmpA protein of <i>Escherichia coli</i>.","authors":"Vanessa Lucía Nuñez Velez, Liseth Daniela Villamizar Gomez, Jhon E Mendoza Ospina, Yasser Hayek-Orduz, Miguel Fernandez-Niño, Silvia Restrepo Restrepo, Óscar Alberto Álvarez Solano, Luis H Reyes Barrios, Andres F Gonzalez Barrios","doi":"10.7717/peerj.17239","DOIUrl":"10.7717/peerj.17239","url":null,"abstract":"<p><p>Surfactants are molecules derived primarily from petroleum that can reduce the surface tension at interfaces. Their slow degradation is a characteristic that could cause environmental issues. This and other factors contribute to the allure of biosurfactants today. Progress has been made in this area of research, which aims to satisfy the need for effective surfactants that are not harmful to the environment. In previous studies, we demonstrated the surface tension activity of the <i>Escherichia coli</i> transmembrane protein OmpA. Here, we carried out DNA shuffling on <i>ompA</i> to improve its interfacial activity. We evaluated changes in interfacial tension when exposing mutants to a water-oil interface to identify the most promising candidates. Two mutants reached an interfacial tension value lower (9.10 mN/m and 4.24 mN/m) than the original protein OmpA (14.98 mN/m). Since predicted isoelectric point values are far from neutral pH, the charge of the protein was a crucial factor in explaining the migration of proteins towards the interface. Low molecular weight mutants did not exhibit a significant difference in their migration to the interface.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e17239"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical screening and <i>in vitro</i> antibacterial activity of <i>Echinops kebericho</i> Mesfin tuber extracts: experimental studies.","authors":"Jiregna Gari Negasa, Ibsa Teshome, Edilu Jorga Sarba, Bekiyad Shasho Daro","doi":"10.7717/peerj.18554","DOIUrl":"10.7717/peerj.18554","url":null,"abstract":"<p><strong>Background: </strong>The application of plant extracts and their phytochemicals as potential treatments for bacterial illnesses has increased significantly in the last few decades. In Ethiopia, <i>Echinops kebericho</i> Mesfin is widely used to treat a range of illnesses in humans and animals. This study aimed to evaluate the antibacterial activity and phytochemical screening of <i>Echinops kebericho</i> Mesfin.</p><p><strong>Methods: </strong>We carried out an <i>in vitro</i> experimental study after collecting the plants from their natural habitats. Then macerated in absolute methanol and petroleum ether solvents and concentrated the extracts using a rotary evaporator. In the experiment, we used Standard cultures of <i>E. coli</i>, <i>K. pneumoniae</i>, <i>S. aureus</i>, and <i>P. aeruginosa</i>. The agar-well diffusion method evaluated the antibacterial activity of the plants. The agar dilution method determined the minimum inhibitory concentration of the plant extract.</p><p><strong>Results: </strong>The percentage yield of the plant extracts ranged from 6.25% to 7.85%. The methanol extract of <i>Echinops kebericho</i> Mesfin had the highest inhibitory effect on <i>S. aureus</i> (ATCC 25923) (16.67 ± 0.58 mm), followed by <i>E. coli</i> (ATCC 25922) (11.0 ± 1.73 mm). Phytochemical screening of leaves from the methanol and petroleum ether extracts of the plant revealed the presence of phytochemicals such as alkaloids, flavonoids, tannins, and cardiac glycosides. The present study revealed that the extracts of these plants have antibacterial activity. However, researchers should conduct further studies on the safety margin and quantitative bioactive isolation of selected medicinal plants.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18554"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients through logistic regression: a model incorporating clinical characteristics, computed tomography (CT) imaging features, and tumor marker levels.","authors":"Jimin Hao, Man Liu, Zhigang Zhou, Chunling Zhao, Liping Dai, Songyun Ouyang","doi":"10.7717/peerj.18618","DOIUrl":"10.7717/peerj.18618","url":null,"abstract":"<p><strong>Background: </strong>Approximately 60% of Asian populations with non-small cell lung cancer (NSCLC) harbor epidermal growth factor receptor (EGFR) gene mutations, marking it as a pivotal target for genotype-directed therapies. Currently, determining EGFR mutation status relies on DNA sequencing of histological or cytological specimens. This study presents a predictive model integrating clinical parameters, computed tomography (CT) characteristics, and serum tumor markers to forecast EGFR mutation status in NSCLC patients.</p><p><strong>Methods: </strong>Retrospective data collection was conducted on NSCLC patients diagnosed between January 2018 and June 2019 at the First Affiliated Hospital of Zhengzhou University, with available molecular pathology results. Clinical information, CT imaging features, and serum tumor marker levels were compiled. Four distinct models were employed in constructing the diagnostic model. Model diagnostic efficacy was assessed through receiver operating characteristic (ROC) area under the curve (AUC) values and calibration curves. DeLong's test was administered to validate model robustness.</p><p><strong>Results: </strong>Our study encompassed 748 participants. Logistic regression modeling, trained with the aforementioned variables, demonstrated remarkable predictive capability, achieving an AUC of 0.805 (95% confidence interval (CI) [0.766-0.844]) in the primary cohort and 0.753 (95% CI [0.687-0.818]) in the validation cohort. Calibration plots suggested a favorable fit of the model to the data.</p><p><strong>Conclusions: </strong>The developed logistic regression model emerges as a promising tool for forecasting EGFR mutation status. It holds potential to aid clinicians in more precisely identifying patients likely to benefit from EGFR molecular testing and facilitating targeted therapy decision-making, particularly in scenarios where molecular testing is impractical or inaccessible.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18618"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationships between peri-implant diseases, periodontal diseases, and conditions: a cross-sectional study.","authors":"Tuğba Şahin","doi":"10.7717/peerj.18663","DOIUrl":"10.7717/peerj.18663","url":null,"abstract":"<p><strong>Introduction: </strong>Peri-implant and periodontal conditions share common underlying factors, including risk factors, microbiology, immunology, and treatment approaches.</p><p><strong>Aims: </strong>This study aims to investigate the potential co-occurrence of peri-implant and periodontal conditions.</p><p><strong>Design: </strong>One hundred twenty-three implants were divided into three groups: peri-implantitis (41 implants), peri-implant mucositis (41 implants), and peri-implant health (41 implants). Peri-implant and periodontal statuses were assessed using the 2017 AAP/EFP World Workshop on Classification of Periodontal and Peri-implant Diseases and Conditions. All measurements were performed by a single clinician (T.Ş.). One-way analysis of variance was used to compare the study groups according to the data. An assessment was conducted regarding the coexistence of periodontal and peri-implant conditions.</p><p><strong>Results: </strong>Patients with peri-implant mucositis predominantly had gingivitis, whereas those with peri-implant health exhibited periodontal health. In contrast, patients with peri-implantitis mostly had gingivitis, with a lower occurrence of periodontitis. A significant difference was observed between the peri-implant and periodontal groups (<i>p</i> = 0.003). Significant differences were observed between peri-implant and periodontal evaluations for plaque indices, gingival indices, probing depth, gingival recession, and clinical attachment level (<i>p</i> = 0.001), (<i>p</i> = 0.006).</p><p><strong>Conclusions: </strong>The findings of this study underscore the intricate influence of implant treatment on periodontal health. This observation emphasizes the importance of elucidating the underlying factors to improve clinical management and outcomes in patients with periodontal and peri-implant diseases, highlighting the relevance and potential impact of this research in the field.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18663"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative genomics analysis of the MYB gene family in barley: preliminary insights into evolution and biological function in Blue Qingke.","authors":"Hongyan Li, Youhua Yao, Xin Li, Yongmei Cui, Likun An, Baojun Ding, Xiaohua Yao, Kunlun Wu","doi":"10.7717/peerj.18443","DOIUrl":"10.7717/peerj.18443","url":null,"abstract":"<p><strong>Background: </strong>The Myeloblastosis related (MYB) family is one of the most widely distributed transcription factor families in plants and plays a significant role in plant growth and development, hormone signal transduction, and stress response. There are many reports on MYB family species, but the research on Qingke is still limited.</p><p><strong>Methods: </strong>This study used comparative genomics methods to analyze gene and protein structure, protein physicochemical properties, chromosome localization, and evolution. A bioinformatics approach was used to systematically analyze the HvMYB gene family. At the milk stage, soft dough stage, and mature stage, White and Blue Qingke grains were selected for RNA sequencing (RNA-seq), among which two proteins interacted (HvMYB and HvMYC). The expression of this gene family was analyzed through RNA-seq, and the expression levels of <i>HvMYB</i> and <i>HvMYC</i> in the grains of two different color varieties were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Finally, the interaction between HvMYB and HvMYC was verified by bimolecular fluorescence complementation (BiFC) experiments.</p><p><strong>Results: </strong>A total of 92 Qingke <i>HvMYB</i> genes were identified and analyzed, and 92 HvMYB proteins were classified into five categories. <i>Cis</i>-acting elements associated with abscisic acid response, light response, and methyl jasmonate (MeJA) response were found in the promoter regions of most <i>MYB</i> genes. Using qRT-PCR combined with RNA-seq analysis showed that MYB gene was highly expressed in the soft dough stage and was varietal specific. Subcellular localization indicated that HvMYB was located in the nucleus and cell membrane, HvMYC was located in the nucleus, cell membrane, and cytoplasm. Through BiFC analysis, it has been proven that HvMYB in the MYB family and HvMYC in the basic helix-loop-helix (bHLH) family can interact. This study provides a preliminary theoretical basis for understanding the function and role of the Qingke MYB gene family and provides a reference for the molecular mechanism of Qingke gene evolution.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18443"},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of genotype by environment and yield performance of tropical maize hybrids using stability statistics and graphical biplots.","authors":"Dedy Supriadi, Yusuf Mufti Bimantara, Yuniel Melvanolo Zendrato, Eko Widaryanto, Kuswanto Kuswanto, Budi Waluyo","doi":"10.7717/peerj.18624","DOIUrl":"https://doi.org/10.7717/peerj.18624","url":null,"abstract":"<p><strong>Background: </strong>Enhancing maize grain yield in tropical regions faces significant challenges due to variability in agroclimate, soil conditions, and agroecosystems. Understanding genotype (G) by environment (E) interaction (GEI) in plant breeding is crucial for selecting and developing high-yielding genotypes adapted to diverse environments.</p><p><strong>Methods: </strong>Ten maize hybrids, including eight candidates and two commercial varieties, were evaluated across ten environments in Indonesia using a randomized complete block design with three replications. The GEI effect and yield stability were assessed using stability statistics, additive main effects and multiplicative interaction model (AMMI), and genotype + genotype × environment (GGE) biplot methods.</p><p><strong>Results and discussion: </strong>Analysis of variance revealed a significant GEI effect, indicating differences in hybrid responses for grain yield (GY), allowing for stability analysis. G01 showed the highest GY based on the best linear unbiased prediction (BLUP) across environments. Correlation analysis indicated strong associations between stability statistics (<i>YS_i</i> and <i>S⁽⁶</i> ⁾) and GY, aiding in the selection of high-yielding hybrids. The integration of AMMI with the BLUP method, and weighted average of absolute scores (WAASB), enabled precise measurement of genotype stability. Overall, G01 (R0211), G04 (R0105), G05 (R0118), and G07 (R0641) emerged as high-yielding, stable hybrids based on stability statistics, AMMI, GGE biplot, and WAASB rankings. These hybrids offer promising candidates for maize genetic improvement programs in tropical regions.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18624"},"PeriodicalIF":2.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of prognostic nutritional index on laboratory parameters and survival in metastatic colorectal cancer patients treated with fruquintinib: a retrospective study.","authors":"Zeng Wang, Sining Zhao, Xuan Zhang, Xinyi Mao, Guonong Yang, Meiqin Yuan, Xiaofang Zhou","doi":"10.7717/peerj.18565","DOIUrl":"https://doi.org/10.7717/peerj.18565","url":null,"abstract":"<p><strong>Objective: </strong>Fruquintinib, a novel anti-angiogenic targeted drug, has gained widespread application in the treatment of metastatic colorectal cancer. This study aims to investigate the impact of the prognostic nutritional index (PNI) on the safety and survival outcomes of patients undergoing fruquintinib treatment for metastatic colorectal cancer.</p><p><strong>Methods: </strong>A cohort of 106 patients with metastatic colorectal cancer, treated with fruquintinib at Zhejiang Cancer Hospital between 2019 and 2023, was included in this study. Clinical and laboratory data were subjected to chi-square and t-tests for analysis. PNI values were calculated using a specific formula. The optimal thresholds (cut-off values) for post-treatment PNI were determined through the ROC curve analysis. Kaplan-Meier analysis and the Log-rank test were employed to evaluate progression-free survival (PFS) and overall survival (OS) based on PNI. Multivariate Cox regression model was used to determine independent prognostic factors which influenced survival time.</p><p><strong>Results: </strong>The study enrolled 106 colorectal cancer patients treated with fruquintinib. Stratified PNI analysis revealed significant differences in various indicators between high and low PNI groups after treatment with fruquintinib. Notably, after fruquintinib treatment, the high PNI group demonstrated elevated levels in white blood cells, lymphocytes, basophils, red blood cells, hemoglobin, platelets, total protein, and albumin compared to the low PNI group. The median OS for patients with high PNI values was 467 days, significantly longer than the 182 days observed for patients with low PNI values (<i>P</i> < 0.05). Cox regression analysis identified wild-type total RAS and BRAF, partial response (PR) + stable disease (SD), and high PNI values as influencing factors for OS in colorectal cancer patients. Additionally, PR + SD was an independent influencing factor for PFS in colorectal cancer patients (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>This study suggests that fuquinitinib can improve the survival of patients with metastatic colorectal cancer. Patients with high levels of PNI have a better prognosis and longer survival time, ensuring the nutritional status of patients can be a help to improve the treatment of fuquinitinib.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"12 ","pages":"e18565"},"PeriodicalIF":2.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}