Pamukkale Medical Journal最新文献_第8页

J wave as a rare ECG finding of malignant cardiac arrhythmia J波是恶性心律失常的罕见心电图表现

Pamukkale Medical Journal Pub Date : 2023-03-03 DOI: 10.31362/patd.1218933

E. Altıntaş, Mehmet Erat, Esma Buşra Güzeş

引用次数: 0

ASSOCIATION BETWEEN TWENTY SERUM MIRNAS AND CLINICOPATHOLOGICAL VARIABLES IN PATIENTS WITH BREAST CANCER 乳腺癌患者20种血清mirna与临床病理变量的关系

Pamukkale Medical Journal Pub Date : 2023-03-02 DOI: 10.31362/patd.1216451

Açelya GÖKDENİZ YILDIRIM, Aydın Demiray, Ali Can Koç, H. Şenol, A. Yaren

{"title":"ASSOCIATION BETWEEN TWENTY SERUM MIRNAS AND CLINICOPATHOLOGICAL VARIABLES IN PATIENTS WITH BREAST CANCER","authors":"Açelya GÖKDENİZ YILDIRIM, Aydın Demiray, Ali Can Koç, H. Şenol, A. Yaren","doi":"10.31362/patd.1216451","DOIUrl":"https://doi.org/10.31362/patd.1216451","url":null,"abstract":"Determining that miRNAs play a role in breast cancer pathogenesis suggests that it may be useful in the diagnosis and treatment of breast cancer. In this study, 39 patients with invasive breast cancer were diagnosed with serum levels of 20 miRNAs(miR-105, miR-21, miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375, miR-34a, miR-133a, miR-155, miR-139-5p, miR-143, miR-145, miR-365, miR-299-5p, miR-411, miR-452, miR-17) were analyzed during diagnosis and after treatment. In the analysis results, it is detected that serum levels of miR-200c(p=0.030), miR-375(p=0.045), miR-34a(p=0.042) were significantly higher in the local advanced/metastatic group. Serum level of miR-141(p=0.062) was lower in patients with positive lymph node involvement, whereas miR-133a(p=0.037) levels were higher in the same patient group. MiR-105(p=0.015), miR-203(p=0.015), miR-375(p=0.033), miR-145(p=0.025) serum levels were significantly higher in the progesterone receptor negative group, likewise miR-105(p=0.053) levels were high in the estrogen receptor negative patient group. The high levels of miR-375 and miR-133a were noticeable in human epidermal growth factor receptor-2 positive patients(p=0.037 and p=0.014, respectively). MiR-143(p=0.009) and miR-145(p=0.017) levels were observed to be higher in the patient group with a ki-67 index>20%. It was found that 2 miRNAs(miR-133a(p=0.018) and miR-139-5p(p=0.004)) were significantly higher in patients in the luminal B group, which were separated by molecular subgroups. Nine of miRNAs that evaluated(miR-105(p=0.0001), miR-21(p=0.001), miR-141(p=0.041), miR-200a(p=0.003), miR-200b(p=0.0001), miR-200c(p=0.0001), miR-203(p=0.0001), miR-34a(p=0.0001), miR-452(p=0.018)) significantly increased after treatment and 5 of the miRNAs(miR-155(p=0.0001), miR-143(p=0.0001), miR-145(p=0.0001), miR-365(p=0.0001), miR-299-5p(p=0.0001)) were significantly reduced after treatment. We think that miRNAs may help in evaluating the follow-up and prognosis of invasive breast cancer.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86288843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary tract infections caused by carbapenem-resistant Klebsiella pneumonia: monotherapy or combined therapy? 耐碳青霉烯肺炎克雷伯菌引起的尿路感染:单药还是联合治疗?

Pamukkale Medical Journal Pub Date : 2023-03-01 DOI: 10.31362/patd.1244480

Fatih Temoçin, Ş. Kayhan, L. Sensoy, T. Kuruoğlu, A. Atilla, E. Tanyel

{"title":"Urinary tract infections caused by carbapenem-resistant Klebsiella pneumonia: monotherapy or combined therapy?","authors":"Fatih Temoçin, Ş. Kayhan, L. Sensoy, T. Kuruoğlu, A. Atilla, E. Tanyel","doi":"10.31362/patd.1244480","DOIUrl":"https://doi.org/10.31362/patd.1244480","url":null,"abstract":"Purpose: In this study, we evaluated healthcare-associated urinary tract infections caused by carbapenem-resistant Klebsiella pneumoniae. \u0000Materials and methods: The study included 134 patients, diagnosed with healthcare-associated urinary tract infection caused by carbapenem-resistant Klebsiella pneumoniae. Demographic features, initial clinical conditions, comorbidities, and Charlson’s comorbidity index of the patients were recorded. In addition, the MIC values of meropenem on the CR-Kp isolates, treatment regimens, clinical and microbiological responses to the treatment, as well as 14- and 28-day mortality rates of the patients, were reviewed. \u0000Results: The 14-day mortality rate was 34.3%, and the 28-day mortality rate was 42.5%. The mean age of the patients who died was significantly higher (p=0.03). Similarly, Charlson’s comorbidity index (p=0.03) and the qSOFA values (p=0.00) were significantly higher in the patients who died. The microbiological response rate was higher in the patients who survived (p=0.01) with no difference in bacteremia between the groups (p=0.29). It was found that combined antibiotherapy provided significantly better 14- and 28-day mortality rates compared to monotherapy in the group of patients with sepsis (p=0.00 and p=0.04, respectively). However, monotherapy and combination therapy in groups of patients without sepsis were insignificant (p=0.72 and p=0.36, respectively) \u0000Conclusion: Our study supports the use of combination therapy in patients with sepsis, and monotherapy with an in-vitro active agent may be used for patients without sepsis in the treatment of urinary tract infections caused by CR-KP.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85760325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of the relationship between radiographic parameters and patient-reported outcomes in Lenke type-1 adolescent idiopathic scoliosis 确定Lenke 1型青少年特发性脊柱侧凸的影像学参数与患者报告结果之间的关系

Pamukkale Medical Journal Pub Date : 2023-03-01 DOI: 10.31362/patd.1251401

İlker Arık, N. Büker, R. Şavkın, N. Ök, A. Kıter

{"title":"Determination of the relationship between radiographic parameters and patient-reported outcomes in Lenke type-1 adolescent idiopathic scoliosis","authors":"İlker Arık, N. Büker, R. Şavkın, N. Ök, A. Kıter","doi":"10.31362/patd.1251401","DOIUrl":"https://doi.org/10.31362/patd.1251401","url":null,"abstract":"Purpose: This study aims to examine sagittal alignment and spinopelvic parameters in patients with surgically treated Lenke type-1 AIS and to determine the relationship between radiographic outcomes and body image, self-esteem, disability and anxiety. \u0000Materials and methods: Twenty-five patients who underwent posterior spinal fusion surgery and followed up for more than 1 years were eveluated (mean age 14.20±1.63 years) retrospectively. Radiographic analysis of A/P and lateral full spine standing radiographs was carried out with the Surgimap software. The patient-reported outcomes were evaluated with Walter Reed Visual Assessment Scale, Rosenberg Self-Esteem Scale, Oswestry Disability Index and Beck Anxiety Inventory. Correlations between deformity measures and patient-reported outcomes were evaluated by the Pearson’s correlation test. \u0000Results: There was a significant decrease in Cobb angle, AVT, trunk shift, T1 tilt and pelvic incidence at early postoperative and final follow up compared with the preoperative measurement (p0.05). \u0000Conclusion: Patient-reported outcomes are important in terms of evaluating the physical and psychosocial effects of scoliosis-related deformity from the patient's perspective. However, low or no correlation was found between radiographic evaluation and patient-reported outcomes. This result indicates that objective and patient-reported results should be interpreted separately.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78945901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Possible Relation of Apelin, Kynurenine and IL-4/IL-10/IL-12/Tnf-alfa Levels with Clinical and Metabolic Parameters in Obesity 肥胖症患者Apelin、Kynurenine、IL-4/IL-10/IL-12/ tnf - α水平与临床及代谢参数关系的探讨

Pamukkale Medical Journal Pub Date : 2023-02-21 DOI: 10.31362/patd.1247216

İkbal Cansu BARIŞ MOĞUL, Y. Dodurga, Ecem PARS UYGUR, G. Yaylali, Zeliha Akdağ

{"title":"Investigation of the Possible Relation of Apelin, Kynurenine and IL-4/IL-10/IL-12/Tnf-alfa Levels with Clinical and Metabolic Parameters in Obesity","authors":"İkbal Cansu BARIŞ MOĞUL, Y. Dodurga, Ecem PARS UYGUR, G. Yaylali, Zeliha Akdağ","doi":"10.31362/patd.1247216","DOIUrl":"https://doi.org/10.31362/patd.1247216","url":null,"abstract":"Purpose \u0000Obesity is a medical condition caused by excess body fat that accumulates at a level that can have a negative impact on health. Altered glucose and lipid metabolism, low-grade chronic inflammation play a role in the pathogenesis of obesity and obesity-related metabolic dysfunction. In our study, we aimed to determine the apelin, kynurenine, IL-4/IL-10/IL-12/TNF-α protein levels in obese individuals and healthy control groups, and to investigate the possible relationship between clinical parameters with the data to be obtained. \u0000Materials and Methods \u0000The levels of Apelin, Kynurenine, IL-4/IL-10/IL-12/TNF-α in serum/plasma samples were measured with enzyme-linked immunosorbent assay. Absorbance of the samples were measured on a microplate reader spectrophotometrically at a wavelength of 450 nm. \u0000Results \u0000The levels of Kinurenin, IL-4, and IL-12 in the serum were higher in control group than in obese patients (p=0.009, p=0.004, p=0.002, respectively). There was no significant difference between the control and obese patients in TNF-α, IL-10 and Apelin levels (p=0.277, p=0.711, p=0.472, respectively). \u0000Conclusion \u0000Inflammation and altered immune response are two important components of obesity. They play a major role in the formation of metabolic diseases associated with obesity. Changes in adipokine levels may lead to the development and maintenance of insulin resistance and systemic inflammation in obesity. The results demonstrate that kynurenine, IL-4, and IL-12 have a complex role in obesity and can be used as therapeutic targets.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87789441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Death and Its Effect on Organ Donation: A 10-Year Analysis 脑死亡及其对器官捐献的影响:一项10年分析

Pamukkale Medical Journal Pub Date : 2023-02-09 DOI: 10.31362/patd.1233178

Aslı Mete, Ilker Kiraz, Burak Eral, İ. H. Akbudak, S. Seri̇n

{"title":"Brain Death and Its Effect on Organ Donation: A 10-Year Analysis","authors":"Aslı Mete, Ilker Kiraz, Burak Eral, İ. H. Akbudak, S. Seri̇n","doi":"10.31362/patd.1233178","DOIUrl":"https://doi.org/10.31362/patd.1233178","url":null,"abstract":"Objective :Brain death can be defined as the irreversible loss of brain functions. It is evident that a delay occurred in the diagnosis of brain death will result in the loss of many cadaveric organs and thus, the number of patients waiting for organ transplantation will increase. Despite there being many studies in the literature about the diagnosis and difficulties of brain death, family interviews, and organ donation, the studies regarding the effects of the regulation change in Turkey on organ donation are limited. The present study includes 10-year retrospective data and it has been conducted to offer an insight to the scientists about the diagnosis of brain death and organ donation. \u0000Method: The study was conducted by using data obtained from the examination of the retrospective files of patients diagnosed with brain death between 2011 and 2021 at Pamukkale University, Faculty of Medicine after obtaining the approval of the ethics committee. \u0000Results: After the study was initiated, the files of 71 patients diagnosed with brain death between 2011 and 2021, were accessed. Due to the missing information in the files of 4 patients, these patients were excluded from the study. Of 67 patients with registered brain death, 36 were male (53.7%) and 31 were female (46.2%). The age average was 49.07. When the treatment units of these patients were evaluated, 50 patients (74.6%) diagnosed with brain death were treated at the neurosurgery intensive care unit, 7 (10.4%) at the neurology intensive care unit, 6 (9%) at the anesthesia intensive care unit, and 4 (6%) at the cardiovascular surgery intensive care unit. \u0000Conclusions:The study concluded that the importance of the diagnosis duration of brain death and the number of specialists who diagnosed brain death in the previous years may have affected this process. It is clear that the formal process, which changed after 2014, showed an acceleration in diagnosis. The importance of the interviews with family members besides the brain death diagnosis has emerged as a result of the study","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91415141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there a superiorıty of the stone volume measured in 3-d non-contrast tomography (3-D NCCT) to the stone area in predicting the stone-freeness of the retrograde intrarenal surgery success (RIRS) 3-d非对比断层扫描(3-d NCCT)测量的结石体积与结石区域在预测逆行肾内手术成功(RIRS)的结石自由度方面是否存在superiorıty关系?

Pamukkale Medical Journal Pub Date : 2023-02-07 DOI: 10.31362/patd.1190940

Yurdaer Kaynak, H. Kilicarslan, E. Okeer, B. Coskun

{"title":"Is there a superiorıty of the stone volume measured in 3-d non-contrast tomography (3-D NCCT) to the stone area in predicting the stone-freeness of the retrograde intrarenal surgery success (RIRS)","authors":"Yurdaer Kaynak, H. Kilicarslan, E. Okeer, B. Coskun","doi":"10.31362/patd.1190940","DOIUrl":"https://doi.org/10.31362/patd.1190940","url":null,"abstract":"Objectives: To examine the predictive effect of preoperative measurements of stone volume (SV) against stone area (SA) on stone-free status (SF) following retrograde intrarenal surgery (RIRS). \u0000 \u0000Methods: We retrospectively examined the medical records of 68 RIRS patients with renal calculi who were eligible. Patients having non-contrast computed tomography ( NCCT ) before and subsequent to RIRS were included, however staghorn stones and inability to access were omitted. SF status was determined by the absence of visible stones on the NCCT three months after RIRS. Using a software reconstruction tool using 3-D NCCT, a radiologist determined stone load characteristics, such as SA and SV. Using a logistic regression model, the assessment of potential SF status determinants was conducted. \u0000 \u0000Results:Age, stone density, quantity and position of stones, usage of access sheath, failed prior Shock Wave Lithotripsy (SWL), and procedures were not substantially linked with non-SF status, however gender (p = 0.014), SA (p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82883847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma Knife Radiosurgery for Central Arteriovenous Malformations— A Single-Center Experience 伽玛刀放射治疗中心动静脉畸形-单中心经验

Pamukkale Medical Journal Pub Date : 2023-01-24 DOI: 10.31362/patd.1228220

B. Karaaslan

{"title":"Gamma Knife Radiosurgery for Central Arteriovenous Malformations— A Single-Center Experience","authors":"B. Karaaslan","doi":"10.31362/patd.1228220","DOIUrl":"https://doi.org/10.31362/patd.1228220","url":null,"abstract":"Introduction: Arteriovenous malformations with basal ganglia, brainstem, and thalamic locations represent difficult vessel anomalies with critical locations. These central aneurysms are related with high morbidity and mortality rates. This retrospective study aims to examine the results of patients with basal ganglia, brainstem, and thalamic arteriovenous malformations remedied with gamma knife radiosurgery (GKS) at our clinic. \u0000Method: May 2005 - December 2020, the results of patients with GKS basal ganglia, thalamus, and brainstem located AVM were analyzed, in Gazi University Gamma Knife Unit. \u0000Results: May 2005 - December 2020, a total of 859 patients with intracranial AVM were treated at the Gamma Knife Unit of the Gazi University Neurosurgery Clinic. Seventy-three patients with basal ganglia, brainstem, and thalamic locations were seen. Of the total 73 patients included in our study, 14 patients (19.2%) in the basal ganglia, 13 patients (17.8) in the brain stem, and 46 patients (63%) in the thalamic region were located. The mean volume of AVMs is 4565,54 mm3. The patients who underwent embolization before gamma knife surgery treatment were found to be 19.2%. The mean of AVMs' obliteration time after SRS is 38.4 months. We detected that there wasn't a remarkable statistical rate relationship between AVMs volume, Spetzler Martin grading scale, nidus type, gender, and prior embolization (p = 0.05). \u0000Conclusions: GKS is an best choice treatment method used for all AVMs today. However, it has been accepted as the first choice treatment method, especially in central AVMs, which are risky in terms of mortality and morbidity, and the results are also quite good.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88792250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Port Site Hernia After Laparoscopic Cholecystectomy: Retrospective Clinical Experience 腹腔镜胆囊切除术后肝部位疝:回顾性临床经验

Pamukkale Medical Journal Pub Date : 2023-01-20 DOI: 10.31362/patd.1207388

Fatih Büyüker, M. Acar, M. Özsoy, M. Sermet, H. Baysal

{"title":"Port Site Hernia After Laparoscopic Cholecystectomy: Retrospective Clinical Experience","authors":"Fatih Büyüker, M. Acar, M. Özsoy, M. Sermet, H. Baysal","doi":"10.31362/patd.1207388","DOIUrl":"https://doi.org/10.31362/patd.1207388","url":null,"abstract":"Abstract \u0000Introduction: Laparoscopic cholecystectomy is the gold standard in patients scheduled for cholecystectomy. Complications related to laparoscopy may occur during or after laparoscopic cholecystectomy. This study is aimed to examine the incidence of port-site hernia and its predisposing factors. \u0000Method: Laparoscopic cholecystectomy operations performed in the general surgery clinic of our hospital between January 2016 and March 2021 were reviewed retrospectively. The pneumoperitoneum was created by entering the abdomen with a mini-incision from the umbilicus using the Hasson technique. All cholecystectomies were performed using the 4-port technique. The umbilical trocar fascia was closed in all patients. Demographic data were evaluated retrospectively. \u0000Result: The incidence of port-site hernia was determined as 0.5%. The umbilical hernia was detected in 15 patients: 11 male and four female. The mean age was 55.4 years. The mean hernia detection time was 14.3 months. The mean body mass index [BMI] was found to be 30.11. Four patients had a chronic disease. Fourteen of the patients underwent surgery. One of the patients was operated on a mini-incision urgently due to the development of strangulation. Recurrence was detected in three patients. No mortality was observed. \u0000Conclusion: Obesity, age, and female gender are considered important risk factors. In our series, fascial closure was performed instead of the umbilical port in all cases, but most of the port site hernias originate from the umbilicus port.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81303841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive and prognostic value of serum vitamin b12 elevation in acute leukemia 血清维生素b12升高对急性白血病的预测和预后价值

Pamukkale Medical Journal Pub Date : 2023-01-13 DOI: 10.31362/patd.1210492

A. Ünlü, Başak Ünver Koluman, S. Hacıoğlu, Gülsüm Akgün Çağlıyan, Nilay Güler

引用次数: 0