2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)最新文献

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A LabVIEW™-developed Biphasic Functional Multichannel Electrical Stimulator LabVIEW™开发的双相功能多通道电刺激器
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757732
I. D. G. De Carvalho, R. R. Kurchchoff, G. N. N. Neto, P. Nohama
{"title":"A LabVIEW™-developed Biphasic Functional Multichannel Electrical Stimulator","authors":"I. D. G. De Carvalho, R. R. Kurchchoff, G. N. N. Neto, P. Nohama","doi":"10.1109/GMEPE/PAHCE55115.2022.9757732","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757732","url":null,"abstract":"The loss of walking ability caused by spinal cord injury, stroke, traumatic brain injury, among others, is a difficult problem to be faced. The transmission of neurological signals to perform muscle contraction is compromised. However, functional electrical stimulation can minimize the impacts caused by these problems, as it evokes nerve action potentials through pulses of electrical current applied to the paralyzed neuromuscular tissue. The objective of this paper was to introduce a biphasic constant-current electrical stimulator with four output channels to evoke functional movements in people who have suffered spinal cord injury or stroke. The stimulation system has a graphical interface implemented in LabVIEW™, splitter circuits, and amplification outputs, where the therapist can change the stimulation parameters according to the muscle to be stimulated and the desired functional movements. With the developed prototype, a modulated signal with trapezoidal envelope was obtained on 1 kΩ load, 85.625 mA maximum current, 1 s duration for rise, plateau, fall and rest time, 25 Hz burst frequency, 1 kHz pulse frequency, and 20% for both pulse and burst duty cycles, corresponding to the settings made in the software; and these parameters are effective for obtaining artificial motor control for gait or grip.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129971366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulation proposal of a transcranial focused magnetic stimulation system 一种经颅聚焦磁刺激系统的仿真方案
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757735
A. E. Medellín-Serafín, A. Vera-Hernández, L. Leija-Salas, M. I. Gutiérrez-Velazco, C. Trujillo-Romero, J. Gutiérrez-Martínez
{"title":"Simulation proposal of a transcranial focused magnetic stimulation system","authors":"A. E. Medellín-Serafín, A. Vera-Hernández, L. Leija-Salas, M. I. Gutiérrez-Velazco, C. Trujillo-Romero, J. Gutiérrez-Martínez","doi":"10.1109/GMEPE/PAHCE55115.2022.9757735","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757735","url":null,"abstract":"Transcranial magnetic stimulation research has yielded promising results with the aim of finding a treatment for motor defects with no adverse effects, so it is important to design safe and economical prototypes to contribute to the study of these conditions. This work presents the development of a simulation of a system for the generation of focused magnetic fields by means of a figure-8 coil using the finite element method. Due to the geometry of the 8-shaped coils and based on the principle of magnetic superposition, it is possible to control the depth and area of stimulation. The characteristics of the coil considering the simulations cover frequencies from 1 Hz to 5 Hz, a maximum magnetic induction of 2 T and a current of 3.6 kA from the discharge of a capacitor with a time of 10 ms were considered as initial conditions of the model., an environmental temperature of 25°C and an absolute pressure of 0.77 atm corresponding to Mexico City, a relative permeability and permittivity of the copper conductor of 1 H/m and F/m respectively, in the same way, these values were taken for the air, adding an electrical conductivity of 0 S/m and for the simulation of the human head, the electrical properties of the skull, brain, scalp and cerebrospinal fluid were considered. The resulting dimensions of the coil, from the simulations, were 6 cm outer radius, 150 turns of each turn with a total of 8 turns, 4 distributed on each wing and a height of 5.5 cm.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131375871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical Infrared Thermography of Patients with Temporomandibular Disorders and Masseter Muscle Pain after TENS Stimulation - Case Study 颞下颌疾患及咬肌疼痛经TENS刺激后的医学红外热成像研究-个案研究
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757773
W. Strasse, M. Clemente, C. Faria, S. B. Machado, J. Amarante, P. Nohama, J. Mendes
{"title":"Medical Infrared Thermography of Patients with Temporomandibular Disorders and Masseter Muscle Pain after TENS Stimulation - Case Study","authors":"W. Strasse, M. Clemente, C. Faria, S. B. Machado, J. Amarante, P. Nohama, J. Mendes","doi":"10.1109/GMEPE/PAHCE55115.2022.9757773","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757773","url":null,"abstract":"Temporomandibular disorder (TMD) is a pathology involving the temporomandibular joint (TMJ) and muscles of the masticatory system, presenting a clinical diagnosis of orofacial pain. The applicability of transcutaneous electrical nerve stimulation (TENS) is a non-invasive technique that induces analgesia without using drugs.The aim of this research was to evaluate the TENS treatment for patients with TMD and orofacial pain, in the temporal muscle (TM), temporomandibular joint (TMJ) and masseter muscle (MM), through medical infrared thermography in three female patients. The obtained results indicate uniformity of the thermal distribution for the three studied patients after a single session the treatment with TENS. Although the sample is rather limited, the results show a decrease in the temperature asymmetry between the ROIs of the contralateral side in all patients, indicating the success of the treatment. Thus, thermography is clearly a promising complementary method for diagnostic and monitor chronic pain within specific treatment protocols ofTENS analgesic therapy in patients with TMD.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122925672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CNN Networks to Classify Cardiopulmonary Signals Redes CNN en Clasificación de Señales Cardiopulmonares CNN网络对心肺信号进行分类参见CNN en Clasificación de Señales Cardiopulmonares
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757779
P. Mayorga, J. A. Valdéz, C. Druzgalski, V. Zeljkovic, L. A. Quintero López
{"title":"CNN Networks to Classify Cardiopulmonary Signals Redes CNN en Clasificación de Señales Cardiopulmonares","authors":"P. Mayorga, J. A. Valdéz, C. Druzgalski, V. Zeljkovic, L. A. Quintero López","doi":"10.1109/GMEPE/PAHCE55115.2022.9757779","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757779","url":null,"abstract":"At the moment, the world lives in a pandemic situation of COVID -19 and related variants, driving urgent needs for expanded assessments. A complementary support of related healthcare can be based on an intelligent system that can diagnose early onset of respiratory disorders. The convolutional neural networks (CNN) were implemented utilizing image data, reflecting bidimensional signals. Specifically, CNN has shown to be powerful tool in the context of cardiopulmonary sounds evaluation. The configurations of CNN contain convolutional layers to extract feature maps and fully connected layers to classify indicators of interest. Even though, learning algorithms use parameters like learning rate which can determine and attain CNN configuration less complex, with excellent results as reflected in the experiments we carried out, and which focused on achieved configuration of CNN with excellent results classifying heart sounds (HS) and lung sounds (LS).","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128866248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Estimation of reference values for the evaluation of respiratory function in infants and adults from Mexicali, Baja California, Mexico 墨西哥下加利福尼亚墨西卡利婴幼儿和成人呼吸功能评价参考值的估计
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757762
O. E. Barreras, M. Reyna, R. L. Avitia
{"title":"Estimation of reference values for the evaluation of respiratory function in infants and adults from Mexicali, Baja California, Mexico","authors":"O. E. Barreras, M. Reyna, R. L. Avitia","doi":"10.1109/GMEPE/PAHCE55115.2022.9757762","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757762","url":null,"abstract":"Objective: To establish reference values for the evaluation of respiratory function in healthy children and adults from Mexicali, Baja California, Mexico.Population and Methods: Observational, retrospective, analytical study. Applying linear regression and semi-logarithmic regression techniques, we sought to find the best normality equation for the reference values of lung function focused on children from 9 to 12 years of age and adults from 21 to 55 years of age in the city of Mexicali, Baja California.Results: Prediction equations were obtained for the main spirometric parameters in the group of adults, based on age, sex, height and weight. Prediction equations were also achieved for the group of infants, based on sex, height and weight. Differences were found with the estimated equations in other populations of the country.Conclusions: The results reinforce the importance of having specific prediction equations for each region or geographical area, and avoiding using those generated in other geographical regions, even if they are from the country itself.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"10 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129047831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FEM modeling to evaluate the effect of plaque formation over the temperature and blood flow 用有限元模型评估斑块形成对温度和血流的影响
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757807
D. Avila-Cabrera, J. Gutiérrez-Martínez, L. Leija-Salas, A. Vera-Hernández, M. I. Gutiérrez- Velazco, C. Trujillo-Romero
{"title":"FEM modeling to evaluate the effect of plaque formation over the temperature and blood flow","authors":"D. Avila-Cabrera, J. Gutiérrez-Martínez, L. Leija-Salas, A. Vera-Hernández, M. I. Gutiérrez- Velazco, C. Trujillo-Romero","doi":"10.1109/GMEPE/PAHCE55115.2022.9757807","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757807","url":null,"abstract":"The global prevalence of peripheral arterial disease (PAD) is 3-10%, which can increase to 15-20% from the age of 70 and has an annual mortality of 4-6%. This disease can trigger more serious problems, such as poor circulation, diabetic foot, amputations.The objective is to understand the relationship between the generation of plaque inside the arteries with variations in blood flow and its temperature, creating a computational simulation based on the finite element method, for which the flow pressure, the flow velocity and heat transfer to nearby tissues, taking the size of the radius of the artery as a multiparametric variable.The change in the size of the arterial radius patient simulates a healthy one if the artery is wide and the reduction of the arterial radius simulates a patient with plaque formation.The results obtained with these simulations show that the velocity decreases when the arterial radius is reduced, which simulates a patient with blood problems, on the other hand, the flow pressure decreases if the patient is healthy. The temperature analysis gives us information about the behavior of the tissues, a decrease in temperature could indicate that there is ischemia or some disease.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129072556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Streamlined Quantitative Evaluation of Brain Structural Anomalies in MRI Images MRI图像中脑结构异常的流线型定量评价
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757792
V. Zeljkovic, N. Y. Abad Quispe, C. Druzgalski, P. Mayorga
{"title":"Streamlined Quantitative Evaluation of Brain Structural Anomalies in MRI Images","authors":"V. Zeljkovic, N. Y. Abad Quispe, C. Druzgalski, P. Mayorga","doi":"10.1109/GMEPE/PAHCE55115.2022.9757792","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757792","url":null,"abstract":"There are different conditions which may affect structure of the brain including aneurysm, brain tumor or brain injury, multiple sclerosis, and other. Evaluation of the brain as a soft tissue is very suitable to MRI as these scans provide more details, although CT is also often used as a quick tool for an initial diagnosis. In particular, the tumor tissue mainly appears as brighter shades than the rest of the regions in the brain. Detection of a brain tumor is a tedious task and its identification often involves segmentation of brain images, extraction of brain features and classification of abnormality in the MRI image. Based on this reflection we propose algorithm for brain structural changes documentation of selected image(s) and a tool assisting doctors in accelerated diagnosis and quantification of the degree of abnormality. Specifically, presented approach includes at the initial stage feature enhancement including minimizing gray-scale shade variations. In its final stage this allows color coding of presumptive tumor or other regions of interest (ROI) areas and gives an opportunity of comparative evaluation of tumor growth or reduction of its size. This is possible by a graphical and accompanied numerical presentation in terms of the percentage of the area classified as a tumor or other anomaly in reference to the total area of the brain reflected on a selected MRI image. Although this paper focuses on brain tumor, developed technique can be applied to images documenting other structural brain anomalies.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114248857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-Time Estimation of Alternative Stress Index for Low-Cost, Mechanical Ventilators for Emergency Use 低成本应急机械呼吸机交替应力指数的实时估计
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757795
R. Caballero, R. Gutierrez, A. Jaramillo, A. Martinez, C. Gonzaléz, A. Von Chong
{"title":"Real-Time Estimation of Alternative Stress Index for Low-Cost, Mechanical Ventilators for Emergency Use","authors":"R. Caballero, R. Gutierrez, A. Jaramillo, A. Martinez, C. Gonzaléz, A. Von Chong","doi":"10.1109/GMEPE/PAHCE55115.2022.9757795","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757795","url":null,"abstract":"Stress index is a useful indicator in mechanical ventilation to assess improper ventilation settings. It can indicate tidal overdistension or tidal recruitment, which are two major mechanisms of ventilator-induced lung injury. However, it’s implementation require dedicated hardware and software and is not a widespread parameter used in commercial ventilators. In this work, an alternative, simple way to visually inspect the concavity of the pressure-time curve during mechanical ventilation is presented, by calculating the pressure difference of the pressure-time curve. This proves useful when implemented in low-cost emergency devices, such as those designed to cope with the COVID-19 pandemic, because of the reduced computational load required to perform its calculation. The method was implemented in a low-cost emergency mechanical ventilator and tested with an artificial lung for a proof-of-concept. Results show that this alternative method can be effectively used to qualitatively assess the concavity of the pressure-time curve.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125478817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of a Simulated Terrestrial Vehicle Through the Real-Time Processing and Classification of Electroencephalogram Data 基于脑电图数据实时处理与分类的模拟地面车辆控制
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757788
A. Guerra-Adames, D. Cáceres, F. Merchan
{"title":"Control of a Simulated Terrestrial Vehicle Through the Real-Time Processing and Classification of Electroencephalogram Data","authors":"A. Guerra-Adames, D. Cáceres, F. Merchan","doi":"10.1109/GMEPE/PAHCE55115.2022.9757788","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757788","url":null,"abstract":"In recent years and in parallel with advances in commercially available computing power, the brain computer interface (BCI) has emerged as a new use for the information obtained from existing electroencephalogram (EEG) acquisition technologies. This system works as a communication pathway between an individual’s central nervous system and a computing unit. The BCI described in this study has as primary directive the control of a simulated vehicle, for which it utilizes both neurological activity associated to an individual’s state of focus in the frequency domain, as well as artifacts produced by intentional blinks, found in the time domain. In order to successfully translate the user’s intention into commands, the acquired signals are spectrally and temporally pre-processed, features of interest are extracted by means of the wavelet packet decomposition (WPD), and are finally fed into a convolutional neural network (CNN) model, which outputs recursive predictions about the user’s mental state. The set of these general steps is capable of emitting navigational commands to the vehicle, and at the same time, return a user’s focus state related to the task in hand in the form of a visual feedback loop. Tests performed with the complete system, demonstrate that a system as the one proposed is satisfactorily functional, being capable of carrying the user’s intent to the simulated vehicle with a latency and margin of error within what’s expected for BCI applications based on EEG readings.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130355701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-Wide Association of Diabetes Mellitus Type 2 in Mitochondrion Genome 线粒体基因组与2型糖尿病的全基因组关联
2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) Pub Date : 2022-03-21 DOI: 10.1109/GMEPE/PAHCE55115.2022.9757808
J. Valdez, P. Mayorga, C. V. Angulo, R. Angulo
{"title":"Genome-Wide Association of Diabetes Mellitus Type 2 in Mitochondrion Genome","authors":"J. Valdez, P. Mayorga, C. V. Angulo, R. Angulo","doi":"10.1109/GMEPE/PAHCE55115.2022.9757808","DOIUrl":"https://doi.org/10.1109/GMEPE/PAHCE55115.2022.9757808","url":null,"abstract":"Type 2 Diabetes Mellitus (DM2) is a complex and multifactorial disorder, it is currently classified as one of the epidemics of the 21st century due to the magnitude with which it is growing, as well as the cardiovascular effects it causes. This work presents an association study of base-pair positions of the human mitochondrial with Type 2 diabetes. The data consisted of 510 complete mitochondrial genomes, of which 437 were from patients with Type 2 Diabetes Mellitus and 73 were from healthy patients. An alignment algorithm allowed to visualize and select one with optional positions, a Principal Components analysis allowed to visualize the structure of the data and the regression analysis allowed to discover 3 associated base-pair regions. After inspecting the genome annotation, 3 genes were found as candidates to be associated, of which one was found in previous studies to be associated with Type 2 Diabetes Mellitus. This study provides new evidence of genomic positional association with Type 2 Diabetes Mellitus.","PeriodicalId":197762,"journal":{"name":"2022 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133372734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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