PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)最新文献

筛选

英文中文

EVALUATION OF THE SECURITY OF THE USE OF GUAJAVA PSIDIUM EXTRACT CAPSULE ON HEART FUNCTION IN DENGUE FEVER AND DENGUE HEMORAGIC FEVER PATIENTS IN TYPE C HOSPITAL 番石榴紫提取物胶囊对丙型医院登革热及登革出血热患者心功能的安全性评价

PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Pub Date : 2022-01-20 DOI: 10.55047/comorbid.v1i1.64

Amalia Agamasi, E. Darmawan, Akrom

{"title":"EVALUATION OF THE SECURITY OF THE USE OF GUAJAVA PSIDIUM EXTRACT CAPSULE ON HEART FUNCTION IN DENGUE FEVER AND DENGUE HEMORAGIC FEVER PATIENTS IN TYPE C HOSPITAL","authors":"Amalia Agamasi, E. Darmawan, Akrom","doi":"10.55047/comorbid.v1i1.64","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.64","url":null,"abstract":"\u0000There are 126,675 DHF sufferers in 34 provinces and 1,229 of them died, while the Incidence Rate (IR) in Central Java is 47.9 per 100,000 population. Based on the safety of Psidium guajava Linn on the liver by calculating the lethal dose average showed that there were no deaths from the two experimental models of Swiss mice and Wistar mice in the dose range up to 2,000 mg/kg BB. Safety tests in rats proved lethal dose 50 (LD50) of guava leaf extract more than 5 g/kg. This study aims to determine the effect of psidii capsules containing guava leaf extract (Psidium guajava Linn.) toward levels (SGOT and SGPT) of DF and DHF patients in PKU Muhammadiyah Wonosobo Hospital. This study belongs to perspective cohort analytic observational using blood plasma patients of PKU Muhammadiyah Wonosobo Hospital of 37 patients in the period of March to August 2018 which were divided into two groups, namely standard therapy + guava leaf extract capsules and the group receiving standard therapy only. Dosage of Psidium guajava 3x2 capsules for 3 to 4 days. Examination of SGOT and SGPT levels used UV-vis spectrophotometry. General linear model was used for analyzing the data. The average SGOT level after treatment was 64 U/L in DF and 99 at DHF while the SGPT levels were 30 U/L and 35 U/L. Average levels of SGOT and SGPT decreased. There were no differences in SGOT and SGPT mean of DF and DHF patients in the two groups after giving guava leaf extract capsules with p>0.05. In SGOT mean, there was an increase in SGOT after giving guava leaf extract probably because there were patients who had chronic liver disorders. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Keywords: Dengue Fever, Dengue Hemorrhagic Fever, Guava extract capsule, SGOT SGPT \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81866264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

THE MANAGEMENT OF RECURRENT MISCARRIAGE TOWARD THE UNDERLYING CAUSE WITH A TREATABLE ETIOLOGY OR PATHOPHYSIOLOGY 复发性流产的管理与可治疗的病因或病理生理学的根本原因

PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Pub Date : 2022-01-10 DOI: 10.55047/comorbid.v1i1.33

Arsana Wiyasa, Muhamad Nofa Cholili

{"title":"THE MANAGEMENT OF RECURRENT MISCARRIAGE TOWARD THE UNDERLYING CAUSE WITH A TREATABLE ETIOLOGY OR PATHOPHYSIOLOGY","authors":"Arsana Wiyasa, Muhamad Nofa Cholili","doi":"10.55047/comorbid.v1i1.33","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.33","url":null,"abstract":"\u0000Miscarriage occurs when the fetus is unable to survive outside the womb and the results of conception are expelled. Although the issue of RPL is still controversial, current information about the suggested treatment offers effective treatment to improve reproductive quality and can provide appropriate therapy in a woman with RPL based on the etiology. The time restriction until the fetus is pronounced viable or capable of surviving outside the womb varies by country. According to the World Health Organization, over 21.6 million abortions occurred worldwide in 2008, with almost all of these cases occur in developing countries. The risk of miscarriage increases most significantly at the age of 35 years. Women aged 35 years have twice the risk of miscarriage compared to women aged < 35 years. Antiphospholipid syndrome is a risk factor for recurrent miscarriage, which occurs in about 15% of patients. The reason of recurrent miscarriage can be linked to both fetal and maternal factors. Diagnostic examinations are not recommended in patients with recurrent miscarriage unless certain criteria are met. However, screening can be used to identify risk factors. The management of recurrent miscarriage should be addressed toward the underlying cause with a treatable etiology or pathophysiology. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79780828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CATECHOL-O-METHYLTRANSFERASE (COMT) ENZYME LEVELS IN PATIENTS WITH PREOPERATIVE ANXIETY 术前焦虑患者的儿茶酚- o -甲基转移酶(comt)水平

PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Pub Date : 2022-01-10 DOI: 10.55047/comorbid.v1i1.37

Akhyar Hamongan Nasution, A. Lelo

{"title":"CATECHOL-O-METHYLTRANSFERASE (COMT) ENZYME LEVELS IN PATIENTS WITH PREOPERATIVE ANXIETY","authors":"Akhyar Hamongan Nasution, A. Lelo","doi":"10.55047/comorbid.v1i1.37","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.37","url":null,"abstract":"\u0000The preoperative anxiety’s incidence is very high and mostly preoperative patients have anxiety. It was found that low COMT levels indicate a tendency to develop anxiety. Hence, this study aims to investigate COMT enzyme levels in patients with preoperative anxiety. This research is a purely experimental research with a pretest-posttest control group design and double-blind. Measurement of COMT enzyme levels was executed by utilizing ELISA technique. Blood samples were taken from preoperative anxiety patients who were assessed with the Amsterdam Preoperative Anxiety Information Scale (APAIS). The research was carried out at Haji Adam Malik General Hospital and Regional General Hospital dr. Pirngadi Medan, and Integrated Laboratory of the Faculty of Medicine, University of North Sumatra. The were 64 samples involved in this research that fit the inclusion and exclusion criteria. The findings show that COMT levels in the anxiety and control groups had differences with p values = 0.014. In addition, COMT levels in the preoperative anxiety group were lower when compared to those without the preoperative anxiety group, where in the anxiety group had COMT enzyme levels of 0,14 ± 0,08 ng/dl, while in the control group had higher COMT levels 0,96 ± 1,11 ng/dl. The results showed that patients with preoperative anxiety had lower levels of the COMT enzyme compared to patients without preoperative anxiety. Researchers suspect there is a role for the COMT enzyme in causing preoperative anxiety. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75451471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

首页上一页