用液相色谱-质谱法(lcms)鉴定对乙酰氨基酚(acetaminophen)的破碎型

Muhammad Taupik, Endah Nurrohwinta Djuwarno, M.Sc Mohammad Adam Mustapa, Muhamad Handoyo Sahumena
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引用次数: 0

摘要

在过去的二十年里,许多查谟或草药都掺入了化学药物。通常添加到草药中的化学药物之一是对乙酰氨基酚。对乙酰氨基酚通常被认为是一种镇痛解热药物。本研究的样本包括6个不同品牌的jamu或草药样品。采用流动相正己烷:乙酸乙酯(1:1)的薄层色谱法进行定性分析,得到3个含对乙酰氨基酚的阳性样品,分别为样品D、E、f。3个含对乙酰氨基酚的阳性样品采用LCMS法计算。采用LCMS进行定量分析,流动相为乙腈:水(15%>:85%> v/v),流速为0.2 mL/min,进样量为5 gL,样品D中对乙酰氨基酚含量为0.16 g/2 g,样品E中为0.63 g/7 g,样品F中为0.56 g/7 g。虽然草药中对乙酰氨基酚的含量相对较少,但根据印度尼西亚卫生部2012年第007号条例,传统药物或草药不应含有合成化学品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
THE IDENTIFICATION AND STUDY OF HERBAL MEDICINE (JAMU) FRAGMENTATION PATTERNS CONFIRMED ACETAMINOPHEN BY USING LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY (LCMS)
In the last twenty years, many of jamu or herbal medicine were adulterated with chemical drugs. One of the chemical drugs that is commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered as an analgesic-antipyretic drug. The sample of this study consisted of 6 samples of jamu or herbal medicine with different brands. Qualitative analysis was conducted by TLC method using the mobile phase n-hexane: ethyl acetate (1:1), it was obtained three positive samples containing acetaminophen, namely sample D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 gL, it was obtained the levels of acetaminophen in sample D as much as 0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and in sample F of 0.56 g/7 g of sample. Although the content of acetaminophen in herbal medicine is relatively small, but according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals.
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