Pharmaceutical Sciences Asia最新文献_第3页

Simulation of pharmacokinetic drug-drug interaction and dosage regimens optimization of nelfinavir and cepharanthine as a potential combination against COVID-19 奈非那韦与头孢酞啶联合抗COVID-19药代动力学相互作用模拟及用药方案优化

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.01.22.375

Wichit Nosoongnoen

{"title":"Simulation of pharmacokinetic drug-drug interaction and dosage regimens optimization of nelfinavir and cepharanthine as a potential combination against COVID-19","authors":"Wichit Nosoongnoen","doi":"10.29090/psa.2023.01.22.375","DOIUrl":"https://doi.org/10.29090/psa.2023.01.22.375","url":null,"abstract":"The pharmacokinetic (PK) drug-drug interactions (DDIs) of nelfinavir and cepharanthine combination is limited information in human. In addition, the dosage regimen of this combination is not available for COVID-19 treatment. The objective of this study was to perform in silico simulations using GastroPlusTM software to predict physicochemical properties, PK parameters using the physiologically based pharmacokinetic (PBPK) model of healthy adults in different dosage regimens. The DDIs analysis of nelfinavir and cepharanthine combination was carried out to optimize the dosage regimens as a potential against COVID-19. The Spatial Data File (SDF) format of nelfinavir and cepharanthine structures obtained from PubChem database were used to carry out in silico predictions for physicochemical properties and PK parameters using several aspects of modules such as ADMET Predictor, Metabolism and Transporter, PBPK model. Subsequently, all data were utilized in the DDIs simulations. The dynamic simulation feature was selected to calculate and investigate the Cmax, AUC0-120, AUC0-inf, Cmax ratio, AUC0-120 ratio, and AUC0-inf ratio. The victim or nelfinavir dosage regimens were used four oral administration regimens of 500 mg and 750 mg in every 8 and 12 hours for simulations. The perpetrator or cepharanthine oral dosage regimens were used in several regimens from 10 mg to 120 mg in every 8, 12, and 24 hours. From all predicted results, the dosage regimen as a potential combination against COVID-19 was nelfinavir 500 mg every 8 hours and cepharanthine 10 mg every 12 hours.Copyright © 2023 by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0. To view a copy of this license, visit https://www.creativecommons.org/licenses/by-nc-nd/4.0/.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88809159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of pharmaceutical care services provided to HIV infected patients on antiretroviral therapy in Rivers state, Nigeria 评估尼日利亚河流州向接受抗逆转录病毒治疗的艾滋病毒感染者提供的药物保健服务

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.02.22.332

Arloe ThankGod, I. Suleiman, T. Aremu

{"title":"Assessment of pharmaceutical care services provided to HIV infected patients on antiretroviral therapy in Rivers state, Nigeria","authors":"Arloe ThankGod, I. Suleiman, T. Aremu","doi":"10.29090/psa.2023.02.22.332","DOIUrl":"https://doi.org/10.29090/psa.2023.02.22.332","url":null,"abstract":"Pharmaceutical care of HIV infected persons on antiretroviral therapy is pertinent in optimal management to achieve viral suppression and improve immune status. The objective of the study was to assess pharmaceutical care services provided to HIV infected patients on antiretroviral therapy. A prospective, cross-sectional study was carried out among 217 pharmacists giving pharmaceutical care services to HIV positive patients in Rivers State, Nigeria. Data collection tool was a structured, pre-tested questionnaire used to assess pharmaceutical care services carried out by pharmacists. The data collected were analyzed using SPSS version 20 and Microsoft Excel. Most of the respondents were female (62.8%). More than half (59.9%) of the subjects involved in provision of pharmaceutical care to HIV infected patients were practicing in the hospital setting. Most respondents (77.8%) did not monitor for drug therapy problems (DTPs), while most (89.9%) did not document interventions to identified drug therapy problems. Majority of respondents (90.3%) established rapport with patients to improve adherence. Most respondents (72.5%) had regular supply of antiretroviral drugs in their health facility. Pharmaceutical care services rendered to HIV infected patients on antiretroviral therapy was sub-optimal. Identification of DTPs and respective interventions, involvement in general patient management, and documentation of activities were the most affected.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"515 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77857129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current advances in nose to brain drug delivery 鼻到脑给药的最新进展

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.03.23.477

Venkatesh Prasad S, P. Sudheer, Kannika Belludi Chandrashekhar Shetty

引用次数: 0

The use of hydrophilic carrier derived from eggshell and novel gel forming technique in a solid dispersion system 在固体分散体系中使用蛋壳亲水性载体和新型凝胶形成技术

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.01.22.339

Zarni Myint, P. Lawanprasert, S. Puttipipatkhachorn, J. Leanpolchareanchai

引用次数: 0

Design, synthesis, and evaluation of indoleamin-2,3-dioxygenase 1 inhibition activity of novel 5/6-amino indazole derivatives with amide template 基于酰胺模板的新型5/6-氨基吲哚胺-2,3-双加氧酶1抑制活性的设计、合成及评价

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.01.22.309

Ngo Xuan Hoang, T. Vo, Van-Hai Hoang, T. K. Nguyen, J. Seo, Phuong-Thao Tran

引用次数: 0

Formulation of topical gel containing Tagetes erecta L. floral extract and its antibacterial activity 万寿菊花提取物外用凝胶的研制及其抑菌活性

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.02.22.369

Papangkorn Meetong, Pattarapol Ananchaiphatthana, Chawalinee Asawahame, Phurit Thanarangsarit, Aranya Jutiviboonsuk

引用次数: 0

Association of the rs1128503 and rs1045642 polymorphisms in the MDR-1 gene with steroid responsiveness in Iraqi children with idiopathic nephrotic syndrome 伊拉克特发性肾病综合征儿童耐多药1基因rs1128503和rs1045642多态性与类固醇反应性的关系

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.03.23.245

A. M. A. Alridha, D. Kadhim, A. Alkhazrajy

{"title":"Association of the rs1128503 and rs1045642 polymorphisms in the MDR-1 gene with steroid responsiveness in Iraqi children with idiopathic nephrotic syndrome","authors":"A. M. A. Alridha, D. Kadhim, A. Alkhazrajy","doi":"10.29090/psa.2023.03.23.245","DOIUrl":"https://doi.org/10.29090/psa.2023.03.23.245","url":null,"abstract":"Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage renal disease in children, with an increasing number of cases. Polymorphisms in the MDR-1 gene were reported to contribute to SRNS development, but with varying results among different ethnicities. Thus, we investigated the association of the MDR-1 rs1128503 (C1236T) and rs1045642 (C3435T) polymorphisms with steroid responsiveness in Iraqi children with idiopathic nephrotic syndrome (INS). This case-control study was conducted at the Babylon Hospital for Maternity and Pediatrics. Children with SRNS (n=32) and steroid-sensitive nephrotic syndrome (SSNS; n=32) were genotyped via the polymerase chain reaction-restriction fragment length polymorphism. The genotypes were subjected to association testing and haplotype analysis. The C1236T TT genotype was associated with a higher risk of developing SRNS compared to the CC and TC genotypes (odds ratio [OR]=10.33, 95% confidence interval [95% CI]=1.208-88.362; p -value=0.026; recessive model). The combination of the two TT genotypes of C1236T and C3435T variants was significantly more frequent ( p -value=0.029) in SRNS (88.9%) than in SSNS (11.1%). The haplotype analysis showed no association between the C1236T and C3435T haplotypes and steroid responsiveness, but the TC haplotype was associated with an age at onset of ≥8 years ( p -value=0.0028). In conclusion, this study revealed that children who have the MRD-1 C1236T TT genotype alone or combined with the C3435T TT genotype may be at increased risk of developing SRNS and in need of other therapeutic strategies. Additional research is required to identify other genetic contributions to steroid responsiveness and further understand their","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81028195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of different sweeteners on the free radical scavenging activities, alcohol contents, sugar reductions, and hedonic properties of green tea kombucha 不同甜味剂对绿茶康普茶自由基清除活性、酒精含量、糖还原和享乐特性的影响

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.01.22.340

Muhammad Shidiq Rukman, Ayu Nala El Muna Haerussana

引用次数: 1

Study on consequences for interaction of myricetin with canagliflozin: A special attention to pharmacokinetics and pharmacodynamics of drug 杨梅素与卡格列净相互作用的后果研究:特别关注药物的药代动力学和药效学

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI: 10.29090/psa.2023.01.22.304

Naga Raju Kandukoori, Deepika B, Kiranmai Mandava

引用次数: 0

Screening for production of amylase and protease by locally-isolated Bacillus spp. from soil collected in Taguig City and Clark Freeport Zone, Philippines 菲律宾塔吉格市和克拉克自由港地区土壤中分离的芽孢杆菌产淀粉酶和蛋白酶的筛选

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.02.21.156

John Paul Matthew Guzman, Sheila Mantaring, E. Panerio

{"title":"Screening for production of amylase and protease by locally-isolated Bacillus spp. from soil collected in Taguig City and Clark Freeport Zone, Philippines","authors":"John Paul Matthew Guzman, Sheila Mantaring, E. Panerio","doi":"10.29090/psa.2022.02.21.156","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.156","url":null,"abstract":"Amylase and protease are two of the most commonly used enzymes in the pharmaceutical industry. Particularly, Bacillus spp. is widely regarded as a “factory” of these enzymes. In this study, a total of 40 isolates were collected from four soil samples from different metropolitan sites namely, near Chemicals and Energy Division (CED), and National Metrology Laboratory (NML) oil tankers parking lot inside the Department of Science and Technology (DOST) Compound in Taguig City, and two metropolitan-volcanic sites in Clark Freeport Zone, Pampanga (CRK1, CRK2). Of these, 33 isolates were deemed putative Bacillus spp. via phenotypic assays and were screened for the production of amylase and protease. Results showed that 26 of the screened isolates were able to produce protease and 12 were positive for amylase production. Molecular identification revealed that the enzyme-producing isolates were Bacillus spp., B. cereus, B. aryabhattai, B. amyloliquefaciens, B. firmus , B. velezensis , and Fictibacillus sp. No isolate was able to produce amylase alone. These results show the potential of Bacillus spp. from metropolitan soil as sources of pharmaceutically-important enzymes.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73496852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1