Formulation of topical gel containing Tagetes erecta L. floral extract and its antibacterial activity

Q4 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical Sciences Asia Pub Date : 2023-01-01 DOI:10.29090/psa.2023.02.22.369

Papangkorn Meetong, Pattarapol Ananchaiphatthana, Chawalinee Asawahame, Phurit Thanarangsarit, Aranya Jutiviboonsuk

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Abstract

Tagetes erecta L. (marigold) flowers were extracted to obtain crude ethanolic extract (MGE), water insoluble extract (MGP), as well as water soluble extract (MGW). All extracts were determined of total flavonoid content and antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa . The results suggested that MGP contained the highest amount of total flavonoids (29.48%w/w quercetin equivalent) with good activity against S. aureus (MIC 6.25 mg/mL and MBC 25.0 mg/mL). This extract was subjected to formulate the topical gels at the concentration of 1 and 2 times of MIC. The gel formulation containing 1.25%w/w MGP with the solvent mixture of propylene glycol and ethanol (1:1) showed good physical properties. Furthermore, it exhibited the most effective antibacterial activity against S. aureus by agar well diffusion method with the inhibition zone of 15.15±0.43 mm. Therefore, the extract of marigold flower could be formulated as topical gel for the treatment of skin infections.

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万寿菊花提取物外用凝胶的研制及其抑菌活性

对万寿菊(Tagetes erecta L.)花进行提取，得到粗乙醇提取物(MGE)、水不溶提取物(MGP)和水溶性提取物(MGW)。测定各提取物的总黄酮含量及对金黄色葡萄球菌和铜绿假单胞菌的抑菌活性。结果表明，MGP总黄酮含量最高(槲皮素当量为29.48%w/w)，对金黄色葡萄球菌具有良好的抑菌活性(MIC为6.25 mg/mL, MBC为25.0 mg/mL)。将该提取物以MIC的1倍和2倍浓度配制外用凝胶。以丙二醇与乙醇(1:1)为溶剂，含1.25%w/w MGP的凝胶配方具有良好的物理性能。琼脂孔扩散法对金黄色葡萄球菌的抑菌效果最好，抑菌带为15.15±0.43 mm。因此，万寿菊提取物可配制成外用凝胶治疗皮肤感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.