Pharmaceutical Sciences Asia最新文献_第10页

Physical stability and subjective efficacy study of liposome loaded with Clitoria ternatea (butterfly pea) flower extract and Eugenia caryophyllus (clove) oil 阴蒂花提取物和丁香油脂质体的物理稳定性及主观药效研究

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.01.21.077

Natchaporn Choochuen, Ampa Jimtaisong

{"title":"Physical stability and subjective efficacy study of liposome loaded with Clitoria ternatea (butterfly pea) flower extract and Eugenia caryophyllus (clove) oil","authors":"Natchaporn Choochuen, Ampa Jimtaisong","doi":"10.29090/psa.2022.01.21.077","DOIUrl":"https://doi.org/10.29090/psa.2022.01.21.077","url":null,"abstract":"Clitoria ternatea, commonly known as butterfly pea or blue pea, is an edible plant species belonging to the Fabaceae family. The plant has several therapeutic activities like a memory enhancer, antidepressant, antistress, sedative agent, anxiolytic and tranquilizing agent . The C. ternatea blue flower contains anthocyanins, which are mainly delphinidin-glucosides. The blue flowers of butterfly peas have good free radical scavenging activity and have potential as antioxidants. The flower is commonly used as a source of natural coloring agent for food and cosmetics and as a natural pH indicator in pharmaceutical industry. It has been reported that the butterfly pea flower fermentation solution can be added to cosmetic formula as a natural raw material of skin care products to improve moisture retention and had whitening effects. The application of crushed fresh butterfly pea flower (also known as Aunchan) directly on the eyebrows and scalp for the benefits of coloring and promoting hair growth is traditionally and commonly found in Thailand. The ability to promote hair growth may be related with its inhibition of the 5α-reductase enzyme activity. Clove (Eugenia caryophyllus) is an important medicinal plant that has been employed for centuries as food preservative and pain reliever. It is also claimed to be the rich source of phenolic antioxidants. Eugenol and eugenyl acetate, which are poorly water soluble","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88295916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of genes coding for anti-HIV proteins MAP30 and MRK29 from Thai bitter melon (Momordica charantia L.) 泰国苦瓜抗hiv蛋白MAP30和MRK29基因编码的研究

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.01.21.104

Paktraporn Mekloy, K. Sakchaisri, W. Jiratchariyakul, S. Bunsupa

{"title":"Investigation of genes coding for anti-HIV proteins MAP30 and MRK29 from Thai bitter melon (Momordica charantia L.)","authors":"Paktraporn Mekloy, K. Sakchaisri, W. Jiratchariyakul, S. Bunsupa","doi":"10.29090/psa.2022.01.21.104","DOIUrl":"https://doi.org/10.29090/psa.2022.01.21.104","url":null,"abstract":"Momordica charantia L. (M. charantia), also known as bitter melon, belongs to the Cucurbitaceae family. M. charantia is cultivated in many regions globally, including Asia, South America, and Africa. It has many varieties and local names, including the Chinese variety (lai-pu-tao, ku-gua), Japanese variety (goya), Indian variety (karela), Vietnamese variety (la khoqua), and Thai variety (mara). Varieties differ substantially in the shape and bitterness of the fruit. However, they have the same scientific name as Momordica charantia L.. The plant has been widely used as herbal anti-aging medicine. Major pharmacological activities that have been observed in bitter melon include abortifacient, antidiabetic, antibacterial, antiviral, and antitumor. These characteristics have been correlated with the presence of phytochemicals, including saponins, alkaloids, triterpenes, steroids, and proteins. Several compounds have been isolated from all plant parts, such as momordicins, charantins, cucurbitins, and goyaglycosides. Charantins, a mixture of steroidal saponins found in the fruits of M. charantia exhibit hypoglycaemic activity. Many proteins and peptides which possess RNA N-glycosidase, DNase-like, antitumor, immunosuppressive, and antimicrobial activities have also been isolated, such as","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85680602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of weight variation and dissolution of Edoxaban split tablets in pharmacy practice 药学实践中艾多沙班片剂重量变化及溶出度的研究

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.02.21.133

M. Nimworapan, Sinwisuth Sutheechai, W. Wongcharoen, A. Phrommintikul, S. Eakanunkul

{"title":"Study of weight variation and dissolution of Edoxaban split tablets in pharmacy practice","authors":"M. Nimworapan, Sinwisuth Sutheechai, W. Wongcharoen, A. Phrommintikul, S. Eakanunkul","doi":"10.29090/psa.2022.02.21.133","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.133","url":null,"abstract":"Edoxaban is available in 60 mg, 30 mg, and 15 mg unscored film-coated tablets. Tablet splitting may be an option to reduce medication costs and reduce the country’s budget. The objectives of this study were to determine the weight variation and the dissolution profile of the 60 mg edoxaban in split half-tablets using a pill splitter. Thirty edoxaban 60 mg tablets were cut into halves by a right-handed pharmacist. The weight variation of the whole and half tablets were compared. For the dissolution test, 6 whole tablets and 12 half-tablets were separately dissolved in three dissolution media. Sixty half-tablets of edoxaban had the expected half-tablet weight within the 75% to 125% range that fell within the proxy United States Pharmacopeia (USP). The mean total weight of the 1 st and 2 nd halves were not significantly different from the mean weight of the intact tablets ( p -value=0.216). The amount of drug release from the whole and half tablets in 0.1 N HCl medium was greater than 85% in 15 minutes which met the acceptance criteria for the dissolution test. Edoxaban tablets splitting had low variations in weight. Therefore, edoxaban tablets can be split into halves by a tablet cutter.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"6 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86412580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pinostrobin attenuates colistin-induced apoptosis of human renal proximal tubular cells Pinostrobin减轻粘菌素诱导的人肾近端小管细胞凋亡

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI: 10.29090/psa.2021.06.21.008

N. Worakajit, Penjai Thongnuanjan, Napason Chabang, Sirima Soodvilai, P. Tuchinda, S. Soodvilai

引用次数: 1

Natural-resin in-situ-forming gels: Physicochemical characteristics and bioactivities 天然树脂原位成型凝胶:物理化学特性和生物活性

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI: 10.29090/psa.2021.05.20.077

E. M. Khaing, Torsak Intaraphairot, Wichai Santimaleeworagu, Yaowalak Phorom, Tiraniti Chuenbarn, T. Phaechamud

引用次数: 6

Medication use evaluation for Clostridium difficile infection: a case of super tertiary care hospital in northeastern Thailand 艰难梭菌感染的用药评价:泰国东北部一家超三级医院一例

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI: 10.29090/psa.2021.04.20.106

C. Soontornpas, P. Mootsikapun, Ratchadaporn Soontornpas

{"title":"Medication use evaluation for Clostridium difficile infection: a case of super tertiary care hospital in northeastern Thailand","authors":"C. Soontornpas, P. Mootsikapun, Ratchadaporn Soontornpas","doi":"10.29090/psa.2021.04.20.106","DOIUrl":"https://doi.org/10.29090/psa.2021.04.20.106","url":null,"abstract":"Clostridium difficile infection (CDI) is a common and serious nosocomial infection worldwide. It is also problem in our hospital, a medical school in Khon Kaen University. Rationale use of antimicrobial in the treatment of CDI is still being questionable. This study aimed to explore the characteristic and evaluate the treatment of CDI in our setting. This retrospective cohort study was performed in 168 CDI patients admitted at Srinagarind Hospital between October 2013 and September 2016. Patient medical records were reviewed for demographics, comorbidities, antimicrobial exposures, treatments and clinical outcomes. Antimicrobial therapy for CDI was then evaluated in accordance with the current CDI guideline. Most CDI patients aged over 50 years (72.6%) and 42.8% aged over 65 years. Common comorbidities in the patients were cardiovascular disease (47.6%), diabetes mellitus (27.4%), chronic kidney disease (20.8%), malignancy (16.7%), cerebrovascular disease (11.3%), chronic hepatitis (3.6%) and chronic obstructive pulmonary disease (2.4%). Patients who had taken antimicrobial during hospitalization prior to CDI diagnosis constituted 83.9% of total study population. Metronidazole, vancomycin and both were initial therapy in 83.9, 4.8 and 11.3% of CDI, respectively. Appropriateness of CDI treatment in all terms was 44% and recovery rate was 62% of assessable cases. Nine patients (5.4%) died during hospitalization. In conclusion, most patients had CDI risk factors including elderly, comorbidity, antimicrobial exposure, and prolonged hospital stay. Inappropriate CDI treatment was found in asymptomatic carriers or inappropriate treatment duration. Initial therapy with metronidazole should change to oral vancomycin which was the first-line therapy in the current guidelines.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77032916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of calcium - vitamin D supplementation on children with abnormal vitamin D status, low BMD, or both in Vietnam 补充钙-维生素D对越南维生素D异常、低骨密度或两者兼而有之儿童的疗效

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI: 10.29090/psa.2021.03.20.038

P. M. Nguyen, Linh V. Pham, K. Nguyen, Dat Tan Nguyen, Hanh Duong Nguyen, Nong Van Lai, B. Nguyen, Yen N Diep, Thang Nguyen

{"title":"Effectiveness of calcium - vitamin D supplementation on children with abnormal vitamin D status, low BMD, or both in Vietnam","authors":"P. M. Nguyen, Linh V. Pham, K. Nguyen, Dat Tan Nguyen, Hanh Duong Nguyen, Nong Van Lai, B. Nguyen, Yen N Diep, Thang Nguyen","doi":"10.29090/psa.2021.03.20.038","DOIUrl":"https://doi.org/10.29090/psa.2021.03.20.038","url":null,"abstract":"The effects of calcium and vitamin D supplementation on representative factors of bone health have been separately evaluated in different study populations worldwide, however, no data from solely one study population that comprehensively assess the supplementation outcomes on the skeletal system are available. We aimed to evaluate how calcium and vitamin D affect vitamin D level, bone mineral density (BMD), parathyroid hormone (PTH), and bone turnover markers as well as growth parameters in schoolchildren with abnormal vitamin D status and/or low BMD. An uncontrolled trial was carried out on 151 schoolchildren, aged 6-14, recruited from Can Tho City, Vietnam. The subjects were prescribed the combinations of calcium and vitamin D based on their age for a course of 6 months. After the intervention, the concentration of 25OHD was significantly improved (P < 0.001) and only 5.3% of the subjects were found to have an abnormal 25OHD level. Only 10.6%, compared with 66.89% before supplementation, had low BMD after the intervention (P < 0.05). The supplementation also increased weight and height and decreased P1NP. However, no significant changes were observed in β-CTx among boys and in PTH among the two genders. There was a negative correlation between vitamin D level and growth parameter, β-CTx. Linear regression analyses show a significant association between height, β-CTx level, and 25OHD level. In conclusion, the findings from our research provide a comprehensive assessment of various factors affected by calcium-vitamin D supplementation.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75967261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of didactic educational intervention on improving knowledge of antibiotics use and resistance in Yogyakarta Community 教学教育干预对提高日惹社区抗生素使用和耐药性知识的影响

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI: 10.29090/psa.2021.04.20.075

S. A. Kristina, Nada Salsabila, Y. Yulianto, G. Fortwengel

{"title":"Effect of didactic educational intervention on improving knowledge of antibiotics use and resistance in Yogyakarta Community","authors":"S. A. Kristina, Nada Salsabila, Y. Yulianto, G. Fortwengel","doi":"10.29090/psa.2021.04.20.075","DOIUrl":"https://doi.org/10.29090/psa.2021.04.20.075","url":null,"abstract":"Lack of knowledge regarding antibiotics use has been widely identified as a main reason for inappropriate antibiotics use which leads to antibiotic resistance phenomenon. This study aimed to evaluate the effects of pharmacist-initiated educational intervention on promoting appropriate use of antibiotics and reducing self-medication with antibiotics. A pre and post intervention study using two validated self-administered questionnaires was performed in Yogyakarta province. A-two hour session of course and case discussion was delivered as method of intervention. Pharmacy customers attended Gema Cermat program were invited conveniently to complete both of pre- and post-educational questionnaires. Descriptive presentation was conducted to show scores on questions. Knowledge scores were categorized as poor, adequate and high. Of 268 respondents, 34.22% respondents had poor level of knowledge before receiving educational intervention, but this number decreased into 12.21% after post-interventional phase. Another 28.23% respondents had adequate level of knowledge before and then elevated into 38.28% after receiving education about appropriate use of antibiotics. Pre-education, 37.43% participants had a high level of knowledge about antibiotics use and resistance, whereas after education the number became slightly higher (49.25%). A vast majority of respondents (75.24%) became more aware about appropriate antibiotics practice after receiving educational inter- vention. Overall, didactic educational intervention imposed higher knowledge and better practice regarding antibiotics use (p < 0.05). This study showed that using didactical education intervention towards antibiotics use and resistance can be an initial strategy that led to substantial improvement of appropriate antibiotics use. Further systemic interventions to educate people should be performed and evaluated in order to promote the appropriate use of antibiotics.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87076591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Simple and rapid dipstick test for detection of dexamethasone adulteration in traditional herbal medicines 简易快速试纸法检测中草药中地塞米松掺假

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI: 10.29090/PSA.2021.02.19.148

B. Kuswandi, Arimbi S Kartika, Nia Kristiningrum, D. K. Pratoko, Indah Purnama Sary

引用次数: 2

Unit cost analysis of medical service in asia: A systematic review 亚洲医疗服务单位成本分析:系统回顾

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI: 10.29090/PSA.2021.02.19.034

Ragil Setia Dianingati, A. Riewpaiboon

引用次数: 2