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Risk of polymyxin B-induced acute kidney injury with a non adjusted dose versus adjusted dose based on renal function. 多粘菌素b非调整剂量与基于肾功能调整剂量的急性肾损伤风险比较。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-07-01 Epub Date: 2022-06-28 DOI: 10.2217/pme-2021-0003
Guanhao Zheng, Jiaqi Cai, Shenghui Zhou, Ning Du, Hao Bai, Juan He, Xiaolan Bian
{"title":"Risk of polymyxin B-induced acute kidney injury with a non adjusted dose versus adjusted dose based on renal function.","authors":"Guanhao Zheng,&nbsp;Jiaqi Cai,&nbsp;Shenghui Zhou,&nbsp;Ning Du,&nbsp;Hao Bai,&nbsp;Juan He,&nbsp;Xiaolan Bian","doi":"10.2217/pme-2021-0003","DOIUrl":"https://doi.org/10.2217/pme-2021-0003","url":null,"abstract":"<p><p><b>Aim:</b> To observe the difference in the risk of polymyxin B (PMB)-induced acute kidney injury (AKI) with or without dose adjustment based on the patients renal function. <b>Materials & methods:</b> This retrospective cohort analysis was carried out in 115 patients treated with PMB from November 2018 to October 2019. <b>Results:</b> No significant difference in the incidence of AKI as well as secondary outcomes was observed between these two groups (47.5 vs 37.14%; p = 0.304). <b>Conclusion:</b> Dosing adjustment based on renal function does not significantly lower the risk of PMB-induced AKI. A non adjusted dosing strategy for PMB is recommended in patients exhibiting various levels of renal impairment.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":"307-314"},"PeriodicalIF":2.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40403216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalized medicine in Nepal: current scenario and challenges. 尼泊尔的个体化医疗:现状和挑战。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-06-17 DOI: 10.2217/pme-2022-0002
Yunima Sapkota, Soniya Dulal, P. Gyawali, Ajnish Ghimire, Prabakaran Shankar
{"title":"Personalized medicine in Nepal: current scenario and challenges.","authors":"Yunima Sapkota, Soniya Dulal, P. Gyawali, Ajnish Ghimire, Prabakaran Shankar","doi":"10.2217/pme-2022-0002","DOIUrl":"https://doi.org/10.2217/pme-2022-0002","url":null,"abstract":"","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47619154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel epigenetic biomarker, plasma miR-138-5p gene promoter-methylated DNA, for colorectal cancer diagnosis. 一种新的表观遗传生物标志物，血浆miR-138-5p基因启动子甲基化DNA，用于结直肠癌诊断。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-06-17 DOI: 10.2217/pme-2021-0095
Masoud Asefi, M. Saidijam, Nayebali Rezvani, A. Soltanian, A. Khalilian, Ali Mahdavinezhad
{"title":"A novel epigenetic biomarker, plasma miR-138-5p gene promoter-methylated DNA, for colorectal cancer diagnosis.","authors":"Masoud Asefi, M. Saidijam, Nayebali Rezvani, A. Soltanian, A. Khalilian, Ali Mahdavinezhad","doi":"10.2217/pme-2021-0095","DOIUrl":"https://doi.org/10.2217/pme-2021-0095","url":null,"abstract":"Aim: The miR-138-5p promoter-methylated DNA level, miR-138-5p and PDL1 expression were investigated in colorectal cancer (CRC) patients. Materials & methods: miR-138-5p promoter methylation status and miR-138-5p expression were investigated using the MethyLight and qPCR method, respectively. For measuring PDL-1, we applied the Bioassay Technology Elisa kit. Results: The percentage of methylated reference values of plasma and tissue samples from patients was higher than control groups. The area under curve presented a sensitivity of 55% and a specificity of 82.5% for plasma samples. Compared with the control groups, lower expression of miR-138-5p and higher concentration of PDL1 protein were observed in the patients group. Conclusion: CRC may be detected early by identifying miR-138-5p methylated DNA in plasma as a diagnostic biomarker.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46359001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Microsatellite instability testing in colorectal patients with Lynch syndrome: lessons learned from a case report and how to avoid such pitfalls. 林奇综合征结直肠患者的微卫星不稳定性测试：从病例报告中吸取的教训以及如何避免此类陷阱。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-06-16 DOI: 10.2217/pme-2021-0128
S. Adeleke, Aidan Haslam, A. Choy, S. Diaz-Cano, J. Galante, C. Mikropoulos, S. Boussios
{"title":"Microsatellite instability testing in colorectal patients with Lynch syndrome: lessons learned from a case report and how to avoid such pitfalls.","authors":"S. Adeleke, Aidan Haslam, A. Choy, S. Diaz-Cano, J. Galante, C. Mikropoulos, S. Boussios","doi":"10.2217/pme-2021-0128","DOIUrl":"https://doi.org/10.2217/pme-2021-0128","url":null,"abstract":"We present the case of a patient with Lynch syndrome and metastatic colorectal carcinoma (mCRC). The initial immunohistochemistry (IHC) test for deficient mismatch repair gave a false negative result. However, the same mutation has accurately has been detected with IHC in other cancers with microsatellite instability (MSI) This supports the determining role of somatic missense mutations in MMR IHC. MSI-PCR testing confirmed MSI and the patient benefited from nivolumab with a complete metabolic response. We explain the rationale for immunotherapy in mCRC, current testing strategies and discuss future developments in MSI testing. We advocate for upfront testing using both IHC and MSI-PCR to direct therapy in mCRC, and a greater understanding of IHC and MSI-PCR testing pitfalls.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43872545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
An international genomics health workforce education priorities assessment. 国际基因组学卫生人力教育重点评估。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-06-16 DOI: 10.2217/pme-2021-0094
D. Johnson, V. Dissanayake, B. Korf, Meredith Towery, R. Haspel
{"title":"An international genomics health workforce education priorities assessment.","authors":"D. Johnson, V. Dissanayake, B. Korf, Meredith Towery, R. Haspel","doi":"10.2217/pme-2021-0094","DOIUrl":"https://doi.org/10.2217/pme-2021-0094","url":null,"abstract":"Aim: Global implementation of genomic medicine will require education of healthcare providers. There are limited international needs assessment data to guide curriculum development. Materials & methods: Genomics education experts developed and distributed a survey to individuals with knowledge of country-specific needs: 113 completed surveys (19% response rate) from 34 countries. A high percentage of respondents ranked non genetics physicians as the #1 target for genetics education. Over 70% indicated a need for moderate/extensive modification in physician training. The majority considered germline and somatic topics and targeting primary care and specialist providers equally important. Conclusion: Regardless of country economic level, there is a clear need for genomics education of healthcare providers. The study results can be used to focus future genomic medicine education efforts.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48809850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Alignment of health plan coverage policies for somatic multigene panel testing with clinical guidelines in select solid tumors. 选定实体瘤的躯体多基因面板检测与临床指南的健康计划覆盖政策的一致性
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-05-01 Epub Date: 2022-02-04 DOI: 10.2217/pme-2021-0174
William B Wong, Daniele Anina, Chia-Wei Lin, Devon V Adams
{"title":"Alignment of health plan coverage policies for somatic multigene panel testing with clinical guidelines in select solid tumors.","authors":"William B Wong,&nbsp;Daniele Anina,&nbsp;Chia-Wei Lin,&nbsp;Devon V Adams","doi":"10.2217/pme-2021-0174","DOIUrl":"https://doi.org/10.2217/pme-2021-0174","url":null,"abstract":"<p><p><b>Aim:</b> Commercial plan coverage policies for multigene panel tests may vary and could result in geographic variation in coverage due to the fragmented nature of the commercial insurance market. This study aimed to characterize the alignment of multigene panel tests coverage policies to that of clinical guidelines, overall and by state. <b>Materials & methods:</b> We reviewed NCCN Guidelines<sup>®</sup> for four tumors. Public coverage policies were identified via web search. Payer policies included those with the largest or second largest number of commercial lives in each state. Policies were classified as 'more restrictive' or 'consistent' with the guidelines. <b>Results:</b> Of 38 plans/policies reviewed, 71% were classified as 'more restrictive' than the guidelines, with variation in the number of commercial lives by state. Among these, 52% restricted on panel size and 63% restricted in all or select tumors. <b>Conclusion:</b> Most coverage policies were more restrictive. Clinical guideline clarity and state policies may improve alignment to guidelines and geographic variations.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 3","pages":"171-180"},"PeriodicalIF":2.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39750516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Association of PON-1 polymorphism with susceptibility to and severity of ischemic stroke in the Chinese population. PON-1多态性与中国人群缺血性卒中易感性和严重程度的关系
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-05-01 Epub Date: 2022-01-31 DOI: 10.2217/pme-2021-0133
Jianmin Huang, Yanfang Yun, Haiyan Chen, Guixin Yang, Yongming Jiang, Yaoxin Pan, Shengshan Yuan, Jianjun Huang, Li Su, Yingning Wu, Dong Lu, Anding Xu, Xuebin Li
{"title":"Association of <i>PON-1</i> polymorphism with susceptibility to and severity of ischemic stroke in the Chinese population.","authors":"Jianmin Huang,&nbsp;Yanfang Yun,&nbsp;Haiyan Chen,&nbsp;Guixin Yang,&nbsp;Yongming Jiang,&nbsp;Yaoxin Pan,&nbsp;Shengshan Yuan,&nbsp;Jianjun Huang,&nbsp;Li Su,&nbsp;Yingning Wu,&nbsp;Dong Lu,&nbsp;Anding Xu,&nbsp;Xuebin Li","doi":"10.2217/pme-2021-0133","DOIUrl":"https://doi.org/10.2217/pme-2021-0133","url":null,"abstract":"<p><p><b>Aim:</b> The authors aimed to investigate whether polymorphisms of <i>PON-1</i> were associated with the susceptibility to and severity of ischemic stroke (IS). <b>Methods:</b> In this study, 302 IS patients and 303 healthy controls were enrolled. Polymorphisms rs854560 and rs854572 of <i>PON-1</i> were detected using SNaPshot single-nucleotide polymorphism typing technology. <b>Results:</b> The rs854572 polymorphism of the <i>PON-1</i> gene showed a significant correlation with IS, and its GG genotype reduced the risk of IS (recessive model, p = 0.001). The GG genotype was also associated with mild stroke (p = 0.032). No association was observed between rs854560 and IS. <b>Conclusion:</b><i>PON-1</i> rs854572 polymorphism was related to the risk of IS and could be a biomarker to access the severity of IS.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 3","pages":"219-228"},"PeriodicalIF":2.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39870835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Blood direct PCR: impact of CYP2C19 and CYP4F2 variants for bleeding prediction in ST-elevation myocardial infarction patients with ticagrelor. 血液直接PCR: CYP2C19和CYP4F2变异对替格瑞洛st段抬高型心肌梗死患者出血预测的影响
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-05-01 Epub Date: 2022-02-17 DOI: 10.2217/pme-2021-0152
Vacis Tatarunas, Ali Aldujeli, Zemyna Kurnickaite, Laurynas Maciulevicius, Marius Burkanas, Jonas Venius, Ieva Ciapiene, Vilius Skipskis, Rita Norvilaite, Agne Giedraitiene, Ramunas Unikas, Giedre Baksyte, Olivija Gustiene, Gintare Sakalyte, Vaiva Lesauskaite
{"title":"Blood direct PCR: impact of <i>CYP2C19</i> and <i>CYP4F2</i> variants for bleeding prediction in ST-elevation myocardial infarction patients with ticagrelor.","authors":"Vacis Tatarunas,&nbsp;Ali Aldujeli,&nbsp;Zemyna Kurnickaite,&nbsp;Laurynas Maciulevicius,&nbsp;Marius Burkanas,&nbsp;Jonas Venius,&nbsp;Ieva Ciapiene,&nbsp;Vilius Skipskis,&nbsp;Rita Norvilaite,&nbsp;Agne Giedraitiene,&nbsp;Ramunas Unikas,&nbsp;Giedre Baksyte,&nbsp;Olivija Gustiene,&nbsp;Gintare Sakalyte,&nbsp;Vaiva Lesauskaite","doi":"10.2217/pme-2021-0152","DOIUrl":"https://doi.org/10.2217/pme-2021-0152","url":null,"abstract":"<p><p><b>Aims:</b> The goals of this study were to develop a new technique that could pave the way for a quicker determination of <i>CYP4F2</i> rs3093135 and <i>CYP2C19</i> rs4244285 variants directly from a patient's blood and to attempt to apply this technique in clinical practice. <b>Patients & methods:</b> The study included 144 consecutive patients admitted with ST elevation myocardial infarction. A blood-direct PCR and real-time PCR were used to detect variants of interest. <b>Results & conclusion:</b> Patients with bleeding events had the <i>CYP2C19</i> GG (*1*1) variant more frequently than patients without bleeding events. The <i>CYP4F2</i> TT variant was more frequently detected in patients with bleeding events 3 months after hospitalization.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 3","pages":"207-217"},"PeriodicalIF":2.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39928624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
SKA3, negatively regulated by miR-128-3p, promotes the progression of non-small-cell lung cancer. 受miR-128-3p负调控的SKA3促进非小细胞肺癌的进展。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-05-01 Epub Date: 2021-09-17 DOI: 10.2217/pme-2020-0095
Linlin Xie, Shaofei Cheng, Zhengyang Fan, Hongyang Sang, Qianping Li, Song Wu
{"title":"<i>SKA3</i>, negatively regulated by <i>miR-128-3p</i>, promotes the progression of non-small-cell lung cancer.","authors":"Linlin Xie,&nbsp;Shaofei Cheng,&nbsp;Zhengyang Fan,&nbsp;Hongyang Sang,&nbsp;Qianping Li,&nbsp;Song Wu","doi":"10.2217/pme-2020-0095","DOIUrl":"https://doi.org/10.2217/pme-2020-0095","url":null,"abstract":"Aim: To investigate the effects of SKA3 on cell proliferation and metastasis in non-small-cell lung cancer (NSCLC) and its underlying mechanism. Methods: Immunohistochemistry was employed to analyze the expression of SKA3 in NSCLC. CCK-8 assay, EdU assay, Transwell assay and flow cytometry analysis were employed to assess cell proliferation, metastatic potential and apoptosis in vitro, respectively. A lung metastasis model was used to evaluate metastasis of NSCLC cells in vivo. A luciferase reporter gene assay was conducted to verify the targeting relationship. Results: SKA3 exhibited high expression in NSCLC tissues and cells. Overexpression of SKA3 remarkably accelerated cell proliferation and metastasis and suppressed apoptosis of NSCLC cells and promoted lung metastasis in a mouse model. miR-128-3p repressed SKA3 expression by targeting it. Conclusion: miR-128-3p inhibited the progression of NSCLC through targeting SKA3.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"19 3","pages":"193-205"},"PeriodicalIF":2.3,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39425147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A precision medicine approach to stress testing using metabolomics and microribonucleic acids. 一种使用代谢组学和微小核糖核酸进行压力测试的精确医学方法。
IF 2.3 4区 医学
Personalized medicine Pub Date : 2022-04-25 DOI: 10.2217/pme-2021-0021
A. Limkakeng, L. Rowlette, A. Hatch, A. Nixon, O. Ilkayeva, D. Corcoran, J. Modliszewski, S. M. Griffin, G. Ginsburg, D. Voora
{"title":"A precision medicine approach to stress testing using metabolomics and microribonucleic acids.","authors":"A. Limkakeng, L. Rowlette, A. Hatch, A. Nixon, O. Ilkayeva, D. Corcoran, J. Modliszewski, S. M. Griffin, G. Ginsburg, D. Voora","doi":"10.2217/pme-2021-0021","DOIUrl":"https://doi.org/10.2217/pme-2021-0021","url":null,"abstract":"Both transcriptomics and metabolomics hold promise for identifying acute coronary syndrome (ACS) but they have not been used in combination, nor have dynamic changes in levels been assessed as a diagnostic tool. We assessed integrated analysis of peripheral blood miRNA and metabolite analytes to distinguish patients with myocardial ischemia on cardiac stress testing. We isolated and quantified miRNA and metabolites before and after stress testing from seven patients with myocardial ischemia and 1:1 matched controls. The combined miRNA and metabolomic data were analyzed jointly in a supervised, dimension-reducing discriminant analysis. We implemented a baseline model (T0) and a stress-delta model. This novel integrative analysis of the baseline levels of metabolites and miRNA expression showed modest performance for distinguishing cases from controls. The stress-delta model showed worse performance. This pilot study shows potential for an integrated precision medicine approach to cardiac stress testing.","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45780431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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